The characteristic town is a dynamic and vivid case of experience of Zhejiang. With the internet town Wuzheng, Aficion chocolate town Jiashan, photovoltaic town Xiuzhou in Zhejiang as the research perspective, the con...The characteristic town is a dynamic and vivid case of experience of Zhejiang. With the internet town Wuzheng, Aficion chocolate town Jiashan, photovoltaic town Xiuzhou in Zhejiang as the research perspective, the concept of development that the production, life and ecology merge together and the development direction and value of New-type urbanization is consistent, and it is the effective path of New-type urbanization development. At the same time, these towns provide a model for the development of the country small town展开更多
P2P systems are categorized into tree-based and mesh-based systems according to their topologies. Mesh-based systems are considered more suitable for large-scale lnternet applications, but require optimization on late...P2P systems are categorized into tree-based and mesh-based systems according to their topologies. Mesh-based systems are considered more suitable for large-scale lnternet applications, but require optimization on latency issue. This paper proposes a content subscribing mechanism （CSM） to eliminate unnecessary time delays during data relaying. A node can send content data to its neighbors as soon as it receives the data segment. No additional time is taken during the interactive stages prior to data segment transmission of streaming content. CSM consists of three steps. First, every node records its historical segments latency, and adopts gamma distribution, which possesses powerful expression ability, to express latency statistics. Second, a node predicts subscribing success ratio of every neighbor by comparing the gamma distribution parameters of the node and its neighbors before selecting a neighbor node to subscribe a data segment. The above steps would not increase latency as they are executed before the data segments are ready at the neighbor nodes. Finally, the node, which was subscribed to, sends the subscribed data segment to the subscriber immediately when it has the data segment. Experiments show that CSM significantly reduces the content data transmission latency.展开更多
Objective. To identify and evaluate mutations in the RPl gene among Chinese patients with retinitis pigmen-tosa (RP).Methods. Leukocyte DNA of 92 RP patients were collected in Hong Kong. Sequence changes of the entire...Objective. To identify and evaluate mutations in the RPl gene among Chinese patients with retinitis pigmen-tosa (RP).Methods. Leukocyte DNA of 92 RP patients were collected in Hong Kong. Sequence changes of the entire coding region of the RP1 gene were examined using PCR, conformation sensitive gel electrophoresis and DNA sequencing.Results. In total, 1 nonsense mutation and 1 nonsense variant as well as 10 missense alterations were identified in the RP1 gene, among which, Arg677Ter was found in 1 RP patient and another nonsense variant, Argl933Ter, was identified in 3 normal individuals and 1 patient with Stargardt' s disease, suggesting its nonpathogenicity. Arg677Ter is expected to lead to large disruptions of the encoded protein.Conclusions. The nonpathogenicity of Argl933Ter indicates that the C - terminal 224 residues of RPl protein may be not critical for RP1. The most C - terminal truncation previously reported was due to Tyr1053 (1 -bp del) and occurred in RP patients. Thus RP can be caused by reduction in the level of the region of RPl protein after codon 1052 but before 1933. To ascertain such a proposition, genotypes of more RP patients may reveal more RP causative mutations and more sequence alterations different than those of other ethnic groups.展开更多
Localizing network legal supervision based on national conditions, legal traditions and the needs of economic and political development is the basis to manage and administrate the network by law. Adjusted to media con...Localizing network legal supervision based on national conditions, legal traditions and the needs of economic and political development is the basis to manage and administrate the network by law. Adjusted to media convergence and the needs of network cultural industry development, China has made the lawmaking of media transform from practical service oriented management to functional oriented management of media. This strategy aims to prevent network medium risk effectively according to network communication regularity.展开更多
文摘The characteristic town is a dynamic and vivid case of experience of Zhejiang. With the internet town Wuzheng, Aficion chocolate town Jiashan, photovoltaic town Xiuzhou in Zhejiang as the research perspective, the concept of development that the production, life and ecology merge together and the development direction and value of New-type urbanization is consistent, and it is the effective path of New-type urbanization development. At the same time, these towns provide a model for the development of the country small town
基金the National Natural Science Foundation of China (Nos. 60533090 and 60525108)the National Basic research Program (973) of China (No. 2002CB312101)+2 种基金the China-US Million Book Digital Library Project (www.cadal.zju.edu.cn)the Science and Technology Project of Zhejiang Province (Nos. 2005C13032 and 2005C11001-05)the Research Project of Education Department of Zhejiang Province (No. 20061352), China
文摘P2P systems are categorized into tree-based and mesh-based systems according to their topologies. Mesh-based systems are considered more suitable for large-scale lnternet applications, but require optimization on latency issue. This paper proposes a content subscribing mechanism （CSM） to eliminate unnecessary time delays during data relaying. A node can send content data to its neighbors as soon as it receives the data segment. No additional time is taken during the interactive stages prior to data segment transmission of streaming content. CSM consists of three steps. First, every node records its historical segments latency, and adopts gamma distribution, which possesses powerful expression ability, to express latency statistics. Second, a node predicts subscribing success ratio of every neighbor by comparing the gamma distribution parameters of the node and its neighbors before selecting a neighbor node to subscribe a data segment. The above steps would not increase latency as they are executed before the data segments are ready at the neighbor nodes. Finally, the node, which was subscribed to, sends the subscribed data segment to the subscriber immediately when it has the data segment. Experiments show that CSM significantly reduces the content data transmission latency.
文摘Objective. To identify and evaluate mutations in the RPl gene among Chinese patients with retinitis pigmen-tosa (RP).Methods. Leukocyte DNA of 92 RP patients were collected in Hong Kong. Sequence changes of the entire coding region of the RP1 gene were examined using PCR, conformation sensitive gel electrophoresis and DNA sequencing.Results. In total, 1 nonsense mutation and 1 nonsense variant as well as 10 missense alterations were identified in the RP1 gene, among which, Arg677Ter was found in 1 RP patient and another nonsense variant, Argl933Ter, was identified in 3 normal individuals and 1 patient with Stargardt' s disease, suggesting its nonpathogenicity. Arg677Ter is expected to lead to large disruptions of the encoded protein.Conclusions. The nonpathogenicity of Argl933Ter indicates that the C - terminal 224 residues of RPl protein may be not critical for RP1. The most C - terminal truncation previously reported was due to Tyr1053 (1 -bp del) and occurred in RP patients. Thus RP can be caused by reduction in the level of the region of RPl protein after codon 1052 but before 1933. To ascertain such a proposition, genotypes of more RP patients may reveal more RP causative mutations and more sequence alterations different than those of other ethnic groups.
文摘Localizing network legal supervision based on national conditions, legal traditions and the needs of economic and political development is the basis to manage and administrate the network by law. Adjusted to media convergence and the needs of network cultural industry development, China has made the lawmaking of media transform from practical service oriented management to functional oriented management of media. This strategy aims to prevent network medium risk effectively according to network communication regularity.
