可疑片剂中新型喹酮类物质的鉴定

通过气相色谱–质谱法(gas chromatography-mass spectrometry, GC-MS)发现一种可疑新型喹酮类物质,进一步利用超高效液相色谱–四极杆飞行时间质谱(ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry, UPLC-QTOF-MS)对甲喹酮、依他喹酮和未知化合物进行结构解析,最后采用核磁共振(nuclear magnetic resonance, NMR)进行验证,建立对可疑片剂中未知喹酮类物质的定性分析。对甲喹酮、依他喹酮和疑似喹酮类物质的UPLC-QTOF-MS谱图进行解析后,预测疑似喹酮类物质的结构式可能为2-甲基-3-(2-甲氧苯基)-4-(3H)-喹唑酮[2-methyl-3-(2-methoxyphenyl)-4(3H)-quinazolinone],NMR分析结果验证了该结构式,建议新喹酮类物质应命名为甲氧喹酮。

甲喹酮中毒的研究进展

甲喹酮又名安眠酮,是一种镇静剂,主要作用于大脑皮层的GABA受体,属于中枢神经系统抑制剂,多为白色结晶粉末,无臭味苦,几乎不溶于水;药物副作用较多,如头昏嗜睡、皮疹、口、舌、四肢发麻及短暂的精神失常,个别患者可有心悸、恶心、呕吐、全身无力和肾脏衰竭等,严重者会引起呼吸功能抑制导致死亡。目前甲喹酮中毒致死的相关报道较少,笔者通过对甲喹酮及其中毒情况、吸收以及检测方法进行综述,希望能帮助读者对此药有一个进一步的了解。

Studies on the Anti-lipid Peroxidative Actions of the Methanolic Extract of the Root of Aegle marmelos and Its Constituents In Vivo and In Vitro

The inhibitory effect of the methanolic extract of the root of Aegle marmelos (MERA) and its constituents on the lipid peroxidation in vivo and in vitro were studied. The results suggested that MERA increased the activities of superoxide dismutase (SOD) and GSH-peroxidase in the liver cytosol of mice, but showed no significant effect on the activity of catalase, and one of its major constituents, 4-methoxy-1-methyl-2-quinolone (MMQ) increased the activity of SOD in liver tissue of mice intoxicated with FeCl2-ascorbic acid (AA)-ADP in vivo. Various constituents isolated from the root of title plant inhibited the lipid peroxidation in rat liver homogenate, which was in vitro induced by FeCl2-ascorbic acid, CCl4-NADPH, or ADP- NADPH. Of the test compounds, MMQ and its derivatives integriquinolone were similar to (-tocopherol in inhibiting MDA production in rat liver microsomes induced by Fe2+-ascorbate, CCl4-NADPH, or ADP-NADPH.

口服氯硝西泮治疗失眠27例

氯硝西泮是苯并二氮杂(艹卓)类衍生物,有抗惊厥和镇静的作用,本文用氯硝西泮与甲喹酮对46例失眠病人进行了对照研究,氯硝西泮组有效率达81％,其效果优于甲喹酮,在服用过程中,未见明显副反应。结果表明:氯硝西泮是一种有效的安眠镇静药。

药品过期还有效吗

很多人对待药品就像对待食品一样,过期不久就随手扔掉了,但美国加州大学旧金山分校、欧文分校及其他机构的一些研究人员在美国《内科学文献》网络版上发表的研究结果显示,很多药品过了标注的有效期几十年后依然有效。研究人员对在药库中存放了很多年、以为早已变质的8种药品进行了检测。这些药品已经超过标注有效期28~40年。研究人员把这些片状和胶囊药品溶解后利用质谱仪进行了化学分析。