目的评价脑磁图（MEG）功能定位在脑功能区肿瘤手术的应用价值。方法回顾性分析24例肿瘤位于功能区及其附近病人的临床资料。术前行MEG功能定位,术中结合神经导航系统实时定位肿瘤及功能区,指导肿瘤切除和功能保护。结果肿瘤位于功能区6...目的评价脑磁图（MEG）功能定位在脑功能区肿瘤手术的应用价值。方法回顾性分析24例肿瘤位于功能区及其附近病人的临床资料。术前行MEG功能定位,术中结合神经导航系统实时定位肿瘤及功能区,指导肿瘤切除和功能保护。结果肿瘤位于功能区6例,与功能区部分重叠6例,功能区边缘5例,功能区外1~2 cm 7例。肿瘤全切除20例,次全切除4例。术后出现一过性神经功能障碍加重6例,持久性功能障碍加重4例。结论 MEG功能定位是术前无创功能定位技术,能够明确肿瘤与功能区位置关系,应用于功能区及附近肿瘤手术,可减少神经功能障碍的发生,提高病人术后生活质量。展开更多
Objective: This study was undertaken to test the hypothesis that brain tumors interfere with normal brain function by disrupting functional connectivity of brain networks. Methods: Functional connectivity was assessed...Objective: This study was undertaken to test the hypothesis that brain tumors interfere with normal brain function by disrupting functional connectivity of brain networks. Methods: Functional connectivity was assessed by computing the synchronization likelihood in a broad band (0.5- 60Hz)or in the gamma band (30- 60Hz) between all pairwise combinations of magnetoencephalography signals. Magnetoencephalography recordings were made at rest in 17 brain tumor patients and 15 healthy control subjects. For a given threshold of synchronization likelihood values, graphs of the suprathreshold connections between each magnetoencephalography channel and the others channels were built. Results: In some regions, a variable number of channels without connectivity (missing connective points) at this threshold was found. The number of missing connective points was higher in patients with brain tumors than in control subjects (p < 0.0001, broad and gamma band) and was higher for left-sided than right-sided tumors (p = 0.008, broad band; p < 0.0001, gamma band). Individual results analysis indicates that the majority of brain tumor patients display several regions with missing connective point alterations in the affected and in the contralateral hemisphere. Interpretation: Our findings suggest that brain tumors induce a loss of functional connectivity that affects multiple brain regions, and that left side brain tumors have the more severe consequences in this respect.展开更多
目的探讨弥散加权成像(DWI)联合灌注加权成像(PWI)诊断不同时期脑梗死的临床价值。方法选择在我院住院治疗的168例老年脑梗死患者,将按发病时间分为超急性期(发病时间≤6h)32例,急性期(发病时间7~72h)64例,亚急性期(发病时间73h^10d)45...目的探讨弥散加权成像(DWI)联合灌注加权成像(PWI)诊断不同时期脑梗死的临床价值。方法选择在我院住院治疗的168例老年脑梗死患者,将按发病时间分为超急性期(发病时间≤6h)32例,急性期(发病时间7~72h)64例,亚急性期(发病时间73h^10d)45例和慢性期(发病时间11~15d)27例。患者进行DWI和PWI检查,比较2种检查所得头部核磁图像的参数差异和异常区域差异。结果超急性期患者和急性期患者患侧脑组织DWI中表观弥散系数(ADC)值显著低于健侧脑组织(0.39±0.08 vs 0.83±0.03;0.32±0.07 vs 0.91±0.05,P<0.01),而亚急性期患者和慢性期患者患侧脑组织DWI中ADC值显著高于健侧脑组织(1.54±0.34 vs 0.85±0.07;2.01±1.29 vs 0.90±0.05,P<0.01)。不同分期患者PWI均表现为脑血流量和脑血容量降低,而平均通过时间和达峰时间延长。信号异常区域DWI<PWI的多见于超急性期患者,DWI>PWI的多见于急性期患者,DWI=PWI的多见于亚急性期和慢性期患者。结论 PWI可显示脑梗死患者的缺血半暗带,DWI则可凸显出脑梗死病灶,两者联合运用可反映不同时期脑梗死患者脑组织血流状态,为临床治疗提供参考。展开更多
