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中医四步疗法治疗慢性乙型肝炎的临床研究
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作者 盖丽丽 《按摩与康复医学》 2012年第24期169-170,共2页
摘要:目的:通过研究和探讨中医四部疗法治疗慢性乙型肝炎的效果,分析其优势和不足,总结经验,以更好地指导慢性乙型肝炎的临床治疗。方法:随机选择我院近3年的70名慢性乙型肝炎患者,平均分成A、B两组,A组为治疗组,采用中医四部... 摘要:目的:通过研究和探讨中医四部疗法治疗慢性乙型肝炎的效果,分析其优势和不足,总结经验,以更好地指导慢性乙型肝炎的临床治疗。方法:随机选择我院近3年的70名慢性乙型肝炎患者,平均分成A、B两组,A组为治疗组,采用中医四部疗法进行治疗;B组为对照组,采用传统的口服拉米夫定进行治疗,将两组治疗后的效果进行对比分析,并加以总结。结果:经过治疗后,A组治疗组患者HBVDNA转阴率、HBeAg转阴率以及HBsAg转阴率明显高于B组对照组患者,有效率高,具有较好的治疗效果。结论:采用中医四部疗法治疗慢性乙型肝炎,患者恢复较快,疗效好,具有较高的临床使用价值和推广价值。 展开更多
关键词 中医四部疗法 慢性乙型肝炎 临床研究
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Treatment of Helicobacter pylori in surgical practice:A randomised trial of triple versus quadruple therapy in a rural district general hospital 被引量:2
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作者 Siok Siong Ching Sivakumaran Sabanathan Lloyd R Jenkinson 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第24期3855-3860,共6页
AIM: To compare a lansoprazole-based triple versus quadruple therapy for Helicobacter pylori (H pylori) eradication with emphasis on side effect prof ile,patient compliance and eradication rate at a rural district gen... AIM: To compare a lansoprazole-based triple versus quadruple therapy for Helicobacter pylori (H pylori) eradication with emphasis on side effect prof ile,patient compliance and eradication rate at a rural district general hospital in Wales,United Kingdom. METHODS: One hundred one patients with H pylori infection were included in the study. Patients were randomised to receive triple therapy comprising of lansoprazole 30 mg,amoxycillin 1 g,clarithromycin 500 mg,all b.d. (LAC),or quadruple therapy comprising of lansoprazole 30 mg b.d.,metronidazole 500 mg t.d.s.,bismuth subcitrate 240 mg b.d.,and tetracycline chloride 500 mg q.d.s. (LMBT). Cure was defi ned as a negative 13C urea breath test 2 mo after treatment. RESULTS: Seven patients were withdrawn after randomisation. Fifty patients were assigned to LAC group and 44 to LMBT group. The intention-to-treat cure rates were 92% and 91%,whereas the per-protocol cure rates were 92% and 97%,respectively. Side effects were common,with 56% experiencingmoderate to severe symptoms in the LAC group and 59% in the LMBT group. Symptoms of vomiting,diarrhoea and black stools were significantly more common in the LMBT group. Patient compliance was 100% for triple therapy and 86% for quadruple therapy (P < 0.01). One-third of patients in both groups were still taking acid-reducing medications at six-month follow-up. CONCLUSION: One-week triple and quadruple therapies have similar intention-to-treat eradication rates. Certain side effects are more common with quadruple therapy,which can compromise patient compliance. Patient education or modifi cations to the regimen are alternative options to improve compliance of the quadruple regimen. 展开更多
关键词 Helicobacter pylori Triple therapy Quadruple therapy Side effects Treatment compliance Eradication rate
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