Introduction Fexofenadine, the primary metabolite of terfenadine, is a selective and peripherally acting Hl receptor antagonist and has been developed as a non-sedating H1 antihistaminic drug. In clinical studies, it ...Introduction Fexofenadine, the primary metabolite of terfenadine, is a selective and peripherally acting Hl receptor antagonist and has been developed as a non-sedating H1 antihistaminic drug. In clinical studies, it is used for the treatment of seasonal allergic rhinitis and chronic urticaria without producing sedation.展开更多
The properties and thickness of the bubbles in the froth control the flotation process. There is no work showing how to measure bubble film composition and thickness by a straightforward manner. In this work, a novel ...The properties and thickness of the bubbles in the froth control the flotation process. There is no work showing how to measure bubble film composition and thickness by a straightforward manner. In this work, a novel approach, a custom-designed bubble cell associated with layer interferometry(in the UV-vis region) and FT-IR spectroscopy was used to investigate the effect of solid particle type(hydrophilic vs hydrophobic), concentration and bubble diameter on stability of a bubble blown in air. Stability was quantified by measuring bubble lifetime and hydrated film thickness. Kerosene with silicone oil as a foaming agent was used to evaluate the impact of bubble diameter(test series I). Frother solutions(MIBC, Dowfroth 250, Hexanol and F-150) were used for the solid type concentration experiments(test series II). In the first series of experiments, it was determined that as the diameter of a bubble increased from 10 to 25 mm, so did the hydrated film thickness from 350 to 1000 nm. In the second series, as the silica concentration increased(0 to 10%), an increase in bubble lifetime and hydrated film thickness was resulted(130%-250%). An impact of solid hydrophobicity was found but to a lesser degree than expected. It is possible that the small particle size(<0.1 m) of silica was responsible for this behavior. The findings are used to interpret the effect of solids in flotation froth.展开更多
This study aims to （1） obtain a pure extract of Sargassumfilipendula fucoxanthin, （2） determine the effect of concentration of fucoxanthin against HeLa cells, and （3） determine the effect of concentration of fuc...This study aims to （1） obtain a pure extract of Sargassumfilipendula fucoxanthin, （2） determine the effect of concentration of fucoxanthin against HeLa cells, and （3） determine the effect of concentration of fucoxanthin against cancer cell lymphocytes. The benefit of this research is to find out that fucoxanthin can be used as an anti-cancer treatment. The study was conducted in September 2013 at the Laboratory of Fishery Product Technology FPIK UB and UB Medical Biomedical Laboratories, Malang. Sampling brown seaweed （Sargassum filipendula） of the District Rural Padike Talango Sumenep Madura. Extracted isolated by column chromatography using silica gel stationary phase and mobile phase hexane：ethyl acetate （6：4, v/v） ± 100 mL, then identified by TLC using the stationary phase, a silica gel F-254 HPLC with ODS stationary phase （C-18） 5 mL with a mobile phase of methanol, acetone and ammonium acetate （IM） （80：10：10, v/v） and a flow rate of 1.0 mL/min pigment solution of 20 mL compared with the standard of Japan. Research results indicate that, spectra maximum wavelength of 450 nm and 446 nm with a minimum of acetone solvent. HPLC has the same retention time = 10.12 standard, namely Sargassum filipendula = 10.11. By giving some of the best concentrations at 100 ppm is lethal HeLa cells ebesar 5236% which means that fucoxanthin effect against HeLa cells have the potential fucoxanthin that can induce cell apoptosis that occurs in HeLa cells, it is possible because of the anti-carcinogenic fucoxanthin mempuyai structure unique. While the cell lymphocytes in the dosage of 100 ppm were dead at 8.788%, the effect of the toxicity of a substance can be observed from how many dead lymphocytes when compared with the state charity by observing level of lymphocyte proliferation.展开更多
文摘Introduction Fexofenadine, the primary metabolite of terfenadine, is a selective and peripherally acting Hl receptor antagonist and has been developed as a non-sedating H1 antihistaminic drug. In clinical studies, it is used for the treatment of seasonal allergic rhinitis and chronic urticaria without producing sedation.
基金Project(2013BAB14B05)supported by National Key Technology Research and Development Program of the Ministry of Science and Technology of China
文摘The properties and thickness of the bubbles in the froth control the flotation process. There is no work showing how to measure bubble film composition and thickness by a straightforward manner. In this work, a novel approach, a custom-designed bubble cell associated with layer interferometry(in the UV-vis region) and FT-IR spectroscopy was used to investigate the effect of solid particle type(hydrophilic vs hydrophobic), concentration and bubble diameter on stability of a bubble blown in air. Stability was quantified by measuring bubble lifetime and hydrated film thickness. Kerosene with silicone oil as a foaming agent was used to evaluate the impact of bubble diameter(test series I). Frother solutions(MIBC, Dowfroth 250, Hexanol and F-150) were used for the solid type concentration experiments(test series II). In the first series of experiments, it was determined that as the diameter of a bubble increased from 10 to 25 mm, so did the hydrated film thickness from 350 to 1000 nm. In the second series, as the silica concentration increased(0 to 10%), an increase in bubble lifetime and hydrated film thickness was resulted(130%-250%). An impact of solid hydrophobicity was found but to a lesser degree than expected. It is possible that the small particle size(<0.1 m) of silica was responsible for this behavior. The findings are used to interpret the effect of solids in flotation froth.
文摘This study aims to （1） obtain a pure extract of Sargassumfilipendula fucoxanthin, （2） determine the effect of concentration of fucoxanthin against HeLa cells, and （3） determine the effect of concentration of fucoxanthin against cancer cell lymphocytes. The benefit of this research is to find out that fucoxanthin can be used as an anti-cancer treatment. The study was conducted in September 2013 at the Laboratory of Fishery Product Technology FPIK UB and UB Medical Biomedical Laboratories, Malang. Sampling brown seaweed （Sargassum filipendula） of the District Rural Padike Talango Sumenep Madura. Extracted isolated by column chromatography using silica gel stationary phase and mobile phase hexane：ethyl acetate （6：4, v/v） ± 100 mL, then identified by TLC using the stationary phase, a silica gel F-254 HPLC with ODS stationary phase （C-18） 5 mL with a mobile phase of methanol, acetone and ammonium acetate （IM） （80：10：10, v/v） and a flow rate of 1.0 mL/min pigment solution of 20 mL compared with the standard of Japan. Research results indicate that, spectra maximum wavelength of 450 nm and 446 nm with a minimum of acetone solvent. HPLC has the same retention time = 10.12 standard, namely Sargassum filipendula = 10.11. By giving some of the best concentrations at 100 ppm is lethal HeLa cells ebesar 5236% which means that fucoxanthin effect against HeLa cells have the potential fucoxanthin that can induce cell apoptosis that occurs in HeLa cells, it is possible because of the anti-carcinogenic fucoxanthin mempuyai structure unique. While the cell lymphocytes in the dosage of 100 ppm were dead at 8.788%, the effect of the toxicity of a substance can be observed from how many dead lymphocytes when compared with the state charity by observing level of lymphocyte proliferation.
