我国肌电控制假肢的新成就

我国肌电控制假肢的新成就手作为人类的劳动器官和生物界最高级的运动器官，它的灵活度和适应性，是任何先进的机器无法比拟的。失去了手甚至双全臂的病人渴望安装性能好、外观美的假肢。肌电控制假肢是当代科技与艺术的结晶。它的臂筒内蕴藏着精密的电子和机械“王国”，...

国静脉肌袢综合疗法治疗小腿慢性溃疡

近年来，我院采用国静脉肌袢为主的综合疗法对35例大面积，长病程，年龄大的各种小腿慢性溃疡的病人进行治疗，取得明显的疗效，其治疗机制为通过促进深静脉血液回流，改善患肢血循环，改善溃疡区的营养状态，促进炎症的消退及伤口的愈合．

膝关节周围的常见肌肉损伤——腘肌损伤(附150例分析)

本文介绍了用按摩疗法治疗150例腘肌损伤患者,治愈率98%。此外,通过动物实验,找到了更为有效的按摩手法,也对胭肌损伤的病因机制进行了讨论。

先天性静脉畸形骨肥大综合征的手术治疗(附38例报道)

目的总结38例KTS综合征的手术方法及预后情况。方法分析该院1990年1月～2007年5月38例KTS患者的手术方法及治疗效果,总结手术治疗KTS综合征的经验和体会。结果35例患者施行月国静脉松解及月国静脉外肌袢代瓣膜术,3例患者施行月国静脉陷迫得松解术,术后症状改善显著。随访35例,随访期间手术效果满意。结论对于KTS患者,月国静脉松解术及月国静脉外肌袢代瓣膜术是一种有效的手术方式。

从米糠、麸皮中提取菲丁一举两得

菲丁,学名植酸钙,是植物与钙、镁等金属离子形成的一种复合盐,系一种贵重医药用品,可以促进人体的新陈代谢,恢复人体内磷的平衡,为一种滋补强壮剂。用菲丁制成的多种成药,有补脑及治疗神经炎、神经衰弱、幼儿佝偻病等功能。菲丁在发酵、油脂、食品、医药等行业上均有广泛应用。而在工业上普遍是用作生产肌醇的原料,我国肌醇产量90％外销。 我国盛产水稻、小麦,副产品米糠、麸皮除部分用以生产米糠油外,

Sarcopenia is associated with Framingham risk score in the Korean population： Korean National Health and Nutrition Examination Survey （KNHANES） 2010-2011

Background Sarcopenia is a risk factor for metabolic disorders and cardiovascular disease, but the association between sarcopenia and cardiovascular risk factors according to age and obesity status in the general population remains unknown. We thus investigated these associations in the Korean population. Methods We included 8,958 and 8,518 subjects from the fifth Korean National Health and Nutrition Examination Survey （KNHANES） （from 2010 and 2011, respectively）. The study was restricted to participants 〉 20 years old who had completed the health examination survey, including whole body dual-energy X-ray absorptiometry scans. After exclusion, 7,366 subjects （3,188 men, 4,178 women） were included in our final analysis. Age was categorized according to three age groups （20-39, 40-59, mad 〉 60 years）, and subjects were catego- rized according to their sarcopenic and obesity status. Cardiovascular risk was assessed with Framingham risk score （FRS）. Results The sarco- penic obese group had a higher FRS than the non-sarcopenic obese group, which had a higher FRS than the non-sarcopenic non-obese group. Age-wise, the 20-39 year-old group showed a non-significant association between sarcopenia and FRS. In the 40-59 year-old group, regardless of obesity status, sarcopenic subjects had a higher FRS than non-sarcopenic subjects. In the 〉 60 year-old group, sarcopenic subjects had a higher FRS than non-sarcopenic subjects for the non-obese group. Conclusions Sarcopenia was associated with cardiovascular disease and may be an early predictor of its susceptibility in both elderly and middle-aged subjects. Thus, management of sarcopenia is necessary to prevent cardiovascu- lar disease.

