Active host-pathogen interactions take place during infection of human immunodeficiency virus type 1 (HIV-1). Outcomes of these interactions determine the efficiency of viral infection and subsequent disease progressi...Active host-pathogen interactions take place during infection of human immunodeficiency virus type 1 (HIV-1). Outcomes of these interactions determine the efficiency of viral infection and subsequent disease progression. HIV- infected cells respond to viral invasion with various defensive strategies such as innate, cellular and humoral immune antiviral mechanisms. On the other hand, the virus has also developed various offensive tactics to suppress these host cellular responses. Among many of the viral offensive strategies, HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in the host-pathogen interaction and thus have significant impacts on the outcome of HIV infection. One of the best examples is the interaction of Vif with a host cytidine deaminase APOBEC3G. Although specific roles of other auxiliary proteins are not as well described as Vif-APOBEC3G interaction, it is the goal of this brief review to summarize some of the preliminary findings with the hope to stimulate further discussion and investiga- tion in this exhilarating area of research.展开更多
In this paper, the author presents an overview of the development of CALL and understanding of CALL research in recent years; and then, indicates the trend of CALL research-AR and the research on AR-could be interpret...In this paper, the author presents an overview of the development of CALL and understanding of CALL research in recent years; and then, indicates the trend of CALL research-AR and the research on AR-could be interpreted as the research framework of CALL in China by introducing the four elements of AR-involvement, improvement, systematization and publicity.展开更多
Il existe des régions qui ont une forme triangulaire dans la région du cou.Ces triangles sont formés par des vaisseaux,des muscles ou des os.Ils sont importants en anatomie topographique et sont des par...Il existe des régions qui ont une forme triangulaire dans la région du cou.Ces triangles sont formés par des vaisseaux,des muscles ou des os.Ils sont importants en anatomie topographique et sont des parties essentielles dans le corps humain.Donc il est necessaire de bien apprendre les compositions de ces triangles et ses significations cliniques.En principe,les triangles du cou sont faits de 2 régions(divisés par le muscle sterno-cléido-mastodien).Tous ces triangles du cou sont très utiles en clinique.Quelques-uns sont les signes pour trouver les vaisseaux ou les nerfs en opération,soit sont les positions de paracentèse,soit sont pour observer l'évolution de maladie.Si on les matrise bien,on peut diminuer l'hémorragie en opration et découvrir des cancers ou maladies le plus tt possible ce qui est très important pour traitement.展开更多
The purpose of this study is to assess the effectiveness of using a computer-lab on oral English fluency amongst all Chinese students at Western Oregon University （WOU）. The participants are oversea Chinese graduate...The purpose of this study is to assess the effectiveness of using a computer-lab on oral English fluency amongst all Chinese students at Western Oregon University （WOU）. The participants are oversea Chinese graduate students who take undergraduate courses at WOU, and some of them regard English as their Second Language. The study adopts the experimental design, There are total of 60 Chinese students participating in the study. The results indicate that the use of a Computer-Lab significantly improved students＇ English oral expression ability.展开更多
Essence of education is to guide. The scene teachers create is like a key to help the students feel the music, and played an active role in the teaching process immeasurably. Through multimedia assisted teaching, the ...Essence of education is to guide. The scene teachers create is like a key to help the students feel the music, and played an active role in the teaching process immeasurably. Through multimedia assisted teaching, the use of a wide range of teaching methods in music teaching, so that the children take the initiative to actively participate in musical activities to develop their musical aesthetic and correct music ability to inspire their interest in learning music, promote classroom further improve the quality of teaching.展开更多
Objective To verify the regulation of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT 2), which is associated with cholesterol metabolism, by saturated fatty acids (SFAs). Methods Palmitic acid (PA), the most abun...Objective To verify the regulation of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT 2), which is associated with cholesterol metabolism, by saturated fatty acids (SFAs). Methods Palmitic acid (PA), the most abundant saturated fatty acid in plasma, and oleic acid (OA), a widely distributed unsaturated fatty acid, were used to treat hepatic cells HepG2, HuH7, and mouse primary hepatocytes. In addition, PA at different concentrations and PA treatment at different durations were applied in HepG2 cells. In in vivo experiment, three-month male C57/BL6 mice were fed with control diet and SFA diet containing hydrogenated coconut oil rich of SFAs. The mRNA level of ACAT2 in those hepatic cells and the mouse livers was detected with real-time polymerase chain reaction (PCR). Results In the three types of hepatic cells treated with PA, that SFA induced significant increase of ACAT2 expression (P<0.01), whereas treatment with OA showed no significant effect. That effect of PA was noticed gradually rising along with the increase of PA concentration and the extension of PA treatment duration (both P<0.05). SFA diet feeding in mice resulted in a short-term and transient increase of ACAT2 expression in vivo, with a peak level appearing in the mice fed with SFA diet for two days (P<0.05). Conclusion SFA may regulate ACAT2 expression in human and mouse hepatic cells and in mouse livers.展开更多
