The research selected 13 factors from individual and family characters, construction site characters and work characters and analyzed the influences on the willingness of purchasing houses on construction sites with L...The research selected 13 factors from individual and family characters, construction site characters and work characters and analyzed the influences on the willingness of purchasing houses on construction sites with Logistic regression mod- el. The results showed that gender, age differences, personality, willingness on fami- ly land conversion, management of enterprises on construction sites, relatives and friends on construction lands, and Job satisfaction were approved by significant testing, but marital status, annual household income, the rate of migrant worker in a household, transportation in work city, and corporate reputation were not approved by significant testing.展开更多
Objective:Triple-negative breast cancer(TNBC)is highly metastatic,and there is an urgent unmet need to develop novel therapeutic strategies leading to the new drug discoveries against metastasis.The transforming growt...Objective:Triple-negative breast cancer(TNBC)is highly metastatic,and there is an urgent unmet need to develop novel therapeutic strategies leading to the new drug discoveries against metastasis.The transforming growth factor-β(TGF-β)is known to promote the invasive and migratory potential of breast cancer cells through induction of epithelial–mesenchymal transition(EMT)via the ERK/NF-κB/Snail signaling pathway,leading to breast cancer metastasis.Targeting this pathway to revert the EMT would be an attractive,novel therapeutic strategy to halt breast cancer metastasis.Methods:Effects of enterolactone(EL)on the cell cycle and apoptosis were investigated using flow cytometry and a cleaved caspase-3 enzyme-linked immunosorbent assay(ELISA),respectively.Effects of TGF-βinduction and EL treatment on the functional malignancy of MDA-MB-231 breast cancer cells were investigated using migration and chemo-invasion assays.The effects of EL on EMT markers and the ERK/NF-κB/Snail signaling pathway after TGF-βinduction were studied using confocal microscopy,quantitative reverse transcription polymerase chain reaction(q RT-PCR),Western blot,and flow cytometry.Results:Herein,we report that EL exhibits a significant antimetastatic effect on MDA-MB-231 cells by almost reverting the TGF-β-induced EMT in vitro.EL downregulates the mesenchymal markers N-cadherin and vimentin,and upregulates the epithelial markers E-cadherin and occludin.It represses actin stress fiber formation via inhibition of mitogen-activated protein kinase p-38(MAPK-p38)and cluster of differentiation 44(CD44).EL also suppresses ERK-1/2,NF-κB,and Snail at the m RNA and protein levels.Conclusions:Briefly,EL was found to inhibit TGF-β-induced EMT by blocking the ERK/NF-κB/Snail signaling pathway,which is a promising target for breast cancer metastasis therapy.展开更多
An ADS (automated dispensing system) was implemented in our hospital pharmacy in 2008 to optimize and secure the medication process. The main objective of this study was to compare the projected and the real ROI (r...An ADS (automated dispensing system) was implemented in our hospital pharmacy in 2008 to optimize and secure the medication process. The main objective of this study was to compare the projected and the real ROI (return on investment), after seven years of use. ROI was calculated annually (from 2008 to 2015), by deducting the cost of investment (ADS buying and implementation, maintenance, repairs and ADS upgrade) from the cost saving (drugs stock reduction and decrease of pharmacy staff dedicated to global dispensing). In 2015, total costs saving (+$1,141,987) were divided between decreasing drug stock value and reduction of pharmacy staff. Total costs of investment (-$978,656) were acquisition, maintenance, repairs and an unplanned upgrade costs. Finally, the real ROI was +$163,331 after seven years of use. In 2008, projected ROI was +$410,786. The real payback period has been increased by approximately two years (six years of use, instead of four years as expected). Despite their cost, ADSs are a worthwhile investment, leading to a ROI within a few years. These economic considerations should be put into perspective with optimization of drugs stock management, greater efficiency of the global dispensing process, securitization of medication process and redeployment of pharmacy staff.展开更多
The science space in a state school in Natal city was built using a composite consisting of gypsum, EPS (expanded polystyrene), shredded tire, cement and water. Mechanical and thermal resistances were evaluated. Ins...The science space in a state school in Natal city was built using a composite consisting of gypsum, EPS (expanded polystyrene), shredded tire, cement and water. Mechanical and thermal resistances were evaluated. Inside the blocks, three types of fillings (EPS plates, aluminum cans and 500 mL bottles of mineral water) were placed in order to obtain a walls with higher thermal resistance, but also to give it an ecologically correct order, considering that both the tire and the EPS occupy a large space in landfills and require years to be degraded when released into the environment. Compression tests were conducted according to the rules. The experiments demonstrated that the temperature difference between the internal and external surfaces on the walls reached levels above 12.0 ℃. It was also demonstrated that the proposed composite has adequate mechanical strength to be used for sealing walls. The proposed use of the composite can contribute to reduce the significant housing deficit of Brazil, producing popular houses at low cost and with little time to work.展开更多
