In this article,based on the acoustic measurements of core samples obtained from the low to medium porosity and permeability reservoirs in the WXS Depression,the densities and P and S wave velocities of these core sam...In this article,based on the acoustic measurements of core samples obtained from the low to medium porosity and permeability reservoirs in the WXS Depression,the densities and P and S wave velocities of these core samples were obtained.Then based on these data,a series of elastic parameters were computed.From the basic theory and previous pore fluid research results,we derived a new fluid identification factor(F).Using the relative variations,Ag/w and Ao/w,of the elastic parameters between gas and water saturated samples and between oil and water saturated samples,λρ,σHSFIF,Kρ,λρ-2μρ,and F as quantitative indicators,we evaluate the sensitivity of the different fluid identification factors to identify reservoir fluids and validate the effects by crossplots.These confirm that the new fluid identification factor(F) is more sensitive for distinguishing oil and water than the traditional method and is more favorable for fliud identification in low to medium porosity and permeability reservoirs.展开更多
Considering the epidemiological, genetic and immunological data, we can conclude that the inflammatory bowel diseases are heterogeneous disorders of multifactorial etiology in which hereditability and environment inte...Considering the epidemiological, genetic and immunological data, we can conclude that the inflammatory bowel diseases are heterogeneous disorders of multifactorial etiology in which hereditability and environment interact to produce the disease. It is probable that patients have a genetic predisposition for the development of the disease coupled with disturbances in immunoregulation. Several genes have so far been related to the diagnosis of Crohn's disease. These genes are related to innate pattern recognition receptors, to epithelial barrier homeostasis and maintenance of epithelial barrier integrity, to autophagy and to lymphocyte differentiation. So far, the strongest and most replicated associations with Crohn's disease have been demonstrated with NOD2 , IL23R and ATG16L1 genes. Many genes have so far been implicated in the prognosis of Crohn's disease and many attempts have been made for classification of genetic profiles in Crohn's disease.CARD15 seems to be not only a susceptibility gene, but also a disease-modifier gene for Crohn's disease. Enriching our understanding of Crohn's disease genetics is of value, but when combining genetic data with functional data the outcome could be of major importance to clinicians.展开更多
Objective Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular ...Objective Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery (HFS). We used high sensitive troponin I (hs-TnI) assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events (MACE) in elderly hip frac^u'e patients. Method From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry. A total of 262 of these patients underwent HFS and hs-TnI assays. MACE was defined as postoperative all-cause deaths, heart failure (HF), new-onset atrial fibrillation (AF), myocardial infarction (MI) and cardiovascular re-hospitalization that occurred within 90 days postoperative. Results Of 262 HFS patients, MACE developed following HFS in 65 (24.8%). Patients with MACE were older and had higher rates of renal insufficiency, coronary artery disease, prior HF, low left ventricular ejection fraction and use of beta blockers; higher levels of hs-Tnl and N-terminal pro-brain natriuretic peptide (NT-proBNP) and higher revised cardiac risk index. A preoperative hs-TnI≥ 6.5 ng/L was associated with high risk of postoperative HF, new-onset AF and MACE. In multivariable analysis, pre-operative independent predictors for MACE were age 〉 80 years [adjusted hazard ratio (HR): 1.79, 95% confident interval (CI): 1.03-3.13, P = 0.04], left ventricular ejection fraction (LVEF) 〈 50% (adjusted HR: 3.17, 95% CI: 1.47-5.82, P 〈 0.01) and hs-TnI 〉 6.5 ng/L (adjusted HR: 3.75, 95% CI: 2.09~5.17, P 〈 0.01). Conclusion In elderly patients with hip fracture who undergo HFS, a preoperative assessment of hs-TnI may help the risk refinement of cardiovascular complications.展开更多
From a pure motor disorder of the bowel,in the past few years,irritable bowel syndrome (IBS) has become a multifactorial disease that implies visceral hypersensitivity,alterations at the level of nervous and humoral c...From a pure motor disorder of the bowel,in the past few years,irritable bowel syndrome (IBS) has become a multifactorial disease that implies visceral hypersensitivity,alterations at the level of nervous and humoral communications between the enteric nervous system and the central nervous system,alteration of the gut microflora,an increased intestinal permeability and minimum intestinal inflammation.Psychological and social factors can interfere with the communication between the central and enteric nervous systems,and there is proof that they are involved in the onset of IBS and influence the response to treatment and outcome.There is evidence that abuse history and stressful life events are involved in the onset of functional gastrointestinal disorders.In order to explain clustering of IBS in families,genetic factors and social learning mechanisms have been proposed.The psychological features,such as anxiety,depression as well as the comorbid psychiatric disorders,health beliefs and coping of patients with IBS are discussed in relation to the symptoms and outcome.展开更多
