AIM:To clarify the similarities and differences in gastric cancer epidemiology between Japan and China.METHODS:A comprehensive literature search of the PubMed database was performed.The relevant literature published i...AIM:To clarify the similarities and differences in gastric cancer epidemiology between Japan and China.METHODS:A comprehensive literature search of the PubMed database was performed.The relevant literature published in China was also been cited.Data on incidence and mortality rates in 2008 were obtained from the Cancer Mondial database,published by International Agency for Research on Cancer at http://www-dep.iarc.fr/.RESULTS:Gastric cancer remains a significant publichealth burden in both Japan and China.The prevalence of Helicobacter pylori(H.pylori)colonization is high in the adult populations of both countries.Accumulating evidence from intervention studies in both countries has shown the effectiveness of H.pylori eradication in reduc-ing gastric cancer incidence.There are differences,however,in many aspects of gastric cancer,including patterns of incidence and mortality,trends in the prevalence of H.pylori infection,H.pylori strains,the magnitude of risk of gastric cancer related to H.pylori infection,and associations with dietary habits.Compared with China,Japan has seen a more rapid decline in H.pylori infection among adolescents.While Japanese cohort studies have dominated the literature concerning the associations between gastric cancer and dietary habits,numerous case-control studies in China suggest a positive association between a high intake of preserved fish and vegetables and gastric cancer risk.There is a need for a multidisciplinary research approach to understand the interactions between various strains of H.pylori,host factors,and other lifestyle and environmental factors in gastric carcinogenesis in both countries.CONCLUSION:The shared high incidence of gastric cancer and high prevalence of H.pylori,as well as differences in many aspects of gastric cancer,provide an excellent opportunity to establish Sino-Japanese collaborations.展开更多
During the financial crisis, the delayed recognition of credit losses on loans and other financial instruments was identified as a weakness in existing incurred loss model of impairment stated by International Account...During the financial crisis, the delayed recognition of credit losses on loans and other financial instruments was identified as a weakness in existing incurred loss model of impairment stated by International Accounting Standards （IAS） 39, because it is believed that this delay might generate pro-cyclical effects. In response to the recommendations of G20, Financial Crisis Advisory Group （FCAG）, and other international bodies, the International Accounting Standards Board （IASB） has undertaken, since 2009, as a part of the project to replace IAS 39, a project （partially shared with Financial Accounting Standards Board （FASB）） aimed at introducing an expected loss model of impairment. Within the scope of this subset project, the IASB has previously issued two exposure documents proposing models to account for expected credit losses： an exposure draft （ED） Financial Instrument： Amortized Cost and Impairment, published in November 2009, and a supplementary document （SD） Financial Instrument： Impairment, published jointly with the FASB in January 2011. However, neither of the two proposals received strong support from interested parties. Recently, the IASB, after the FASB＇s decision to withdraw from the joint project and to develop a separate expected credit loss model based on a single measurement approach consisting in the sole recognition of lifetime expected credit losses, published a third proposal--Ahe so-called expected credit losses model （ED/2013/3 Financial Instruments： Expected Credit Losses）.展开更多
Malignant melanoma, characterized by invasive local growth and early formation of metastases, is the most aggressive type of skin cancer. Melanoma inhibitory activity （MIA）, secreted by malignant melanoma cells, int...Malignant melanoma, characterized by invasive local growth and early formation of metastases, is the most aggressive type of skin cancer. Melanoma inhibitory activity （MIA）, secreted by malignant melanoma cells, interacts with the cell adhesion receptors, integrins a4131 and 05131, facilitating cell detachment and promoting formation of me- tastases. In the present study, we demonstrate that MIA secretion is confined to the rear end of migrating cells, while in non-migrating cells MIA accumulates in the actin cortex. MIA protein takes a conventional secretory pathway including coat protein complex I （COPI）- and coat protein complex II （COPII）-dependent protein transport to the cell periphery, where its final release depends on intracellular Ca2＋ ions. Interestingly, the Ca2＋-activated K＋-channel, subfamily N, member 4 （KCa3.1）, known to be active at the rear end of migrating cells, was found to support MIA secretion. Secretion was diminished by the specific KCa3.1 channel inhibitor TRAM-34 and by expression of dominant- negative mutants of the channel. In summary, we have elucidated the migration-associated transport of MIA protein to the cell rear and also disclosed a new mechanism by which KCa3.1 potassium channels promote cell migration.展开更多