American ginseng supplementation attenuates creatine kinase level induced by submaximal exercise in human beings

AIM: To investigate whether American ginseng (AG, Panax quinquefolium) supplementation was able to improve endurance exercise performance.METHODS: Thirteen physically active male college students were divided into two groups (AG or placebo)and received supplementation for 4 wk, before the exhaustive running exercise. Treadmill speed was increased to a pace equivalent to 80% VO2max of the subject. A 4-wk washout period followed before the subjects crossed over and received the alternate supplement for the next 4 wk.They then completed a second exhaustive running exercise. The physiological variables that were examined included time to exhaustion and oxygen pulse. Moreover,the plasma creatine kinase (CK) and lactate were measured prior to the exercise, at 15 and 30 min during exercise,immediately after exercise, and 20, 40, 60, and 120 min after exercise.RESULTS: The major finding of this investigation was that the production plasma CK during the exercise significantly decreased for group AG than for group P. Secondary physiological finding was that 80% VO2max running was not improved over a 4-wk AG supplementation regimen.CONCLUSION: Supplementation with AG for 4 wk prior to an exhaustive aerobic treadmill running reduced the leakage of CK during exercise, but did not enhance aerobic work capacity. The reduction of plasma CK may be due to the fact that AG is effective for the decrease of skeletal muscle cell membrane damage, induced by exercise during the high-intensity treadmill run.

Five-year major clinical outcomes between first-generation ana second- generation drug-eluting stents in acute myocardial infarction patients underwent percutaneous coronary intervention

Background There were limited data comparing the major clinical outcomes between first-generation （1G）-drug eluting stentts （DES） and second-generation （2G）-DES in patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI） during very long follow-up periods. We thought to investigate the comparative efficacy and safety of 2G-DES compared with 1G-DES in AMI patients during 5-year follow-up periods. Method A total of 1016 eligible AMI patients who underwent PCI with 1G-DES [paclitaxel-, sirolimus-, 1G-zotarolimus-eluting stent （endeavor~ or endeavor sprintS）, n = 554] or 2G-DES [2G-zotarolimus （endeavor resolute~）- or everolimus-eluting stent, n = 462] were enrolled. The primary endpoint was the occurrence of major adverse cardiac events （MACE） defined as total death, non-fatal myocardial infarction （MI）, target lesion revascularization （TLR）, target vessel revascularization （TVR）, non-target vessel revascularization （Non-TVR） and the secondary endpoint was stem thrombosis （ST） at 5 years. Results Two propensity score-ma- tched （PSM） groups （232 pairs, n = 464, C-statistic = 0.802） were generated. During the 5-year follow-up period, the cumulative incidence of TLR [hazard ratio （HR）： 3.133; 95% confidence interval （CI）： 1.539-6.376; P = 0.002], TVR （HR： 3.144; 95% CI： 1.59645.192; P = 0.001） and total revascularization rate （FIR： 1.874; 95% CI： 1.086-3.140; P = 0.023） were significantly higher in 1G-DES compared with 2G-DES after PSM. However, the incidence of total death, non-fatal MI and ST were similar between the two groups. Conclusion In this single-center and all-comers registry, 2G-DES＇s superiorities for TLR, TVP, and total revascularization in AMI patients suggested during 5-year clinical follow-up periods.

ENDOMYOCARDIAL FIBROSIS IN CHINA

To introduce the epidemical, pathological, and clinical characteristics as well as the diagnostic and therapeutical experiences of endomyocardial fibrosis(EMF) in China. [WT5”BX] Data sources.[WT5”BZ]A CMBdisc search was done of the Chinese language literature published from January 1983 through June 1997 about EMF and/or restrictive cardiomyopathy. A manual search was then done for other contributions, including abstracts, between January 1965 and June 1997. [WT5”BX] Results. [WT5”BZ]Eighty seven Chinese cases of EMF were collected in this paper. There were 49 men and 38 women, with a mean age of 28±13 years(range, 8 to 68 years). The distribution of the cases is mainly in the south of China. Combined right and left ventricular disease occurs in 48 percent of cases, with pure right ventricular involvement occurring in 42 percent and pure left ventricular involvement in the remaining 10 percent of patients who are examined postmortem. The diagnosis of EMF was confirmed in 21 cases at autopsy, and in 66 cases by echocardiography, angiocardiography, and/or endomyocardial biopsy which showed the characteristic changes. Clinically, right sided disease is the commonest variety. Endocardiectomy and tricuspid(n=7) or mitral(n=1) valves replacement have been performed in 8 patients. There were 2 operative deaths. Six patients had a satisfactory recovery postoperatively and living well in the follow up duration. [WT5”BX] Conclusion.