Objectives:This study aimed to explore the dignity and related factors among older adults in long-term care facilities.Methods:Cross-sectional data were obtained from a sample of 253 Chinese older adults dwelling in l...Objectives:This study aimed to explore the dignity and related factors among older adults in long-term care facilities.Methods:Cross-sectional data were obtained from a sample of 253 Chinese older adults dwelling in long-term care facilities.Dignity among older adults was measured using the Dignity Scale,and its potential correlates were explored using multiple linear regressions.Results:Results showed that the total score of the Dignity Scale is 151.95±11.75.From high to low,the different factors of dignity among older adults in long-term care facilities were as follows:caring factors(4.83±0.33),social factors(4.73±0.41),psychological factors(4.66±0.71),value factors(4.56±0.53),autonomous factors(4.50±0.57),and physical factors(4.38±0.55).A higher score of the Dignity Scale was associated with higher economic status,fewer chronic diseases,less medication,better daily living ability and long-time lived in cities.Conclusion:Older adults with low economic status,more chronic diseases,and poor daily living ability,taking more medications,or the previous residence in rural areas seem to be most at low-level dignity in long-term care facilities and thus require more attention than their peers.展开更多
AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction frag...AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men.展开更多
Forty-eight interviews were undertaken with residents in Timaru, Wanganui and Napier, New Zealand, in 2008 to explore how people understand and use information about earthquake hazards and preparedness, and how this p...Forty-eight interviews were undertaken with residents in Timaru, Wanganui and Napier, New Zealand, in 2008 to explore how people understand and use information about earthquake hazards and preparedness, and how this process affects actual preparedness. Three main types of information were identified as being utilized by people: passive information (e.g., newspapers, brochures, TV, radio, websites), interactive information (e.g., community activities, school activities~ and workplace activities), and experiential information (e.g., experiencing a hazardous event, responding to an event, and working in an organization that deals with hazards). People tended to either contextualize hazard and preparedness information around any prevailing beliefs they had or form new beliefs on exposure to information. A number of core beliefs were identified as crucial for helping people consider that preparing is important and motivating actual adjustment adoption. Society also has an influence on how people interpret information and form intentions to prepare. People are often influenced by the opinions of others, and as preparing for disasters is not seen as a societal norm, this can cause people not to prepare. Feeling a responsibility for others (e.g., children) appears to be a major driver of preparedness. Other societal factors such as trust, leadership and sense of community also influence interpretation, dissemination and use of hazards and preparedness information. Finally, a number of resource issues can help or hinder preparedness.展开更多
the left-behind children is appeared in our city in the process, there are many factors that influence the well-being, in this paper I conducted about the influence of left-behind children happiness questionnaire, foc...the left-behind children is appeared in our city in the process, there are many factors that influence the well-being, in this paper I conducted about the influence of left-behind children happiness questionnaire, focuses on the analysis of the influence factors from three aspects of environmental factors, personality factors and social factors. Based on the analys:is results, put forward and strengthen left-behind chi]dren well-being measures.展开更多
Transhumant pastoralism is an important activity in southern Morocco. Migration pattern of transhumant pastoralists can be affected by physical factors (e.g. droughts and diseases) or socioeconomic factors (e.g. schoo...Transhumant pastoralism is an important activity in southern Morocco. Migration pattern of transhumant pastoralists can be affected by physical factors (e.g. droughts and diseases) or socioeconomic factors (e.g. schooling options for children and migration costs). We studied the spatio-temporal rangeland usage of the three tribes Ait Mgoun, Ait Zekri, and Ait Toumert in the south-central Atlas region with a two-fold approach. First, we tracked the migration movements of one representative transhumant herd using the Advanced Research and Global Observation Satellite (ARGOS) collars, which record coordinates from satellite signals. Second, we interviewed herders to obtain information about general grazing practices of the respective tribe and to gain more direct information on motivations underlying decisions. For each tribe we observed small-, medium- and large-scale movements. We found that the most important drivers of migration decisions were seasonal fodder availability and weather conditions in combination with herd-specific risk and cost assessment, as well as personal factors. In conclusion, general migration patterns vary in time, both between and within the tribes, but according to a regulatory framework. Moreover, it appears that both the customary rules and its flexible adaptation to physical constraints are generally beneficial in terms of conservation of the arid and semiarid rangeland resources.展开更多
