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新常态下影响中国出口贸易升级的因素分析
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作者 谢丹 蒋涛 《现代商贸工业》 2017年第19期28-32,共5页
运用1999-2014年相关数据,以基本要素为切入点,分析基本要素对于贸易升级的影响作用。通过实证研究发现,劳动投入(高素质劳动投入)、资本投入以及实际利用外商直接投资和汇率变动均对贸易升级起促进作用,但影响程度有所差异。资本投入... 运用1999-2014年相关数据,以基本要素为切入点,分析基本要素对于贸易升级的影响作用。通过实证研究发现,劳动投入(高素质劳动投入)、资本投入以及实际利用外商直接投资和汇率变动均对贸易升级起促进作用,但影响程度有所差异。资本投入和汇率的波动是影响出口贸易升级的重要因素;高素质劳动投入以及实际利用外商投资量逐年递减,致使劳动投入和FDI对于出口贸易升级的影响并不显著。 展开更多
关键词 出口贸易 升级 因素分素
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广州市中小学生自杀意念及影响因素研究 被引量:11
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作者 陈薇 李芳健 +5 位作者 王家骥 麦锦城 王心旺 李亮昌 方耀华 卡德尔 《中国学校卫生》 CAS 北大核心 2006年第3期193-194,共2页
目的了解广州市中小学生自杀意念的发生情况及影响因素,为预防中小学生自杀提供依据。方法采用统一调查表,应用分层整群抽样的方法调查广州市8所中学和8所小学学生7 527名,通过多因素Logistic回归模型筛选自杀意念的危险因素。结果广州... 目的了解广州市中小学生自杀意念的发生情况及影响因素,为预防中小学生自杀提供依据。方法采用统一调查表,应用分层整群抽样的方法调查广州市8所中学和8所小学学生7 527名,通过多因素Logistic回归模型筛选自杀意念的危险因素。结果广州市中小学生自杀意念发生率为14.5%。多因素分析显示,自杀意念的影响因素为性别、学生类型、健康状况、因病缺勤、吸烟、饮酒、被恐吓或伤害、轻微自伤行为和伤心绝望。结论自杀意念在中小学生中较为常见。应加强综合干预措施,防止自杀行为的发生。 展开更多
关键词 自杀 意识 因素分素 统计学 学生
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Somatostatin adjunctive therapy for non-variceal upper gastrointestinal rebleeding after endoscopic therapy 被引量:16
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作者 Cheol Woong Choi Dae Hwan Kang +5 位作者 Hyung Wook Kim Su Bum Park Kee Tae Park Gwang Ha Kim Geun Am Song Mong Cho 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第29期3441-3447,共7页
AIM:To evaluate the effect of pantoprazole with a somatostatin adjunct in patients with acute non-variceal upper gastrointestinal bleeding(NVUGIB).METHODS:We performed a retrospective analysis of a prospective databas... AIM:To evaluate the effect of pantoprazole with a somatostatin adjunct in patients with acute non-variceal upper gastrointestinal bleeding(NVUGIB).METHODS:We performed a retrospective analysis of a prospective database in a tertiary care university hospital.From October 2006 to October 2008,we enrolled 101 patients with NVUGIB that had a high-risk stigma on endoscopy.Within 24 h of hospital admission,all patients underwent endoscopic therapy.After successful endoscopic hemostasis,all patients received an 80-mg bolus of pantoprazole followed by continuous intravenous infusion(8 mg/h for 72 h).The somatostatin adjunct group(n=49)also received a 250-μg bolus of somatostatin,followed by continuous infusion (250μg/h for 72 h).Early rebleeding rates,disappearance of endoscopic stigma and risk factors associated with early rebleeding were examined.RESULTS:Early rebleeding rates were not significantly different between treatment groups(12.2%vs 14.3%,P=0.766).Disappearance of endoscopic stigma on the second endoscopy was not significantly different between treatment groups(94.2%vs 95.9%,P=0.696).Multivariate analysis showed that the complete Rockall score was a significant risk factor for early rebleeding(P =0.044,OR:9.080,95%CI:1.062-77.595).CONCLUSION:The adjunctive use of somatostatin was not superior to pantoprazole monotherapy after successful endoscopic hemostasis in patients with NVUGIB. 展开更多
关键词 SOMATOSTATIN PANTOPRAZOLE Gastrointestinal bleeding REBLEEDING
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Prognostic factors of T4 gastric cancer patients undergoing potentially curative resection 被引量:8
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作者 Naoto Fukuda Yasuyuki Sugiyama Joji Wada 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第9期1180-1184,共5页