Both the Siberian Crane(Leucogeranus leucogeranus) and Hooded Crane(Grus monacha) have limited population sizes and are considered endangered by domestic Chinese and international agencies.To document the current size...Both the Siberian Crane(Leucogeranus leucogeranus) and Hooded Crane(Grus monacha) have limited population sizes and are considered endangered by domestic Chinese and international agencies.To document the current size of their respective populations and characterize their groups,between October 2012 and April 2013 we undertook fieldwork at four nature reserve areas within the Poyang Lake wetlands.We divided Poyanghu National Nature Reserve(PYH) into the Wucheng(PWC) and Hengfeng areas(PHF),because each are each located in different counties.Our fieldwork showed that the Siberian Crane occurred mainly in PYH(364 in the PHF,158 in the PWC) and the Nanjishan Wetland National Nature Reserve(NJS,with 200 individuals).The Hooded Crane was mainly distributed in PYH(302 in the PHF and 154 in the PWC).Family groups accounted for more than 50% of the total number of groups among both species,with Hooded Cranes forming more family groups than Siberian Cranes.Typically,these groups were formed of two adults with one offspring(Siberian Crane),and two adults with two offspring(Hooded Crane),with the mean family group size of the Siberian Crane and Hooded Crane being respectively 2.65±0.53(n=43) and 3.09±0.86(n=47) individuals per group.The mean collective group size of the Siberian Crane and Hooded Crane included 28.09±24.94(n=23) and 28.94±27.97(n=16) individuals per group,respectively,with the proportion of juveniles among Hooded Cranes being more than double that seen among the Siberian Cranes.展开更多
AIM:To assess the safety,yield and clinical utility of percutaneous transgastric computed tomography(CT)-guided biopsy of pancreatic tumor using large needles, in selected patients. METHODS:We reviewed 34 CT-guided bi...AIM:To assess the safety,yield and clinical utility of percutaneous transgastric computed tomography(CT)-guided biopsy of pancreatic tumor using large needles, in selected patients. METHODS:We reviewed 34 CT-guided biopsies in patients with pancreas mass,of whom 24(71%)had a direct path to the mass without passing through a major organ.The needle passed through the liver in one case(3%).Nine passes(26%)were made through the stomach.These nine transgastric biopsies which used a coaxial technique(i.e.a 17-gauge coaxial introducer needle and an 18-gauge biopsy needle)were the basis of this study.Immediate and late follow-up CT images to detect complications were obtained. RESULTS:Tumor tissues were obtained in nine pancreatic biopsies,and histologic specimens for diagnosis were obtained in all cases.One patient,who had a rare sarco-matoid carcinoma,received a second biopsy.One patient had a complication of transient pneumoperitoneum but no subjective complaints.An immediate imaging study and clinical follow-up detected neither hemorrhage nor peritonitis.No delayed procedure-related complication was seen during the survival period of our patients.CONCLUSION:Pancreatic biopsy can be obtained by a transgastric route using a large needle as an alternative method,without complications of peritonitis or bleeding.展开更多
After the linear analytical method of unsteady flow theory is further improved,an innovative and faster algorithm is introduced.The water storage in a confined aquifer is derived from the water transmissivity coeffici...After the linear analytical method of unsteady flow theory is further improved,an innovative and faster algorithm is introduced.The water storage in a confined aquifer is derived from the water transmissivity coefficient and the water-pressure conductivity coefficient.The water transmissivity coefficient is approximated by a Taylorseries expansion of drawdown,and the water-pressure conductivity coefficient is obtained by the average drawdown.In this algorithm,the distance of the observation points from the pumping well must be short.When the distance is as short as the radius of the main pumping well,the data of the drawdown difference between the sidewall and the center of pumping well are difficult to measure,but the same results can be achieved based on the assumption that the drawdown difference approximates to the drawdown of the observation wells at a radial distance from the pumping well according to the algorithm.Without the help of charts,this algorithm is more concise and efficient,which has been verified by the test of water pumping project in Tianjin Binhai International Airport.展开更多
