Metastasis accounts for more than 90% of cancer patients＇ mortality. The metastatic process involves multiple steps [1]. Initially, cancer cells from the primary tumor invade adjacent stroma. To acquire this capacity...Metastasis accounts for more than 90% of cancer patients＇ mortality. The metastatic process involves multiple steps [1]. Initially, cancer cells from the primary tumor invade adjacent stroma. To acquire this capacity, cells undergo a process called epithelial-mesenchymal transition （EMT）, in which cells in response to signals from the surrounding stroma, undergo a switch between cell phenotypes and acquire mesenchymal properties and show reduced intercellular adhesion, allowing cells to become motile.展开更多
文摘Metastasis accounts for more than 90% of cancer patients＇ mortality. The metastatic process involves multiple steps [1]. Initially, cancer cells from the primary tumor invade adjacent stroma. To acquire this capacity, cells undergo a process called epithelial-mesenchymal transition （EMT）, in which cells in response to signals from the surrounding stroma, undergo a switch between cell phenotypes and acquire mesenchymal properties and show reduced intercellular adhesion, allowing cells to become motile.
