AIM: To characterize gene polymorphism of several cytokine gene in-patients with AIH and PBC and to analyze the difference of the polymorphism distribution between Chinese patients and healthy controls.METHODS: The st...AIM: To characterize gene polymorphism of several cytokine gene in-patients with AIH and PBC and to analyze the difference of the polymorphism distribution between Chinese patients and healthy controls.METHODS: The study population consisted of 62 patients with AIH, and 77 patients with PBC. The genetic profile of four cytokines was analyzed by restriction fragmentlength polymorphism after specific PCR amplification (PCR-RFLP) or sequence-specific primers PCR (SSP-PCR). The analyzed gene polymorphism included interleukin-1 (IL-1) (at position +3 953 and IL-1RN intron 2), IL-6 (atposition -174), IL-10 promoter (at position -1 082, -819, and -592). The control group consisted of 160 healthyblood donors.RESULTS: The majority of Chinese people including patients and healthy controls exhibited IL-1B 1,1genotype, and there was no significant difference in AIH, PBC patients and controls. There were highly statistically significant differences in the distribution of the IL-1RN gene polymorphism between the patients with PBCcompared with controls. The frequency of IL-1RN 1,1was significantly higher (90.9% vs 79.4%, P = 0.03)and the frequency of IL-1RN 1,2 was significantly lower in PBC patients (6.5% vs 17.5%, P = 0.01). No statistical difference was observed between AIH patients and controls. All of the 160 healthy controls and 62 cases of AIH patients exhibited IL-6-174GG genotype, and there were four cases, which expressed IL-6-174GC genotype in 77 cases of PBC patients. The frequency of IL-6-174GC was markedly significantly higher in PBC patients compared with controls (5.2% vs 0%, P = 0.004). No statistically significant difference was found in the distribution of IL-10 promoter genotype in AIH and PBC patients compared with controls. CONCLUSION: The polymorphisms of IL-1RN and IL-6 -174G/C appear to be associated with PBC in Chinese patients.展开更多
AIM: To conduct a retrospective study to determine the risk factors for development of metaplastic gastritis in Korean population. METHODS: The database of 113449 subjects who underwent a gastroscopy for the purpose...AIM: To conduct a retrospective study to determine the risk factors for development of metaplastic gastritis in Korean population. METHODS: The database of 113449 subjects who underwent a gastroscopy for the purpose of a regular check-up at center for health promotion, Samsung medical center during 5 years was collected and retrospectively analyzed. Among them, 5847 subjects who had endoscopically diagnosed as a metaplastic gastritis or 10076 normal as well as answered to questionnaire were included for present study. The subjects were divided into 2 groups; Group Ⅰ, normal and Group Ⅱ, metaplastic gastritis. Age, gender, Helicobacter pylori (H pylori) seropositivity, body mass index (BMI), family history of cancer, smoking, alcohol consumption, total daily calories, folate and salt intake and dietary habit (out-eating, overeating, irregular eating) were retrieved from questionnaire or electronic medical record and compared between group Ⅰ and group Ⅱ. RESULTS: The prevalence of group Ⅱwas 11% (13578/113449) increasing its prevalence with age (P=0.000). But, there was no significant association between 2 groups in BMI, family history of cancer, alcohol consumption, total daily calories, folate and salt intake and dietary habit (out-eating, overeating, irregular eating). Old age (P=0.000), male gender (P=0.000), H pylori seropositivity (P= 0.010) and current smoker (P=0.000) were significantly more common in group II at multiple logistic regression model. CONCLUSION: Our data suggested that old age, male gender, H pylori seropositivity and smoking were risk factors for metaplastic gastritis, precancerous lesion of gastric cancer.展开更多
The paper expresses the view that China's essential way out for developing nuclear power lies in localization of manu facture, based on her technical level and capability in designing and manufacturing nuclear pow...The paper expresses the view that China's essential way out for developing nuclear power lies in localization of manu facture, based on her technical level and capability in designing and manufacturing nuclear power equipment. Moreover, the paper opines that domestically manufactured nuclear power equipment has a certain competitive potential with respect to quality and price, the crux lying in the neces sity of reforming the management system of nuclear power.展开更多