In the context of a room-and-pillar mining gob in Shanxi province in China,this paper numerically investigates the stress distribution and deformation rules of roadway surrounding rocks at various locations of residua...In the context of a room-and-pillar mining gob in Shanxi province in China,this paper numerically investigates the stress distribution and deformation rules of roadway surrounding rocks at various locations of residual coal pillars in room-and-pillar mining gobs using software FLAC3 D.It is found that the concentrated stress beneath coal pillars distributes in a shape of ellipse.A reasonable roadway layout is then proposed.In this design,it is indicated that roadways should be designed to avoid the supporting zones of pillars with increasing compression and take into account the roof falling and crushing in the upper gob.According to the surrounding rock deformation characteristics and mining roadway locations as well as the supporting principles of timely support,rock reinforcing,piecewise management and suiting local conditions,a new asymmetric shield supporting plan is proposed.The field surveying results show that this supporting plan can effectively control the roadway rock deformation,thus guarantee the safe and smooth construction of roadways.展开更多
The purpose of this paper is to investigate the relationships among the variables, and how interest rate, unemployment, stock market, and consumer confidence affect housing market index (HM1) in the U.S.. We constru...The purpose of this paper is to investigate the relationships among the variables, and how interest rate, unemployment, stock market, and consumer confidence affect housing market index (HM1) in the U.S.. We construct vector autoregression (VAR) model with variables such as unemployment rate (UMR), consumer confidence index (CCI), the Dow Jones industrial index (DJI), and interest rate, etc., to forecast the HMI. Our model and analysis show that U.S. HMI very sensitive to unemployment and interest rates. Every 1% moves in unemployment and interest rates will result in HMI to move in the opposite direction by 11.7% and 11.4% respectively. However, changes in CCI and stock mark index have only minor impacts on HMI--0.49% and 0.3%, changes for 1% fluctuation in CCI and DJI. Our research also shows that relationships among these variables associated with housing market are very stable in the long run.展开更多
The article presents the development unemployment and interest rates against the average of important economic variables such as GDP dynamics, transaction prices in one of the local property markets in Poland in the y...The article presents the development unemployment and interest rates against the average of important economic variables such as GDP dynamics, transaction prices in one of the local property markets in Poland in the years 2000-2002. The strength, direction and time delay of the relationships between these variables and transaction prices have been considered during the only period of decline in property prices in the years 2000-2002. The specified relationships have been described using linear regression equations.展开更多
Abstract: The search for "new materials" to manufacture building elements for economical housing is the aim of this work. These materials are the following recycled plastics: Low-density polyethylene (LDPE), rec...Abstract: The search for "new materials" to manufacture building elements for economical housing is the aim of this work. These materials are the following recycled plastics: Low-density polyethylene (LDPE), recycled out of discarded soft drink packs: Polyethylene-terephthalate (PET), recycled out of discarded soft drink bottles; and several plastics, from the printed films used like packages of candies (remainder of production plant by faults in the thickness of the films or in the inked process of themt. These conveniently grounded plastics were taken as "arids" to be mixed with Normal Portland cement, replacing heavy sand and gravel habitually used in these mixtures. These materials are used in constructive elements such as bricks, blocks and plates for economical houses closures or traditional construction. The developed constructive elements offer high thermal insulation, so they can be used in closures with a smaller thickness than conventional bricks and blocks. Besides, they have a lower specific weight than these traditiunal constructive elements. Recycling means lowering costs, making part of the environment contaminating waste useful and providing the unemployed and/or unqualified work force with jobs through uncomplicated technologies. Therefore, this recycling technology has an economic as well as an ecological purpose.展开更多
AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis...AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: "intervascular background coloration"; "proliferation of intrapapillary capillary loops(IPCL)"; and "dilation", "tortuosity", "change in caliber", and "various shapes(VS)" of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME.展开更多
基金Supported by National Natural Science Foundation of China(71363027)Humanities and Social Sciences of Ministry of Education(11YJA790088)Jiangxi Humanities and Social Sciences(10YJ17)~~
文摘The research selected 13 factors from individual and family characters, construction site characters and work characters and analyzed the influences on the willingness of purchasing houses on construction sites with Logistic regression mod- el. The results showed that gender, age differences, personality, willingness on fami- ly land conversion, management of enterprises on construction sites, relatives and friends on construction lands, and Job satisfaction were approved by significant testing, but marital status, annual household income, the rate of migrant worker in a household, transportation in work city, and corporate reputation were not approved by significant testing.
