The correlation between Renminbi(RMB) internationalization and nonferrous metal prices was studied using the nonlinear Granger causality test and the dynamic conditional correlation-generalized autoregressive conditio...The correlation between Renminbi(RMB) internationalization and nonferrous metal prices was studied using the nonlinear Granger causality test and the dynamic conditional correlation-generalized autoregressive conditional heteroskedastic(DCC-GARCH) model. The results indicate that the relationship between RMB internationalization and nonferrous metal prices reflects a complex nonlinear mechanism. There was no mutual influence between RMB internationalization and nonferrous metal prices prior to the trials of the RMB settlement in the cross-border trade in July 2009. Since then, however, a bidirectional causal relationship between RMB internationalization and the price of copper and a unidirectional causal relationship from the price of aluminum to RMB internationalization were examined. In addition, due to the impact of extreme events, such as economic and financial crises, RMB internationalization and nonferrous metal prices are not always positively correlated but are rather occasionally negatively correlated.展开更多
A substantial part of the human genome is derived from transposable elements;remnants of ancient retroviral infections.Conservative estimates set the percentage of human endogenous retroviruses(HERVs) in the genome at...A substantial part of the human genome is derived from transposable elements;remnants of ancient retroviral infections.Conservative estimates set the percentage of human endogenous retroviruses(HERVs) in the genome at 8%.For the most part,the interplay between mutations,epigenetic mechanisms and posttranscriptional regulations silence HERVs in somatic cells.We first highlight mechanisms by which activation of members of several HERV families may be associated with tumor development before discussing the arising chances for both diagnosis and therapy.It has been shown that at least in some cases,tumor cells expressing HERV open reading frames(ORFs) thus gain tumor-promoting functions.However,since these proteins are not expressed in healthy tissues,they become prime target structures.Of potential pharmacological interest are the prevention of HERV transposition,the inhibition of HERV-encoded protein expression and the interference with these proteins' activities.Evidence from recent studies unequivocally proves that HERV ORFs represent a very interesting source of novel tumor-specific antigens with even the potential to surpass entity boundaries.The development of new tumor(immune-) therapies is a very active field and true tumor-specific targets are of outstanding interest since they minimize the risk of autoimmunity and could reduce side effects.Finally,we postulate on main future research streams in order to stimulate discussion on this hot topic.展开更多
Microscopic colitis(MC) is considered an "umbrella term",comprising two subtypes,i.e.,collagenous colitis(CC) and lymphocytic colitis(LC).They are classically associated with normal or unremarkable colonosco...Microscopic colitis(MC) is considered an "umbrella term",comprising two subtypes,i.e.,collagenous colitis(CC) and lymphocytic colitis(LC).They are classically associated with normal or unremarkable colonoscopy.In the last few years,reports have been published revealing findings that are thought to be characteristic or pathognomonic of MC,especially CC.A systematic electronic and manual search of PubMed and EMBASE(to December 2010),for publications on distinct endoscopic findings in MC,resulted in 42 relevant reports for inclusion in this review.Eighty eight patients with collagenous colitis were presented.Only one publication describing a distinct endoscopic pattern in LC was found.Typical findings in CC are alteration of the vascular mucosal pattern,mucosal nodularity,a sequence of change from mucosal defects to mucosal cicatricial lesions,and perhaps(although of doubtful relevance) mucosal pseudomembranes.A causal connection of mucosal defects with the use of lansoprazole seems to exist.Adoption of the proposed lesion description herein is recommended in order to improve homogeneity of future reports.展开更多
A brief overview of some open questions in general relativity with important consequences for causality theory is presented, aiming to a better understanding of the causal structure of the spacetime. Special attention...A brief overview of some open questions in general relativity with important consequences for causality theory is presented, aiming to a better understanding of the causal structure of the spacetime. Special attention is accorded to the problem of fundamental causal stability conditions. Several questions are raised and some of the potential consequences of recent results regarding the causality problem in general relativity are presented. A key question is whether causality violating regions are locally allowed. The new concept of almost stable causality is introduced; meanwhile, related conditions and criteria for the stability and almost stability of the causal structure are discussed.展开更多