A field experiment was conducted in Jungar Banner,Inner Mongolia,China to study the effects of plant types on the physical structure and chemical properties of open-cast mining soils reclaimed for 15 years,and to anal...A field experiment was conducted in Jungar Banner,Inner Mongolia,China to study the effects of plant types on the physical structure and chemical properties of open-cast mining soils reclaimed for 15 years,and to analyze the triggering factors of the soil formation.Results indicate that plant types affect soil-forming process especially in the upper layer (0-20 cm),and the spatial structure of reclaimed plant is the main reason for variability of the soil-forming process.In the upper soil layer at the site reclaimed with mixed plants,the concentrations of soil organic matter (SOM) and soil organic carbon (SOC) are the highest,and they were significantly higher at the sites reclaimed with Leymus chinensis,Caragana sinica,which is mainly due to a large amount of litter fall and root exudation in herbages and shrubs.However,the concentrations of SOM and SOC in the soils at the reclaimed sites are quite low comparing with those in local primary soil,which indicates the importance of using organic amendments during the ecological restoration in the study area.展开更多
This paper reports on a mixed method inquiry into the use of vocabulary learning strategies and their development as strategic vocabulary learners in a key middle school on the Chinese mainland. In the inquiry, 475 fi...This paper reports on a mixed method inquiry into the use of vocabulary learning strategies and their development as strategic vocabulary learners in a key middle school on the Chinese mainland. In the inquiry, 475 first year junior secondary school pupils (247 boys and 228 girls) were surveyed about their strategy use in learning English vocabulary. Sixteen pupils (8 boys and 8 girls) participated in paired semi-structured interviews about their experiences of learning English vocabulary. Drawing on socio-cultural perspectives on language learning, the inquiry established the interconnections between the participants' strategy use and beliefs and identified the roles that agency played in their vocabulary learning. The analysis of interview data further revealed that the participants' strategy use emerged from interaction between their agency and the mediation of contextual resources and social agents including parents and teachers. These findings suggest that it is important for language teachers to collaborate with social agents such as parents in their efforts to support young learners' strategic vocabulary learning.展开更多
文摘AIM: To characterize gene polymorphism of several cytokine gene in-patients with AIH and PBC and to analyze the difference of the polymorphism distribution between Chinese patients and healthy controls.METHODS: The study population consisted of 62 patients with AIH, and 77 patients with PBC. The genetic profile of four cytokines was analyzed by restriction fragmentlength polymorphism after specific PCR amplification (PCR-RFLP) or sequence-specific primers PCR (SSP-PCR). The analyzed gene polymorphism included interleukin-1 (IL-1) (at position +3 953 and IL-1RN intron 2), IL-6 (atposition -174), IL-10 promoter (at position -1 082, -819, and -592). The control group consisted of 160 healthyblood donors.RESULTS: The majority of Chinese people including patients and healthy controls exhibited IL-1B 1,1genotype, and there was no significant difference in AIH, PBC patients and controls. There were highly statistically significant differences in the distribution of the IL-1RN gene polymorphism between the patients with PBCcompared with controls. The frequency of IL-1RN 1,1was significantly higher (90.9% vs 79.4%, P = 0.03)and the frequency of IL-1RN 1,2 was significantly lower in PBC patients (6.5% vs 17.5%, P = 0.01). No statistical difference was observed between AIH patients and controls. All of the 160 healthy controls and 62 cases of AIH patients exhibited IL-6-174GG genotype, and there were four cases, which expressed IL-6-174GC genotype in 77 cases of PBC patients. The frequency of IL-6-174GC was markedly significantly higher in PBC patients compared with controls (5.2% vs 0%, P = 0.004). No statistically significant difference was found in the distribution of IL-10 promoter genotype in AIH and PBC patients compared with controls. CONCLUSION: The polymorphisms of IL-1RN and IL-6 -174G/C appear to be associated with PBC in Chinese patients.