AIM:To investigate the prognostic factors of T4 gastric cancer patients without distant metastasis who could undergo potentially curative resection. METHODS:We retrospectively analyzed the clinical data of 71 consecut... AIM:To investigate the prognostic factors of T4 gastric cancer patients without distant metastasis who could undergo potentially curative resection. METHODS:We retrospectively analyzed the clinical data of 71 consecutive patients diagnosed with T4 gastric cancer and who underwent curative gastrectomy at our institutions.The clinicopathological factors that could be associated with overall survival were evaluated.The cumulative survival was determined by the Kaplan-Meier method,and univariate comparisons between the groups were performed using the log-rank test.Multivariate analysis was performed using the Cox proportional hazard model and a step-wise procedure. RESULTS:The study patients comprised 53 men (74.6%)and 18 women(25.4%)aged 39-89 years (mean,68.9 years).Nineteen patients(26.8%)had postoperative morbidity:pancreatic fistula developed in 6 patients(8.5%)and was the most frequent complication,followed by anastomosis stricture in 5 patients (7.0%).During the follow-up period,28 patients(39.4%)died because of gastric cancer recurrence,and 3(4.2%) died because of another disease or accident.For all patients,the estimated overall survival was 34.1%at 5 years.Univariate analyses identified the following statistically significant prognostic factors in T4 gastric cancer patients who underwent potentially curative resection: peritoneal washing cytology(P<0.01),number of metastatic lymph nodes(P<0.05),and venous invasion(P <0.05).In multivariate analyses,only peritoneal washing cytology was identified as an independent prognostic factor(HR=3.62,95%CI=1.37-9.57)for longterm survival. CONCLUSION:Positive peritoneal washing cytology was the only independent poor prognostic factor for T4 gastric cancer patients who could be treated with potentially curative resection. 展开更多
关键词 Gastric cancer T4 Prognostic factors Peritoneal cytology Venous invasion
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Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment 被引量:5
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作者 Jun Zhao Chang-Zheng Du +1 位作者 Ying-Shi Sun Jin Gu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期7015-7020,共6页
AIM:To investigate the patterns and decisive prognostic factors for local recurrence of rectal cancer treated with a multidisciplinary team(MDT) modality.METHODS:Ninety patients with local recurrence were studied,out ... AIM:To investigate the patterns and decisive prognostic factors for local recurrence of rectal cancer treated with a multidisciplinary team(MDT) modality.METHODS:Ninety patients with local recurrence were studied,out of 1079 consecutive rectal cancer patients who underwent curative surgery from 1999 to 2007.For each patient,the recurrence pattern was assessed by specialist radiologists from the MDT using imaging,and the treatment strategy was decided after discussion by the MDT.The associations between clinicopathological factors and long-term outcomes were evaluated using both univariate and multivariate analysis.RESULTS:The recurrence pattern was classified as follows:Twenty-seven(30%) recurrent tumors were evaluated as axial type,21(23.3%) were anterior type,8(8.9%) were posterior type,and 13(25.6%) were lateral type.Forty-one patients had tumors that were evaluated as resectable by the MDT and ultimately received surgery,and R0 resection was achieved in 36(87.8%) of these patients.The recurrence pattern was closely associated with resectability and R0 resection rate(P < 0.001).The recurrence pattern,interval to recurrence,and R0 resection were significantly associated with 5-year survival rate in univariate analysis.Multivariate analysis showed that the R0 resection was the unique independent factor affecting long-term survival.CONCLUSION:The MDT modality improves patient selection for surgery by enabling accurate classification of the recurrence pattern;R0 resection is the most significant factor affecting long-term survival. 展开更多
关键词 Rectal cancer Local recurrence PROGNOSIS SURVIVAL SURGERY
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Analysis of infections in the first 3-month after living donor liver transplantation 被引量:27
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作者 Chuan Li Tian-Fu Wen +3 位作者 Kai Mi Chuan Wang Lu-Nan Yan Bo Li 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第16期1975-1980,共6页