目的应用脑磁图观察针刺太冲穴引起的脑部能量变化。方法将16名健康志愿者随机分为两组,对8名针刺左侧太冲穴(针刺太冲穴组),对另外8名针刺附近假穴(针刺非穴组)。于针刺前行MR和脑磁图检查,针刺后1、3、5min分别行脑磁图扫描,采样率为3...目的应用脑磁图观察针刺太冲穴引起的脑部能量变化。方法将16名健康志愿者随机分为两组,对8名针刺左侧太冲穴(针刺太冲穴组),对另外8名针刺附近假穴(针刺非穴组)。于针刺前行MR和脑磁图检查,针刺后1、3、5min分别行脑磁图扫描,采样率为300Hz,以MEG Processor软件分析脑磁图数据。结果两两比较,针刺太冲穴1、3、5min后脑波平均增幅差异均有统计学意义(3min vs 1min:F=0.27,P<0.001;5min vs 3min:F=0.41,P<0.001);激活脑区为双侧额叶、双侧颞叶、扣带回、对侧丘脑、双侧小脑、脑干,能量较高部位为双侧额叶、双侧颞叶、扣带回。结论针灸太冲穴可引起大脑不同部位发生能量变化,并由此达到治疗功效。展开更多
文摘目的评价脑磁图（MEG）功能定位在脑功能区肿瘤手术的应用价值。方法回顾性分析24例肿瘤位于功能区及其附近病人的临床资料。术前行MEG功能定位,术中结合神经导航系统实时定位肿瘤及功能区,指导肿瘤切除和功能保护。结果肿瘤位于功能区6例,与功能区部分重叠6例,功能区边缘5例,功能区外1~2 cm 7例。肿瘤全切除20例,次全切除4例。术后出现一过性神经功能障碍加重6例,持久性功能障碍加重4例。结论 MEG功能定位是术前无创功能定位技术,能够明确肿瘤与功能区位置关系,应用于功能区及附近肿瘤手术,可减少神经功能障碍的发生,提高病人术后生活质量。
文摘Objective: This study was undertaken to test the hypothesis that brain tumors interfere with normal brain function by disrupting functional connectivity of brain networks. Methods: Functional connectivity was assessed by computing the synchronization likelihood in a broad band (0.5- 60Hz)or in the gamma band (30- 60Hz) between all pairwise combinations of magnetoencephalography signals. Magnetoencephalography recordings were made at rest in 17 brain tumor patients and 15 healthy control subjects. For a given threshold of synchronization likelihood values, graphs of the suprathreshold connections between each magnetoencephalography channel and the others channels were built. Results: In some regions, a variable number of channels without connectivity (missing connective points) at this threshold was found. The number of missing connective points was higher in patients with brain tumors than in control subjects (p < 0.0001, broad and gamma band) and was higher for left-sided than right-sided tumors (p = 0.008, broad band; p < 0.0001, gamma band). Individual results analysis indicates that the majority of brain tumor patients display several regions with missing connective point alterations in the affected and in the contralateral hemisphere. Interpretation: Our findings suggest that brain tumors induce a loss of functional connectivity that affects multiple brain regions, and that left side brain tumors have the more severe consequences in this respect.
文摘目的探讨弥散加权成像(DWI)联合灌注加权成像(PWI)诊断不同时期脑梗死的临床价值。方法选择在我院住院治疗的168例老年脑梗死患者,将按发病时间分为超急性期(发病时间≤6h)32例,急性期(发病时间7~72h)64例,亚急性期(发病时间73h^10d)45例和慢性期(发病时间11~15d)27例。患者进行DWI和PWI检查,比较2种检查所得头部核磁图像的参数差异和异常区域差异。结果超急性期患者和急性期患者患侧脑组织DWI中表观弥散系数(ADC)值显著低于健侧脑组织(0.39±0.08 vs 0.83±0.03;0.32±0.07 vs 0.91±0.05,P<0.01),而亚急性期患者和慢性期患者患侧脑组织DWI中ADC值显著高于健侧脑组织(1.54±0.34 vs 0.85±0.07;2.01±1.29 vs 0.90±0.05,P<0.01)。不同分期患者PWI均表现为脑血流量和脑血容量降低,而平均通过时间和达峰时间延长。信号异常区域DWI<PWI的多见于超急性期患者,DWI>PWI的多见于急性期患者,DWI=PWI的多见于亚急性期和慢性期患者。结论 PWI可显示脑梗死患者的缺血半暗带,DWI则可凸显出脑梗死病灶,两者联合运用可反映不同时期脑梗死患者脑组织血流状态,为临床治疗提供参考。
文摘目的应用脑磁图观察针刺太冲穴引起的脑部能量变化。方法将16名健康志愿者随机分为两组,对8名针刺左侧太冲穴(针刺太冲穴组),对另外8名针刺附近假穴(针刺非穴组)。于针刺前行MR和脑磁图检查,针刺后1、3、5min分别行脑磁图扫描,采样率为300Hz,以MEG Processor软件分析脑磁图数据。结果两两比较,针刺太冲穴1、3、5min后脑波平均增幅差异均有统计学意义(3min vs 1min:F=0.27,P<0.001;5min vs 3min:F=0.41,P<0.001);激活脑区为双侧额叶、双侧颞叶、扣带回、对侧丘脑、双侧小脑、脑干,能量较高部位为双侧额叶、双侧颞叶、扣带回。结论针灸太冲穴可引起大脑不同部位发生能量变化,并由此达到治疗功效。