基金Supported by Grant-in-Aid from the Third Term Comprehensive Control Research for Cancer,the Ministry of Health,La-bour and Welfare,Japan
文摘AIM:To clarify the similarities and differences in gastric cancer epidemiology between Japan and China.METHODS:A comprehensive literature search of the PubMed database was performed.The relevant literature published in China was also been cited.Data on incidence and mortality rates in 2008 were obtained from the Cancer Mondial database,published by International Agency for Research on Cancer at http://www-dep.iarc.fr/.RESULTS:Gastric cancer remains a significant publichealth burden in both Japan and China.The prevalence of Helicobacter pylori(H.pylori)colonization is high in the adult populations of both countries.Accumulating evidence from intervention studies in both countries has shown the effectiveness of H.pylori eradication in reduc-ing gastric cancer incidence.There are differences,however,in many aspects of gastric cancer,including patterns of incidence and mortality,trends in the prevalence of H.pylori infection,H.pylori strains,the magnitude of risk of gastric cancer related to H.pylori infection,and associations with dietary habits.Compared with China,Japan has seen a more rapid decline in H.pylori infection among adolescents.While Japanese cohort studies have dominated the literature concerning the associations between gastric cancer and dietary habits,numerous case-control studies in China suggest a positive association between a high intake of preserved fish and vegetables and gastric cancer risk.There is a need for a multidisciplinary research approach to understand the interactions between various strains of H.pylori,host factors,and other lifestyle and environmental factors in gastric carcinogenesis in both countries.CONCLUSION:The shared high incidence of gastric cancer and high prevalence of H.pylori,as well as differences in many aspects of gastric cancer,provide an excellent opportunity to establish Sino-Japanese collaborations.
文摘During the financial crisis, the delayed recognition of credit losses on loans and other financial instruments was identified as a weakness in existing incurred loss model of impairment stated by International Accounting Standards （IAS） 39, because it is believed that this delay might generate pro-cyclical effects. In response to the recommendations of G20, Financial Crisis Advisory Group （FCAG）, and other international bodies, the International Accounting Standards Board （IASB） has undertaken, since 2009, as a part of the project to replace IAS 39, a project （partially shared with Financial Accounting Standards Board （FASB）） aimed at introducing an expected loss model of impairment. Within the scope of this subset project, the IASB has previously issued two exposure documents proposing models to account for expected credit losses： an exposure draft （ED） Financial Instrument： Amortized Cost and Impairment, published in November 2009, and a supplementary document （SD） Financial Instrument： Impairment, published jointly with the FASB in January 2011. However, neither of the two proposals received strong support from interested parties. Recently, the IASB, after the FASB＇s decision to withdraw from the joint project and to develop a separate expected credit loss model based on a single measurement approach consisting in the sole recognition of lifetime expected credit losses, published a third proposal--Ahe so-called expected credit losses model （ED/2013/3 Financial Instruments： Expected Credit Losses）.
文摘Malignant melanoma, characterized by invasive local growth and early formation of metastases, is the most aggressive type of skin cancer. Melanoma inhibitory activity （MIA）, secreted by malignant melanoma cells, interacts with the cell adhesion receptors, integrins a4131 and 05131, facilitating cell detachment and promoting formation of me- tastases. In the present study, we demonstrate that MIA secretion is confined to the rear end of migrating cells, while in non-migrating cells MIA accumulates in the actin cortex. MIA protein takes a conventional secretory pathway including coat protein complex I （COPI）- and coat protein complex II （COPII）-dependent protein transport to the cell periphery, where its final release depends on intracellular Ca2＋ ions. Interestingly, the Ca2＋-activated K＋-channel, subfamily N, member 4 （KCa3.1）, known to be active at the rear end of migrating cells, was found to support MIA secretion. Secretion was diminished by the specific KCa3.1 channel inhibitor TRAM-34 and by expression of dominant- negative mutants of the channel. In summary, we have elucidated the migration-associated transport of MIA protein to the cell rear and also disclosed a new mechanism by which KCa3.1 potassium channels promote cell migration.