We show that the quantum world with non-local states and original statistics is statistically separable. According to relativistic dynamics, the super-luminal signal transmission is impossible. The present quantum the...We show that the quantum world with non-local states and original statistics is statistically separable. According to relativistic dynamics, the super-luminal signal transmission is impossible. The present quantum theory is therefore consistent with the relativity and the causality.展开更多
By applying two nonlinear Granger causality testing methods and rolling window strategy to explore the relationship between speculative activities and crude oil prices, the unidirectional Granger causality from specul...By applying two nonlinear Granger causality testing methods and rolling window strategy to explore the relationship between speculative activities and crude oil prices, the unidirectional Granger causality from speculative activities to returns of crude oil prices during the high price phase is discovered. It is proved that speculative activities did contribute to high crude oil prices after the Asian financial crisis and OPEC's output cut in 1998. The unidirectional Granger causality from returns of crude oil prices to speculative activities is significant in general. But after 2000, with the sharp rise in crude oil prices, this unidirectional Granger causality became a complex nonlinear relationship, which cannot be detected by any linear Granger causaIity test.展开更多
supported by the National Natural Science Foundation of China under Grant Nos.71125005 70871108 and 70810107020;; Outstanding Talents Funds of Organization Department Beijing Committee of CPC
Detection and clarification of cause-effect relationships among variables is an important problem in time series analysis. Traditional causality inference methods have a salient limitation that the model must be linea...Detection and clarification of cause-effect relationships among variables is an important problem in time series analysis. Traditional causality inference methods have a salient limitation that the model must be linear and with Gaussian noise. Although additive model regression can effectively infer the nonlinear causal relationships of additive nonlinear time series, it suffers from the limitation that contemporaneous causal relationships of variables must be linear and not always valid to test conditional independence relations. This paper provides a nonparametric method that employs both mutual information and conditional mutual information to identify causal structure of a class of nonlinear time series models, which extends the additive nonlinear times series to nonlinear structural vector autoregressive models. An algorithm is developed to learn the contemporaneous and the lagged causal relationships of variables. Simulations demonstrate the effectiveness of the nroosed method.展开更多
In response to the tricky problem, raised by Hume, of the relationship between causality and freedom, Kant came up with the concept of two kinds of causality: causality of nature and causality of freedom. While the f...In response to the tricky problem, raised by Hume, of the relationship between causality and freedom, Kant came up with the concept of two kinds of causality: causality of nature and causality of freedom. While the former belongs in the phenomenal realm in the context of speculative reason, the latter, no more than a negative notion in the transcendental realm of things-in-themselves, nevertheless acquires actual objectivity in the context of practical reason. What causality of freedom confirms is freedom in the transcendental rather than the psychological sense. As Kant saw it, these two kinds of causality coexist in divided form in man, who is an existing being both in the realm of phenomena and in that of things-in-themselves. After Kant, it was Marx who, critically synthesizing the contributions of Hegel and Sehopenhauer, succeeded in revealing the hidden answer to the question of Kant's concept of two kinds of causality. That is productive labor, which implies both the dimension of goals and the causality of freedom and that of the causality of nature and historical causality. In the context of Marx's historical materialism, productive labor emerges as a kingdom of necessity at the very basis of the kingdom of freedom.展开更多