AIM:To identify factors related to serious postoperative bacterial and fungal infections in the first 3 mo after living donor liver transplantation(LDLT).METHODS:In the present study,the data of 207 patients from 2004... AIM:To identify factors related to serious postoperative bacterial and fungal infections in the first 3 mo after living donor liver transplantation(LDLT).METHODS:In the present study,the data of 207 patients from 2004 to 2011 were reviewed.The pre-,intra-and post-operative factors were statistically analyzed.All transplantations were approved by the ethics committee of West China Hospital,Sichuan University.Patients with definitely preoperative infections and infections within 48 h after transplantation were excluded from current study.All potential risk factors were analyzed using univariate analyses.Factors significant at a P < 0.10 in the univariate analyses were involved in the multivariate analyses.The diagnostic accuracy of the identified risk factors was evaluated using receiver operating curve.RESULTS:The serious bacterial and fungal infection rates were 14.01% and 4.35% respectively.Enterococcus faecium was the predominant bacterial pathogen,whereas Candida albicans was the most common fungal pathogen.Lung was the most common infection site for both bacterial and fungal infections.Recipient age older than 45 years,preoperative hyponatremia,intensive care unit stay longer than 9 d,postoperative bile leak and severe hyperglycemia were independent risk factors for postoperative bacterial infection.Massive red blood cells transfusion and postoperative bacterial infection may be related to postoperative fungal infection.CONCLUSION:Predictive risk factors for bacterial and fungal infections were indentified in current study.Pre-,intra-and post-operative factors can cause postoperative bacterial and fungal infections after LDLT. 展开更多
关键词 Bacterial infection Fungal infection Living donor liver transplantation
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Hepatic Resection is Safe for Metachronous Hepatic Metastases from Ovarian Cancer 被引量:1
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作者 Guang-cai Niu Chang-ming Shen +1 位作者 Wei Cui Qiang Li 《Clinical oncology and cancer researeh》 CAS CSCD 2012年第3期182-187,共6页
Objective To explore the efficacy of hepatic resection(HR) in a relatively unselected group of patients with ovarian cancer liver metastases(OCLM). Methods A study was conducted between September 2000 and September 20... Objective To explore the efficacy of hepatic resection(HR) in a relatively unselected group of patients with ovarian cancer liver metastases(OCLM). Methods A study was conducted between September 2000 and September 2011 on 60 ovarian cancer patients with hepatic metastases(24 solitary and 36 multiple),40 of whom had extrahepatic metastases.HR was done in all patients provided that curative hepatic resection was feasible,and extrahepatic disease was controlled with medical and/or surgical therapy. Results Most patients(n=54;90.0% ) had a negative hepatic margin(R0),whereas 6 patients(10.0% ) had microscopic disease at the margin(R1).The prognostic value of each study variable was assessed using log rank tests for univariate analysis and Cox proportional hazard models for multivariate analysis.The result was a median survival of 39 months and 5-year overall survival rate of 30% .Univariate analysis showed that surgery result(P=0.001),disease free interval(P=0.018) and the number of hepatic lesions (P=0.018) were significantly related to survival.Furthermore,the surgery result(P=0.004) remained significant for prognosis in multivariate analysis. Conclusions For patients with OCLM,HR is safe and may provide a significant survival benefit compared with medical therapy alone.A long interval time,the number of hepatic lesions,and surgery results are key prognostic factors.Favorable outcomes can be achieved even in patients with medically controlled or surgically resectable extrahepatic disease,indicating that surgery should be considered more frequently in the multidisciplinary care of patients with OCLM. 展开更多
关键词 ovarian cancer liver metastasis hepatectomy.
