[Objective] A total of 260 swine samples of dead or sick pigs collected from 7 provinces (municipalities) Jiangsu, Anhui, Shanghai, Shandong, Zhejiang, Fujian and Jiangxi of China during 2008-2010 were detected for ...[Objective] A total of 260 swine samples of dead or sick pigs collected from 7 provinces (municipalities) Jiangsu, Anhui, Shanghai, Shandong, Zhejiang, Fujian and Jiangxi of China during 2008-2010 were detected for porcine reproductive and respiratory syndrome virus (PRRSV). And the ORF5 genes of some isolates were amplified and sequenced for understanding the molecule epidemiology and the genetic evolution of PRRSV in East China. [Method] Using RT-PCR method, PRRSV was detected by RT-PCR from samples. The complete ORF5 genes of 36 PRRSV positive samples was amplified, sequenced and analyzed with other 15 strains available on GenBank. [Result] PRRSV was detected in 118/260 of the clinical samples, with a positive rate was 45.4%. Sequence analysis showed that the 36 isolates of this study belonged to the North American-type PRRSV strains and were closely related to the highly pathogenic PRRSV (HP-PRRSV) with 94.6%-100% amino acid sequence identities. The sequence analysis combined with the phylogenetic analysis indicated that all these North American-type PRRSV strains in East China were further divided into five subgenotypes, subgenotype Ⅲ showed closer identity with HPPRRSV; almost all subgenotypes were found to be variable in the primary neutralizing epitope; subgenotypes Ⅲ and IV had more glycosylation sites than others. Although these 36 isolates were collected from different provinces in East China, there were no obvious relations between the distribution of PRRSV and the region. [Conclusion] The PRRSV infection was widespread and HP-PRRSV was the popular strain in East China during 2008-2010. However some different genetic characteristics appeared in the genomes, the genetic evolution was relatively stable. There exists a cross-cutting phenomenon on the genetic relationship of PRRSV isolates obtained from different provinces. Subgenotypes IV and V only appeared in some provinces, but the distribution of PRRSV did not show apparent geographical characteristics.展开更多
Northeast China is the largest old industrial base of China that endured persistent influence of the past planned economy system. This region has lost its leading place since the reform and opening up, and became a ba...Northeast China is the largest old industrial base of China that endured persistent influence of the past planned economy system. This region has lost its leading place since the reform and opening up, and became a backward region by contrast with the coastal areas. This paper elaborates the evolutionary process of the old industrial base of Northeast China, analyses the main reasons for the decline, gives a preliminary evaluation on the revitalizing polices in recent years, and points out major long-term challenges for future revitalization. It concludes that for Northeast China, a relative declining area: 1) it is indispensable to get the long-term policy support from the central government; 2) system reform and structure adjustment are the crucial strategies, particularly the reform of the large and medium state-owned enterprises; and devel-oping new industries is as important as upgrading traditional advantaged industries; 3) the local governments should play an indirect role, avoiding from any unnecessary intervention on economic activity; and 4) social security and investment climate must be improved simultaneously. In addition, the author stresses that the lack of knowledge on the nature of old industrial base had led to failures of the past initiatives, and revitalizing the old industrial base should be treated as a holis-tic regional project including economy growth, society progress and environment improvement.展开更多
AIM: To identify alterations in genes and molecular functional pathways in esophageal cancer in a high incidence region of India where there is a widespread use of tobacco and betel quid with fermented areca nuts. ME...AIM: To identify alterations in genes and molecular functional pathways in esophageal cancer in a high incidence region of India where there is a widespread use of tobacco and betel quid with fermented areca nuts. METHODS: Total RNA was isolated from tumor and matched normal tissue of 16 patients with esophageal squamous cell carcinoma. Pooled tumor tissue RNA was labeled with Cy3-dUTP and pooled normal tissue RNA was labeled with Cy5-dUTP by direct labeling method. The labeled probes were hybridized with human 10K cDNA chip and expression profiles were analyzed by Genespring GX V 7.3 (Silicon Genetics). RESULTS: Nine hundred twenty three genes were differentially expressed. Of these, 611 genes were upregulated and 312 genes were downregulated. Using stringent criteria (P ≤ 0.05 and ≥ 1.5 fold change), 127 differentially expressed genes (87 upregulated and 40 downregulated) were identified in tumor tissue. On the basis of Gene Ontology, four different molecular functional pathways (HAPK pathway, G-protein coupled receptor family, ion transport activity, and serine or threonine kinase activity)were most significantly upregulated and six different molecular functional pathways (structural constituent of ribosome, endopeptidase inhibitor activity, structural constituent of cytoskeleton, antioxidant activity, acyl group transferase activity, eukaryotic translation elongation factor activity)were most significantly downregulated. CONCLUSION: Several genes that showed alterations in our study have also been reported from a high incidence area of esophageal cancer in China. This indicates that molecular profiles of esophageal cancer in these two different geographic locations are highly consistent.展开更多