文摘Objective:Triple-negative breast cancer(TNBC)is highly metastatic,and there is an urgent unmet need to develop novel therapeutic strategies leading to the new drug discoveries against metastasis.The transforming growth factor-β(TGF-β)is known to promote the invasive and migratory potential of breast cancer cells through induction of epithelial–mesenchymal transition(EMT)via the ERK/NF-κB/Snail signaling pathway,leading to breast cancer metastasis.Targeting this pathway to revert the EMT would be an attractive,novel therapeutic strategy to halt breast cancer metastasis.Methods:Effects of enterolactone(EL)on the cell cycle and apoptosis were investigated using flow cytometry and a cleaved caspase-3 enzyme-linked immunosorbent assay(ELISA),respectively.Effects of TGF-βinduction and EL treatment on the functional malignancy of MDA-MB-231 breast cancer cells were investigated using migration and chemo-invasion assays.The effects of EL on EMT markers and the ERK/NF-κB/Snail signaling pathway after TGF-βinduction were studied using confocal microscopy,quantitative reverse transcription polymerase chain reaction(q RT-PCR),Western blot,and flow cytometry.Results:Herein,we report that EL exhibits a significant antimetastatic effect on MDA-MB-231 cells by almost reverting the TGF-β-induced EMT in vitro.EL downregulates the mesenchymal markers N-cadherin and vimentin,and upregulates the epithelial markers E-cadherin and occludin.It represses actin stress fiber formation via inhibition of mitogen-activated protein kinase p-38(MAPK-p38)and cluster of differentiation 44(CD44).EL also suppresses ERK-1/2,NF-κB,and Snail at the m RNA and protein levels.Conclusions:Briefly,EL was found to inhibit TGF-β-induced EMT by blocking the ERK/NF-κB/Snail signaling pathway,which is a promising target for breast cancer metastasis therapy.
文摘An ADS (automated dispensing system) was implemented in our hospital pharmacy in 2008 to optimize and secure the medication process. The main objective of this study was to compare the projected and the real ROI (return on investment), after seven years of use. ROI was calculated annually (from 2008 to 2015), by deducting the cost of investment (ADS buying and implementation, maintenance, repairs and ADS upgrade) from the cost saving (drugs stock reduction and decrease of pharmacy staff dedicated to global dispensing). In 2015, total costs saving (+$1,141,987) were divided between decreasing drug stock value and reduction of pharmacy staff. Total costs of investment (-$978,656) were acquisition, maintenance, repairs and an unplanned upgrade costs. Finally, the real ROI was +$163,331 after seven years of use. In 2008, projected ROI was +$410,786. The real payback period has been increased by approximately two years (six years of use, instead of four years as expected). Despite their cost, ADSs are a worthwhile investment, leading to a ROI within a few years. These economic considerations should be put into perspective with optimization of drugs stock management, greater efficiency of the global dispensing process, securitization of medication process and redeployment of pharmacy staff.
