乙烯二噻烯对新西兰兔胆固醇、甘油三酯的影响

目的考察乙烯二噻烯抗家兔实验性高胆固醇及高甘油三酯的影响。方法将30只雄性健康新西兰兔按照生化指标随机分为5组(n=6),模型对照组及受试物组给予高脂饲料;空白对照组给予基础饲料,受试物组高、低剂量组同时分别灌胃给予30、10 mg/kg乙烯二噻烯西黄芪胶溶液,阳性对照组给予相同体积的辛伐他汀5 mg/kg西黄芪胶溶液,空白组、模型组对照组给予相同体积的20%西黄芪胶溶液。实验结束考察动物的胆固醇、甘油三酯变化情况。结果 9周后受试物低剂量组血清总胆固醇(TC)水平组显著低于模型组(P<0.05);受试物低、高剂量甘油三酯(TG)水平显著低于模型组(P<0.01);低密度脂蛋白胆固醇(LDL-C)水平均显著高于空白对照组(P<0.001),低于模型组(P<0.05),高密度脂蛋白胆固醇(HDL-C)水平显著高于模型组(P<0.05)。结论乙烯二噻烯高、低剂量组均可降低实验动物的胆固醇、甘油三酯。

噻烯衍生物的水相合成

探讨了无气味和稳定的1-[1,2-亚乙基(或1,3-亚丙基)二硫]亚甲基丙酮(1c)作为代硫醇试剂的水相噻烯合成反应。在4-十二烷基苯磺酸(DBSA)-水体系和回流条件下,1c与α-溴代酮/安息香(2)能有效地进行缩合反应,合成噻烯衍生物(3)。反应过程中没有闻到硫醇的恶臭气味。

基于二芳炔硫醚的2,6-二芳基-1,4-二噻烯的合成

描述了一种基于二芳炔硫醚（Ar—C—C—S—C；C—Ar）底物合成2,6-二芳基-1，4-二噻烯的方法．将二芳炔硫醚和Na2S·9H2O在C2HsOH／C2H5ONa体系中回流反应，以80％~96％的产率合成了一系列2,6-二芳基-1，4-二噻烯化合物．该方法反应条件温和、产率高并且表现出很好的选择性．反应机理涉及硫负离子对底物分子的两个C=C键的选择性亲核加成，即硫负离子（包括S2和中间体B硫负离子）总是选择性地加到芳基一侧的炔碳上形成1，4-二噻烯．对化合物1a进行了X线晶体结构解析．分子中的六元杂环呈“船式”构型．C（1）-C（2）和C（1A）-C（2A）具有典型的双键性质，S（1）-C（2）和S（2）-C（1）的键长数则比一般C—S单键稍短，显示硫原子上的孤对电子与C（1）=C（2）双键上的π电子存在一定程度的共轭作用．1a的晶体学参数：属正交晶系，Pnma空间群，0=10．1330（11）A°，b=27．318（3）A，c=5．5402（6）A°，a=90．00°，β=90．00°，γ=90．00°，V=1533．6（3）A°，Z=4，ρcalcd=1．422g／cm^3．最终偏离因子R=0．038，RW=0．102。

45%烯·苯·噻FS种子包衣防治小麦病虫害效果试验

于2017-2018年开展了45%烯·苯·噻FS包衣处理对小麦蚜虫、纹枯病等病虫害的防治效果试验,结果表明,45%烯·苯·噻FS小麦包衣处理后,能促进小麦分蘖,小麦长势较好,且出苗安全;45%烯·苯·噻FS小麦包衣处理对小麦纹枯病、蚜虫具有较好的防治效果,增产效果明显。生产中,建议45%烯·苯·噻FS小麦包衣用量为5~6mL/kg种子。

Synthesis of 1-(5-nitro-3-benzopseudothiazolyl)-3-(4-phenylazophenyl)-triazene and Its Color Reaction with Cobalt

A new chromogenic reagent, 1 -（5 - nitro- 3 - benzopsendothiazde）- 3 -（4 - phenylazophenyl） - triazene （NBPTPAPT） has been synthesized and used as a sensitive reagent for the spectrophotometric determination of cobalt. In the presence of Tween - 80, the reagent with Co （ Ⅱ ） forms a yellow complex （1 ： 2） in the buffer solution of Na2B4O7 - NaOH at pH 10.54. The apparent molar absorptivity is 1.220× 10^5 L· mol^- 1· cm^- 1 with the linear range of 0 - 240μg/ L for Co （Ⅱ） by dual-wavelength spectrophotometry. Trace cobalt in vitamin B12 and tea samples has been determined with satisfactory results.