基金supported by the National Natural Science Foundation of China(3126051731101651)
文摘Both the Siberian Crane(Leucogeranus leucogeranus) and Hooded Crane(Grus monacha) have limited population sizes and are considered endangered by domestic Chinese and international agencies.To document the current size of their respective populations and characterize their groups,between October 2012 and April 2013 we undertook fieldwork at four nature reserve areas within the Poyang Lake wetlands.We divided Poyanghu National Nature Reserve(PYH) into the Wucheng(PWC) and Hengfeng areas(PHF),because each are each located in different counties.Our fieldwork showed that the Siberian Crane occurred mainly in PYH(364 in the PHF,158 in the PWC) and the Nanjishan Wetland National Nature Reserve(NJS,with 200 individuals).The Hooded Crane was mainly distributed in PYH(302 in the PHF and 154 in the PWC).Family groups accounted for more than 50% of the total number of groups among both species,with Hooded Cranes forming more family groups than Siberian Cranes.Typically,these groups were formed of two adults with one offspring(Siberian Crane),and two adults with two offspring(Hooded Crane),with the mean family group size of the Siberian Crane and Hooded Crane being respectively 2.65±0.53(n=43) and 3.09±0.86(n=47) individuals per group.The mean collective group size of the Siberian Crane and Hooded Crane included 28.09±24.94(n=23) and 28.94±27.97(n=16) individuals per group,respectively,with the proportion of juveniles among Hooded Cranes being more than double that seen among the Siberian Cranes.
文摘AIM:To assess the safety,yield and clinical utility of percutaneous transgastric computed tomography(CT)-guided biopsy of pancreatic tumor using large needles, in selected patients. METHODS:We reviewed 34 CT-guided biopsies in patients with pancreas mass,of whom 24(71%)had a direct path to the mass without passing through a major organ.The needle passed through the liver in one case(3%).Nine passes(26%)were made through the stomach.These nine transgastric biopsies which used a coaxial technique(i.e.a 17-gauge coaxial introducer needle and an 18-gauge biopsy needle)were the basis of this study.Immediate and late follow-up CT images to detect complications were obtained. RESULTS:Tumor tissues were obtained in nine pancreatic biopsies,and histologic specimens for diagnosis were obtained in all cases.One patient,who had a rare sarco-matoid carcinoma,received a second biopsy.One patient had a complication of transient pneumoperitoneum but no subjective complaints.An immediate imaging study and clinical follow-up detected neither hemorrhage nor peritonitis.No delayed procedure-related complication was seen during the survival period of our patients.CONCLUSION:Pancreatic biopsy can be obtained by a transgastric route using a large needle as an alternative method,without complications of peritonitis or bleeding.
基金Supported by Major State Basic Research Development Program of China("973" Program,No.2010CB732106)
文摘After the linear analytical method of unsteady flow theory is further improved,an innovative and faster algorithm is introduced.The water storage in a confined aquifer is derived from the water transmissivity coefficient and the water-pressure conductivity coefficient.The water transmissivity coefficient is approximated by a Taylorseries expansion of drawdown,and the water-pressure conductivity coefficient is obtained by the average drawdown.In this algorithm,the distance of the observation points from the pumping well must be short.When the distance is as short as the radius of the main pumping well,the data of the drawdown difference between the sidewall and the center of pumping well are difficult to measure,but the same results can be achieved based on the assumption that the drawdown difference approximates to the drawdown of the observation wells at a radial distance from the pumping well according to the algorithm.Without the help of charts,this algorithm is more concise and efficient,which has been verified by the test of water pumping project in Tianjin Binhai International Airport.
