笔者在医院从事临床药学的工作实践中,收集到有关利巴韦林制剂的几例不良反应.其中3例为药物过敏症状,1例为严重的剥脱性角膜炎,现报道如下.[病例1]女.8mo.因腹泻3d入我院住院治疗.本人无药物过敏史,家属(双亲)也无药物过敏史.给予注射...笔者在医院从事临床药学的工作实践中,收集到有关利巴韦林制剂的几例不良反应.其中3例为药物过敏症状,1例为严重的剥脱性角膜炎,现报道如下.[病例1]女.8mo.因腹泻3d入我院住院治疗.本人无药物过敏史,家属(双亲)也无药物过敏史.给予注射用头孢拉定0.75g加5%葡萄糖输液50ml iv gtt qd;利巴韦林注射液0.15g加10%葡萄糖输液100ml iV gtt qd.病人在输注完头孢拉定葡萄糖输液后.无任何不良症状发生,当继续输注第2瓶液体约50ml时,患者突然出现双颊潮红。展开更多
The reactive crystallization process of dexamethasone sodium phosphate was investigated in a continuous mixed-suspension, mixed-product-removal(MSMPR) crystallizer. Analyzing experimental data, it was found that the g...The reactive crystallization process of dexamethasone sodium phosphate was investigated in a continuous mixed-suspension, mixed-product-removal(MSMPR) crystallizer. Analyzing experimental data, it was found that the growth of product crystal was size-dependent. The Bransom, CR, ASL, M J2 and M J3 size-dependent growth models were discussed in details. Using experimental steady state population density data of dexamethasone sodium phosphate, parameters of five size-dependent growth models were determined by the method of non-linear least-squares. By comparison of experimental population density and linear growth rate data with those obtained from the five size-dependent growth models, it was found that the MJ3 model predicts the growth more accurately than do the other four models. Based on the theory of population balance, the crystal nucleation and growth rate equations of dexamethasone sodium phosphate were determined by non-linear regression method. The effects of different operation parameters such as supersaturation, magma density and temperature on the quality of product crystal were also discussed, and the optimal operation conditions were derived.展开更多
文摘笔者在医院从事临床药学的工作实践中,收集到有关利巴韦林制剂的几例不良反应.其中3例为药物过敏症状,1例为严重的剥脱性角膜炎,现报道如下.[病例1]女.8mo.因腹泻3d入我院住院治疗.本人无药物过敏史,家属(双亲)也无药物过敏史.给予注射用头孢拉定0.75g加5%葡萄糖输液50ml iv gtt qd;利巴韦林注射液0.15g加10%葡萄糖输液100ml iV gtt qd.病人在输注完头孢拉定葡萄糖输液后.无任何不良症状发生,当继续输注第2瓶液体约50ml时,患者突然出现双颊潮红。
文摘The reactive crystallization process of dexamethasone sodium phosphate was investigated in a continuous mixed-suspension, mixed-product-removal(MSMPR) crystallizer. Analyzing experimental data, it was found that the growth of product crystal was size-dependent. The Bransom, CR, ASL, M J2 and M J3 size-dependent growth models were discussed in details. Using experimental steady state population density data of dexamethasone sodium phosphate, parameters of five size-dependent growth models were determined by the method of non-linear least-squares. By comparison of experimental population density and linear growth rate data with those obtained from the five size-dependent growth models, it was found that the MJ3 model predicts the growth more accurately than do the other four models. Based on the theory of population balance, the crystal nucleation and growth rate equations of dexamethasone sodium phosphate were determined by non-linear regression method. The effects of different operation parameters such as supersaturation, magma density and temperature on the quality of product crystal were also discussed, and the optimal operation conditions were derived.