Studies of causal understanding of tool relationships in captive chimpanzees have yielded disparate findings, particularly those reported by Povinelli & colleagues (2000) for tool tasks by laboratory chimpanzees. T...Studies of causal understanding of tool relationships in captive chimpanzees have yielded disparate findings, particularly those reported by Povinelli & colleagues (2000) for tool tasks by laboratory chimpanzees. The present set of experiments tested nine enculturated chimpanzees on three versions of a support task, as described by Povinelli (2000), during which food re- wards were presented in different experimental configurations. In Experiment 1, stimulus pairs included a choice between a cloth with a reward on the upper right comer or with a second reward off the cloth, adjacent to a comer, with the second pair comprised of a cloth with food on the upper right comer, and a second cloth with the reward on the substrate, partially covered. All subjects were successful with both test conditions in Experiment 1. In a second study, the experimental choices included one of two possi- ble correct options, paired with one of three incorrect options, with the three incorrect choices all involving varying degrees of perceptual containment. All nine chimpanzees scored significantly above chance across all six conditions. In Experiment 3, four unique conditions were presented, combining one of two possible correct choices with one of two incorrect choices. Six of the subjects scored significantly above chance across the four conditions, and group performance on individual conditions was also significant. Superior performance was demonstrated by female subjects in Experiment 3, similar to sex differences in tool use previously reported for wild chimpanzees and some tool tasks in captive chimpanzees. The present results for Experiments 2 & 3 were significantly differed from those reported by Povinelli et al. (2000) for laboratory-born, peer-reared chimpanzees. One contribution towards the dramatic differences between the two study populations may be the significant rearing and housing differences of the chimpanzee groups. One explanation is that under conditions of enculturation, rich social interactions with humans and conspecifics, as well as active exploration of artifacts, materials, and other aspects of their physical environment had a significant impact on the animals' ability to recognize the support relationships among the stimulus choices. Overall, the present findings provide strong support for the hypothesis that our chimpanzee subjects based their responses on an understanding of functional support which represented one facet of their folk physics repertoire [Current Zoology 57 (4): 429-440, 2011].展开更多
The shear viscosity bound violation in Einstein gravity for anisotropic black branes is discussed, with the aim of constraining the deviation of the shear viscosity-entropy density ratio from the shear viscosity bound...The shear viscosity bound violation in Einstein gravity for anisotropic black branes is discussed, with the aim of constraining the deviation of the shear viscosity-entropy density ratio from the shear viscosity bound using causality and thermodynamics analysis.The results show that no stringent constraints can be imposed. The diffusion bound in anisotropic plaases is also studied. Ultimately, it is concluded that shear viscosity violation always occurs in cases where the equation of motion of the metric fluctuations cannot be written in a form identical to that of the minimally coupled massless scalar fields.展开更多
基金Projects(71874210,71633006,71874207,71974208)supported by the National Natural Science Foundation of ChinaProject(2020CX049)supported by Innovation-Driven Foundation of Central South University,China+1 种基金Project(2018dcyj031)supported by Postgraduate Survey Research Foundation of Central South University,ChinaProject(17K103)supported by the Innovation Platform Open Fund Project of Hunan Education Department,China。
文摘The correlation between Renminbi(RMB) internationalization and nonferrous metal prices was studied using the nonlinear Granger causality test and the dynamic conditional correlation-generalized autoregressive conditional heteroskedastic(DCC-GARCH) model. The results indicate that the relationship between RMB internationalization and nonferrous metal prices reflects a complex nonlinear mechanism. There was no mutual influence between RMB internationalization and nonferrous metal prices prior to the trials of the RMB settlement in the cross-border trade in July 2009. Since then, however, a bidirectional causal relationship between RMB internationalization and the price of copper and a unidirectional causal relationship from the price of aluminum to RMB internationalization were examined. In addition, due to the impact of extreme events, such as economic and financial crises, RMB internationalization and nonferrous metal prices are not always positively correlated but are rather occasionally negatively correlated.
