AIM:To evaluate the diagnosis of chest pain with foregut symptoms in Chinese patients. METHODS:Esophageal manometric studies, 24-h introesophageal pH monitoring and 24-h electrocardiograms(Holter electrocardiography)w...AIM:To evaluate the diagnosis of chest pain with foregut symptoms in Chinese patients. METHODS:Esophageal manometric studies, 24-h introesophageal pH monitoring and 24-h electrocardiograms(Holter electrocardiography)were performed in 61 patients with chest pain. RESULTS:Thirty-nine patients were diagnosed with non-specific esophageal motility disorders(29 patients with abnormal gastroesophageal reflux and eight patients with myocardial ischemia).Five patients had diffuse spasm of the esophagus plus abnormal gastroesophageal reflux(two patients had concomitant myocardial ischemia),and one patient was diagnosed with nutcracker esophagus. CONCLUSION:The esophageal manometric studies, 24-h intra-esophageal pH monitoring and Holter electrocardiography are significant for the differential diagnosis of chest pain,particularly in patients with foregut symptoms.In cases of esophageal motility disorders,pathological gastroesophageal reflux may be a major cause of chest pain with non-specific esophageal motility disorders.Spasm of the esophageal smooth muscle might affect the heart-coronary smooth muscle,leading to myocardial ischemia.展开更多
AIM： To develop and characterize a practical model of Hepatopulmonary syndrome. （HPS） in rats.METHODS： The experimental animals were randomized into five feeding groups： （1） control （fed standard diet）, （2）...AIM： To develop and characterize a practical model of Hepatopulmonary syndrome. （HPS） in rats.METHODS： The experimental animals were randomized into five feeding groups： （1） control （fed standard diet）, （2） control plus intraperitoneal injection with lipopolysaccharide （LPS）, （3） cirrhosis （fed a diet of maize flour, lard, cholesterol, and alcohol plus subcutaneously injection with carbon tetrachloride （CCI4） oil solution）, （4） cirrhosis plus LPS, and （5） cirrhosis plus glycine and LPS. The blood, liver and lung tissues of rats were sampled for analysis and characterization. Technetium 99m-labeled macroaggregated albumin （Tc99m-MAA） was used to test the dilatation of pulmonary microvasculature.RESULTS： Typical cirrhosis and subsequent hepato- pulmonary syndrome was observed in the cirrhosis groups after an 8 wk feeding period. In rats with cirrhosis, there were a decreased PaO2 and PaCO2 in arterial blood, markedly decreased arterial 02 content, a significantly increased alveolar to arterial oxygen gradient, an increased number of bacterial translocated within mesenteric lymph node, a significant higher level of LPS and tumor necrosis factor-α （TNF-α） in plasma, and a significant greater ratio of Tc99m-MAA brain-overlung radioactivity. After LPS administration in rats with cirrhosis, various pathological parameters got worse and pulmonary edema formed. The predisposition of glycine antagonized the effects of LPS and significantly alleviated various pathological alterations.展开更多
Biological, physical and chemical agents, recognized as food safety hazards, cause potential risks in modem food productions. Although the use of antibiotics in intensive animal productions is impossible to avoid the ...Biological, physical and chemical agents, recognized as food safety hazards, cause potential risks in modem food productions. Although the use of antibiotics in intensive animal productions is impossible to avoid the presence and remaining amount of their residues in food, it is possible to reduce them by using the principles of good veterinary, good manufacturing practices, and continuous control of food and risk assessment approach. This study was conducted to determine exposure risk to antibiotic drug residues in pork consumed in the Philippines and aimed to estimate dietary exposure of benzylpenicillin and tetracycline residues by age and gender groups. Dietary modeling, validated method used, combines food consumption data with food chemical concentration data to estimate dietary exposure to food chemicals. The results had shown that the dietary exposure of benzylpenicillin and tetracycline residues for children from 1 to 〈 3 years old had the highest exposure followed by adolescents, adults and infants while males were significantly lower than females （P 〈 0.05）. This is the initial study to determine risk assessment of dietary exposure to antibiotic residue of different population of Filipino groups.展开更多
