BackgroundPocket hematoma is one of the major complications associated with cardiovascular implantable electronic devices （CIEDs） implantation. The aim of this study is to evaluate the impact of body mass index （BM...BackgroundPocket hematoma is one of the major complications associated with cardiovascular implantable electronic devices （CIEDs） implantation. The aim of this study is to evaluate the impact of body mass index （BMI） on the occurrence of pocket hematoma after CIEDs implantation.MethodsThe study is a retrospective review of 972 patients receiving CIEDs implantation between 2008 and 2012 in a tertiary hospital.ResultsTwenty two patients （2.2%） developed severe pocket hematoma requiring re-intervention. The hematoma rate （4.6%,n = 15） of patients with a BMI of 〈 23 kg/m2 was significantly higher compared with that of patients with a BMI of≥23 kg/m2 （1.1%, n = 7,P〈 0.001）. In multivariate regression analysis, a BMI 〈 23.0 kg/m2 may be associated with the development of severe pocket hema-toma. An increase of 1.0 kg/m2 in BMI was associated with lower incidence of hematoma formation （OR： 0.84; 95% CI： 0.74-0.95;P = 0.006）.ConclusionBMI 〈 23 kg/m2 was associated with a higher incidence of pocket hematoma, requiring re-intervention. The data sup-port that great care must be taken when patients were with a lower BMI received CIEDs implantation.展开更多
OBJECTIVE Though doxorubicin is highly active in the treatment of multiple myeloma, its toxicity profile limits its therapeutic index. We performed this study to evaluate the efficacy and liposomal doxorubicin （PLD, ...OBJECTIVE Though doxorubicin is highly active in the treatment of multiple myeloma, its toxicity profile limits its therapeutic index. We performed this study to evaluate the efficacy and liposomal doxorubicin （PLD, Ca of pegylated , vincristine, and reduced-dose dexamethasone combination therapy in newly diagnosed multiple myeloma （MM） patients in a Chinese population. METHODS This was an open-label, single-arm study in which newly diagnosed patients with MM received PLD 40 mg/m2 intravenously on Day 1, vincristine 1.4 mg/m2 intravenously （maximum 2 rag） on Day 1, and 40 mg of dexamethasone （intravenously or orally） from Day 1 to Day 4. Treatment was repeated every 28 days for at least 4 cycles. RESULTS In the intent-to-treat （ITT） analysis, the overall response rate was 68.29%, and the complete remission rate was 10.98%. The incidence of all adverse events was 46.34%. The most common non-hematologic toxicities were palmar-plantar erythrodysesthesia （13.4%） and stomatitis （6.1%）. CONCLUSION PLD, vincristine, and a reduceddose dexamethasone combination （DVd） is an effective and safe regimen in newly diagnosed MM patients in a Chinese population.展开更多
Dear Editor, Shortly after initiating the ＂Physical Anthropological Re- search on Han Chinese＂ research project, we applied uni- form sampling methods as well as methods and instruments of measurement to obtain a co...Dear Editor, Shortly after initiating the ＂Physical Anthropological Re- search on Han Chinese＂ research project, we applied uni- form sampling methods as well as methods and instruments of measurement to obtain a complete set of measurements of physical anthropological indicators among Han popula- tions across China. Among these measurements, body stat- ure was a key indicator. Currently, there should be reliable and complete basic data of stature around the Chinese peo- ple. We analyzed the current status of statures among Han adults.展开更多
文摘BackgroundPocket hematoma is one of the major complications associated with cardiovascular implantable electronic devices （CIEDs） implantation. The aim of this study is to evaluate the impact of body mass index （BMI） on the occurrence of pocket hematoma after CIEDs implantation.MethodsThe study is a retrospective review of 972 patients receiving CIEDs implantation between 2008 and 2012 in a tertiary hospital.ResultsTwenty two patients （2.2%） developed severe pocket hematoma requiring re-intervention. The hematoma rate （4.6%,n = 15） of patients with a BMI of 〈 23 kg/m2 was significantly higher compared with that of patients with a BMI of≥23 kg/m2 （1.1%, n = 7,P〈 0.001）. In multivariate regression analysis, a BMI 〈 23.0 kg/m2 may be associated with the development of severe pocket hema-toma. An increase of 1.0 kg/m2 in BMI was associated with lower incidence of hematoma formation （OR： 0.84; 95% CI： 0.74-0.95;P = 0.006）.ConclusionBMI 〈 23 kg/m2 was associated with a higher incidence of pocket hematoma, requiring re-intervention. The data sup-port that great care must be taken when patients were with a lower BMI received CIEDs implantation.
文摘OBJECTIVE Though doxorubicin is highly active in the treatment of multiple myeloma, its toxicity profile limits its therapeutic index. We performed this study to evaluate the efficacy and liposomal doxorubicin （PLD, Ca of pegylated , vincristine, and reduced-dose dexamethasone combination therapy in newly diagnosed multiple myeloma （MM） patients in a Chinese population. METHODS This was an open-label, single-arm study in which newly diagnosed patients with MM received PLD 40 mg/m2 intravenously on Day 1, vincristine 1.4 mg/m2 intravenously （maximum 2 rag） on Day 1, and 40 mg of dexamethasone （intravenously or orally） from Day 1 to Day 4. Treatment was repeated every 28 days for at least 4 cycles. RESULTS In the intent-to-treat （ITT） analysis, the overall response rate was 68.29%, and the complete remission rate was 10.98%. The incidence of all adverse events was 46.34%. The most common non-hematologic toxicities were palmar-plantar erythrodysesthesia （13.4%） and stomatitis （6.1%）. CONCLUSION PLD, vincristine, and a reduceddose dexamethasone combination （DVd） is an effective and safe regimen in newly diagnosed MM patients in a Chinese population.
基金supported by the National Natural Science Foundation of China(30830062)
文摘Dear Editor, Shortly after initiating the ＂Physical Anthropological Re- search on Han Chinese＂ research project, we applied uni- form sampling methods as well as methods and instruments of measurement to obtain a complete set of measurements of physical anthropological indicators among Han popula- tions across China. Among these measurements, body stat- ure was a key indicator. Currently, there should be reliable and complete basic data of stature around the Chinese peo- ple. We analyzed the current status of statures among Han adults.