文摘AIM: To conduct a retrospective study to determine the risk factors for development of metaplastic gastritis in Korean population. METHODS: The database of 113449 subjects who underwent a gastroscopy for the purpose of a regular check-up at center for health promotion, Samsung medical center during 5 years was collected and retrospectively analyzed. Among them, 5847 subjects who had endoscopically diagnosed as a metaplastic gastritis or 10076 normal as well as answered to questionnaire were included for present study. The subjects were divided into 2 groups; Group Ⅰ, normal and Group Ⅱ, metaplastic gastritis. Age, gender, Helicobacter pylori (H pylori) seropositivity, body mass index (BMI), family history of cancer, smoking, alcohol consumption, total daily calories, folate and salt intake and dietary habit (out-eating, overeating, irregular eating) were retrieved from questionnaire or electronic medical record and compared between group Ⅰ and group Ⅱ. RESULTS: The prevalence of group Ⅱwas 11% (13578/113449) increasing its prevalence with age (P=0.000). But, there was no significant association between 2 groups in BMI, family history of cancer, alcohol consumption, total daily calories, folate and salt intake and dietary habit (out-eating, overeating, irregular eating). Old age (P=0.000), male gender (P=0.000), H pylori seropositivity (P= 0.010) and current smoker (P=0.000) were significantly more common in group II at multiple logistic regression model. CONCLUSION: Our data suggested that old age, male gender, H pylori seropositivity and smoking were risk factors for metaplastic gastritis, precancerous lesion of gastric cancer.
文摘The paper expresses the view that China's essential way out for developing nuclear power lies in localization of manu facture, based on her technical level and capability in designing and manufacturing nuclear power equipment. Moreover, the paper opines that domestically manufactured nuclear power equipment has a certain competitive potential with respect to quality and price, the crux lying in the neces sity of reforming the management system of nuclear power.
基金Under the auspices of Major State Basic Research Development Program of China (No. 2007CB106801)the Seventh Framework Program of European Union (No. 226818)Testing Foundation of Northeast Normal University
文摘A field experiment was conducted in Jungar Banner,Inner Mongolia,China to study the effects of plant types on the physical structure and chemical properties of open-cast mining soils reclaimed for 15 years,and to analyze the triggering factors of the soil formation.Results indicate that plant types affect soil-forming process especially in the upper layer (0-20 cm),and the spatial structure of reclaimed plant is the main reason for variability of the soil-forming process.In the upper soil layer at the site reclaimed with mixed plants,the concentrations of soil organic matter (SOM) and soil organic carbon (SOC) are the highest,and they were significantly higher at the sites reclaimed with Leymus chinensis,Caragana sinica,which is mainly due to a large amount of litter fall and root exudation in herbages and shrubs.However,the concentrations of SOM and SOC in the soils at the reclaimed sites are quite low comparing with those in local primary soil,which indicates the importance of using organic amendments during the ecological restoration in the study area.
文摘This paper reports on a mixed method inquiry into the use of vocabulary learning strategies and their development as strategic vocabulary learners in a key middle school on the Chinese mainland. In the inquiry, 475 first year junior secondary school pupils (247 boys and 228 girls) were surveyed about their strategy use in learning English vocabulary. Sixteen pupils (8 boys and 8 girls) participated in paired semi-structured interviews about their experiences of learning English vocabulary. Drawing on socio-cultural perspectives on language learning, the inquiry established the interconnections between the participants' strategy use and beliefs and identified the roles that agency played in their vocabulary learning. The analysis of interview data further revealed that the participants' strategy use emerged from interaction between their agency and the mediation of contextual resources and social agents including parents and teachers. These findings suggest that it is important for language teachers to collaborate with social agents such as parents in their efforts to support young learners' strategic vocabulary learning.