China is one of the countries with the most serious flooding disasters.In China,above 70% of big cities,50% of population and 75% of industrial and agricultural output value are distributed in eastern coastal areas wi...China is one of the countries with the most serious flooding disasters.In China,above 70% of big cities,50% of population and 75% of industrial and agricultural output value are distributed in eastern coastal areas with serious flooding.Therefore,enhancement of theoretical study and experience summarization of urban flood control is of great theoretical and practical significance.As economy is developing rapidly,urban scale is expanding fast,and urban flood control stand is promoted.Urban flood control calls for new concept and methods.This paper makes a systematic summarization of concept evolution and advanced methods concerning urban flood control at home and abroad.The concept of urban flood control has transformed from simple flood control and drainage to coexistence with and use of flood.Flood control measures have transferred form emphasis upon engineering ones to priority to both engineering and non-engineering ones,with special attention to ecological flood control,such as making full use of ecological revetment,ecological realignment of a river,multi-objective management of urban flood detention region,turning flood into resources and utilization of wetlands.展开更多
Marriage is one of the valued institutions in the traditional African society. Incidentally, it has its own challenges. When a young man or woman gets to a certain age and he/she is not married, society frowns at it. ...Marriage is one of the valued institutions in the traditional African society. Incidentally, it has its own challenges. When a young man or woman gets to a certain age and he/she is not married, society frowns at it. Thus, many couples enter into marriage relationships with a lot of excitements and expectations. However, losing one's spouse to death robs one of all these excitements and expectations and exposes the bereaved spouse to some dehumanizing challenges. These challenges are mostly experienced by women in the Eastern Region of Nigeria. These women are subjected to dehumanizing practices which are socially accepted in the region. This paper attempts a comparative study of some of the practices imposed on widows in Eastern Nigeria. A sample of 200 participants was purposively selected from two states in the Eastern Region of Nigeria. The study adopted the qualitative research method. Thus, the analysis was made using descriptive method. The study showed that these inhuman traditional practices in Eastern Nigeria are initiated and perpetrated by the kinsmen (Umunna and Umuada). It also showed that the widowhood treatment is meted out on all widows, but the severity or less severity of these treatments are dependent on the socio-economic and other attributes of the widow. Finally, recommendations were made, which include the need to protect the fundamental rights of widows and their children.展开更多
The world today is .faced with the critical challenge of developing industries .for both high technological efficiency and possibly less impact on resources and the environment. This paper employs the Slacks-based mea...The world today is .faced with the critical challenge of developing industries .for both high technological efficiency and possibly less impact on resources and the environment. This paper employs the Slacks-based measure (SBM) to conduct an empirical analysis of China's industrial environmental efficiency between 1998 and 2008. We.found a slight decline in SBM nationwide due to the combined effects of resource^environmental constraint as well as technological progress. From a static perspective, there is a clear disparity in coordination among regions, particularly between western regions and eastern coastal regions. From a dynamic perspective, there is limited change in the coordination of industries with natural resources and the environment in coastal and central regions, but a marked decline in the northeast and western regions. This contrast can be traced to the .following reasons: the capital-intensive structure of the economy and the high proportion of large industrial enterprises that restrict the improvement of SBM environmental efficiency. Higher living standards, indigenous innovation, acquisition of new technologies, and foreign direct investment will be conducive to industries'synchronous development with natural resources and the environment.展开更多