Computer assisted audit techniques （CAATs） are audit technologies that allow auditors to perform their audit work efficiently and effectively. However, little is known about CAATs adoption process by audit firms. Th...Computer assisted audit techniques （CAATs） are audit technologies that allow auditors to perform their audit work efficiently and effectively. However, little is known about CAATs adoption process by audit firms. Therefore, this paper adapts the technology readiness theory （TRI）, the unified theory of acceptance and use of technology （UTAUT） and the technology-organization environment （TOE） framework and Denison organizational culture theory, and presents a new theory of unified technology readiness and cultural-technological-organizational-environmental model （UTR-CTOE）, to explain CAATs adoption at both individual level and firm level. The methodology used in the study consists of a random sampling among the auditors through the administration of questionnaire. A total of 581 auditors registered with Mauritius Institute of Professional Accountants （MIPA） respond to the survey. Our main findings of this paper confirm that the relation between beliefs, such as perceived usefulness, perceived ease of use, facilitating condition and social influence, and motivation is positively correlated, while beliefs have a negative correlation with inhibition towards CAATs adoption. Results also indicate that firm＇s decision for CAATs adoption is positively influenced by cultural, technological, organizational, and environmental factors. Furthermore, there is an indirect impact of firm＇s internal and external influences on auditors＇ adoption of CAATs.展开更多
It is widely accepted nowadays that intelligibility is the essential goal for most learners of English,and it is not necessary for them to mimic all aspects of native-speaker English in order to achieve a high level o...It is widely accepted nowadays that intelligibility is the essential goal for most learners of English,and it is not necessary for them to mimic all aspects of native-speaker English in order to achieve a high level of intelligibility.However,the features that are needed in order to make oneself easily understood by listeners from elsewhere remain controversial.The current research focuses on thirteen five-minute recordings of conversations between young speakers of English in central China and an interviewer from Britain,in order to determine which features of their speech gave rise to misunderstandings.It was found that,in the 18 tokens of misunderstanding identified,4 resulted from lexical semantics(22%),3 from Chinese place names(17%),3 from grammar(17%),and 11 from pronunciation(61%)(with some tokens cross-classified).The most common phonological factors giving rise to loss of intelligibility were omission of syllables and simplification of word-initial consonant clusters.展开更多
文摘Active host-pathogen interactions take place during infection of human immunodeficiency virus type 1 (HIV-1). Outcomes of these interactions determine the efficiency of viral infection and subsequent disease progression. HIV- infected cells respond to viral invasion with various defensive strategies such as innate, cellular and humoral immune antiviral mechanisms. On the other hand, the virus has also developed various offensive tactics to suppress these host cellular responses. Among many of the viral offensive strategies, HIV-1 viral auxiliary proteins (Tat, Rev, Nef, Vif, Vpr and Vpu) play important roles in the host-pathogen interaction and thus have significant impacts on the outcome of HIV infection. One of the best examples is the interaction of Vif with a host cytidine deaminase APOBEC3G. Although specific roles of other auxiliary proteins are not as well described as Vif-APOBEC3G interaction, it is the goal of this brief review to summarize some of the preliminary findings with the hope to stimulate further discussion and investiga- tion in this exhilarating area of research.
文摘In this paper, the author presents an overview of the development of CALL and understanding of CALL research in recent years; and then, indicates the trend of CALL research-AR and the research on AR-could be interpreted as the research framework of CALL in China by introducing the four elements of AR-involvement, improvement, systematization and publicity.
文摘Il existe des régions qui ont une forme triangulaire dans la région du cou.Ces triangles sont formés par des vaisseaux,des muscles ou des os.Ils sont importants en anatomie topographique et sont des parties essentielles dans le corps humain.Donc il est necessaire de bien apprendre les compositions de ces triangles et ses significations cliniques.En principe,les triangles du cou sont faits de 2 régions(divisés par le muscle sterno-cléido-mastodien).Tous ces triangles du cou sont très utiles en clinique.Quelques-uns sont les signes pour trouver les vaisseaux ou les nerfs en opération,soit sont les positions de paracentèse,soit sont pour observer l'évolution de maladie.Si on les matrise bien,on peut diminuer l'hémorragie en opration et découvrir des cancers ou maladies le plus tt possible ce qui est très important pour traitement.
