单一神经囊泡的电分析化学研究

近年来,神经活动过程中化学递质的储存、释放和作用规律成为研究热点。神经囊泡作为执行化学递质储存和释放的主要亚细胞器,一直备受关注。与常见的囊泡分析技术相比,电分析化学方法由于具有较高的时间分辨率和灵敏度,特别是微纳米电极的使用,使电分析化学在单一神经囊泡的分析方面显示出独特的优势。近年来,单囊泡电化学计数法和阻抗脉冲法在单囊泡分析方面的研究进展迅速。单囊泡电化学计数法基于电场作用下囊泡膜在电极表面破裂,可实现单一囊泡内储存神经递质的定量分析。阻抗脉冲法可通过测定囊泡通过微纳米孔时引起的离子电流信号的变化,研究囊泡的尺寸、表面电荷、浓度及柔韧性等参数或特性。本文以单一神经囊泡分析为切入点,介绍了近年来单囊泡电化学计数法与阻抗脉冲法在单一囊泡分析领域的重要进展,展望了这两种方法在神经化学和生物医学等领域的应用前景。

中空聚合物微粒的研究进展

介绍了目前国内外在空心核壳结构聚合物粒子的制备及应用方面的研究现状,并简要地对中空聚合物微球的发展前景进行了展望。

中空聚合物微球的制备及其在涂料中的应用

近年来,中空聚合物微球由于其独特的结构特点,表现出普通材料不具备的性能,引起研究者广泛的兴趣。阐述了当前合成中空聚合物微球的研究现状,并展望了中空聚合物微球在涂料中的应用前景。

支撑磷脂双层膜的研究进展

支撑磷脂双层膜(supported phospholipid bilayers,SPBs)是细胞膜研究中普及的模型,是固定生物活性物质的理想材料,不仅可以保持生物分子的活性,还能有效抑制其他生物分子的非特异性吸附,在跨膜蛋白、仿生膜、水处理、生物医学和生物传感器等研究领域具有广泛的应用前景。本文介绍了支撑磷脂双层膜的表征方法和制备方法,包括Langmuir Blodgett(LB)膜提拉法、囊泡融合法和LB膜提拉法与囊泡融合联合法;详细阐述了囊泡融合法制备SPBs的机理;综述了囊泡融合法制备SPBs的影响因素,包括囊泡浓度、缓冲溶液、温度、囊泡和基底表面电荷等因素;列举了支撑磷脂膜的应用,并展望了支撑磷脂双层膜的研究趋势。

Preparation and stability studies of dimethyl curcumin niosomes

In the present work, we aimed to optimize the preparation technology of dimethyl curcumin niosomes, improve its solubility and assess its stability. The novel anti-androgen dimethyl curcumin niosomes were prepared by thin-film dispersion-ultrasonic method, and the prescription composition and preparation process were optimized by single-factor investigation method. Certainly, the solubility and quality evaluation of dimethyl curcumin niosomes were also investigated. The average particle size of prepared dimethyl curcumin niosomes was （310.3＋0.9） nm. The highest encapsulation rate was 88.1%± 1.7%, and the drug-loading amount was 4.03%±1.05%. Moreover, the leakage rate was below 2% within 45 d. Collectively, all these findings indicated that the niosomes, as a vector, could significantly improve the solubility and stability of dimethyl curcumin, offering a theoretical basis for dimethyl curcumin as an anticancer drug in medicine application.