This paper discusses the constraining factors to sustainable utilization ofwater resources in China, and the countermeasures to realize sustainable water utilization. Theresult of comprehensive analysis shows that con...This paper discusses the constraining factors to sustainable utilization ofwater resources in China, and the countermeasures to realize sustainable water utilization. Theresult of comprehensive analysis shows that constraining factors to sustainable utilization of waterresources in China are complicated, including physical geographical factors and socio-economicfactors, such as uneven distribution of water resources at temporal and spatial scales,inappropriate institutional arrangement and non-water-saving and non-wter-conservation productionand life mode. The countermeasures against constraining factors to water resources sustainabledevelopment are put forward as follows: 1) using wetlands and forests, and through spatialconversion to realize temporally sustainable supply of water resources; 2) transferring waterbetween basins and areas and developing various water resources in water shortage area; 3)establishing water-saving society; 4) strengthening water pollution control and water resourcesprotection; and 5) establishing unified water resources management mechanism.展开更多
AIM:To determine the expression and clinical significance of transcriptional intermediary factor 1 gamma (TIF1γ),Smad4 and transforming growth factor-beta (TGFβR) across a spectrum representing colorectal cancer (CR...AIM:To determine the expression and clinical significance of transcriptional intermediary factor 1 gamma (TIF1γ),Smad4 and transforming growth factor-beta (TGFβR) across a spectrum representing colorectal cancer (CRC) development.METHODS:Tissue microarrays were prepared from archival paraffin embedded tissue,including 51 colorectal carcinomas,25 tubular adenomas (TA) and 26 HPs,each with matched normal colonic epithelium.Immunohistochemistry was performed using antibodies against TIF1γ,Smad4 and TGFβ RⅡ.The levels of expression were scored semi-quantitatively (score 0-3 or loss and retention for Smad4).RESULTS:Overexpression of TIF1γ was detected in 5/26 (19%) HP;however,it was seen in a significantly higher proportion of neoplasms,15/25 (60%) TAs and 24/51 (47%) CRCs (P<0.05).Normal colonic mucosa,HP,and TAs showed strong Smad4 expression,while its expression was absent in 22/51 (43%) CRCs.Over-expression of TGFβ RⅡ was more commonly seen in neoplasms,13/25 (52%) TAs and 29/51 (57%) CRCs compared to 9/26 (35%) HP (P<0.05).Furthermore,there was a correlation between TIF1γ overexpression and Smad4 loss in CRC (Kendall tau rank correlation value=0.35,P<0.05).The levels of TIF1γ overexpression were significantly higher in stage Ⅲ than in stage Ⅰ and Ⅱ CRC (P<0.05).CONCLUSION:The findings suggest that over-expression of TIF1γ occurs in early stages of colorectal carcinogenesis,is inversely related with Smad4 loss,and may be a prognostic indicator for poor outcome.展开更多
Many people believe that democracy is something that can lead everyone toward a better nation and a free and fair society. In 1954, Brown v. Board of Education fundamentally changed the education system in the United ...Many people believe that democracy is something that can lead everyone toward a better nation and a free and fair society. In 1954, Brown v. Board of Education fundamentally changed the education system in the United States and was a turning point in the evolution of U,S. democracy that made the beautiful American dream available for each individual. However, six decades later, the debate over educational inequality continues. People are still fighting for their equality and well-being. Along with dramatically influential political, economic, and social factors in the United States, educational inequality destroys the commitment of this democratic nation to offer equal opportunity, care, and social justice to younger members of the community. This paper discusses the current problem of educational inequality as it relates to racial and socioeconomic discrimination in urban schools. The aim of this study is to explore knowledge of inequality in the U.S. school system and to raise social and educational awareness to help American children to have equal chances in education and to achieve future success.展开更多
To examine the importance of kin selection in shaping human societies, this study analyzed the kinship system practiced in traditional China for two millennia and teased apart its underlying genetic and other, presuma...To examine the importance of kin selection in shaping human societies, this study analyzed the kinship system practiced in traditional China for two millennia and teased apart its underlying genetic and other, presumably cultural, components. The results demonstrate that, in the traditional patrilineal Chinese family, both genetic relatedness and the cultural factor of generation were important in determining kinship status for male agnates (genetically related relatives). For female agnates, however, only genetic relatedness was important. Another surprising finding was that the influence of gender was not as important as genetic relatedness. The most interesting finding in this study, however, was that kin selection and culture (i.e., seniority in generation and age) played vastly different roles in different lineages in the Chinese family: for collateral (indirect) agnates, genetic relatedness was the most important factor in determining their kinship status, but for lineal (direct) agnates, its importance was overridden by seniority in generation and age, a cultural factor. Several other bio-cultural factors also explained a considerable amount of variance in kinship status. Since kinship profoundly affected, and was often the foundation of, the legal and social systems in dynastic China, kin selection, while its strength may differ remarkably between lineal and collateral relatives, could act as a selective force in Chinese families展开更多