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Extracapsular invasion as a risk factor for disease recurrence in colorectal cancer 被引量:2
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作者 Takaaki Fujii Yuichi Tabe +4 位作者 Reina Yajima Satoru Yamaguchi Soichi Tsutsumi Takayuki Asao Hiroyuki Kuwano 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第15期2003-2006,共4页
AIM: To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS: Two hundred and twenty-eight consecutive patients who underwe... AIM: To evaluate the presence of extracapsular invasion (ECI) in positive nodes as a predictor of disease recurrence disease in colorectal cancer. METHODS: Two hundred and twenty-eight consecutive patients who underwent colorectal resection were identified for inclusion in this study, of which 46 had positive lymph nodes. Among 46 cases with stage Ⅲcolorectal cancer, 16 had ECI at positive nodes and 8 had disease recurrence. The clinical and pathological features of these cases were reviewed. RESULTS: In the univariate analysis, the number of positive lymph nodes and depth of tumor invasion were significantly associated with the presence of ECI at positive nodes. Multivariate analysis demonstrated that only ECI was a predictor of recurrence. The recurrence-free interval differed significantly among patients with ECI at positive nodes.CONCLUSION: Our results suggest that ECI at metastatic nodes can identify which cases are at high risk of short-term disease recurrence in colorectal cancer. 展开更多
关键词 Extracapsular invasion Lymph node METASTASIS Colorectal cancer Risk factor Adjuvant therapy
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Problems associated with glucose toxicity:Role of hyperglycemia-induced oxidative stress 被引量:45
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作者 Shinji Kawahito Hiroshi Kitahata Shuzo Oshita 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第33期4137-4142,共6页
Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic super-physiological glucose concentration negatively affects a lar... Glucose homeostasis deficiency leads to a chronic increase in blood glucose concentration. In contrast to physiological glucose concentration, chronic super-physiological glucose concentration negatively affects a large number of organs and tissues. Glucose toxicity means a decrease in insulin secretion and an increase in insulin resistance due to chronic hyperglycemia. It is now generally accepted that glucose toxicity is involved in the worsening of diabetes by affecting the secretion of B-cells. Several mechanisms have been proposed to explain the adverse effects of hyperglycemia. It was found that persistent hyperglycemia caused the functional decline of neutrophils. Infection is thus the main problem resulting from glucose toxicity in the acute phase. In other words, continued hyperglycemia is a life-threatening risk factor, not only in the chronic but also the acute phase, and it becomes a risk factor for infection, particularly in the perioperative period. 展开更多
关键词 Glucose toxicity DIABETES COMPLICATION SURGERY Surgical site infection Emergency medicine Critical care medicine
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Extraprofessional and Occupational Risk Factors for Colorectal Cancer
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作者 Olfa El Maalel Wided Boughattas +8 位作者 Maher Maoua Houda Kalboussi Iheb Bougmiza Houssem Rhif Souhaiel Chatti Kader N'Daye Faten Debbabi Ali Mtiraoui Noejib Mrizak 《Journal of Life Sciences》 2012年第8期848-857,共10页
Colorectal cancers (CRC) account for frequent and serious cancers which result from the interaction between individual genetic factors and environmental factors, and in particular widely studied nutritional ones. Th... Colorectal cancers (CRC) account for frequent and serious cancers which result from the interaction between individual genetic factors and environmental factors, and in particular widely studied nutritional ones. The role of other occupational factors remains a controversial subject. The objective of this study is to evaluate the possible impact of occupational factors on the risk of developing CRC. Materials and Methods: This is a retrospective case-control study. The cases and the control group were enlisted in the general surgical ward of Farhat Hached Teaching Hospital of Sousse (Tunisia) during the period extending from 2004 to 2008, and they were age and gender-matched. The data were analyzed using SPSS 11.0 software with a signification threshold fixed at 5%. A univariate analysis was carried out as well as a multiple binary logistical regression. Results: During the period of the study, 40 cases of colorectal cancers have been colligated including 28 men and 12 women with a sex ratio of 0.43. The average age of the cases was 61.55 ± 13.3 years and 60.40 ± 12.84 years for the control group, with a non significant difference (P = 0.69). The univariate analysis has objectivized significant associations between colorectal cancer and the housing conditions, the neoplastic and digestive family history, the occupational activity sector, exposure to pesticides, and lack of periodic medical supervision. After logistical regression, the occurrence risk of CRC was significantly associated with: alcohol and smoking (ORa = 3.43; Pa = 0.05), meat consumption (ORa = 3.34; Pa = 0.03), exposure to pesticides (ORa = 20.44; Pa = 0.012) and lack of periodic medical supervision (OR = 7.45; P = 0.004). Conclusion: The occupational risk factors might play a role in the etiopathogenesis of colorectal cancers. With regard to our study, pesticides seem to be most implicated and necessitate suitable preventive measures. Nevertheless, it seems useful to multiply the studies to a much larger scale in order to further explore such relationship and to further reinforce the prevention of such serious disease. 展开更多
关键词 Colorectal cancer occupational risk factors extraprofessional factors epidemiology.