Comparison of GFR by Creatinine Clearance with Estimated GFR by Various Prediction Equations in a Bangladeshi Population

Glomerular filtration rate （GFR） is considered as the best marker of kidney function. Evaluation of various prediction equations to estimate GFR is rare in our population. The aim of this study was to compare GFR estimated by various prediction equations with GFR by creatinine clearance （GFRer） in Bangladeshi population. Serum creatinine and 24 hours urinary creatinine concentrations were measured in 216 adult Bangladeshi subjects （100 males and 116 females）. Creatinine clearance rate was calculated and adjusted for body surface area to obtain GFRcr. GFR was also calculated by CKD-EPI, MDRD4, Cockcroft-Gault, Jelliffe, Mawer, Bjornsson, Gates, Apollo-Chennai and Mayo Clinic prediction equations and compared with GFRcr. Results were expressed as mean ＋ SD and compared by two-tailed paired t-test, precision （r2） and receiver-operating characteristic curve. Mean ± SD of age of the total subjects was 57.15 ±10.96 years. The mean GFILzr was 42.41 ± 22.95 mL/min/1.73m2. Estimated GFR （eGFR） by CKD-EPI, MDRD4, Cockcroft-Gault, Jelliffc 1, Jelliffe 2, Mawer, Bjornsson, Gates, Apollo-Chennai and Mayo Clinic prediction equations were 8.19 ± 13.80, 5.30 ±13.61, 11.54 ± 16.86, 8.66± 18.64, 17.25 ± 19.98, 10.86 ± 22.48, 14.60 ± 17.92, 12.18 ± 16.42, 39.86 ± 21.96 and 20.47 ± 20.49 mL/min/1.73m2 higher than GFR, （P 〈 0.001）. The precision （r2） of eGFRs were 0.7114, 0.6924, 0.6431, 0.4802, 0.5048, 0.5921, 0.6286, 0.6158, 0.1635, and 0.5586 for CKD-EPI, MDRD4, Cockcroft-Gault, Jelliffe 1, Jelliffe 2, Mawer, Bjornsson, Gates, Apollo-Chennai and Mayo Clinic prediction equations, respectively. The area under receiver-operating characteristic curve was the lowest for MDRD4 equation. This study revealed that GFR estimated by standardized MDRD4 variables equation is closer to creatinine clearance rate in the study population.

Restrictive Cardiomyopathy Resulting from a Troponin Ⅰ Type 3 Mutation in a Chinese Family

Objective To identify the pathogenic variant responsible for restrictive cardiomyopathy （RCM） in aChinese family.Methods Next generation sequencing was used for detecting the mutation and results verified bysequencing. We used restriction enzyme digestion to test the mutation in the family members and 200 unrelatednormal subjects without any cardiac inherited diseases when the mutation was identified.Results Five individuals died from cardiac diseases, two of whom suffered from sudden cardiacdeath. Two individuals have suffered from chronic cardiac disorders. Mutation analysis revealed a novelmissense mutation in exon 7 of troponin I type 3 （TNNI3）, resulting in substitution of serine （S） withproline （P） at amino acid position 150, which cosegregated with the disease in the family, which is predictedto be probably damaging using PolyPhen-2. The mutation was not detected in the 200 unrelated subjectswe tested.Conclusion Using next generation sequencing, which has very recently been shown to be successfulin identifying novel causative mutations of rare Mendelian disorders, we found a novel mutation of TNNI3 in aChinese family with RCM.

A new radiolarian species Clathrocorys gracilis from northern South China Sea

A new species, Clathrocorys gracilis nov. spec., of Tripocyrtidae (Radiolarians: Nassellaria) from surface water in northern South China Sea, is described in this paper. The new species has four radial beams arising from the cephalic base centre, each foot with cup-shaped structure and ramified bar in the proximal section (near cephalic base), and each wing with a large mesh in the middle, a medium mesh and a small mesh on each side respectively.

Transradial Versus Transfemoral Approach for Percutaneous Coronary Intervention in Elderly Patients in China： A Retrospective Analysis