In this paper, the authors present a method to construct a simulation experiment system which used to prove how social network affects the stock market. The authors construct a model considered of three main stock mar...In this paper, the authors present a method to construct a simulation experiment system which used to prove how social network affects the stock market. The authors construct a model considered of three main stock market effect factors: cognitive factors, social factors and economic factors. In the simulation system, free-scale social network is generated for information relations among investors in stock market. The authors simulate the organization information propaganda processes and generate stock related news. The generated news contains economy factors and sudden events. Stockholders cooperate with the related stockholders in their social network, and make stock exchange decision based on this news and their cognitive understanding of this news. Simulation results shows that the social network news propaganda effect stock prices. If social network in stock market have circles, the news affection will be amplified.展开更多
Background: Physical activity participation(PAP) has been proven to improve health and promote optimal growth among adolescents. However,most adolescents do not meet the current physical activity(PA) recommendations i...Background: Physical activity participation(PAP) has been proven to improve health and promote optimal growth among adolescents. However,most adolescents do not meet the current physical activity(PA) recommendations in Turkey. The role of the social environment and social factors on PAP is being increasingly recognized. Although social capital(SC) indicators have been examined in high-income countries, there are few studies on developing countries. The aim of this study was to examine the relationship between SC indicators and PAP among Turkish adolescents.Methods: A survey was conducted among 19 high schools in 4 different cities in Turkey in 2016. A total of 506 female and 729 male high school students participated in this study. The dependent variable was overall PAP, which was measured using the short form of the International Physical Activity Questionnaire. The independent variables included self-perceived family, neighborhood, and school SC. Self-rated health and obesity status, measured by body mass index, were other study covariates in multiple binary logistic regression models. Chi-square tests were used to assess the differences between genders.Results: PAP levels were significantly different between males and females. A higher percentage of males reported PAP(77.4%) compared to females(51.0%). Among males, teacher–student interpersonal trust and informal social control were inversely associated with PAP, while high students interpersonal trust was positively associated with increased odds of PAP. For females, students interpersonal trust was inversely associated with PAP.Conclusion: Various SC indicators are associated with PAP for males and females. These associations are different from findings of studies conducted in developed countries. Therefore, health-promotion interventions and policies should consider gender and different social agents on the social and cultural background to improve PAP among Turkish adolescents.展开更多
AIM:To examine if dietary and socio-economic factors contribute to Helicobacter pylori(H pylori)re-infection. METHODS:The population of patients consisted of subjects in whom H pylori infection had been successfully t...AIM:To examine if dietary and socio-economic factors contribute to Helicobacter pylori(H pylori)re-infection. METHODS:The population of patients consisted of subjects in whom H pylori infection had been successfully treated in the past.Patients were divided into two groups:Ⅰ-examined group(111 persons with H pylori re-infection)andⅡ-control group(175 persons who had not been re-infected).The respondents were interviewed retrospectively on their dietary habits and socio-economic factors. RESULTS:A statistically significant lower frequency of fermented dairy products(P<0.0001),vegetables (P=0.02),and fruit(P=0.008)consumption was noted among patients with H pylori re-infection as compared to those who had not been re-infected. CONCLUSION:High dietary intake of probiotic bacteria,mainly Lactobacillus,and antioxidants,mainly vitamin C(contained in fruit and vegetables),might decrease the risk of H pylori re-infection.展开更多
With the majority of young people increasingly becoming the main force of the use of the network, the network as a new kind of social factors on the growth of young people is increasingly prominent. Network not only h...With the majority of young people increasingly becoming the main force of the use of the network, the network as a new kind of social factors on the growth of young people is increasingly prominent. Network not only help young people broaden their horizons, accept avant-garde concept, concern about the world cutting-edge issues, but also spread some violence, pornographic or reactionary spare, as well as network addiction problem which will cause a serious negative impact on the healthy growth of young people and lead to increasing juvenile crime. The number of juvenile criminals has increased every year in China and has trended to lowering ages, regiment turn and malignant development, which will cause great harm to social stability. Of course, there are many causes of juvenile delinquency, but showing characteristics are also diverse.展开更多
With the translation studies leaning to target-language, the translator's subjectivity has been paid more and more attention by translation scholars. It is noticed gradually that translation is actually a dynamic and...With the translation studies leaning to target-language, the translator's subjectivity has been paid more and more attention by translation scholars. It is noticed gradually that translation is actually a dynamic and complex process, during which the translator, acting as a reader of the source text and also a writer of the target text, will unavoidably add something subjective in his or her translation. Since literary translation is interwoven with more cultural and social elements, the translator has to make a choice between loyalty and violation, getting freedom and being restricted when he or she confronts with all the clashes and conflicts between the source language culture and the target language culture.展开更多
AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was ...AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively). CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.展开更多
In recent years, a number of organisations have implemented Executive Information Systems (EIS) including Computer-Based Information Systems (CBIS) in order to improve the performance of their executives' jobs th...In recent years, a number of organisations have implemented Executive Information Systems (EIS) including Computer-Based Information Systems (CBIS) in order to improve the performance of their executives' jobs though the majority of executives are unwilling to use EIS applications because of their design defects. Present researches on Executive Information Systems (EIS) are limited and less focused on the factors associated with EIS successful usage. This research adopts an extension of the Technology Acceptance Model (TAM) to derive useful variables to address the problem of the low usage of EIS by executives due to social factors, habits and facilitation conditions variables in Triandis' Framework. It reports on the adoption and usage of EIS by the executives in Organizations. The results show that experience in EIS usage was high with most respondents having used EIS for between 0 to 4 years (72.41%), followed by the 5-9 years group with 25.86%. However, in terms of ability to use EIS, most executives were at the expert (knowledgeable), casual user with 37.93%, followed by novice frequent user group with 31.03%. From this research, the authors propose a model that incorporates the habits, social factors and facilitating conditions in an Executive Information Systems.展开更多
基金supported by the the Key Project of Chinese Ministry of Education (Grant No.109035)the National Natural Science Foundation Key Project (Grant No.40830423)Key Projects of Students Extra-curricular Science and Technology Research Program of Schlumberger (Grant No.SLBX0908)
文摘In this article,based on the acoustic measurements of core samples obtained from the low to medium porosity and permeability reservoirs in the WXS Depression,the densities and P and S wave velocities of these core samples were obtained.Then based on these data,a series of elastic parameters were computed.From the basic theory and previous pore fluid research results,we derived a new fluid identification factor(F).Using the relative variations,Ag/w and Ao/w,of the elastic parameters between gas and water saturated samples and between oil and water saturated samples,λρ,σHSFIF,Kρ,λρ-2μρ,and F as quantitative indicators,we evaluate the sensitivity of the different fluid identification factors to identify reservoir fluids and validate the effects by crossplots.These confirm that the new fluid identification factor(F) is more sensitive for distinguishing oil and water than the traditional method and is more favorable for fliud identification in low to medium porosity and permeability reservoirs.
文摘Considering the epidemiological, genetic and immunological data, we can conclude that the inflammatory bowel diseases are heterogeneous disorders of multifactorial etiology in which hereditability and environment interact to produce the disease. It is probable that patients have a genetic predisposition for the development of the disease coupled with disturbances in immunoregulation. Several genes have so far been related to the diagnosis of Crohn's disease. These genes are related to innate pattern recognition receptors, to epithelial barrier homeostasis and maintenance of epithelial barrier integrity, to autophagy and to lymphocyte differentiation. So far, the strongest and most replicated associations with Crohn's disease have been demonstrated with NOD2 , IL23R and ATG16L1 genes. Many genes have so far been implicated in the prognosis of Crohn's disease and many attempts have been made for classification of genetic profiles in Crohn's disease.CARD15 seems to be not only a susceptibility gene, but also a disease-modifier gene for Crohn's disease. Enriching our understanding of Crohn's disease genetics is of value, but when combining genetic data with functional data the outcome could be of major importance to clinicians.
文摘Objective Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery (HFS). We used high sensitive troponin I (hs-TnI) assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events (MACE) in elderly hip frac^u'e patients. Method From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry. A total of 262 of these patients underwent HFS and hs-TnI assays. MACE was defined as postoperative all-cause deaths, heart failure (HF), new-onset atrial fibrillation (AF), myocardial infarction (MI) and cardiovascular re-hospitalization that occurred within 90 days postoperative. Results Of 262 HFS patients, MACE developed following HFS in 65 (24.8%). Patients with MACE were older and had higher rates of renal insufficiency, coronary artery disease, prior HF, low left ventricular ejection fraction and use of beta blockers; higher levels of hs-Tnl and N-terminal pro-brain natriuretic peptide (NT-proBNP) and higher revised cardiac risk index. A preoperative hs-TnI≥ 6.5 ng/L was associated with high risk of postoperative HF, new-onset AF and MACE. In multivariable analysis, pre-operative independent predictors for MACE were age 〉 80 years [adjusted hazard ratio (HR): 1.79, 95% confident interval (CI): 1.03-3.13, P = 0.04], left ventricular ejection fraction (LVEF) 〈 50% (adjusted HR: 3.17, 95% CI: 1.47-5.82, P 〈 0.01) and hs-TnI 〉 6.5 ng/L (adjusted HR: 3.75, 95% CI: 2.09~5.17, P 〈 0.01). Conclusion In elderly patients with hip fracture who undergo HFS, a preoperative assessment of hs-TnI may help the risk refinement of cardiovascular complications.