SYNTHESIS OF A NOVEL CHELATING RESIN WITH HETEROCYCLIC RING OF S AND N

By the reaction of poly(bromoacetyl styrene) (EBPS) with thiaurea (TU), a kind of novel chelating resin with heterocyaclic ring of sulfur and nitrogen, poly[4-(2-amino)thiazoleyl-4- vinylbenzene], was synthesized. Its structure was characterized by FTIR and elemental analysis. The factors which have influence on the reaction such as reaction time, solvents, and molar ratio of reactants were investigated.

Superparamagnetic Supported Catalyst H_3PW_(12)O_40/γ-Fe_2O_3 for Alkylation of Thiophene with Olefine

The alkylation of sulfur compounds with olefine is considered to be an attractive way to attain high level of sulfur removal by raising the boiling point of sulfur-containing compounds to ease their separation from lighl fractions by distillation. A series of superparamagnetic supported catalysts, used for alkylation of thiophene with 1-octene, were prepared by loading H3PW12040 （HPW） onto commercially available nanoparticles γ-Fe2O3 through incipient wet impregnation method. The catalysts were characterized by X-ray diffraction （XRD）, Fourier transform infra-red （FT-IR）, thermo gravimetric analysis （TG）, N2-adsorption and vibrating sample magnetometer （VSM）. The physicochemical characterization reveals that 7-Fe203 could be accommodated to immobilize and disperse HPW. Moreover, possessing high magnetization of 26.1 A.mZ.kg-1 and with mesoporous structure with specific surface area of 35.9 m2·g^-1, the 40% （by mass） HPW loading catalyst is considered the proper catalyst for olefinic alkylation of thiophenic sulfur （OATS） and can be separated in an external magnetic field. The catalytic activity was investigated in the alkylation reaction of thiophene with 1-octene, and the conversion of thiophene is up to 46% at 160 ℃ in 3 h. The 40% （by mass） H3PW12O40/γ-Fe2O3 catalyst can be reused 6 times without too much loss of activit and keeps its property of superparamagnetism.

Large open-circuit voltage polymer solar cells by poly(3-hexylthiophene) with multi-adducts fullerenes

Polymer solar cells (PSCs) made by poly(3-hexylthiophene) (P3HT) with multi-adducts fullerenes, [6,6]-phenyl-C61-butyric acid methyl ester (PC61BM), PC61BM-bisadduct (bisPC61BM) and PC61BM-trisadduct (trisPC61BM), were reported. Electrochemistry studies indicated that PC61BM, bisPC61BM and trisPC61BM had step-up distributional lowest unoccupied molecular orbital (LUMO) energy. PSCs made by P3HT with above PC61BMs show a trend of enlarged open-circuit voltages, which is in good agreement with the energy difference between the LUMO of PC61BMs and the HOMO of P3HT. On the contrary, reduced short-circuit currents (Jsc) were observed. The investigation of photo responsibility, dynamics analysis based on photo-induced absorption of composite films, P3HT:PC61BMs and n-channel thin film field-effect transistors of PC61BMs suggested that the short polaron lifetimes and low carrier mobilities were response for reduced Jsc. All these results demonstrated that it was important to develop an electron acceptor which has both high carrier mobility, and good compatibility with the electron donor conjugated polymer for approaching high performance PSCs.

A-D-A-type small molecular acceptor with one hexyl-substituted thiophene as π bridge for fullerene-free organic solar cells

An A-D-A-type small molecule, DCF-2HT, was synthesized using fluorene as the central block and 2- （2,3-dihydro-3-oxo- 1H-inden- 1-ylidene）propanedinitrile as the end groups, with one hexyl-substituted thiophene as a n bridge, for use as an acceptor material in organic solar cells. Devices based on DCF-2HT and the polymer donors PBDB-T or PTB7-Th were fabricated and optimized. Power conversion efficiencies of 5.71% and 4.83% were obtained for PBDB-T： DCF-2HT- and PTB7-Th： DCF-2HT-based devices, respectively.

Enhancing the performance of poly(3-hexylthiophene)/ZnO nanorod arrays based hybrid solar cells through incorporation of a third component

Sparse ZnO nanorod arrays(NRAs)are fabricated on transparent conducting oxide coated glass substrates by using a modified liquid phase epitaxial growth method.By adjusting the polymer concentrations and the spin-coating parameters,full infiltration of poly(3-hexylthiophene)(P3HT)into the as-prepared ZnO NRAs is achieved at 130°C in vacuum.A third component is incorporated into the P3HT/ZnO NRAs ordered bulk heterojunctions(BHJs)either through ZnO surface modification with N719dye or CdS shell layer or by inclusion of a fullerene derivative into the P3HT matrix.Experimental results indicate that performances of the hybrid solar cells are improved greatly with the incorporation of a third component.However,the working principles of these third components differ from one another,according to morphology,structure,optical property,charge transfer and interfacial properties of the composite structures.An ideal device architecture for hybrid solar cells based on P3HT/ZnO NRAs ordered BHJs is proposed,which can be used as a guidance to further increase the power conversion efficiency of such solar cells.