Objective:To observe the clinical efficacy of Nie-pinching the spine,puncturing Sifeng(EX-UE 10)plus Chinese herbs in treating pediatric anorexia due to dysfunction of spleen in transportation.Methods:A total of 64 ki...Objective:To observe the clinical efficacy of Nie-pinching the spine,puncturing Sifeng(EX-UE 10)plus Chinese herbs in treating pediatric anorexia due to dysfunction of spleen in transportation.Methods:A total of 64 kids were randomized into an observation group and a control group by the random number table method,with 32 cases in each group.Patients in both groups received Jian Pi Kai Wei(strengthening spleen and stomach)powder according to pattern differentiation of traditional Chinese medicine(TCM).In addition,patients in the observation group received Nie-pinching the spine and puncturing Sifeng(EX-UE 10).Nie-pinching the spine was applied twice a week,and puncturing Sifeng(EX-UE 10)was performed once a week,with 2 weeks counted as 1 course of treatment.After 2 courses of treatment,the body mass index(BMI),peripheral blood leptin level and the microelements Zn,Fe and Se were compared at different time points(before treatment,after the first and second courses of treatment),as well as the therapeutic efficacy and onset time.Results:After 2 courses of treatment,31 cases in each group were evaluated.After the 1st course and the 2nd course,the BMI and serum Zn,Fe and Se levels in the observation group increased significantly(all P<0.05),the leptin level decreased substantially(both P<0.05);the BMI in the control group showed a substantial rise(P<0.05),while the Zn,Fe and Se levels slightly increased showing no statistical significance(all P>0.05),and the leptin level decreased but the difference showed no statistical significance(P>0.05).After the 1st and the 2nd courses of treatment,the BMI,serum Zn,Fe and Se levels increased more significantly(all P<0.05),and the serum leptin level decreased more significantly(both P<0.05)in the observation group than in the control group.After the 2nd course,the total effective rate and recovery rate in the observation group were both higher than those in the control group(both P<0.05),together with a quicker onset time(P<0.05).Conclusion:Nie-pinching the spine,puncturing Sifeng(EX-UE 10)plus Chinese herbs is effective for pediatric anorexia due to dysfunction of spleen in transportation.It can decrease leptin,increase Zn,Fe and Se levels,alleviate apositic symptoms and increase BMI in the kids.展开更多
文摘AIM:To evaluate the diagnosis of chest pain with foregut symptoms in Chinese patients. METHODS:Esophageal manometric studies, 24-h introesophageal pH monitoring and 24-h electrocardiograms(Holter electrocardiography)were performed in 61 patients with chest pain. RESULTS:Thirty-nine patients were diagnosed with non-specific esophageal motility disorders(29 patients with abnormal gastroesophageal reflux and eight patients with myocardial ischemia).Five patients had diffuse spasm of the esophagus plus abnormal gastroesophageal reflux(two patients had concomitant myocardial ischemia),and one patient was diagnosed with nutcracker esophagus. CONCLUSION:The esophageal manometric studies, 24-h intra-esophageal pH monitoring and Holter electrocardiography are significant for the differential diagnosis of chest pain,particularly in patients with foregut symptoms.In cases of esophageal motility disorders,pathological gastroesophageal reflux may be a major cause of chest pain with non-specific esophageal motility disorders.Spasm of the esophageal smooth muscle might affect the heart-coronary smooth muscle,leading to myocardial ischemia.