基金Supported by The Sectorial Operational Programme Human Resources Development,Contract POSDRU 6/1.5/S/3-,Doctoral studies: through science towards society
文摘From a pure motor disorder of the bowel,in the past few years,irritable bowel syndrome (IBS) has become a multifactorial disease that implies visceral hypersensitivity,alterations at the level of nervous and humoral communications between the enteric nervous system and the central nervous system,alteration of the gut microflora,an increased intestinal permeability and minimum intestinal inflammation.Psychological and social factors can interfere with the communication between the central and enteric nervous systems,and there is proof that they are involved in the onset of IBS and influence the response to treatment and outcome.There is evidence that abuse history and stressful life events are involved in the onset of functional gastrointestinal disorders.In order to explain clustering of IBS in families,genetic factors and social learning mechanisms have been proposed.The psychological features,such as anxiety,depression as well as the comorbid psychiatric disorders,health beliefs and coping of patients with IBS are discussed in relation to the symptoms and outcome.
基金This work was supported by the Health Commission of Zhejiang Province(Grant number 2018KY544,2018).
文摘Objectives:This study aimed to explore the dignity and related factors among older adults in long-term care facilities.Methods:Cross-sectional data were obtained from a sample of 253 Chinese older adults dwelling in long-term care facilities.Dignity among older adults was measured using the Dignity Scale,and its potential correlates were explored using multiple linear regressions.Results:Results showed that the total score of the Dignity Scale is 151.95±11.75.From high to low,the different factors of dignity among older adults in long-term care facilities were as follows:caring factors(4.83±0.33),social factors(4.73±0.41),psychological factors(4.66±0.71),value factors(4.56±0.53),autonomous factors(4.50±0.57),and physical factors(4.38±0.55).A higher score of the Dignity Scale was associated with higher economic status,fewer chronic diseases,less medication,better daily living ability and long-time lived in cities.Conclusion:Older adults with low economic status,more chronic diseases,and poor daily living ability,taking more medications,or the previous residence in rural areas seem to be most at low-level dignity in long-term care facilities and thus require more attention than their peers.
基金Supported by The Portuguese League Against Cancer (Liga Portuguesa Contra o Cancro-Núcleo Regional do Norte) and AstraZeneca Foundation
文摘AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men.
文摘Forty-eight interviews were undertaken with residents in Timaru, Wanganui and Napier, New Zealand, in 2008 to explore how people understand and use information about earthquake hazards and preparedness, and how this process affects actual preparedness. Three main types of information were identified as being utilized by people: passive information (e.g., newspapers, brochures, TV, radio, websites), interactive information (e.g., community activities, school activities~ and workplace activities), and experiential information (e.g., experiencing a hazardous event, responding to an event, and working in an organization that deals with hazards). People tended to either contextualize hazard and preparedness information around any prevailing beliefs they had or form new beliefs on exposure to information. A number of core beliefs were identified as crucial for helping people consider that preparing is important and motivating actual adjustment adoption. Society also has an influence on how people interpret information and form intentions to prepare. People are often influenced by the opinions of others, and as preparing for disasters is not seen as a societal norm, this can cause people not to prepare. Feeling a responsibility for others (e.g., children) appears to be a major driver of preparedness. Other societal factors such as trust, leadership and sense of community also influence interpretation, dissemination and use of hazards and preparedness information. Finally, a number of resource issues can help or hinder preparedness.
文摘the left-behind children is appeared in our city in the process, there are many factors that influence the well-being, in this paper I conducted about the influence of left-behind children happiness questionnaire, focuses on the analysis of the influence factors from three aspects of environmental factors, personality factors and social factors. Based on the analys:is results, put forward and strengthen left-behind chi]dren well-being measures.
基金funded by the German Federal Ministry of Research and Education (Grant no. 01 LC 0601A)
文摘Transhumant pastoralism is an important activity in southern Morocco. Migration pattern of transhumant pastoralists can be affected by physical factors (e.g. droughts and diseases) or socioeconomic factors (e.g. schooling options for children and migration costs). We studied the spatio-temporal rangeland usage of the three tribes Ait Mgoun, Ait Zekri, and Ait Toumert in the south-central Atlas region with a two-fold approach. First, we tracked the migration movements of one representative transhumant herd using the Advanced Research and Global Observation Satellite (ARGOS) collars, which record coordinates from satellite signals. Second, we interviewed herders to obtain information about general grazing practices of the respective tribe and to gain more direct information on motivations underlying decisions. For each tribe we observed small-, medium- and large-scale movements. We found that the most important drivers of migration decisions were seasonal fodder availability and weather conditions in combination with herd-specific risk and cost assessment, as well as personal factors. In conclusion, general migration patterns vary in time, both between and within the tribes, but according to a regulatory framework. Moreover, it appears that both the customary rules and its flexible adaptation to physical constraints are generally beneficial in terms of conservation of the arid and semiarid rangeland resources.