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Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk 被引量:15
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作者 Mathilde Touvier Léopold Fezeu +8 位作者 Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第22期2805-2812,共8页
AIM: To examine the relationships between pre-diag- nostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first... AIM: To examine the relationships between pre-diag- nostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplemen- tation en VItamines et Min^raux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected con- trols (n = 100). Conditional logistic regression models were used to investigate the associations between pre- diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-I, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory poten- tial of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend -- 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improve- ment = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diag- nostic plasma adiponectin and sVCAM-1 levels are as- sociated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. 展开更多
关键词 Colorectal cancer ADIPONECTIN Soluble vascu-lar cell adhesion molecule-l Nested case-control study Prospective study
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Determining Topographic Shielding from Digital Elevation Models for Cosmogenic Nuclide Analysis:a GIS Approach and Field Validation 被引量:8
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作者 LI Ying-kui 《Journal of Mountain Science》 SCIE CSCD 2013年第3期355-362,共8页
Topographic shielding of cosmic radiation flux is a key parameter in using cosmogenic nuclides to determine surface exposure ages or erosion rates. Traditionally, this parameter is measured in the field and uncertaint... Topographic shielding of cosmic radiation flux is a key parameter in using cosmogenic nuclides to determine surface exposure ages or erosion rates. Traditionally, this parameter is measured in the field and uncertainty and/or inconsistency may exist among different investigators. This paper provides an ArcGIS python code to determine topographic shielding factors using digital elevation models (DEMs). This code can be imported into ArcGIS as a geoprocessing tool with a user-friendly graphical interface. The DEM-derived parameters using this method were validated with field measurements in central Tian Shan. Results indicate that DEM-derived shielding factors are consistent with field-measured values. It provides a valuable tool to save fieldwork efforts and has the potential to provide consistent results for different regions in the world to facilitate the comparison of cosmogenie nuclide results. 展开更多
关键词 Cosmogenic nuclides Topographicshielding ARCGIS PYTHON Digital elevation models(DEMs)
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Risk Factors for Lymph Node Metastasis and Endoscopic Treatment Strategies of Undifferentiated Early Gastric Cancer
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作者 Yi FANG Tao YAN Ji-dong GAO Xin-yu BI Hong ZHAO Hai-tao ZHOU Zhen HUANG Jian-qiang CAI 《Clinical oncology and cancer researeh》 CAS CSCD 2011年第3期181-184,共4页
OBJECTIVE To discuss the effects of clinico-pathological features on lymph node metastasis (LNM) in undifferentiated EGC (early gastric cancer), as well as identify the appropriate medical management. METHODS From... OBJECTIVE To discuss the effects of clinico-pathological features on lymph node metastasis (LNM) in undifferentiated EGC (early gastric cancer), as well as identify the appropriate medical management. METHODS From January 1999 to June 2011, 352 patients were treated for undifferentiated EGC in our hospital. All patients had undergone gastrectomy with regional lymphadenectomy. We used univariate and multivariate associated with lymph node entiated EGC. analyses to determine the features metastasis in patients with undiffer- RESULTS Signet ring cell carcinoma (SRC) was more common in patients with undifferentiated EGC than other undifferentiated carcinoma (UDC). SRC had a tendency to be confined to the mucosa, with a smaller size than other UDC. The incidence of LNM for SRC was lower than that for other UDC. Multivariate analysis showed that LNM was associated with the sex, tumor size, depth of invasion, lymphovascular invasion, and histological type. CONCLUSION Complete endoscopic resection is suitable for SRC- type intramucosal EGC, which is less than 2 cm in diameter without lymphovascular invasion in the postoperative histological examination. 展开更多