文摘The science space in a state school in Natal city was built using a composite consisting of gypsum, EPS (expanded polystyrene), shredded tire, cement and water. Mechanical and thermal resistances were evaluated. Inside the blocks, three types of fillings (EPS plates, aluminum cans and 500 mL bottles of mineral water) were placed in order to obtain a walls with higher thermal resistance, but also to give it an ecologically correct order, considering that both the tire and the EPS occupy a large space in landfills and require years to be degraded when released into the environment. Compression tests were conducted according to the rules. The experiments demonstrated that the temperature difference between the internal and external surfaces on the walls reached levels above 12.0 ℃. It was also demonstrated that the proposed composite has adequate mechanical strength to be used for sealing walls. The proposed use of the composite can contribute to reduce the significant housing deficit of Brazil, producing popular houses at low cost and with little time to work.
基金the National 973 Programs of China (No.2014CB046905)the National Natural Science Foundation of China(Nos.51274191 and 51404245)the Doctoral Fund of Ministry of Education(No.20130095110018)
文摘In the context of a room-and-pillar mining gob in Shanxi province in China,this paper numerically investigates the stress distribution and deformation rules of roadway surrounding rocks at various locations of residual coal pillars in room-and-pillar mining gobs using software FLAC3 D.It is found that the concentrated stress beneath coal pillars distributes in a shape of ellipse.A reasonable roadway layout is then proposed.In this design,it is indicated that roadways should be designed to avoid the supporting zones of pillars with increasing compression and take into account the roof falling and crushing in the upper gob.According to the surrounding rock deformation characteristics and mining roadway locations as well as the supporting principles of timely support,rock reinforcing,piecewise management and suiting local conditions,a new asymmetric shield supporting plan is proposed.The field surveying results show that this supporting plan can effectively control the roadway rock deformation,thus guarantee the safe and smooth construction of roadways.
文摘The purpose of this paper is to investigate the relationships among the variables, and how interest rate, unemployment, stock market, and consumer confidence affect housing market index (HM1) in the U.S.. We construct vector autoregression (VAR) model with variables such as unemployment rate (UMR), consumer confidence index (CCI), the Dow Jones industrial index (DJI), and interest rate, etc., to forecast the HMI. Our model and analysis show that U.S. HMI very sensitive to unemployment and interest rates. Every 1% moves in unemployment and interest rates will result in HMI to move in the opposite direction by 11.7% and 11.4% respectively. However, changes in CCI and stock mark index have only minor impacts on HMI--0.49% and 0.3%, changes for 1% fluctuation in CCI and DJI. Our research also shows that relationships among these variables associated with housing market are very stable in the long run.
文摘The article presents the development unemployment and interest rates against the average of important economic variables such as GDP dynamics, transaction prices in one of the local property markets in Poland in the years 2000-2002. The strength, direction and time delay of the relationships between these variables and transaction prices have been considered during the only period of decline in property prices in the years 2000-2002. The specified relationships have been described using linear regression equations.
文摘Abstract: The search for "new materials" to manufacture building elements for economical housing is the aim of this work. These materials are the following recycled plastics: Low-density polyethylene (LDPE), recycled out of discarded soft drink packs: Polyethylene-terephthalate (PET), recycled out of discarded soft drink bottles; and several plastics, from the printed films used like packages of candies (remainder of production plant by faults in the thickness of the films or in the inked process of themt. These conveniently grounded plastics were taken as "arids" to be mixed with Normal Portland cement, replacing heavy sand and gravel habitually used in these mixtures. These materials are used in constructive elements such as bricks, blocks and plates for economical houses closures or traditional construction. The developed constructive elements offer high thermal insulation, so they can be used in closures with a smaller thickness than conventional bricks and blocks. Besides, they have a lower specific weight than these traditiunal constructive elements. Recycling means lowering costs, making part of the environment contaminating waste useful and providing the unemployed and/or unqualified work force with jobs through uncomplicated technologies. Therefore, this recycling technology has an economic as well as an ecological purpose.
文摘AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: "intervascular background coloration"; "proliferation of intrapapillary capillary loops(IPCL)"; and "dilation", "tortuosity", "change in caliber", and "various shapes(VS)" of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's criteria.RESULTS Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria, respectively.CONCLUSION The combination of proliferation and VS may serve as simplified criteria for the diagnosis of SESCC using NBIME.