文摘This paper discusses the constraining factors to sustainable utilization ofwater resources in China, and the countermeasures to realize sustainable water utilization. Theresult of comprehensive analysis shows that constraining factors to sustainable utilization of waterresources in China are complicated, including physical geographical factors and socio-economicfactors, such as uneven distribution of water resources at temporal and spatial scales,inappropriate institutional arrangement and non-water-saving and non-wter-conservation productionand life mode. The countermeasures against constraining factors to water resources sustainabledevelopment are put forward as follows: 1) using wetlands and forests, and through spatialconversion to realize temporally sustainable supply of water resources; 2) transferring waterbetween basins and areas and developing various water resources in water shortage area; 3)establishing water-saving society; 4) strengthening water pollution control and water resourcesprotection; and 5) establishing unified water resources management mechanism.
基金Supported by Department of Pathology Research Fund,NYU School of Medicine,New York,NY 10016,United States
文摘AIM:To determine the expression and clinical significance of transcriptional intermediary factor 1 gamma (TIF1γ),Smad4 and transforming growth factor-beta (TGFβR) across a spectrum representing colorectal cancer (CRC) development.METHODS:Tissue microarrays were prepared from archival paraffin embedded tissue,including 51 colorectal carcinomas,25 tubular adenomas (TA) and 26 HPs,each with matched normal colonic epithelium.Immunohistochemistry was performed using antibodies against TIF1γ,Smad4 and TGFβ RⅡ.The levels of expression were scored semi-quantitatively (score 0-3 or loss and retention for Smad4).RESULTS:Overexpression of TIF1γ was detected in 5/26 (19%) HP;however,it was seen in a significantly higher proportion of neoplasms,15/25 (60%) TAs and 24/51 (47%) CRCs (P<0.05).Normal colonic mucosa,HP,and TAs showed strong Smad4 expression,while its expression was absent in 22/51 (43%) CRCs.Over-expression of TGFβ RⅡ was more commonly seen in neoplasms,13/25 (52%) TAs and 29/51 (57%) CRCs compared to 9/26 (35%) HP (P<0.05).Furthermore,there was a correlation between TIF1γ overexpression and Smad4 loss in CRC (Kendall tau rank correlation value=0.35,P<0.05).The levels of TIF1γ overexpression were significantly higher in stage Ⅲ than in stage Ⅰ and Ⅱ CRC (P<0.05).CONCLUSION:The findings suggest that over-expression of TIF1γ occurs in early stages of colorectal carcinogenesis,is inversely related with Smad4 loss,and may be a prognostic indicator for poor outcome.
文摘Many people believe that democracy is something that can lead everyone toward a better nation and a free and fair society. In 1954, Brown v. Board of Education fundamentally changed the education system in the United States and was a turning point in the evolution of U,S. democracy that made the beautiful American dream available for each individual. However, six decades later, the debate over educational inequality continues. People are still fighting for their equality and well-being. Along with dramatically influential political, economic, and social factors in the United States, educational inequality destroys the commitment of this democratic nation to offer equal opportunity, care, and social justice to younger members of the community. This paper discusses the current problem of educational inequality as it relates to racial and socioeconomic discrimination in urban schools. The aim of this study is to explore knowledge of inequality in the U.S. school system and to raise social and educational awareness to help American children to have equal chances in education and to achieve future success.
文摘To examine the importance of kin selection in shaping human societies, this study analyzed the kinship system practiced in traditional China for two millennia and teased apart its underlying genetic and other, presumably cultural, components. The results demonstrate that, in the traditional patrilineal Chinese family, both genetic relatedness and the cultural factor of generation were important in determining kinship status for male agnates (genetically related relatives). For female agnates, however, only genetic relatedness was important. Another surprising finding was that the influence of gender was not as important as genetic relatedness. The most interesting finding in this study, however, was that kin selection and culture (i.e., seniority in generation and age) played vastly different roles in different lineages in the Chinese family: for collateral (indirect) agnates, genetic relatedness was the most important factor in determining their kinship status, but for lineal (direct) agnates, its importance was overridden by seniority in generation and age, a cultural factor. Several other bio-cultural factors also explained a considerable amount of variance in kinship status. Since kinship profoundly affected, and was often the foundation of, the legal and social systems in dynastic China, kin selection, while its strength may differ remarkably between lineal and collateral relatives, could act as a selective force in Chinese families
文摘In this paper, the authors present a method to construct a simulation experiment system which used to prove how social network affects the stock market. The authors construct a model considered of three main stock market effect factors: cognitive factors, social factors and economic factors. In the simulation system, free-scale social network is generated for information relations among investors in stock market. The authors simulate the organization information propaganda processes and generate stock related news. The generated news contains economy factors and sudden events. Stockholders cooperate with the related stockholders in their social network, and make stock exchange decision based on this news and their cognitive understanding of this news. Simulation results shows that the social network news propaganda effect stock prices. If social network in stock market have circles, the news affection will be amplified.
