嘧啶环衍生物及其金属配合物的合成研究

采用双亲电基团方法进行嘧啶环衍生物及其金属配合物合成,在碱催化下发生加成反应,结合新型四炔模块与咔唑类衍生物进行多元杂环化合处理,提高金属配合物的稳定性和惰性,将在有机发光材料制备中具有较好的应用价值。本文首先对嘧啶环衍生物及其金属配合物的合成及分子结构进行分析,采用化学实验方法进行材料制备和特性分析。研究表明,该合成方法得到的嘧啶环衍生物及其金属配合物具有较好的稳定性和惰性,展现了较好的应用性。

嘧啶环衍生物合成镁配合物化学分析研究

配合物是化合物中比较大的一个类别。在日常生活、工业生产及生命科学中被广泛应用。尤其是近年来发展比较迅速,它与有机化合物、有机金属化合物、原子簇化学、配位催化及分子生物都有很重要的关联。本文着重讨论嘧啶环衍生物合成镁配合物的化学分析与研究。利用金属镁是无毒的,嘧啶环衍生物是简单易得的配体,合成高效环保的催化剂并对其性质进行系统研究,对这种稳定结构的镁配合物应用进行了展望。

Synthesis and Mollucicidal Activity of Some New Bicyclic and Polycyclic Pyrimidine Derivatives

Hydrazinolysis ofethylthiopyrimidine derivative 2 gave 2-hydrazinopyrimidine 3 which used as a convenient precursor for the synthesis of pyrazolylpyrimidines, hydrazones and pyrimidotriazines. Also, treatment of 2 with ethyl chloroacetate yielded N^-carbethoxymethyl-2-ethylthio-pyrimidine 15, which on reaction with ethyl carbazate and hydrazine hydrate afforded pyrimidotriazine and imidazopyrimidine, respectively. Chlorination of 2 using phosphorous oxycbloride yielded 4-chloropyrimidine 18, which reacted with some heterocyclic compounds having vicinal amino cyano groups to give some new polynuclear heterocyclic system. Also, the effect of some active methylene compounds on 18 was also studied. Some of the newly synthesized compounds were tested as mollucicidal agents against Biomphlaria alexandrina snails that caused intestinal bilharzias, the national problem in Egypt.