Objective: To quantify more reliably the benefits and risks of monoamine oxidase type B inhibitors (MAOBIs) in early Parkinsons disease. Data sources: Searches of the Cochrane Library, Medline, Embase, PubMed, and W...Objective: To quantify more reliably the benefits and risks of monoamine oxidase type B inhibitors (MAOBIs) in early Parkinsons disease. Data sources: Searches of the Cochrane Library, Medline, Embase, PubMed, and We b of Science for years 1966-2003, plus major journals in the field, abstract bo oks, and proceedings of meetings, for randomised trials comparing MAOBIs with pl acebo or levodopa. Data extraction: Available data on mortality, motor complicat ions, side effects, treatment compliance, and clinician rated disability (for ex ample, unified Par kinsons disease rating scale) were extracted from 17 trial s and combined using standard meta analytic methods. Results: No significant di fference in mortality existed between patients on MAOBIs and control patients (o dds ratio 1.13, 95%confidence interval 0.94 to 1.34; P=0.2). Patients randomise d to MAOBIs had significantly better total scores, motor scores, and activities of daily living scores on the unified Parkinsons disease rating scale at three months compared with patients taking placebo; they were also less likely to nee d additional levodopa (0.57, 0.48 to 0.67; P < 0.00001) or to develop motor fluc tuations (0.75, 0.59 to 0.95; P = 0.02). No difference existed between the two g roups in the incidence of side effects or withdrawal of patients. Conclusions: M AOBIs reduce disability, the need for levodopa, and the incidence of motor fluct uations, without substantial side effects or increased mortality. However, becau se few trials have compared MAOBIs with other antiparkinsonian drugs, uncertaint y remains about the relative benefits and risks of MAOBIs. Further large, long t erm comparative trials that include patient rated quality of life measures are n eeded.展开更多
采用果蝇寿命试验,小鼠肝脂质过氧化物,心肌脂褐质含量及离体脑 B 型单胺氧化酶活力的测定,证明中医益肾健脾方剂具有抗氧化作用,能显著延长果蝇寿命,克服四氯化碳引起的小鼠肝脂质过氧化作用的亢进状态,显著下降小鼠心肌脂褐质含量,明...采用果蝇寿命试验,小鼠肝脂质过氧化物,心肌脂褐质含量及离体脑 B 型单胺氧化酶活力的测定,证明中医益肾健脾方剂具有抗氧化作用,能显著延长果蝇寿命,克服四氯化碳引起的小鼠肝脂质过氧化作用的亢进状态,显著下降小鼠心肌脂褐质含量,明显抑制离体的小鼠脑 B 型单胺氧化酶活性。为探讨中医延缓衰老的理论与现代医学的关系提供科学依据。展开更多
采用 D-半乳糖所致小鼠亚急性衰老模型,观察复方桑椹健脑冲剂对衰老动物学习功能的影响。结果:复方桑椹健脑冲剂可明显提高衰老小鼠学习记忆功能,降低脑组织中过氧化脂质含量和 B 型单胺氧化酶活性。证明复方桑椹健脑冲剂具有拮抗衰老...采用 D-半乳糖所致小鼠亚急性衰老模型,观察复方桑椹健脑冲剂对衰老动物学习功能的影响。结果:复方桑椹健脑冲剂可明显提高衰老小鼠学习记忆功能,降低脑组织中过氧化脂质含量和 B 型单胺氧化酶活性。证明复方桑椹健脑冲剂具有拮抗衰老而引起的学习记忆衰退和脑老化的作用。展开更多
文摘Objective: To quantify more reliably the benefits and risks of monoamine oxidase type B inhibitors (MAOBIs) in early Parkinsons disease. Data sources: Searches of the Cochrane Library, Medline, Embase, PubMed, and We b of Science for years 1966-2003, plus major journals in the field, abstract bo oks, and proceedings of meetings, for randomised trials comparing MAOBIs with pl acebo or levodopa. Data extraction: Available data on mortality, motor complicat ions, side effects, treatment compliance, and clinician rated disability (for ex ample, unified Par kinsons disease rating scale) were extracted from 17 trial s and combined using standard meta analytic methods. Results: No significant di fference in mortality existed between patients on MAOBIs and control patients (o dds ratio 1.13, 95%confidence interval 0.94 to 1.34; P=0.2). Patients randomise d to MAOBIs had significantly better total scores, motor scores, and activities of daily living scores on the unified Parkinsons disease rating scale at three months compared with patients taking placebo; they were also less likely to nee d additional levodopa (0.57, 0.48 to 0.67; P < 0.00001) or to develop motor fluc tuations (0.75, 0.59 to 0.95; P = 0.02). No difference existed between the two g roups in the incidence of side effects or withdrawal of patients. Conclusions: M AOBIs reduce disability, the need for levodopa, and the incidence of motor fluct uations, without substantial side effects or increased mortality. However, becau se few trials have compared MAOBIs with other antiparkinsonian drugs, uncertaint y remains about the relative benefits and risks of MAOBIs. Further large, long t erm comparative trials that include patient rated quality of life measures are n eeded.
文摘采用果蝇寿命试验,小鼠肝脂质过氧化物,心肌脂褐质含量及离体脑 B 型单胺氧化酶活力的测定,证明中医益肾健脾方剂具有抗氧化作用,能显著延长果蝇寿命,克服四氯化碳引起的小鼠肝脂质过氧化作用的亢进状态,显著下降小鼠心肌脂褐质含量,明显抑制离体的小鼠脑 B 型单胺氧化酶活性。为探讨中医延缓衰老的理论与现代医学的关系提供科学依据。