文摘Background: Physical activity participation(PAP) has been proven to improve health and promote optimal growth among adolescents. However,most adolescents do not meet the current physical activity(PA) recommendations in Turkey. The role of the social environment and social factors on PAP is being increasingly recognized. Although social capital(SC) indicators have been examined in high-income countries, there are few studies on developing countries. The aim of this study was to examine the relationship between SC indicators and PAP among Turkish adolescents.Methods: A survey was conducted among 19 high schools in 4 different cities in Turkey in 2016. A total of 506 female and 729 male high school students participated in this study. The dependent variable was overall PAP, which was measured using the short form of the International Physical Activity Questionnaire. The independent variables included self-perceived family, neighborhood, and school SC. Self-rated health and obesity status, measured by body mass index, were other study covariates in multiple binary logistic regression models. Chi-square tests were used to assess the differences between genders.Results: PAP levels were significantly different between males and females. A higher percentage of males reported PAP(77.4%) compared to females(51.0%). Among males, teacher–student interpersonal trust and informal social control were inversely associated with PAP, while high students interpersonal trust was positively associated with increased odds of PAP. For females, students interpersonal trust was inversely associated with PAP.Conclusion: Various SC indicators are associated with PAP for males and females. These associations are different from findings of studies conducted in developed countries. Therefore, health-promotion interventions and policies should consider gender and different social agents on the social and cultural background to improve PAP among Turkish adolescents.
基金Supported by Statutory action of National Food and Nutrition Institute
文摘AIM:To examine if dietary and socio-economic factors contribute to Helicobacter pylori(H pylori)re-infection. METHODS:The population of patients consisted of subjects in whom H pylori infection had been successfully treated in the past.Patients were divided into two groups:Ⅰ-examined group(111 persons with H pylori re-infection)andⅡ-control group(175 persons who had not been re-infected).The respondents were interviewed retrospectively on their dietary habits and socio-economic factors. RESULTS:A statistically significant lower frequency of fermented dairy products(P<0.0001),vegetables (P=0.02),and fruit(P=0.008)consumption was noted among patients with H pylori re-infection as compared to those who had not been re-infected. CONCLUSION:High dietary intake of probiotic bacteria,mainly Lactobacillus,and antioxidants,mainly vitamin C(contained in fruit and vegetables),might decrease the risk of H pylori re-infection.
文摘With the majority of young people increasingly becoming the main force of the use of the network, the network as a new kind of social factors on the growth of young people is increasingly prominent. Network not only help young people broaden their horizons, accept avant-garde concept, concern about the world cutting-edge issues, but also spread some violence, pornographic or reactionary spare, as well as network addiction problem which will cause a serious negative impact on the healthy growth of young people and lead to increasing juvenile crime. The number of juvenile criminals has increased every year in China and has trended to lowering ages, regiment turn and malignant development, which will cause great harm to social stability. Of course, there are many causes of juvenile delinquency, but showing characteristics are also diverse.
文摘With the translation studies leaning to target-language, the translator's subjectivity has been paid more and more attention by translation scholars. It is noticed gradually that translation is actually a dynamic and complex process, during which the translator, acting as a reader of the source text and also a writer of the target text, will unavoidably add something subjective in his or her translation. Since literary translation is interwoven with more cultural and social elements, the translator has to make a choice between loyalty and violation, getting freedom and being restricted when he or she confronts with all the clashes and conflicts between the source language culture and the target language culture.
基金Supported by Shanghai "Phosphor" Science Foundation, China, No. 09QB1403100the National High Technology Researchand Development Program of China, No. 2006AA020704 and 2006AA02A407the Funds for Key Programs of Ministry ofHealth of China, No.2008ZX10002-017
文摘AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively). CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.
文摘In recent years, a number of organisations have implemented Executive Information Systems (EIS) including Computer-Based Information Systems (CBIS) in order to improve the performance of their executives' jobs though the majority of executives are unwilling to use EIS applications because of their design defects. Present researches on Executive Information Systems (EIS) are limited and less focused on the factors associated with EIS successful usage. This research adopts an extension of the Technology Acceptance Model (TAM) to derive useful variables to address the problem of the low usage of EIS by executives due to social factors, habits and facilitation conditions variables in Triandis' Framework. It reports on the adoption and usage of EIS by the executives in Organizations. The results show that experience in EIS usage was high with most respondents having used EIS for between 0 to 4 years (72.41%), followed by the 5-9 years group with 25.86%. However, in terms of ability to use EIS, most executives were at the expert (knowledgeable), casual user with 37.93%, followed by novice frequent user group with 31.03%. From this research, the authors propose a model that incorporates the habits, social factors and facilitating conditions in an Executive Information Systems.