关键词 undifferentiated early gastric cancer endoscopic submucosal dissection lymph node metastasis
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Prognostic factors analysis of 138 patients with stage IV gastric cancer
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作者 Zhixiang Zhuang Yufeng Lu Liqin Shen 《The Chinese-German Journal of Clinical Oncology》 CAS 2010年第12期714-717,共4页
Ab Objective: We evaluated the prognostic factors of patients with stage IV gastric cancer. Methods: In the current retrospective study, 138 patients of stage I gastric cancer treated with platinum-based chemotherap... Ab Objective: We evaluated the prognostic factors of patients with stage IV gastric cancer. Methods: In the current retrospective study, 138 patients of stage I gastric cancer treated with platinum-based chemotherapy were analyzed. Survival rate was estimated by using Kaplan-Meier method. The prognostic factors were analyzed using univariate (Log rank) and multivariate (Cox model) analysis methods. Results: Univariate analysis showed and multivariate analysis showed that poor performance status (P = 0.001), weight loss (P = 0.001), depth of invasion (P = 0.000), presence of peritoneal metastasis (P = 0.005), more than 1 metastatic site (P = 0.029) and elevated total bilirubin (P = 0.018) were confirmed as independent prognostic factors. According to the outcomes of the Cox model analysis, a formula of the prognostic index was developed. According to the values of PI, 16 patients were categorized as the good risk group, 28 patients were categorized as the moderate risk group and 8 patients were categorized as the poor risk group, respectively. The survival ratios of 6 months, 12 months and 24 months of the good risk group were 75.00%, 50.00%, 25.00%, respectively. The survival ratios of 6 month, 1-year and 2-year of the moderate risk group were 71.79%, 28.57%, 7.14%, respectively. While the survival ratios of 6 month, 12 months and 24 months of the poor risk group were 50%, 0, 0, respectively. The overall survival ratios of the 3 groups were compared in pairs. Conclusion: Poor performance status, depth of invasion, elevated total bilirubin, more than 1 metastatic site, presence of peritoneal metastasis ,weight loss were the independent prognostic factors. A formula of the prognostic index was developed, and it could help clinicians and patients in clinical decision-making and treatment tailoring based on the estimated prognosis. 展开更多
关键词 gastric cancer prognostic factors PLATINUM CHEMOTHERAPY
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Is adjuvant chemotherapy necessary for patients with microinvasive breast cancer after surgery? 被引量:1
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作者 Hai-Fei Niu Li-Juan Wei +4 位作者 Jin-Pu Yu Zhen Lian Jing Zhao Zi-Zheng Wu Jun-Tian Liu 《Cancer Biology & Medicine》 SCIE CAS CSCD 2016年第1期142-149,共8页
Objective: Survival and treatment of patients with microinvasive breast cancer(MIBC) remain controversial. In this paper, we evaluated whether adjuvant chemotherapy is necessary for patients with MIBC to identify risk... Objective: Survival and treatment of patients with microinvasive breast cancer(MIBC) remain controversial. In this paper, we evaluated whether adjuvant chemotherapy is necessary for patients with MIBC to identify risk factors influencing its prognosis and decide the indication for adjuvant chemotherapy.Methods: In this retrospective study, 108 patients with MIBC were recruited according to seventh edition of the staging manual of the American Joint Committee on Cancer(AJCC). The subjects were divided into chemotherapy and non-chemotherapy groups.We compared the 5-year disease-free survival(DFS) and overall survival(OS) rates between