目的:本文旨在探讨回肠巨大原发性弥漫性大B细胞淋巴瘤的临床表现、影像学特点及诊治要点。方法:对延安市人民医院胃肠外科收治的回肠巨大原发性弥漫性大B细胞淋巴瘤合并肠梗阻1例患者进行病例回顾并复习相关文献。结果:回肠巨大原发性...目的:本文旨在探讨回肠巨大原发性弥漫性大B细胞淋巴瘤的临床表现、影像学特点及诊治要点。方法:对延安市人民医院胃肠外科收治的回肠巨大原发性弥漫性大B细胞淋巴瘤合并肠梗阻1例患者进行病例回顾并复习相关文献。结果:回肠巨大原发性弥漫性大B细胞淋巴瘤,发病率低,临床表现不典型;合并肠梗阻者,往往容易误诊及漏诊,最终确诊要需手术探查及病理。结论:回肠原发性弥漫性大B细胞淋巴瘤合并肠梗阻缺乏特异性临床表现,手术为首选治疗方法,需结合手术病理及免疫组化进行确诊。Objective: To explore the clinical manifestations, imaging characteristics, and key points of diagnosis and treatment of giant primary diffuse large B-cell lymphoma in the ileum. Method: A case review and literature review were conducted on a patient with giant primary diffuse large B-cell lymphoma of the ileum and intestinal obstruction admitted to the Department of Gastroenterology at Yan’an People’s Hospital. Results: The large primary diffuse large B-cell lymphoma of the ileum had a low incidence rate and atypical clinical manifestations;Patients with combined intestinal obstruction are often prone to misdiagnosis and missed diagnosis, and the final diagnosis requires surgical exploration and pathology. Conclusion: Primary diffuse large B-cell lymphoma of the ileum with intestinal obstruction lacks specific clinical manifestations, and surgery is the preferred treatment method. Diagnosis should be based on surgical pathology and immunohistochemistry.展开更多
N-(3′,4′,5′-Trimethoxycinnamoyl)ortho-aminobenzoic acid(TOA),at the concentration of 80μg/ml,significantly inhibited the antigen-induced contraction of ileum isolated from the actively sensitized guinea-pig.At the...N-(3′,4′,5′-Trimethoxycinnamoyl)ortho-aminobenzoic acid(TOA),at the concentration of 80μg/ml,significantly inhibited the antigen-induced contraction of ileum isolated from the actively sensitized guinea-pig.At the concentrations of 25 and 50μg/ml, TOA inhibited homocytotropic antibody-mediated degranulation of mast cells in the rat mesentery,and also inhibited anaphylactic histamine release from rat peritoneal mast cells.展开更多
AIM： To pharmacologically modulate Th polarization in the ileum exposed to ionizing radiation by using the immuno-modulatory/apoptotic properties of Caffeic Acid Phenethyl Ester （CAPE）. METHODS： Rats received CAPE...AIM： To pharmacologically modulate Th polarization in the ileum exposed to ionizing radiation by using the immuno-modulatory/apoptotic properties of Caffeic Acid Phenethyl Ester （CAPE）. METHODS： Rats received CAPE （30 mg/kg） treatment ip 15 min prior to intestinal 10 Gy γ-irradiation and once a day for a 6 d period alter irradiation. Expression of genes implicated in Th differentiation in ileal mucosa （IL-23/IL-12Rβ2）, Th cytokine responses （IFN-γ, IL-2, IL-4, IL-13）, Th migratory behaviour （CXCR3, CCR5, CCR4）, Th signalling suppressors （SOCS1, SOCS3）, transcription factor （T-Bet, GATA-3） and apoptosis （FasL/Fas, TNF/TNFR, XIAP, Bax, caspase-3） was analyzed by RT-PCR 6 h and 7 d post-irradiation. CD4^＋ and TUNEL positive cells were visualized by immunostaining. RESULTS： The expression of Thl-related cytokine/ chemokine receptors （IFN-γ, IL-2, CXCR3, CCR5） was repressed at 7 d post-irradiation while Th2 cell cytokine/ chemokines （IL-4, IL-13, CCR4） were not repressed or even upregulated. The irradiation-induced Th2 profile was confirmed by the upregulation of both Th2-specific transcription factor GATA-3 and SOCS3. Although an apoptosis event occurred 6 h alter 10 Gy of intestinal γ-irradiation, apoptotic mediator analysis showed a tendency to apoptotic resistance 7 d post-irradiation. CAPE amplified apoptotic events at 6h and normalized Bax/FasL expressions at 7 d. CONCLUSION： CAPE prevented the ileal Th2 immune response by modulating the irradiation-influenced cytokine environment and apoptosis.展开更多
