糖尿病和糖尿病视网膜病变相关的自然发病啮齿动物模型(英文)

糖尿病是一种复杂的异质性疾病,目前世界各地有超过一亿人感染此病,造成极其严重社会和经济问题。自然发病的糖尿病啮齿动物模型对于糖尿病发病机制,糖尿病并发症和增加糖尿病危险性的遗传或环境影响等的研究有着无可比拟的重要作用。我们综述了与糖尿病视网膜病变相关的自然发病啮齿动物模型的发生发展和其特性特点。

Effect analysis of friction and damping on anti-backlash gear based on dynamics model with time-varying mesh stiffness

A nonlinear model of anti-backlash gear with time-varying friction and mesh stiffness was proposed for the further study on dynamic characteristics of anti-backlash gear. In order to improve the model precision, applied force analysis was completed in detail, and single or double tooth meshing states of two gear pairs at any timing were determined according to the meshing characteristic of anti-backlash gear. The influences of friction and variations of damping ratio on dynamic transmission error were analyzed finally by numerical calculation and the results show that anti-backlash gear can increase the composite mesh stiffness comparing with the mesh stiffness of the normal gear pair. At the pitch points where the frictions change their signs, additional impulsive effects are observed. The width of impulsive in the same value of center frequency is wider than that without friction, and the amplitude is lower. When gear pairs mesh in and out, damping can reduce the vibration and impact.

Mathematical model of slotting manufacture and simulation for cosine gears

A slotting method for cosine gears was proposed by using the involute cutter based on the conjugate theories of digital surface and gear meshing. The slotting model between the cosine tooth surface represented by discrete points and the cutter figuration determined by analytic function was built for their geometrical relationship and conjugate motion during the machining process. Conjugate points in the cutter section corresponding to the discrete points on the cosine gear tooth surface and the conjugate movements were solved. By using the flexible control of the CNC procedure, the active control of the cutting trace of the slotting cutter was accomplished and the envelop forming of the cosine gear was obtained. Based on the software C++ and Matlab, the computer aided manufacturing(CAM) system of the cosine gear was developed, and the simulation of the slotting process was accomplished. Several examples were provided to illustrate the approach. The result of the simulation demonstrates that the proposed slotting method is feasible.

Modelling and Vibration of Gear Drive Systems Influenced by Real Face Width

Gear drives are one of the most common parts in many rotating machinery. If the gear drive runs under lower torque load, nonlinear effects like gear mesh interruption can occur and vibration is accompanied by impact motions of the gears, This paper presents an original method of the mathematical modelling of gear drive nonlinear vibrations by using the modal synthesis method with degrees of freedom number reduction. The model respects nonlinearities caused by gear mesh interruption, parametric gearing excitation caused by time-varying meshing stiffness and nonlinear contact forces acting between journals of the rolling-element bearings and the outer housing. The nonlinear model is then used for investigation of gear drive vibration, especially for constant gear mesh determination. The theoretical method is applied for investigating of test gear drive nonlinear vibration.

Determinants of uterine aging:lessons from rodent models

The uterus is an indispensable organ for the development of a new life in eutherian mammals.The female mammalian reproductive capacity diminishes with age.In this respect,the senescence of uterine endometrium is convinced to contribute to this failure.This review focuses on the physiological function of the uterus and the related influence of aging mainly in rodent models.A better understanding of the underlying mechanisms governing the process of uterine aging is hoped to generate new strategies to prolong the reproductive lifespan in humans.

Changes in metabotropic glutamate receptor 4 expression and the effects of L-2-amino-4-phosphonobutyrate in a rodent model of diffuse brain injury

Objective: To examine the changes in the express ion of mGluR4 after diffuse brain injury (DBI) and to determine the role of its specific agonist L-2-amino-4-phosphonobutyrate (L-AP4) in vivo. Methods: A total of 161 male SD rats were randomized into the f ollowing groups. Group A included normal control,sham-operated control and DBI group. DBI was produced according to Marmarous diffuse head injury model. mRN A expression of mGluR4 was detected by hybridization in situ. Group B included D BI alone,DBI treated with normal saline and DBI treated with L-AP4. All DBI ra ts were trained in a series of performance tests,following which they were subj ected to DBI. At 1 and 12 hours,animals were injected intraventricularly with L -AP4 ( 100 mmol/L ,10 μl) or normal saline. Motor and cognitive performance s were tested at 1,3,7,14 days after injury and the damaged neurons were also detected. Results: There was no significant difference between normal con trol group and sham-operated group in the expression of mGluR4 ( P > 0.05 ) . The animals exposed to DBI showed significantly increased expression of mRNA o f mGluR4 compared with the sham-operated animals 1 h after injury ( P < 0.05 ). At 6 hours,the evolution of neuronal expression of mGluR4 in the trauma al one group was relatively static. Compared with saline-treated control animals,rats treated with L-AP4 showed an effective result of decreased number of damag ed neurons and better motor and cognitive performances.Conclusions: Increased expression of mGluR4 is important in the pathophysiological process of DBI and its specific agonist L-AP4 can provide r emarkable neuroprotection against DBI not only at the histopathological level bu t also in the motor and cognitive performance.

Mesh stiffness evaluation of an internal spur gear pair with tooth profile shift

Tooth profile shift will change the thickness of gear teeth and a part of geometrical parameters of a gear pair, thus influencing its mesh stiffness and consequently the dynamic performances. In this paper, an analytical mesh stiffness calculation model for an internal gear pair in mesh considering the tooth profile shift is developed based on the potential energy principle. Geometrical representations of the tooth profile shift are firstly derived, and then fitted into the analytical tooth stiffness model of gears. This model could supply a convenient way for mesh stiffness calculation of profile shifted spur gears. Then, simulation studies are conducted based on the developed model to demonstrate the effects of tooth profile shift coefficient on the tooth compliances and the mesh stiffness of the internal spur gear pair. The results show that tooth profile shift has an obvious influence on the mean value, amplitude variation and phase of the mesh stiffness, from which it can be predicted that the dynamic response of an internal gear transmission system will be affected by the tooth profile shift.