groups. Furthermore, we analyzed the factors related to prognosis for patients with MIBC using univariate and multivariate analyses. We also evaluated the impact of adjuvant chemotherapy on the prognostic factors by subgroup analysis after median follow-up time of 33 months(13-104months).Results: The 5-year DFS and OS rates for the chemotherapy group were 93.7% and 97.5%, whereas those for the nonchemotherapy group were 89.7% and 100%. Results indicate that 5-year DFS was superior, but OS was inferior, in the former group compared with the latter group. However, no statistical significance was observed in the 5-year DFS(P=0.223) or OS(P=0.530) rate of the two groups. Most relevant poor-prognostic factors were Ki-67 overexpression and negative hormonal receptors. Cumulative survival was 98.2% vs. 86.5% between low Ki-67(≤20%) and high Ki-67(>20%). The hazard ratio of patients with high Ki-67 was 16.585 [95% confidence interval(CI), 1.969-139.724; P=0.010]. Meanwhile, ER(-)/PR(-) patients with MIBC had cumulative survival of 79.3% compared with 97.5% for ER(+) or PR(+) patients with MIBC. The hazard ratio for ER(-)/PR(-) patients with MIBC was 19.149(95% CI, 3.702-99.057; P<0.001). Subgroup analysis showed that chemotherapy could improve the outcomes of ER(-)/PR(-) patients(P=0.014), but not those who overexpress Ki-67(P=0.105).Conclusions: Patients with MIBC who overexpress Ki-67 and with negative hormonal receptors have relatively substantial risk of relapse within the first five years after surgery. However, adjuvant chemotherapy can only improve the outcomes of ER(-)/PR(-)patients, but not those who overexpress Ki-67. Further studies with prolonged follow-up of large cohorts are recommended to assess the prognostic significance and treatment of this lesion. 展开更多
关键词 Microinvasive breast cancer adjuvant chemotherapy survival
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Cyanide Contents of Leaves of Commonly Consumed Cassava Varieties from Three Geographical Regions of Ghana
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作者 William Opoku-Nkoom Ebenezer Asibey-Berko Anna Lartey 《Journal of Food Science and Engineering》 2013年第12期648-656,共9页
Consuming a cyanogenic plant is an etiological factor to the persistence of iodine deficiency in the post salt iodization phase. Ghana, notably the Northern belt, still reports of iodine deficiency after 14 years of m... Consuming a cyanogenic plant is an etiological factor to the persistence of iodine deficiency in the post salt iodization phase. Ghana, notably the Northern belt, still reports of iodine deficiency after 14 years of mandatory consumption of iodized salt by an Act of Parliament. The study aimed at determining the cyanide contents of leaves of commonly consumed cassava varieties in Ghana and investigating the effects of some environmental factors on cyanide content. Three communities each from Southern, Middle and Northern Ghana served as the study sites from where young, non-diseased and fully-spread cassava leaves were sampled from plants of commonly consumed cassava varieties. Cyanide was analyzed by the standard color^metric method based on the chloramine-T/pyridine-barbituric acid protocol (4500-CN E). Cassava leaves from Northern Ghana had significantly higher mean cyanide content (177.22 ± 20.82 ppm) than those from Middle (130.83± 33.00 ppm) and Southern Ghana (127.24 ± 37.54 ppm) (P 〈 0.001). Two-factor ANOVA showed significantly higher adverse environmental effects on cyanide contents of leaves of unimproved cassava varieties than improved ones (R2 = 0.627, P = 0.023). From multiple regression analysis, temperature was the most significant environmental factor explaining 33% of the variability in cyanide content (R2 = 0.331, P = 0.002), followed by altitude (R2 = 0.106, P = 0.049) and rainfall (R2 = 0.084, P = 0.062). The high cyanide contents of cassava leaves from Northern Ghana, due principally to the high atmospheric temperature, may be a contributory factor to the high prevalence of goiter and the persistence of iodine deficiency in that geographic region. 展开更多
关键词 Cassava leaves cyanide content iodine deficiency Ghana.