基金Supported by Grants from the State Mecklenburg-Vorpommern and from Deutsche Krebshilfe,No.108446
文摘A substantial part of the human genome is derived from transposable elements;remnants of ancient retroviral infections.Conservative estimates set the percentage of human endogenous retroviruses(HERVs) in the genome at 8%.For the most part,the interplay between mutations,epigenetic mechanisms and posttranscriptional regulations silence HERVs in somatic cells.We first highlight mechanisms by which activation of members of several HERV families may be associated with tumor development before discussing the arising chances for both diagnosis and therapy.It has been shown that at least in some cases,tumor cells expressing HERV open reading frames(ORFs) thus gain tumor-promoting functions.However,since these proteins are not expressed in healthy tissues,they become prime target structures.Of potential pharmacological interest are the prevention of HERV transposition,the inhibition of HERV-encoded protein expression and the interference with these proteins' activities.Evidence from recent studies unequivocally proves that HERV ORFs represent a very interesting source of novel tumor-specific antigens with even the potential to surpass entity boundaries.The development of new tumor(immune-) therapies is a very active field and true tumor-specific targets are of outstanding interest since they minimize the risk of autoimmunity and could reduce side effects.Finally,we postulate on main future research streams in order to stimulate discussion on this hot topic.
文摘Microscopic colitis(MC) is considered an "umbrella term",comprising two subtypes,i.e.,collagenous colitis(CC) and lymphocytic colitis(LC).They are classically associated with normal or unremarkable colonoscopy.In the last few years,reports have been published revealing findings that are thought to be characteristic or pathognomonic of MC,especially CC.A systematic electronic and manual search of PubMed and EMBASE(to December 2010),for publications on distinct endoscopic findings in MC,resulted in 42 relevant reports for inclusion in this review.Eighty eight patients with collagenous colitis were presented.Only one publication describing a distinct endoscopic pattern in LC was found.Typical findings in CC are alteration of the vascular mucosal pattern,mucosal nodularity,a sequence of change from mucosal defects to mucosal cicatricial lesions,and perhaps(although of doubtful relevance) mucosal pseudomembranes.A causal connection of mucosal defects with the use of lansoprazole seems to exist.Adoption of the proposed lesion description herein is recommended in order to improve homogeneity of future reports.
文摘A brief overview of some open questions in general relativity with important consequences for causality theory is presented, aiming to a better understanding of the causal structure of the spacetime. Special attention is accorded to the problem of fundamental causal stability conditions. Several questions are raised and some of the potential consequences of recent results regarding the causality problem in general relativity are presented. A key question is whether causality violating regions are locally allowed. The new concept of almost stable causality is introduced; meanwhile, related conditions and criteria for the stability and almost stability of the causal structure are discussed.
基金The project supported by National Natural Science Foundation of China under Grant No. 10305001
文摘We show that the quantum world with non-local states and original statistics is statistically separable. According to relativistic dynamics, the super-luminal signal transmission is impossible. The present quantum theory is therefore consistent with the relativity and the causality.
基金supported by the National Natural Science Foundation of China
文摘By applying two nonlinear Granger causality testing methods and rolling window strategy to explore the relationship between speculative activities and crude oil prices, the unidirectional Granger causality from speculative activities to returns of crude oil prices during the high price phase is discovered. It is proved that speculative activities did contribute to high crude oil prices after the Asian financial crisis and OPEC's output cut in 1998. The unidirectional Granger causality from returns of crude oil prices to speculative activities is significant in general. But after 2000, with the sharp rise in crude oil prices, this unidirectional Granger causality became a complex nonlinear relationship, which cannot be detected by any linear Granger causaIity test.
基金supported by the National Natural Science Foundation of China under Grant Nos.71001096,70933003,and 71071170
文摘supported by the National Natural Science Foundation of China under Grant Nos.71125005 70871108 and 70810107020;; Outstanding Talents Funds of Organization Department Beijing Committee of CPC
基金supported by the National Natural Science Foundation of China under Grant Nos.60972150 and 10926197
文摘Detection and clarification of cause-effect relationships among variables is an important problem in time series analysis. Traditional causality inference methods have a salient limitation that the model must be linear and with Gaussian noise. Although additive model regression can effectively infer the nonlinear causal relationships of additive nonlinear time series, it suffers from the limitation that contemporaneous causal relationships of variables must be linear and not always valid to test conditional independence relations. This paper provides a nonparametric method that employs both mutual information and conditional mutual information to identify causal structure of a class of nonlinear time series models, which extends the additive nonlinear times series to nonlinear structural vector autoregressive models. An algorithm is developed to learn the contemporaneous and the lagged causal relationships of variables. Simulations demonstrate the effectiveness of the nroosed method.