Crohn’s disease may prinicipally involve the whole gastrointestinal tract. Most commonly, the inflammation occurs in the small intestine and/or in the colon with stable disease location over the years. The pathogenes...Crohn’s disease may prinicipally involve the whole gastrointestinal tract. Most commonly, the inflammation occurs in the small intestine and/or in the colon with stable disease location over the years. The pathogenesis of both disease phenotypes is complex, the likely primary defect lies in the innate rather than adaptive immunity, particularly in the chemical antimicrobial barrier of the mucosa. Crohn’s ileitis is associated with a reduced expression of the Wnt signalling pathway transcription factor T-cell factor 4 (TCF4), which is regulating Paneth cell differentiation. As a result, the alpha-defensins and principal Paneth cell products HD5 and HD6 are deficiently expressed in ileal disease, independent of current inflammation. In contrast, Crohn’s colitis is typically associated with an impaired induction of the beta-defensins HBD2 and HBD3 caused by fewer gene copy numbers in the gene locus of the beta-defensins on chromosome 8. This ileal and colonic defect in innate defence mediated by a deficiency of the protective alpha- and beta- defensins may enable the luminal microbes to invade the mucosa and trigger the inflammation. A better understanding of the exact molecular mechanisms behind ileal and colonic Crohn’s disease may give rise to new therapeutic strategies based on a stimulation of the protective innate immune system.展开更多
Cytomegalovirus enteritis is most usually associated with patients positive for human immunodeficiency virus or immunosuppressed transplant patients. The gastrointestinal tract may be affected anywhere from the esopha...Cytomegalovirus enteritis is most usually associated with patients positive for human immunodeficiency virus or immunosuppressed transplant patients. The gastrointestinal tract may be affected anywhere from the esophagus to the colon, but the small bowel involvement is rare. We report a case of cytomegalovirus ileitis in an immunocompetent adult, which was confirmed by histopathologic findings through colonoscopic biopsy.展开更多
文摘目的:本文旨在探讨回肠巨大原发性弥漫性大B细胞淋巴瘤的临床表现、影像学特点及诊治要点。方法:对延安市人民医院胃肠外科收治的回肠巨大原发性弥漫性大B细胞淋巴瘤合并肠梗阻1例患者进行病例回顾并复习相关文献。结果:回肠巨大原发性弥漫性大B细胞淋巴瘤,发病率低,临床表现不典型;合并肠梗阻者,往往容易误诊及漏诊,最终确诊要需手术探查及病理。结论:回肠原发性弥漫性大B细胞淋巴瘤合并肠梗阻缺乏特异性临床表现,手术为首选治疗方法,需结合手术病理及免疫组化进行确诊。Objective: To explore the clinical manifestations, imaging characteristics, and key points of diagnosis and treatment of giant primary diffuse large B-cell lymphoma in the ileum. Method: A case review and literature review were conducted on a patient with giant primary diffuse large B-cell lymphoma of the ileum and intestinal obstruction admitted to the Department of Gastroenterology at Yan’an People’s Hospital. Results: The large primary diffuse large B-cell lymphoma of the ileum had a low incidence rate and atypical clinical manifestations;Patients with combined intestinal obstruction are often prone to misdiagnosis and missed diagnosis, and the final diagnosis requires surgical exploration and pathology. Conclusion: Primary diffuse large B-cell lymphoma of the ileum with intestinal obstruction lacks specific clinical manifestations, and surgery is the preferred treatment method. Diagnosis should be based on surgical pathology and immunohistochemistry.