Objective To compare hospital costs and clinical outcomes between transradial intervention （TRI） and transfemoral intervention （TFI） in elderly patients aged over 65 years. Methods We identified 1229 patients aged over 65 years who underwent percutaneous coronary intervention （PCI） in Fuwai Hospital, Beijing, China, between January 1 and December 31, 2010. Total hospital costs and in-hospital outcomes were compared between TRI and TFI. An inverse probability weighting （IPW） model was introduced to control potential biases. Results Patients who underwent TRI were younger, less often female, more likely to receive PCI for single-vessel lesions, and less likely to undergo the procedure for ostial lesions. TRI was associated with a cost saving of CNY7495 （95%CI： CNY4419-10 420）. Such differences were mainly driven by lower PCI-related costs. TRI patients had shorter length of stay （1.9 days, 95%CI： 1.1-2.7 days）, shorter post-procedural stay （0.7 days, 95%CI： 0.3-1.1 days）, and fewer major adverse cardiac events （adjusted odds ratio = 0.47, 95%CI： 0.31-0.73）. There was no statistical significance in the incidence of post-PCI bleeding between TRI and TFI （P〉0.05）. Such differences remained consistent in clinically relevant subgroups of acute myocardial infarction, acute coronary syndrome, and stable angina. Conclusion The use of TRI in patients aged over 65 years was associated with significantly reduced hospital costs and more favorable clinical outcomes.

Structural analysis of DMD gene and its clinical application in Chinese.Ⅰ. Bgl Ⅱ exon-containing fragment,RFLP and carrier detection

This article is one of the serial studies oll the characteristics of the molecular structure for dystrophin gene in Chinese. By using the entire dystrophin cDNA (14 kb) as a probe- the number and RFLPs of Bgl Ⅱ exon-containing fragments of the dystrophin gene were analysed. Four new Bgl Ⅱ fragments were found, two of them (3.7 and 6.2 kb) detected by comparing the hybridization patterns with cDNA1-2a. 1a and 2a, one (9.3 kb) from the hybridization pattern with cDNA 9 by lengthening migrating distance of DNA fragments in electrophoresis. and another one (4.0 kb) by comparing the patterns with cDNA 11-14,11a- 11b’ 11c-12a and 14. The results indicated that the number of Bgl Ⅱ exon-containing fragments should be 59 rather than 55 reported previously, which laid the foundation of the Bgl Ⅱ partial restriction map for dystrophin gene. Three of the four RFLPs found in Caucacian appear in the hybridization patterns of three subclones, i.e.cDNA 2b-3. cDNA 4-5, and cDNA 5b-7.’ The values of expected heterozygote frequency (EHF) were 0.33, 0.33and 0.40 and the observed heterozygote frequency (OHF)were 0.40. 0.40 and 0.48 respectively. Meanwhile, two new rare allelic fragments (15 kb) were found in RFLPs from Bgl Ⅱ/2b-3 and Bgl Ⅱ/4-5a patterns respectively. These Bgl Ⅱ RFLPs and four XbaI RFLPs documented in our laboratory, have been used to detect the carrier in 7 DMDfamilies and 1 BMD family. Of the 69 individuals from the 8 families- 11 females were diagnosed as the carriers with DMD mutation, 4 females as the doubtful carriers, 12 females were defined as normal genotype and 2 females as probably normal. The results suggest that the carrier testing method based on dosage intensity analysis and genotype analysis by using dystrophin cDNA as a probe will be more sensitive and accurate.

Acute coronary syndrome in the older adults

Coronary heart disease remains the leading cause of death in the developed world. Advanced age is the single strongest risk factor for coronary artery disease （CAD） and independent predictor for poor outcomes following an acute coronary syndrome （ACS）. ACS refers to a spectrum of conditions compatible with acute myocardial ischemia and/or infarction due to various degrees of reduction in co- ronary blood flow as a result of plaque rupture/erosion and thrombosis formation or supply and demand mismatch.

Effect of Genotype on Fatty Acid Composition of Several Muscles （LD, ST, PM） of Young Fattening Bulls

We examined the effect of linseed supplementation in finishing diet on intramuscular fat level and fatty acid composition of three bovine muscles （longissimus dorsi-LD, semitendinosus-ST, psoas major-PM）, total of sixty-two young bulls, from six different genotypes Angus （A）, Charolais （CH）, Holstein-Friesian （H）, Hungarian Grey （HG）, Hungarian Simmental （HS）, Charolais x Hungarian Grey F1 （CHxHG）. The results showed that A bulls had the highest intramuscular fat （IM） level （3.76）, particularly in PM （4.74）, followed by HG （3.40）, crossbred HG （3.05）, CH （2.33）, HS （2.21）, with the lowest level for H （2.11） bulls. IMF for LD （2.87） and ST （1.77） muscles were significantly lower than PM （3.60） for all groups. SFA was significantly higher for PM than the other two, due to the high level oflM. The highest MUFA was detected in LD, significantly different from others. ST contained the highest PUFA （12.99）, followed by LD （10.30） and PM （10.19）. The n-6 fatty acids were affected either by breed, or by muscle type. The linoleic acid was the highest in muscle samples of Holstein bulls except for PM, while the lowest was in A bulls in all cases. The same tendency can be seen in all cases for long chain n-6 fatty acids. The overall mean of n-3 fatty acids varied among genotypes from 1.36 to 1.80%. The highest level was measured in ST of CH and H （2.19）, whereas the lowest one in LD of HG （1.22）. Significant differences among genotypes were shown only for PM. The level of n-3 series long chain fatty acids was the highest for ST, for LD and PM in H, CH and HS, respectively. The ratio of n-6/n-3 ranged from 4.48 to 6.22 and was significantly less favorable in H than in A bulls. The highest CLA level was detected in all cases in HG bulls.

