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奥氮平双羟萘酸盐的制备及体外释放度的研究 被引量:2
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作者 刘留成 伏世建 陈国广 《海峡药学》 2013年第10期12-16,共5页
目的采用无菌生产工艺制备由不同粒度组成的奥氮平双羟萘酸盐,并对其体外累计释放度进行评价。方法 研究了奥氮平双羟萘酸盐在不同溶剂及不同浓度条件下的溶解度,找到其漏槽条件,通过体外释放度试验,对比制备的不同粒径奥氮平双羟萘酸... 目的采用无菌生产工艺制备由不同粒度组成的奥氮平双羟萘酸盐,并对其体外累计释放度进行评价。方法 研究了奥氮平双羟萘酸盐在不同溶剂及不同浓度条件下的溶解度,找到其漏槽条件,通过体外释放度试验,对比制备的不同粒径奥氮平双羟萘酸盐与原研制剂体外释放行为的差异。结果 为了保证奥氮平双羟萘酸盐在体内能够缓慢、持续、有效地释放,我们需要对奥氮平双羟萘酸盐的粒度及其分布进行控制,即d(0.1)约为0.7μm,d(0.5)约为1.7μm,d(0.9)约为3.7μm。结论 通过气流磨粉碎技术适合于控制奥氮平双羟萘酸盐的粒度及其分布,制备的样品较普通制剂体外释放具有明显的缓释特征,能够提高患者的顺应性,更方便用药。 展开更多
关键词 奥氮平双羟萘酸盐 制备 漏槽条件 粒度及其分布 固体形态学 体外释放度
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Influence of sulfur addition/solids content ratio on removal of heavy metals from mine tailings by bioleaching 被引量:4
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作者 贺仲兵 廖婷 +3 位作者 刘云国 肖玉 李婷婷 王慧 《Journal of Central South University》 SCIE EI CAS 2012年第12期3540-3545,共6页
The effect of sulfur addition/solids content(SA/SC)ratio on heavy metals(e.g.copper,zinc and lead)obtained from mine tailings by indigenous sulfur-oxidizing bacteria was studied,and the changes in the chemical forms o... The effect of sulfur addition/solids content(SA/SC)ratio on heavy metals(e.g.copper,zinc and lead)obtained from mine tailings by indigenous sulfur-oxidizing bacteria was studied,and the changes in the chemical forms of heavy metals after bioleaching were explored.The results show that the solubilization of metals is significantly influenced by SA/SC ratio,and SA/SC ratio of 2.50 is found to be the best for bacterial activity and metal solubilization among six SA/SC ratios tested(such as 1.00,1.33,1.50,1.67,2.00 and 2.50)under the chosen experimental conditions.The pH decreases fast and the maximum solubilizations of copper and zinc are respectively 81.76% and 84.35% while that of lead only reaches 40.36%.After bioleaching,the chemical forms of heavy metals have changed.The metals remained in mine tailings are mainly found in residual fractions,which is harmless to the surrounding environment. 展开更多
关键词 BIOLEACHING mine tailings sulfur addition solid content heavy metals
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