文摘The purpose of this study is to assess the effectiveness of using a computer-lab on oral English fluency amongst all Chinese students at Western Oregon University （WOU）. The participants are oversea Chinese graduate students who take undergraduate courses at WOU, and some of them regard English as their Second Language. The study adopts the experimental design, There are total of 60 Chinese students participating in the study. The results indicate that the use of a Computer-Lab significantly improved students＇ English oral expression ability.
文摘Essence of education is to guide. The scene teachers create is like a key to help the students feel the music, and played an active role in the teaching process immeasurably. Through multimedia assisted teaching, the use of a wide range of teaching methods in music teaching, so that the children take the initiative to actively participate in musical activities to develop their musical aesthetic and correct music ability to inspire their interest in learning music, promote classroom further improve the quality of teaching.
基金Supported by National Natural Science Foundation of China (30721063)National High Technology Research and Development Program of China (863 Program) (2006AA02A406)+1 种基金National Basic Research Program of China (973 Program) (2006CB503801)Special Fund of the National Laboratory of China (2060204)
文摘Objective To verify the regulation of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT 2), which is associated with cholesterol metabolism, by saturated fatty acids (SFAs). Methods Palmitic acid (PA), the most abundant saturated fatty acid in plasma, and oleic acid (OA), a widely distributed unsaturated fatty acid, were used to treat hepatic cells HepG2, HuH7, and mouse primary hepatocytes. In addition, PA at different concentrations and PA treatment at different durations were applied in HepG2 cells. In in vivo experiment, three-month male C57/BL6 mice were fed with control diet and SFA diet containing hydrogenated coconut oil rich of SFAs. The mRNA level of ACAT2 in those hepatic cells and the mouse livers was detected with real-time polymerase chain reaction (PCR). Results In the three types of hepatic cells treated with PA, that SFA induced significant increase of ACAT2 expression (P<0.01), whereas treatment with OA showed no significant effect. That effect of PA was noticed gradually rising along with the increase of PA concentration and the extension of PA treatment duration (both P<0.05). SFA diet feeding in mice resulted in a short-term and transient increase of ACAT2 expression in vivo, with a peak level appearing in the mice fed with SFA diet for two days (P<0.05). Conclusion SFA may regulate ACAT2 expression in human and mouse hepatic cells and in mouse livers.
文摘Computer assisted audit techniques （CAATs） are audit technologies that allow auditors to perform their audit work efficiently and effectively. However, little is known about CAATs adoption process by audit firms. Therefore, this paper adapts the technology readiness theory （TRI）, the unified theory of acceptance and use of technology （UTAUT） and the technology-organization environment （TOE） framework and Denison organizational culture theory, and presents a new theory of unified technology readiness and cultural-technological-organizational-environmental model （UTR-CTOE）, to explain CAATs adoption at both individual level and firm level. The methodology used in the study consists of a random sampling among the auditors through the administration of questionnaire. A total of 581 auditors registered with Mauritius Institute of Professional Accountants （MIPA） respond to the survey. Our main findings of this paper confirm that the relation between beliefs, such as perceived usefulness, perceived ease of use, facilitating condition and social influence, and motivation is positively correlated, while beliefs have a negative correlation with inhibition towards CAATs adoption. Results also indicate that firm＇s decision for CAATs adoption is positively influenced by cultural, technological, organizational, and environmental factors. Furthermore, there is an indirect impact of firm＇s internal and external influences on auditors＇ adoption of CAATs.
基金funded by State Administration of Foreign Expert Affairs(project GDT20173200030&project G20190214022).
文摘It is widely accepted nowadays that intelligibility is the essential goal for most learners of English,and it is not necessary for them to mimic all aspects of native-speaker English in order to achieve a high level of intelligibility.However,the features that are needed in order to make oneself easily understood by listeners from elsewhere remain controversial.The current research focuses on thirteen five-minute recordings of conversations between young speakers of English in central China and an interviewer from Britain,in order to determine which features of their speech gave rise to misunderstandings.It was found that,in the 18 tokens of misunderstanding identified,4 resulted from lexical semantics(22%),3 from Chinese place names(17%),3 from grammar(17%),and 11 from pronunciation(61%)(with some tokens cross-classified).The most common phonological factors giving rise to loss of intelligibility were omission of syllables and simplification of word-initial consonant clusters.