Analysis on the Developmental Trend and Characteristics of Modern Oil Painting from Perspectives of the Texture and Color

In this paper, we conduct research on the developmental trend and characteristics of the modern oil painting from perspectives ofthe texture and color. Image oil painting is not just a simple art genre and style, it is a western oil painting the foreign art in the Chinese culturalenvironment to generate the types of oil painting is a kind of Chinese national culture characteristic of painting art for the purpose of art topresent true feelings and true feelings should be created by the artist’s technique, form, style, texture effects such as external factors. And manyof the current oil painting art works are showing the true feelings, because of the wrong style, texture and other external factors as the purpose ofart. Master of art means the long-term growth path is essentially in express their true feelings, and to form the style need to constantly supplementand perfect process. We provide the novel perspective on the corresponding issues that will be meaningful and important.

Lack of Gender Effect on the Pharmacokinetics of Oxytetracycline in Fenneropenaeus chinensis After Intramuscular Administration

Fenneropenaeus chinensis, an economically important shrimp species, currently suffers from epizootic diseases due to high density stocking and bacterial infections. Oxytetracycline （OTC） has been widely used to treat various systemic bacterial infec- tions in shrimp farming. In the present study, the effect of gender on pharmacokinetics of OTC in F. chinensis was investigated. The OTC concentrations in hemolymph of shrimp after single intramuscular administration （75 mg OTC per kg body weight） were ana- lyzed by high performance liquid chromatography and best described with a two-compartment open model which is characterized by a short elimination half-life, low clearance, and a relatively large apparent volume of distribution. The pharmacokinetic equations were Ct= 58.54e-0.38t＋ 11.67e-0.04t for females; and Ct= 27.94e-0.28t＋ 14.87e-0.04t for males. The distribution and elimination half-lives of OTC were 1.82 and 19.58 h, respectively, in females and 2.50 and 16.11 h, respectively, in males at 22 ℃. The areas under the drug concentration curve were 480 mg L-1 h-1 in females and 430 mg L-1 h-1 in males. The total body clearance of the drug was 157.11 mL kg-1 h-l in females and 172.47mLkg-1 h-1 in males. The apparent volume distribution was 4.44 in females and 4.01 Lkg-1 in males. There was no significant difference in pharmacokinetic parameters between female and male shrimps, indicating that there is no need to consider the gender effect in clinical use of OTC in F. chinensis farming.

Analysis of Muscle Strength Measurement on Chinese Young Males

To establish a database of muscle strength of the Chinese people. The study sampled data of 843 Chinese young males all over the country. Back force, hand twisting force and arm force of four different exerting directions (pull, push, adduction and abduction) were measured. Comparisons are made between the results of this study and those from other documents. Different types strength were also compared. The factors of stature and weight influenced on muscle force were analyzed. There are obvious differences of arm strength in four directions and it can be ordered as push, pull, adduction and abduction, the push force is the largest and the abduction force is the least. The significant correlation exists between different types force. Weight has an obvious influence on one's force among above three factors. The database of Chinese young males is established for the first time. Results of the study can provide help for ergonomist, the worker of occupation health and the researcher of rehabilitation.

Pharmacological effects of Chinese herb aconite(Fuzi) on cardiovascular system

Fuzi(aconite,Radix Aconiti praeparata),a widely used Chinese herb,plays a significant role in the cardiovascular system.This is mainly reflected by Fuzi's cardiotonic effect,its protective effect on myocardial cells,and its effect on heart rate and rhythm,blood pressure,and hemodynamics.In this article,the pharmacological effects and the corresponding mechanisms of Fuzi(aconite) and its active components on cardiovascular system are reviewed.