目的通过对基于国家健康和营养检查调查(NHANES)数据库在肝脏疾病领域相关研究进行文献计量学统计及可视化分析,分析近20年该领域的热点和挖掘趋势。方法基于Web of Science核心数据库合集(WoSCC)以及CiteSpace分析软件,对1998年12月至2...目的通过对基于国家健康和营养检查调查(NHANES)数据库在肝脏疾病领域相关研究进行文献计量学统计及可视化分析,分析近20年该领域的热点和挖掘趋势。方法基于Web of Science核心数据库合集(WoSCC)以及CiteSpace分析软件,对1998年12月至2022年12月发表文献进行计量学可视化分析,分析内容为发表文章的年度分布、被引情况、关键词的共现、聚类、时间线图和国家、机构、基金等。结果通过对313篇基于NHANES数据库的肝脏疾病领域文献进行可视化分析显示,该领域的发文量呈逐年递增,美国是发文量及中心性居首,伊诺瓦卫生系统为发文量最多的机构,美国卫生部人类服务部是资助该领域最多的基金资助机构,对关键词共现、聚类、时间线图分析提示非酒精性脂肪性肝病、代谢相关脂肪性肝病(MAFLD)、肝纤维化、代谢综合征方面为研究热门。结论代谢性肝病、病毒性肝炎和肝纤维化是肝病的主要研究热点。流行病学调查、危险因素评估和诊断方法是主要的分析方法。营养干预和肝病预防是未来的研究方向。机器学习在数据挖掘中具有广泛的适用性。展开更多
Introduction: There has been an interest to explore whether serum leptin plays any role in the pathogenesis of chronic liver disease. We conducted a case-control study to evaluate the relationship between unexplained ...Introduction: There has been an interest to explore whether serum leptin plays any role in the pathogenesis of chronic liver disease. We conducted a case-control study to evaluate the relationship between unexplained elevations in ALT and serum leptin in NHANES III participants. Methods: A total of 6343 adults who had fasting serum leptin and ALT measured as part of NHANES III constituted our study group. From this database, we have constructed cohorts of patients with unexplained elevations in ALT according to published criteria and compared their serum leptin levels to matched controls without liver disease and matched controls with hepatitis C. Leptin was also compared between patients with unexplained elevations in ALT with and without metabolic syndrome. Results: Serum leptin in 288 patients with unexplained elevations in ALT was 13.3 ±9.9 ng/mL and was not significantly different than 720 controls without liver disease (13.6 ±11.9 ng/mL, P = 0.6). Serum leptin in another group of patients with unexplained elevations in ALT and hepatitis C controls was also not significantly different (8.0 ±4.8 vs. 8.8 ±7.4 ng/mL, respectively, P = 0.5). There was no independent relationship between the presence of metabolic syndrome and serum leptin in individuals with unexplained elevations in ALT (P = 0.8). Conclusions: Individuals with unexplained elevations in ALT did not have higher levels of serum leptin than the matched controls. As unexplained elevations in ALT may signify the presence of non-alcoholic fatty liver disease in NHANES III participants, our data provide indirect evidence against a role for serum leptin in the pathogenesis of nonalcoholic fatty liver disease.展开更多
目的调查双能X线吸收测量仪(dual-energy X-ray absorptiometry,DXA)机器参考数据库使用现状及选用不同数据库对DXA骨密度(bone mineral density,BMD)T值的影响。方法收集全国139家医院DXA机器的骨密度报告,记录每家医院使用的DXA品牌...目的调查双能X线吸收测量仪(dual-energy X-ray absorptiometry,DXA)机器参考数据库使用现状及选用不同数据库对DXA骨密度(bone mineral density,BMD)T值的影响。方法收集全国139家医院DXA机器的骨密度报告,记录每家医院使用的DXA品牌及选用的参考数据库。其中48家医院在各种临床研究中,采用欧洲脊柱体模(European spine phantom,ESP)进行DXA质控扫描,即ESP重复扫描10次,打印BMD结果。记录所选用参数数据库和T值,并对数据进行统计学分析。结果139台DXA,74家(53.24%)使用GE,57家(41.01%)使用Hologic,另有8家(5.76%)使用Medilink。72台DXA(51.80%)采用中国参考数据库;66台DXA(47.48%)采用美国国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)白种人数据库;另有1台采用亚洲人数据库。同一个ESP在48台DXA行BMD重复扫描研究中,采用中国人数据库平均T值为0.2(0,0.3)SD,采用NHANES数据库平均T值为-0.6(-0.9,-0.56)SD,两者相差0.8 SD,差异有统计学意义(P<0.001)。结论本研究发现DXA骨密度采用中国人数据库和美国人数据库计算所得T值平均相差0.8 SD,这个差异会影响骨质疏松症的诊断和检出率,建议使用DXA应该遵循我国骨质疏松症诊疗指南采用中国人数据库计算T值。展开更多