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The partitioning patterns of nutrients between pods and seeds of Zanthoxylum fruits impacted by environmental factors
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作者 Hechun Piao Siliang Li Zhifeng Yan 《Acta Geochimica》 EI CAS CSCD 2018年第5期676-683,共8页
The nutritive quality in plant organs is related to the different partitioning patterns of nutrient resources among the organs under various environmental conditions.This study examined the relationship between the nu... The nutritive quality in plant organs is related to the different partitioning patterns of nutrient resources among the organs under various environmental conditions.This study examined the relationship between the nutritive quality of pods and seeds in Zanthoxylum and environmental factors, such as temperature and preciptation by using numerous samples collected from Southwest China to the East China of Shandong peninsula. The increasing accumulations of N, P and C in seeds implied that the nutritive quality in seeds was higher at the regions with relative higher mean annual temperature(MAT) and mean annual precipitation(MAP), while that in pods was on the contrary. By contrast, pod nutritive content was relatively high, but seed nutritive content was relatively low at the regions with relative high MAT and MAP. In addition, C:N ratio in pods was significantly and negatively correlated with MAT and MAP, while that in seed was significantly and positively correlated with MAT and MAP. The partitioning patterns of N-compounds between pods and seeds reflected different nitrogen translocations in the plant organs under various climate condition. The N:P ratios were negatively correlated with MAP, implying a higher proportional allocation of P to seeds than that of N in the areas with a relative high MAP. Therefore, the strategies to assess pod nutritional quality should be taken into accountfor nutritive translocation under various environmental conditions. 展开更多
关键词 Partitioning pattern Nutritional quality C:Nratio Zanthoxylum fruits Mean annual temperature Mean annual precipitation
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Change in Fresh Snow Density in Tianshan Mountains,China 被引量:2
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作者 CHEN Xia WEI Wenshou LIU Mingzhe 《Chinese Geographical Science》 SCIE CSCD 2011年第1期36-47,共12页
The fresh snow density was observed with snow analyzer (Snow Fork) at Tianshan Station for Snowcover and Avalanche Research, Chinese Academy of Sciences from February 21 to March 5, 2009. Results show that fresh snow ... The fresh snow density was observed with snow analyzer (Snow Fork) at Tianshan Station for Snowcover and Avalanche Research, Chinese Academy of Sciences from February 21 to March 5, 2009. Results show that fresh snow density increases from the 5th h to the 291st h after the snowfall, with an average rate of increase of 4.0×10-4 g/(cm3·h) (R2 = 0.943). Analysis shows that fresh snow density is negatively correlated with the compac-tion rate of fresh snow (R2 = -0.960). Inversely, it is positively correlated with fresh snow viscosity (R2 = 0.896). In relation to meteorological factors, ground temperature rising at a depth of 40 cm is the major driving factor of snow density increase. The temperature increase in fresh snow layer and the decrease in depth hoar layer have the most prominent impacts on the snow density increase in the afternoon. Principal component analysis shows that the de-terminant factors of fresh snow density change can be grouped into 3 types as follows: 1) dynamic factor contributes about 69.71% to fresh snow density change, with a significant effect from the 5th h to the 106th h after the snowfall; 2) exogenous energy factor contributes about 20.91% to it, with a significant effect at the 130th h; and c) endoge-nous energy factor contributes about 9.38% to it, with a significant effect at the 130th h and the 195th h. 展开更多
关键词 fresh snow density compaction rate energy conversion principal component analysis Tianshan Mountains China
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Discussion on the Application of Sentiment Elements to Advertising Design
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作者 Yunying WANG 《International Journal of Technology Management》 2013年第6期113-115,共3页
With the continuous increase of social and economic competitiveness, the position of advertising becomes more and more important. For attracting people's attention to the advertising, merchants should not only rely o... With the continuous increase of social and economic competitiveness, the position of advertising becomes more and more important. For attracting people's attention to the advertising, merchants should not only rely on novel advertising creativity and also add some sentiment elements in advertising design under the background of today's advertising all over the world. Sentiments are the most capable of touching human nerves so as to leave a deep impression in the minds of people, so the quality of advertising can be well improved if appropriate sentiment elements are added in advertising design. In this paper, the application of emotional elements to advertising design is specifically discussed from emotional elements classification, main application methods, and matters needing attention. 展开更多
关键词 SENTIMENT Advertising Design APPLICATION SIGNIFICANCE
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Empirical analysis on China money multiplier
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作者 SHANG Hua-juan 《Chinese Business Review》 2009年第8期43-49,共7页
The paper firstly represents two kind statements of China money multipliers and theoretically analyzes the relationship between each structure factor and China money multiplier. Secondly, it summarizes the several fea... The paper firstly represents two kind statements of China money multipliers and theoretically analyzes the relationship between each structure factor and China money multiplier. Secondly, it summarizes the several features and the move trends of China narrow and broad money multipliers and their structure factors. Thirdly, the paper empirically analyzes how and what degree the each structure factor affects China narrow and broad money multipliers holding everything else constant. At last two important conclusions are got, that is, the required reserve ratio is the most associated with China money multipliers and the saving deposit ratio is more associated with that, the required reserve ratio and the interest rates can be used as the ways of affecting money aggregate by the People's Bank of China. 展开更多
关键词 empirical analysis China money multiplier narrow money multiplier broad money multiplier structure factors of China money multiplier
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