Objectives: Oesophageal pH monitoring is a useful test for the diagnosis of gastro-oesophageal reflux disease (GORD) but has some limitations related to the nasopharyngeal electrode. Recently, a telemetric catheter fr...Objectives: Oesophageal pH monitoring is a useful test for the diagnosis of gastro-oesophageal reflux disease (GORD) but has some limitations related to the nasopharyngeal electrode. Recently, a telemetric catheter free system (CFS) (Bra vo; Medtronic) was developed. The aim of this study was to determine the concord ance of data between the conventional pH measurement system (CPHMS) and the CFS Bravo. Methods: Forty patients with symptoms suggestive of GORD underwent 24 hou r oesophageal pH monitoring using the CPHMS with a nasopharyngeal electrode and the Bravo CFS simultaneously. The sensitive tips of both electrodes were positio ned at the same level under fluoroscopy. In addition to automatic analysis, each reflux episode was checked visually and characterised. Results: There was a sig nificant correlation (r=0.87, p < 0.0001) between the 24 hour oesophageal acid e xposures recorded by the CPHMS and the CFS. Twenty four hour oesophageal acid ex posure was significantly lower with the CFS than with the CPHMS (2.4 (0.4-8.7) v 3.6 (0.7-8.6); p < 0.0001). Consequently, with the CFS, the cut off level for the diagnosis of GORD, as calculated from the regression equation, was 2.9%(fo r the 4.2%cut off determined in controls with the CPHMS). After this adjustment , concordance of the diagnosis of GORD was 88%(kappa 0.760). Diagnosis of GORD was established in more patients with the CFS 48 hour results than with the 24 h our results. Conclusions: Despite strong correlations between oesophageal acid e xposure recorded with the two devices, the Bravo CFS significantly under recorde d acid exposure compared with the CPHMS. Provided some correcting factors are us ed, the Bravo CFS can improve the sensitivity of pHmetry for the diagnosis of GO RD by allowing more prolonged recordings.展开更多
基金This work was supported by grant No.9187006-02 of the Major Item of Chinese National Science Foundation,No.1870605 of CNSP and key Item of Chinese Academy of Sciences:"Research on whole Behaviors trial-Solar System in the 22th Cycle of Solar Activity"8
文摘Objectives: Oesophageal pH monitoring is a useful test for the diagnosis of gastro-oesophageal reflux disease (GORD) but has some limitations related to the nasopharyngeal electrode. Recently, a telemetric catheter free system (CFS) (Bra vo; Medtronic) was developed. The aim of this study was to determine the concord ance of data between the conventional pH measurement system (CPHMS) and the CFS Bravo. Methods: Forty patients with symptoms suggestive of GORD underwent 24 hou r oesophageal pH monitoring using the CPHMS with a nasopharyngeal electrode and the Bravo CFS simultaneously. The sensitive tips of both electrodes were positio ned at the same level under fluoroscopy. In addition to automatic analysis, each reflux episode was checked visually and characterised. Results: There was a sig nificant correlation (r=0.87, p < 0.0001) between the 24 hour oesophageal acid e xposures recorded by the CPHMS and the CFS. Twenty four hour oesophageal acid ex posure was significantly lower with the CFS than with the CPHMS (2.4 (0.4-8.7) v 3.6 (0.7-8.6); p < 0.0001). Consequently, with the CFS, the cut off level for the diagnosis of GORD, as calculated from the regression equation, was 2.9%(fo r the 4.2%cut off determined in controls with the CPHMS). After this adjustment , concordance of the diagnosis of GORD was 88%(kappa 0.760). Diagnosis of GORD was established in more patients with the CFS 48 hour results than with the 24 h our results. Conclusions: Despite strong correlations between oesophageal acid e xposure recorded with the two devices, the Bravo CFS significantly under recorde d acid exposure compared with the CPHMS. Provided some correcting factors are us ed, the Bravo CFS can improve the sensitivity of pHmetry for the diagnosis of GO RD by allowing more prolonged recordings.
