Objective To explore the clinical value of computer-assisted pathologic imaging analysis in evaluating urinary red blood cell morphology. Method 24 nephropathy patients were treated as study group, and 28 patients who...Objective To explore the clinical value of computer-assisted pathologic imaging analysis in evaluating urinary red blood cell morphology. Method 24 nephropathy patients were treated as study group, and 28 patients whose haematuria due to shockwave lithotomy were treated as control. Urine sediment of each patient was stained,and red blood morphology analysis with computer-assisted imaging system was made. Result The sensitivity and specificity were 83.3% and 90.9% respectively in diagnosis of glomerular haematuria; for non-glomerular haematuria,the sensitivity and specificity all were 100%. Conclusion There are high sensitivity and specificity in diagnosis of glomerular haematuria using computer-assisted imaging analysis.It is reliable and has significant clinical value.展开更多
目的探讨细胞增殖与细胞凋亡在贲门癌发生发展中的作用。方法应用免疫组化法检测PC N A、p53、Bcl-2在30例贲门癌、10例胃溃疡胃壁组织中的表达和分布,采用病理图像分析的方法进行灰度检测,并对胃壁上皮组织或癌组织中凋亡细胞进行计数...目的探讨细胞增殖与细胞凋亡在贲门癌发生发展中的作用。方法应用免疫组化法检测PC N A、p53、Bcl-2在30例贲门癌、10例胃溃疡胃壁组织中的表达和分布,采用病理图像分析的方法进行灰度检测,并对胃壁上皮组织或癌组织中凋亡细胞进行计数。结果观察和比较自胃远端切缘、癌旁至癌灶等胃壁组织中的变化,发现PC N A呈显著的增高趋势,癌灶组织中PC N A呈强阳性表达;p53在正常胃黏膜组织中不表达,在癌灶组织中呈强阳性表达;Bcl-2在癌旁组织中呈强阳性表达,显著高于癌灶组织;细胞凋亡指数在癌灶组织中显著降低。胃溃疡病灶边缘的胃黏膜组织PC N A呈阳性表达,p53呈阴性表达,Bc1-2呈弱阳性表达,细胞凋亡指数显著增高。结论在非典型增生的贲门黏膜组织中,细胞增殖和细胞凋亡均非常活跃,而一旦细胞凋亡受到严重抑制,即可导致贲门癌的发生。展开更多
Objective:The aim of the study was to discuss the X-ray and CT manifestations and characteristics of pulmonary inflammatory pseudotumors.Methods:The 36 patients with pathological diagnosis of pulmonary inflammatory ps...Objective:The aim of the study was to discuss the X-ray and CT manifestations and characteristics of pulmonary inflammatory pseudotumors.Methods:The 36 patients with pathological diagnosis of pulmonary inflammatory pseudotumor were tested by thoracic X-ray and CT scan,and their imaging characteristics were analyzed.Results:Most of masses had intact capsule and smooth border.It was very important to diagnose pulmonary inflammatory pseudotumor when the mass was closed to or adhered to the pleura with irregular shadow or being sharply circumscribed.Conclusion:X-ray and CT scan are very important ways to diagnose the pulmonary inflammatory pseudotumor,and to accurately diagnose it,the clinical data,complete analysis are also necessary.展开更多
文摘Objective To explore the clinical value of computer-assisted pathologic imaging analysis in evaluating urinary red blood cell morphology. Method 24 nephropathy patients were treated as study group, and 28 patients whose haematuria due to shockwave lithotomy were treated as control. Urine sediment of each patient was stained,and red blood morphology analysis with computer-assisted imaging system was made. Result The sensitivity and specificity were 83.3% and 90.9% respectively in diagnosis of glomerular haematuria; for non-glomerular haematuria,the sensitivity and specificity all were 100%. Conclusion There are high sensitivity and specificity in diagnosis of glomerular haematuria using computer-assisted imaging analysis.It is reliable and has significant clinical value.
文摘目的:探讨组织谐波成像(Tissue harmonic imaging,THI)时肝癌(Hepatocellular carcinoma,HCC)的定量参数与病理组织学改变的关系。方法:41例HCC患者,术前行THI,其中21例经术后病理图像分析与THI定量进行对比分析。THI采用的谐波频率分别为5.0MHz、4.8MHz、和4.6MHz(发射频率分别为2.5MHz、2.4MHz和2.3MHz)。分别测定病灶和周围组织的平均回波强度(Meanscale,MS),回波强度标准差(Standard deviation,SD)。计算信噪比(Signal-to-noiseRatio,SNR),结构变异系数(Coefficient of variation of tissue,CTV)。术后病理切片HE染色。以病理图像分析仪行图像分析,分别测定脂肪、纤维组织、肿瘤细胞所占视野面积百分比,取其平均值做对比分析。结果:纤维组织及纤维组织与脂肪含量百分比与MS,SNR呈正相关,与CTV呈负相关。肿瘤细胞含量百分比与MS,SNR呈负相关,与CTV呈正相关。结论:THI的定量参数MS,SNR及CTV能客观地反映HCC的病理组织学改变。
文摘目的探讨细胞增殖与细胞凋亡在贲门癌发生发展中的作用。方法应用免疫组化法检测PC N A、p53、Bcl-2在30例贲门癌、10例胃溃疡胃壁组织中的表达和分布,采用病理图像分析的方法进行灰度检测,并对胃壁上皮组织或癌组织中凋亡细胞进行计数。结果观察和比较自胃远端切缘、癌旁至癌灶等胃壁组织中的变化,发现PC N A呈显著的增高趋势,癌灶组织中PC N A呈强阳性表达;p53在正常胃黏膜组织中不表达,在癌灶组织中呈强阳性表达;Bcl-2在癌旁组织中呈强阳性表达,显著高于癌灶组织;细胞凋亡指数在癌灶组织中显著降低。胃溃疡病灶边缘的胃黏膜组织PC N A呈阳性表达,p53呈阴性表达,Bc1-2呈弱阳性表达,细胞凋亡指数显著增高。结论在非典型增生的贲门黏膜组织中,细胞增殖和细胞凋亡均非常活跃,而一旦细胞凋亡受到严重抑制,即可导致贲门癌的发生。
文摘Objective:The aim of the study was to discuss the X-ray and CT manifestations and characteristics of pulmonary inflammatory pseudotumors.Methods:The 36 patients with pathological diagnosis of pulmonary inflammatory pseudotumor were tested by thoracic X-ray and CT scan,and their imaging characteristics were analyzed.Results:Most of masses had intact capsule and smooth border.It was very important to diagnose pulmonary inflammatory pseudotumor when the mass was closed to or adhered to the pleura with irregular shadow or being sharply circumscribed.Conclusion:X-ray and CT scan are very important ways to diagnose the pulmonary inflammatory pseudotumor,and to accurately diagnose it,the clinical data,complete analysis are also necessary.