文摘目的通过对基于国家健康和营养检查调查(NHANES)数据库在肝脏疾病领域相关研究进行文献计量学统计及可视化分析,分析近20年该领域的热点和挖掘趋势。方法基于Web of Science核心数据库合集(WoSCC)以及CiteSpace分析软件,对1998年12月至2022年12月发表文献进行计量学可视化分析,分析内容为发表文章的年度分布、被引情况、关键词的共现、聚类、时间线图和国家、机构、基金等。结果通过对313篇基于NHANES数据库的肝脏疾病领域文献进行可视化分析显示,该领域的发文量呈逐年递增,美国是发文量及中心性居首,伊诺瓦卫生系统为发文量最多的机构,美国卫生部人类服务部是资助该领域最多的基金资助机构,对关键词共现、聚类、时间线图分析提示非酒精性脂肪性肝病、代谢相关脂肪性肝病(MAFLD)、肝纤维化、代谢综合征方面为研究热门。结论代谢性肝病、病毒性肝炎和肝纤维化是肝病的主要研究热点。流行病学调查、危险因素评估和诊断方法是主要的分析方法。营养干预和肝病预防是未来的研究方向。机器学习在数据挖掘中具有广泛的适用性。
文摘Introduction: There has been an interest to explore whether serum leptin plays any role in the pathogenesis of chronic liver disease. We conducted a case-control study to evaluate the relationship between unexplained elevations in ALT and serum leptin in NHANES III participants. Methods: A total of 6343 adults who had fasting serum leptin and ALT measured as part of NHANES III constituted our study group. From this database, we have constructed cohorts of patients with unexplained elevations in ALT according to published criteria and compared their serum leptin levels to matched controls without liver disease and matched controls with hepatitis C. Leptin was also compared between patients with unexplained elevations in ALT with and without metabolic syndrome. Results: Serum leptin in 288 patients with unexplained elevations in ALT was 13.3 ±9.9 ng/mL and was not significantly different than 720 controls without liver disease (13.6 ±11.9 ng/mL, P = 0.6). Serum leptin in another group of patients with unexplained elevations in ALT and hepatitis C controls was also not significantly different (8.0 ±4.8 vs. 8.8 ±7.4 ng/mL, respectively, P = 0.5). There was no independent relationship between the presence of metabolic syndrome and serum leptin in individuals with unexplained elevations in ALT (P = 0.8). Conclusions: Individuals with unexplained elevations in ALT did not have higher levels of serum leptin than the matched controls. As unexplained elevations in ALT may signify the presence of non-alcoholic fatty liver disease in NHANES III participants, our data provide indirect evidence against a role for serum leptin in the pathogenesis of nonalcoholic fatty liver disease.
文摘目的调查双能X线吸收测量仪(dual-energy X-ray absorptiometry,DXA)机器参考数据库使用现状及选用不同数据库对DXA骨密度(bone mineral density,BMD)T值的影响。方法收集全国139家医院DXA机器的骨密度报告,记录每家医院使用的DXA品牌及选用的参考数据库。其中48家医院在各种临床研究中,采用欧洲脊柱体模(European spine phantom,ESP)进行DXA质控扫描,即ESP重复扫描10次,打印BMD结果。记录所选用参数数据库和T值,并对数据进行统计学分析。结果139台DXA,74家(53.24%)使用GE,57家(41.01%)使用Hologic,另有8家(5.76%)使用Medilink。72台DXA(51.80%)采用中国参考数据库;66台DXA(47.48%)采用美国国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)白种人数据库;另有1台采用亚洲人数据库。同一个ESP在48台DXA行BMD重复扫描研究中,采用中国人数据库平均T值为0.2(0,0.3)SD,采用NHANES数据库平均T值为-0.6(-0.9,-0.56)SD,两者相差0.8 SD,差异有统计学意义(P<0.001)。结论本研究发现DXA骨密度采用中国人数据库和美国人数据库计算所得T值平均相差0.8 SD,这个差异会影响骨质疏松症的诊断和检出率,建议使用DXA应该遵循我国骨质疏松症诊疗指南采用中国人数据库计算T值。
文摘目的:越来越多的证据表明反式脂肪酸(trans-fatty acids,TFAs)会影响人们的健康状况。然而,循环TFA浓度与总前列腺特异性抗原(prostate-specific antigen,PSA)之间是否存在关系尚不清楚。因此,本文在美国国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)数据库的基础上进行了一项横断面人群研究,以分析血浆TFAs和总PSA浓度之间的关系。方法:经过筛选,从NHANES数据库2009-2010年周期中纳入312名参与者。采用单变量、多变量线性回归模型和分层分析检验血浆TFAs(棕榈反油酸、反式异油酸、反油酸、反式亚油酸)浓度与血清总PSA浓度的相关性。结果:在充分调整混杂变量后,数据显示,在老年男性患者中每增加1个单位的log2转换的反式亚油酸,总PSA浓度增加1.14ng/mL(P<0.05)。然而棕榈反油酸、反式异油酸、反油酸与总PSA浓度无相关性。此外,分层分析显示反式亚油酸与总PSA浓度的相关性在无体力活动参与者间存在显著差异,表明这种正相关性与参与者无体力活动显著相关(交互作用检验P<0.05)。结论:总PSA浓度的升高与上升的循环反式亚油酸浓度相关。这种关系在无体力活动的患者中被进一步放大。因此,反式脂肪酸的摄入可能会导致正常人患前列腺癌的风险增高,尤其是在无体力活动的人群里。减少反式脂肪酸的摄入,有助于身体健康。
