目的:探讨吉西他滨固定速率输注二线治疗晚期铂类耐药鼻咽癌的临床疗效。方法:选取2016年1月-2018年3月在本院就诊的晚期铂类耐药鼻咽癌患者30例。行单药吉西他滨固定速率静脉输注2 h化疗,采用WHO化疗毒副反应分级标准进行化疗毒副反应...目的:探讨吉西他滨固定速率输注二线治疗晚期铂类耐药鼻咽癌的临床疗效。方法:选取2016年1月-2018年3月在本院就诊的晚期铂类耐药鼻咽癌患者30例。行单药吉西他滨固定速率静脉输注2 h化疗,采用WHO化疗毒副反应分级标准进行化疗毒副反应的评估,分为0～Ⅳ级;记录患者的疾病进展时间(time to progression,TTP)、治疗失败时间(time to failure,TTF);采用欧洲癌症患者生活质量调查问卷(QLQ-C30)对患者治疗前后的生活质量进行调查,对患者的治疗效果进行评价。结果:30例患者中,0例完全缓解,15例(50.00%)部分缓解,5例(16.67%)疾病稳定,10例(33.33%)疾病进展,疾病控制率为66.7%,中位TTP为5.42个月,中位TTF为6.94个月。鼻咽癌患者恶心呕吐、贫血、血小板减少Ⅲ级发生率均为3.33%,肝功能损害较为少见,无Ⅳ级毒副反应患者;治疗后鼻咽癌患者生活质量各项评分均显著高于治疗前,差异均有统计学意义(P<0.05)。结论:单药吉西他滨固定速率输注二线治疗晚期铂类耐药鼻咽癌,具有较好的疾病控制率,提高患者的生活质量,且患者机体毒副反应较小,具有较好的耐受性,值得临床推广。展开更多
针对毫微微蜂窝(femtocell)网络中多种业务(固定速率业务和可变速率业务)环境下如何公平分配毫微微蜂窝基站(femtocell base station,FBS)资源的问题,提出了一种基于比例公平算法的femto-macro异构网络资源分配算法。该算法以基于比例...针对毫微微蜂窝(femtocell)网络中多种业务(固定速率业务和可变速率业务)环境下如何公平分配毫微微蜂窝基站(femtocell base station,FBS)资源的问题,提出了一种基于比例公平算法的femto-macro异构网络资源分配算法。该算法以基于比例公平法则的可变速率用户的吞吐量为优化目标,并以每个用户的服务质量(quality of service,Qo S)、FBS的下行传输总功率和宏蜂窝(macrocell)用户的跨层同频干扰门限值为约束组成优化问题。在上述资源分配最优化问题为凸优化问题的基础上,采用对偶分解算法进行求解。仿真结果表明,提出的算法在保证不同用户Qo S的同时,不仅能够有效地公平分配资源给可变速率用户,而且降低了macrocell用户受到来自FBS的跨层同频干扰。展开更多
The solid-liquid interracial morphology evolution was investigated in directional solidification （DS） of Al-1.5%Cu alloy （mass fraction）. The results show that the solidified microstructural evolution is gradual o...The solid-liquid interracial morphology evolution was investigated in directional solidification （DS） of Al-1.5%Cu alloy （mass fraction）. The results show that the solidified microstructural evolution is gradual other than sharp, and the microstructure patterns are interesting and diversiform at the pulling rate ranging from 30 μm/s to 1500 μm/s. Indeed, dendrite to cell transition follows this sequence： dendrites→→banded cellular dendrites→elongated cells and part of dendrites→main elongated cells and little dendrites. Moreover, the present microstructure is not normal microstructure as we saw before. Further, according to the experimental phenomenon, the dendrite to cell transition was studied theoretically. Dendrite tip shape is an important parameter to characterize the dendrite to cell transition. As the dendrite to cell transition is far from equilibrium solidification, non-equilibrium solidification is taken into consideration in calculation. Finally, it is speculated that the dendrite to cell transition would occur at the minimum tip radius.展开更多
文摘目的:探讨吉西他滨固定速率输注二线治疗晚期铂类耐药鼻咽癌的临床疗效。方法:选取2016年1月-2018年3月在本院就诊的晚期铂类耐药鼻咽癌患者30例。行单药吉西他滨固定速率静脉输注2 h化疗,采用WHO化疗毒副反应分级标准进行化疗毒副反应的评估,分为0～Ⅳ级;记录患者的疾病进展时间(time to progression,TTP)、治疗失败时间(time to failure,TTF);采用欧洲癌症患者生活质量调查问卷(QLQ-C30)对患者治疗前后的生活质量进行调查,对患者的治疗效果进行评价。结果:30例患者中,0例完全缓解,15例(50.00%)部分缓解,5例(16.67%)疾病稳定,10例(33.33%)疾病进展,疾病控制率为66.7%,中位TTP为5.42个月,中位TTF为6.94个月。鼻咽癌患者恶心呕吐、贫血、血小板减少Ⅲ级发生率均为3.33%,肝功能损害较为少见,无Ⅳ级毒副反应患者;治疗后鼻咽癌患者生活质量各项评分均显著高于治疗前,差异均有统计学意义(P<0.05)。结论:单药吉西他滨固定速率输注二线治疗晚期铂类耐药鼻咽癌,具有较好的疾病控制率,提高患者的生活质量,且患者机体毒副反应较小,具有较好的耐受性,值得临床推广。
文摘针对毫微微蜂窝(femtocell)网络中多种业务(固定速率业务和可变速率业务)环境下如何公平分配毫微微蜂窝基站(femtocell base station,FBS)资源的问题,提出了一种基于比例公平算法的femto-macro异构网络资源分配算法。该算法以基于比例公平法则的可变速率用户的吞吐量为优化目标,并以每个用户的服务质量(quality of service,Qo S)、FBS的下行传输总功率和宏蜂窝(macrocell)用户的跨层同频干扰门限值为约束组成优化问题。在上述资源分配最优化问题为凸优化问题的基础上,采用对偶分解算法进行求解。仿真结果表明,提出的算法在保证不同用户Qo S的同时,不仅能够有效地公平分配资源给可变速率用户,而且降低了macrocell用户受到来自FBS的跨层同频干扰。
基金Project(SKLSP201418)supported by the Fund of the State Key Laboratory of Solidification Processing in North China University of Technology,ChinaProjects(51171151,51331005)supported by the National Natural Science Foundation of China
文摘The solid-liquid interracial morphology evolution was investigated in directional solidification （DS） of Al-1.5%Cu alloy （mass fraction）. The results show that the solidified microstructural evolution is gradual other than sharp, and the microstructure patterns are interesting and diversiform at the pulling rate ranging from 30 μm/s to 1500 μm/s. Indeed, dendrite to cell transition follows this sequence： dendrites→→banded cellular dendrites→elongated cells and part of dendrites→main elongated cells and little dendrites. Moreover, the present microstructure is not normal microstructure as we saw before. Further, according to the experimental phenomenon, the dendrite to cell transition was studied theoretically. Dendrite tip shape is an important parameter to characterize the dendrite to cell transition. As the dendrite to cell transition is far from equilibrium solidification, non-equilibrium solidification is taken into consideration in calculation. Finally, it is speculated that the dendrite to cell transition would occur at the minimum tip radius.