Influence of the replacement of alkoxyl with alkylthienyl on photovoltaic properties of two small molecule donors for organic solar cells

Two benzo[1,2-b:4,5-b￠]dithiophene(BDT)-based small molecule(SM) donor materials with identical conjugated backbones but different substitution groups, named as DRTB-O and DRTB-T, were well explored to demonstrate the influence of the replacement of alkoxy with alkylthienyl on their photovoltaic properties in fullerene-based and fullerene-free organic solar cells(OSCs). The study shows that the two SM donors possess similar absorption spectra and energy levels but different crystalline structures in solid films. The carrier transport property and phase separation morphologies of the blend films have also been fully investigated.By employing PC71 BM as the acceptor, the power conversion efficiency(PCE) of DRTB-O:PC71BM and DRTB-T:PC71BM based devices were 4.91% and 7.08%, respectively. However, by blending with IDIC, the two SM donors exhibited distinctly different photovoltaic properties in fullerene-free OSCs, and the PCE of DRTB-O:IDIC and DRTB-T:IDIC based devices were 0.15% and9.06%, respectively. These results indicate that the replacement of alkoxyl with alkylthienyl in designing SM donor materials plays an important role in the application of fullerene-free OSCs.

Alkoxy substituted benzodithiophene-alt-fluorobenzotriazole copolymer as donor in non-fullerene polymer solar cells

A new benzodithiophene （BDT）-alt-fluorobenzotriazole （FBTA） D-A copolymer J40 was designed and synthesized by introducing 2-octyldodecyloxy side chains on its BDT units, for expanding the family of the BDT- alt-FBTA-based copolymers and investigating the side chain effect on the photovoltaic performance of the polymer in non-fullerene polymer solar cells （PSCs）. J40 exhibits complementary absorption spectra and matched electronic energy levels with the n-type organic semiconductor （n-OS） （3,9-bis（2-methylene-（3-（1,1-dicyanomethylene）-indanone））-5,5,11,11-tetrakis（4-hexylphenyl）-dithieno[2,3-d：2＇,3＇-d＇]-s- indaceno[1,2-b：5,6-b＇]dithiophene） （ITIC） acceptor, and was used as polymer donor in the non-fullerene PSCs with ITIC as acceptor. The power conversion efficiency （PCE） of the PSCs based on J40：ITIC （1：1, w/w） with thermal annealing at 120 ~C for l0 min reached 6.48% with a higher open-circuit voltage （Voc） of 0.89 V. The high Voc of the PSCs is benefitted from the lower-lying highest occupied molecular orbital （HOMO） energy level of J40. Although the photovoltaic performance of the polymer J40 with alkoxy side chain is lower than that of J60 and J61 with alkylthio-thienyl conjugated side chains, the PCE of 6.48% for the J40-based device is still a relatively higher photovoltaic efficiency in the non-fullerene PSCs reported so far. The results indicate that the family of the BDT-alt-FBTA-based D-A copolymers are high performance polymer donor materials for non-fullerene PSCs and the side chain engineering plays an important role in the design of high performance polymer donors in the non-fullerene PSCs.

Synthetic promoters consisting of defined cis-acting elements link multiple signaling pathways to probenazole-inducible system

Probenazole （3-allyloxy-l,2-benzisothiazole-1,1-dioxide, PBZ）, the active component of Oryzemate, could induce systemic acquired resistance （SAR） in plants through the induction of salicylic acid （SA） biosynthesis. As a widely used chemical inducer, PBZ is a good prospect for establishing a new chemical-inducible system. We first designed artificially synthetic promoters with tandem copies of a single type of cis-element （SARE, JERE, GCC, GST1, HSRE, and W-box） that could mediate the expression of the tS-glucuronidase （GUS） reporter gene in plants upon PBZ treatment. Then we combined different types of elements in order to improve inducibility in the PBZ-inducible system. On the other hand, we were surprised to find that the cis-elements, which are responsive to jasmonic acid （JA） and ethylene, also responded to PBZ, implying that SA, JA, and ethylene pathways also would play important roles in PBZ＇s action. Further analysis demonstrated that PBZ also induced early events of innate immunity via a signaling pathway in which Ca2＋ influx and mitogen-activated protein kinase （MAPK） activity were involved. We constructed synthesized artificial promoters to establish a PBZ chemical-inducible system, and preliminarily explored SA, JA, ethylene, calcium, and MAPK signaling pathways via PBZ-inducible system, which could provide an insight for in-depth study.