The world is marching into a new development period when the digital technology,physical technology,and biological technology have achieved an unprecedented development respectively in their own fields,and at the same...The world is marching into a new development period when the digital technology,physical technology,and biological technology have achieved an unprecedented development respectively in their own fields,and at the same time their applications are converging greatly.These are the three major technological drivers for the Fourth Industrial Revolution.This paper discusses the specific technology niches of each kind technological driver behind the Fourth Industrial Revolution,and then evaluates impacts of the Fourth Industrial Revolution on global industrial,economic,and social development.At last this paper proposes possible measures and policies for both firms and governments to cope with the changes brought by the Fourth Industrial Revolution.展开更多
MNS16A, a variable number of tandem repeats polymorphism in the TERT gene, has been suggested to regulate telomerase activity. As telomerase activity has been reported to be related to life-span, we hypothesized that ...MNS16A, a variable number of tandem repeats polymorphism in the TERT gene, has been suggested to regulate telomerase activity. As telomerase activity has been reported to be related to life-span, we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere. To test this hypothesis, we collected 446 unrelated pericentenarian individuals （age）90, mean 94.45±3.45 years） and 332 normal controls （age 22-53, mean 35.0±12.0 years） from Dujiangyan, Sichuan, China. We typed the MNS16A polymorphism in both groups, and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test. There was no significant difference between the peri-centenarian and control groups. Thus, the MNS16A polymorphism in TERT might not influence human life-span, at least in the Hart Chinese population studied here.展开更多
Nucleocapsid(N) protein plays crucial roles in the life cycle of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), including the formation of ribonucleoprotein(RNP) complex with the viral RNA.Here we report...Nucleocapsid(N) protein plays crucial roles in the life cycle of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), including the formation of ribonucleoprotein(RNP) complex with the viral RNA.Here we reported the crystal structures of the N-terminal domain(NTD) and C-terminal domain(CTD) of the N protein and an NTD-RNA complex. Our structures reveal a unique tetramer organization of NTD and identify a distinct RNA binding mode in the NTD-RNA complex, which could contribute to the formation of the RNP complex. We also screened small molecule inhibitors of N-NTD and N-CTD and discovered that ceftriaxone sodium, an antibiotic, can block the binding of RNA to NTD and inhibit the formation of the RNP complex. These results together could facilitate the further research of antiviral drug design targeting N protein.展开更多
基金Under the auspices of National Natural Science Foundation of China(No.41671120,41401125)
文摘The world is marching into a new development period when the digital technology,physical technology,and biological technology have achieved an unprecedented development respectively in their own fields,and at the same time their applications are converging greatly.These are the three major technological drivers for the Fourth Industrial Revolution.This paper discusses the specific technology niches of each kind technological driver behind the Fourth Industrial Revolution,and then evaluates impacts of the Fourth Industrial Revolution on global industrial,economic,and social development.At last this paper proposes possible measures and policies for both firms and governments to cope with the changes brought by the Fourth Industrial Revolution.
基金supported by the National Basic Research Program of China(2013CB530802)Yunnan Province(2011FA024)+1 种基金the National Natural Science Foundation of China(31100909)the Chinese Academy of Sciences
文摘MNS16A, a variable number of tandem repeats polymorphism in the TERT gene, has been suggested to regulate telomerase activity. As telomerase activity has been reported to be related to life-span, we hypothesized that this polymorphism might affect human longevity by controlling the length of the telomere. To test this hypothesis, we collected 446 unrelated pericentenarian individuals （age）90, mean 94.45±3.45 years） and 332 normal controls （age 22-53, mean 35.0±12.0 years） from Dujiangyan, Sichuan, China. We typed the MNS16A polymorphism in both groups, and compared the allele and genotype frequencies between the peri-centenarian and control groups using the chi-squared test. There was no significant difference between the peri-centenarian and control groups. Thus, the MNS16A polymorphism in TERT might not influence human life-span, at least in the Hart Chinese population studied here.
基金supported by Beijing Natural Science Foundation(M21016)Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences (2021-I2M-1-003 and 2021-CAMS-JZ004)+1 种基金Tsinghua-Peking Center for Life Sciences (045-61020100122)Beijing Advanced Innovation Center for Structural Biology
文摘Nucleocapsid(N) protein plays crucial roles in the life cycle of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), including the formation of ribonucleoprotein(RNP) complex with the viral RNA.Here we reported the crystal structures of the N-terminal domain(NTD) and C-terminal domain(CTD) of the N protein and an NTD-RNA complex. Our structures reveal a unique tetramer organization of NTD and identify a distinct RNA binding mode in the NTD-RNA complex, which could contribute to the formation of the RNP complex. We also screened small molecule inhibitors of N-NTD and N-CTD and discovered that ceftriaxone sodium, an antibiotic, can block the binding of RNA to NTD and inhibit the formation of the RNP complex. These results together could facilitate the further research of antiviral drug design targeting N protein.