文摘In response to the tricky problem, raised by Hume, of the relationship between causality and freedom, Kant came up with the concept of two kinds of causality: causality of nature and causality of freedom. While the former belongs in the phenomenal realm in the context of speculative reason, the latter, no more than a negative notion in the transcendental realm of things-in-themselves, nevertheless acquires actual objectivity in the context of practical reason. What causality of freedom confirms is freedom in the transcendental rather than the psychological sense. As Kant saw it, these two kinds of causality coexist in divided form in man, who is an existing being both in the realm of phenomena and in that of things-in-themselves. After Kant, it was Marx who, critically synthesizing the contributions of Hegel and Sehopenhauer, succeeded in revealing the hidden answer to the question of Kant's concept of two kinds of causality. That is productive labor, which implies both the dimension of goals and the causality of freedom and that of the causality of nature and historical causality. In the context of Marx's historical materialism, productive labor emerges as a kingdom of necessity at the very basis of the kingdom of freedom.
文摘Studies of causal understanding of tool relationships in captive chimpanzees have yielded disparate findings, particularly those reported by Povinelli & colleagues (2000) for tool tasks by laboratory chimpanzees. The present set of experiments tested nine enculturated chimpanzees on three versions of a support task, as described by Povinelli (2000), during which food re- wards were presented in different experimental configurations. In Experiment 1, stimulus pairs included a choice between a cloth with a reward on the upper right comer or with a second reward off the cloth, adjacent to a comer, with the second pair comprised of a cloth with food on the upper right comer, and a second cloth with the reward on the substrate, partially covered. All subjects were successful with both test conditions in Experiment 1. In a second study, the experimental choices included one of two possi- ble correct options, paired with one of three incorrect options, with the three incorrect choices all involving varying degrees of perceptual containment. All nine chimpanzees scored significantly above chance across all six conditions. In Experiment 3, four unique conditions were presented, combining one of two possible correct choices with one of two incorrect choices. Six of the subjects scored significantly above chance across the four conditions, and group performance on individual conditions was also significant. Superior performance was demonstrated by female subjects in Experiment 3, similar to sex differences in tool use previously reported for wild chimpanzees and some tool tasks in captive chimpanzees. The present results for Experiments 2 & 3 were significantly differed from those reported by Povinelli et al. (2000) for laboratory-born, peer-reared chimpanzees. One contribution towards the dramatic differences between the two study populations may be the significant rearing and housing differences of the chimpanzee groups. One explanation is that under conditions of enculturation, rich social interactions with humans and conspecifics, as well as active exploration of artifacts, materials, and other aspects of their physical environment had a significant impact on the animals' ability to recognize the support relationships among the stimulus choices. Overall, the present findings provide strong support for the hypothesis that our chimpanzee subjects based their responses on an understanding of functional support which represented one facet of their folk physics repertoire [Current Zoology 57 (4): 429-440, 2011].
基金the National Natural Science Foundation of China(Grant No.11375110)
文摘The shear viscosity bound violation in Einstein gravity for anisotropic black branes is discussed, with the aim of constraining the deviation of the shear viscosity-entropy density ratio from the shear viscosity bound using causality and thermodynamics analysis.The results show that no stringent constraints can be imposed. The diffusion bound in anisotropic plaases is also studied. Ultimately, it is concluded that shear viscosity violation always occurs in cases where the equation of motion of the metric fluctuations cannot be written in a form identical to that of the minimally coupled massless scalar fields.