基金awards to University Academic Leaders granted by the Government of Shanxi Province of China to Hui-Ying Zhang and partially by the National Institute of Alcohol Abuse and Alcoholism of United States, grant R01 AA014428 to Cheng Ji
文摘AIM： To develop and characterize a practical model of Hepatopulmonary syndrome. （HPS） in rats.METHODS： The experimental animals were randomized into five feeding groups： （1） control （fed standard diet）, （2） control plus intraperitoneal injection with lipopolysaccharide （LPS）, （3） cirrhosis （fed a diet of maize flour, lard, cholesterol, and alcohol plus subcutaneously injection with carbon tetrachloride （CCI4） oil solution）, （4） cirrhosis plus LPS, and （5） cirrhosis plus glycine and LPS. The blood, liver and lung tissues of rats were sampled for analysis and characterization. Technetium 99m-labeled macroaggregated albumin （Tc99m-MAA） was used to test the dilatation of pulmonary microvasculature.RESULTS： Typical cirrhosis and subsequent hepato- pulmonary syndrome was observed in the cirrhosis groups after an 8 wk feeding period. In rats with cirrhosis, there were a decreased PaO2 and PaCO2 in arterial blood, markedly decreased arterial 02 content, a significantly increased alveolar to arterial oxygen gradient, an increased number of bacterial translocated within mesenteric lymph node, a significant higher level of LPS and tumor necrosis factor-α （TNF-α） in plasma, and a significant greater ratio of Tc99m-MAA brain-overlung radioactivity. After LPS administration in rats with cirrhosis, various pathological parameters got worse and pulmonary edema formed. The predisposition of glycine antagonized the effects of LPS and significantly alleviated various pathological alterations.
文摘Biological, physical and chemical agents, recognized as food safety hazards, cause potential risks in modem food productions. Although the use of antibiotics in intensive animal productions is impossible to avoid the presence and remaining amount of their residues in food, it is possible to reduce them by using the principles of good veterinary, good manufacturing practices, and continuous control of food and risk assessment approach. This study was conducted to determine exposure risk to antibiotic drug residues in pork consumed in the Philippines and aimed to estimate dietary exposure of benzylpenicillin and tetracycline residues by age and gender groups. Dietary modeling, validated method used, combines food consumption data with food chemical concentration data to estimate dietary exposure to food chemicals. The results had shown that the dietary exposure of benzylpenicillin and tetracycline residues for children from 1 to 〈 3 years old had the highest exposure followed by adolescents, adults and infants while males were significantly lower than females （P 〈 0.05）. This is the initial study to determine risk assessment of dietary exposure to antibiotic residue of different population of Filipino groups.
文摘Objective:To observe the clinical efficacy of Nie-pinching the spine,puncturing Sifeng(EX-UE 10)plus Chinese herbs in treating pediatric anorexia due to dysfunction of spleen in transportation.Methods:A total of 64 kids were randomized into an observation group and a control group by the random number table method,with 32 cases in each group.Patients in both groups received Jian Pi Kai Wei(strengthening spleen and stomach)powder according to pattern differentiation of traditional Chinese medicine(TCM).In addition,patients in the observation group received Nie-pinching the spine and puncturing Sifeng(EX-UE 10).Nie-pinching the spine was applied twice a week,and puncturing Sifeng(EX-UE 10)was performed once a week,with 2 weeks counted as 1 course of treatment.After 2 courses of treatment,the body mass index(BMI),peripheral blood leptin level and the microelements Zn,Fe and Se were compared at different time points(before treatment,after the first and second courses of treatment),as well as the therapeutic efficacy and onset time.Results:After 2 courses of treatment,31 cases in each group were evaluated.After the 1st course and the 2nd course,the BMI and serum Zn,Fe and Se levels in the observation group increased significantly(all P<0.05),the leptin level decreased substantially(both P<0.05);the BMI in the control group showed a substantial rise(P<0.05),while the Zn,Fe and Se levels slightly increased showing no statistical significance(all P>0.05),and the leptin level decreased but the difference showed no statistical significance(P>0.05).After the 1st and the 2nd courses of treatment,the BMI,serum Zn,Fe and Se levels increased more significantly(all P<0.05),and the serum leptin level decreased more significantly(both P<0.05)in the observation group than in the control group.After the 2nd course,the total effective rate and recovery rate in the observation group were both higher than those in the control group(both P<0.05),together with a quicker onset time(P<0.05).Conclusion:Nie-pinching the spine,puncturing Sifeng(EX-UE 10)plus Chinese herbs is effective for pediatric anorexia due to dysfunction of spleen in transportation.It can decrease leptin,increase Zn,Fe and Se levels,alleviate apositic symptoms and increase BMI in the kids.
