Poly(ε-caprolactone)(PCL)holds unique bioresorbability and competent biomechanical properties for tissueengineering application.However,PCL is hydrophobic intrinsically and poor in cell-biomaterial interaction.In thi...Poly(ε-caprolactone)(PCL)holds unique bioresorbability and competent biomechanical properties for tissueengineering application.However,PCL is hydrophobic intrinsically and poor in cell-biomaterial interaction.In this study,we prepared a composite based on PCL and bioactive tantalum(Ta)to understand the effects of direct laser micropatterning on composite surface properties.The PCL/Ta composite after preparation was surface-patterned by femtosecond laser and characterized with surface morphology,crystal structure,chemical composition,wettability and cellular response of fibroblast.It was found that laser micropatterning enlarged the difference of wetting properties(~15°)on PCL and PCL/Ta surfaces.The wetting changes was dependent on both material composition and lasermachined geometry.The blending of Ta enhanced surface wettability with prolonged contact time on the laser-machined line and rectangle microarrays.In vitro culture results showed beneficial effects of laser micropatterning on cell morphology of the fibroblasts.On the PCL/Ta surfaces with line and rectangle microarrays,the cells were more likely to bridge the sidewalls of the microgrooves,showing adaptive 3D morphologies to the micro/nano topographies on the sidewalls.These findings are envisaged to facilitate surface design and micropattern optimization for favorable tuning the cell response to biomedical PCL/Ta composites.展开更多
The study is meant to describe the evolution of American short-story writing with patterns where visual images have become central and not peripheral for the understanding of stories. Hemingway＇s use of objective cor...The study is meant to describe the evolution of American short-story writing with patterns where visual images have become central and not peripheral for the understanding of stories. Hemingway＇s use of objective correlatives was a trace mark, and the literary editors at The New Yorker urged their writers to slow down the emphasis on movement and plot in order to recreate a certain mood which would favour the perception of objects, anecdotes, and details. The impressionistic device works very much in the same way that an advertisement would do. It is meant to persuade the audience. The apparently non-commitant vision of reality shows in fact the author＇s point of view. The apparent simplicity is meant for a very wide audience and its deepest meaning suggests the scope of the particular visual aids working at the deepest level of consciousness展开更多
基金Project(LY19A040001)supported by the Natural Science Foundation of Zhejiang Province,ChinaProjects(12147219,12035006)supported by the National Natural Science Foundation of China+1 种基金Project(531107050927)supported by the Fundamental Research Funds for the Central Universities,ChinaProject(JY-Q/008/2016)supported by the Hunan University for the Yuelu Young Scholars,China。
文摘Poly(ε-caprolactone)(PCL)holds unique bioresorbability and competent biomechanical properties for tissueengineering application.However,PCL is hydrophobic intrinsically and poor in cell-biomaterial interaction.In this study,we prepared a composite based on PCL and bioactive tantalum(Ta)to understand the effects of direct laser micropatterning on composite surface properties.The PCL/Ta composite after preparation was surface-patterned by femtosecond laser and characterized with surface morphology,crystal structure,chemical composition,wettability and cellular response of fibroblast.It was found that laser micropatterning enlarged the difference of wetting properties(~15°)on PCL and PCL/Ta surfaces.The wetting changes was dependent on both material composition and lasermachined geometry.The blending of Ta enhanced surface wettability with prolonged contact time on the laser-machined line and rectangle microarrays.In vitro culture results showed beneficial effects of laser micropatterning on cell morphology of the fibroblasts.On the PCL/Ta surfaces with line and rectangle microarrays,the cells were more likely to bridge the sidewalls of the microgrooves,showing adaptive 3D morphologies to the micro/nano topographies on the sidewalls.These findings are envisaged to facilitate surface design and micropattern optimization for favorable tuning the cell response to biomedical PCL/Ta composites.
文摘The study is meant to describe the evolution of American short-story writing with patterns where visual images have become central and not peripheral for the understanding of stories. Hemingway＇s use of objective correlatives was a trace mark, and the literary editors at The New Yorker urged their writers to slow down the emphasis on movement and plot in order to recreate a certain mood which would favour the perception of objects, anecdotes, and details. The impressionistic device works very much in the same way that an advertisement would do. It is meant to persuade the audience. The apparently non-commitant vision of reality shows in fact the author＇s point of view. The apparent simplicity is meant for a very wide audience and its deepest meaning suggests the scope of the particular visual aids working at the deepest level of consciousness
