A 56-year-old man with a history of Wegener granulomatosis presented with 6 days of sinus congestion, fever, malaise, myalgias, episcleritis, and a morbilli form rash. An exacerbation of Wegener granulomatosis was the...A 56-year-old man with a history of Wegener granulomatosis presented with 6 days of sinus congestion, fever, malaise, myalgias, episcleritis, and a morbilli form rash. An exacerbation of Wegener granulomatosis was the principal concern because of the frequency of flares in that disease. The patient developed acute r enal failure, thrombocytopenia, transaminitis, and, finally, severe myocarditis that led to congestive heart failure. Additional history-taking and the evoluti on of his clinical features led to empirical treatment with doxycycline for huma n monocytic ehrlichiosis(HME). The diagnosis of HME was confirmed by both a poly merase chain reaction assay for Ehrlichia chaffeensis and by the demonstration of morulae within peripheral blood mononuclear cells. The patient improved prompt ly followinginstitution of doxycycline, and his cardiac function returned to nor mal over a period of 4 months.展开更多
据Med Mat Infect(1997;27:256)载法国Bronzi报告称,人埃里希氏体病是一种新出现的传染病。埃里希氏体病是一种寄生于循环血细胞内的严格细胞内细菌引起的人畜共患传染病。基因序列分析表明,这些细菌属于原生细菌又亚组,与立克次氏体密...据Med Mat Infect(1997;27:256)载法国Bronzi报告称,人埃里希氏体病是一种新出现的传染病。埃里希氏体病是一种寄生于循环血细胞内的严格细胞内细菌引起的人畜共患传染病。基因序列分析表明,这些细菌属于原生细菌又亚组,与立克次氏体密切相关。它们能够在吞噬细胞内存活是因为它们能够抑制吞噬溶酶体。人埃里希氏体病有三种:1.展开更多
文摘A 56-year-old man with a history of Wegener granulomatosis presented with 6 days of sinus congestion, fever, malaise, myalgias, episcleritis, and a morbilli form rash. An exacerbation of Wegener granulomatosis was the principal concern because of the frequency of flares in that disease. The patient developed acute r enal failure, thrombocytopenia, transaminitis, and, finally, severe myocarditis that led to congestive heart failure. Additional history-taking and the evoluti on of his clinical features led to empirical treatment with doxycycline for huma n monocytic ehrlichiosis(HME). The diagnosis of HME was confirmed by both a poly merase chain reaction assay for Ehrlichia chaffeensis and by the demonstration of morulae within peripheral blood mononuclear cells. The patient improved prompt ly followinginstitution of doxycycline, and his cardiac function returned to nor mal over a period of 4 months.
文摘据Med Mat Infect(1997;27:256)载法国Bronzi报告称,人埃里希氏体病是一种新出现的传染病。埃里希氏体病是一种寄生于循环血细胞内的严格细胞内细菌引起的人畜共患传染病。基因序列分析表明,这些细菌属于原生细菌又亚组,与立克次氏体密切相关。它们能够在吞噬细胞内存活是因为它们能够抑制吞噬溶酶体。人埃里希氏体病有三种:1.