文摘N-(3′,4′,5′-Trimethoxycinnamoyl)ortho-aminobenzoic acid(TOA),at the concentration of 80μg/ml,significantly inhibited the antigen-induced contraction of ileum isolated from the actively sensitized guinea-pig.At the concentrations of 25 and 50μg/ml, TOA inhibited homocytotropic antibody-mediated degranulation of mast cells in the rat mesentery,and also inhibited anaphylactic histamine release from rat peritoneal mast cells.
文摘AIM： To pharmacologically modulate Th polarization in the ileum exposed to ionizing radiation by using the immuno-modulatory/apoptotic properties of Caffeic Acid Phenethyl Ester （CAPE）. METHODS： Rats received CAPE （30 mg/kg） treatment ip 15 min prior to intestinal 10 Gy γ-irradiation and once a day for a 6 d period alter irradiation. Expression of genes implicated in Th differentiation in ileal mucosa （IL-23/IL-12Rβ2）, Th cytokine responses （IFN-γ, IL-2, IL-4, IL-13）, Th migratory behaviour （CXCR3, CCR5, CCR4）, Th signalling suppressors （SOCS1, SOCS3）, transcription factor （T-Bet, GATA-3） and apoptosis （FasL/Fas, TNF/TNFR, XIAP, Bax, caspase-3） was analyzed by RT-PCR 6 h and 7 d post-irradiation. CD4^＋ and TUNEL positive cells were visualized by immunostaining. RESULTS： The expression of Thl-related cytokine/ chemokine receptors （IFN-γ, IL-2, CXCR3, CCR5） was repressed at 7 d post-irradiation while Th2 cell cytokine/ chemokines （IL-4, IL-13, CCR4） were not repressed or even upregulated. The irradiation-induced Th2 profile was confirmed by the upregulation of both Th2-specific transcription factor GATA-3 and SOCS3. Although an apoptosis event occurred 6 h alter 10 Gy of intestinal γ-irradiation, apoptotic mediator analysis showed a tendency to apoptotic resistance 7 d post-irradiation. CAPE amplified apoptotic events at 6h and normalized Bax/FasL expressions at 7 d. CONCLUSION： CAPE prevented the ileal Th2 immune response by modulating the irradiation-influenced cytokine environment and apoptosis.
基金The Robert Bosch Foundation, Stuttgart, Germany the Emmy Noether program (J.W.) of the Deutsche Forschungsgemeinschaft (DFG)
文摘Crohn’s disease may prinicipally involve the whole gastrointestinal tract. Most commonly, the inflammation occurs in the small intestine and/or in the colon with stable disease location over the years. The pathogenesis of both disease phenotypes is complex, the likely primary defect lies in the innate rather than adaptive immunity, particularly in the chemical antimicrobial barrier of the mucosa. Crohn’s ileitis is associated with a reduced expression of the Wnt signalling pathway transcription factor T-cell factor 4 (TCF4), which is regulating Paneth cell differentiation. As a result, the alpha-defensins and principal Paneth cell products HD5 and HD6 are deficiently expressed in ileal disease, independent of current inflammation. In contrast, Crohn’s colitis is typically associated with an impaired induction of the beta-defensins HBD2 and HBD3 caused by fewer gene copy numbers in the gene locus of the beta-defensins on chromosome 8. This ileal and colonic defect in innate defence mediated by a deficiency of the protective alpha- and beta- defensins may enable the luminal microbes to invade the mucosa and trigger the inflammation. A better understanding of the exact molecular mechanisms behind ileal and colonic Crohn’s disease may give rise to new therapeutic strategies based on a stimulation of the protective innate immune system.
文摘Cytomegalovirus enteritis is most usually associated with patients positive for human immunodeficiency virus or immunosuppressed transplant patients. The gastrointestinal tract may be affected anywhere from the esophagus to the colon, but the small bowel involvement is rare. We report a case of cytomegalovirus ileitis in an immunocompetent adult, which was confirmed by histopathologic findings through colonoscopic biopsy.