Spatially explicit modeling techniques recently emerged as an alternative to monitor land use changes. This study adopted the well-known CLUE-S(Conversion of Land Use and its Effects at Small regional extent) model to...Spatially explicit modeling techniques recently emerged as an alternative to monitor land use changes. This study adopted the well-known CLUE-S(Conversion of Land Use and its Effects at Small regional extent) model to analyze the spatio-temporal land use changes in a hot-spot in Northeast China(NEC). In total,13 driving factors were selected to statistically analyze the spatial relationships between biophysical and socioeconomic factors and individual land use types. These relationships were then used to simulate land use dynamic changes during 1980–2010 at a 1 km spatial resolution,and to capture the overall land use change patterns. The obtained results indicate that increases in cropland area in NEC were mainly distributed in the Sanjiang Plain and the Songnen Plain during 1980–2000,with a small reduction between 2000 and 2010. An opposite pattern was identified for changes in forest areas. Forest decreases were mainly distributed in the Khingan Mountains and the Changbai Mountains between 1980 and 2000,with a slight increase during 2000–2010. The urban areas have expanded to occupy surrounding croplands and grasslands,particularly after the year 2000. More attention is needed on the newly gained croplands,which have largely replaced wetlands in the Sanjiang Plain over the last decade. Land use change patterns identified here should be considered in future policy making so as to strengthen local eco-environmental security.展开更多
Up to now, all analysis of the distribution of water vapor over the Taklimakan desert area only depends on limited ground measurements and radio soundings setting mostly on the outer margin area. This paper establishe...Up to now, all analysis of the distribution of water vapor over the Taklimakan desert area only depends on limited ground measurements and radio soundings setting mostly on the outer margin area. This paper establishes an approach to retrieve the water vapor over the desert at high temporal and spatial resolutions by the use of FY2C geostationary satellite split-window channels in cooperation with ground-based GPS water vapor measurement. Results show that the water vapor distribution over the Taklimakan desert is affected highly by topography and surface properties. The outer margin area has generally more water vapor than the inner area. Over the outer margin area, the western part has more water vapor than the eastern part, and the northern part has more than the southern part. The driest area lies to the south of Tazhong, east of Hotan River, and extended to the south boundary of the desert. Similar to elsewhere, water vapor over the desert area shows diurnal, monthly, seasonal and annual variations even at the driest inner area of the desert. In summer, the water vapor is transported from west to east over a long distance along the westerlies at a height between 700-400 hPa and with the average speed of 50 km h-1.展开更多
基金Supported by Funds for Agricultural Science and Technology Innovation in Jiangsu Province (cx(10)424)~~
文摘[Objective] A total of 260 swine samples of dead or sick pigs collected from 7 provinces (municipalities) Jiangsu, Anhui, Shanghai, Shandong, Zhejiang, Fujian and Jiangxi of China during 2008-2010 were detected for porcine reproductive and respiratory syndrome virus (PRRSV). And the ORF5 genes of some isolates were amplified and sequenced for understanding the molecule epidemiology and the genetic evolution of PRRSV in East China. [Method] Using RT-PCR method, PRRSV was detected by RT-PCR from samples. The complete ORF5 genes of 36 PRRSV positive samples was amplified, sequenced and analyzed with other 15 strains available on GenBank. [Result] PRRSV was detected in 118/260 of the clinical samples, with a positive rate was 45.4%. Sequence analysis showed that the 36 isolates of this study belonged to the North American-type PRRSV strains and were closely related to the highly pathogenic PRRSV (HP-PRRSV) with 94.6%-100% amino acid sequence identities. The sequence analysis combined with the phylogenetic analysis indicated that all these North American-type PRRSV strains in East China were further divided into five subgenotypes, subgenotype Ⅲ showed closer identity with HPPRRSV; almost all subgenotypes were found to be variable in the primary neutralizing epitope; subgenotypes Ⅲ and IV had more glycosylation sites than others. Although these 36 isolates were collected from different provinces in East China, there were no obvious relations between the distribution of PRRSV and the region. [Conclusion] The PRRSV infection was widespread and HP-PRRSV was the popular strain in East China during 2008-2010. However some different genetic characteristics appeared in the genomes, the genetic evolution was relatively stable. There exists a cross-cutting phenomenon on the genetic relationship of PRRSV isolates obtained from different provinces. Subgenotypes IV and V only appeared in some provinces, but the distribution of PRRSV did not show apparent geographical characteristics.
基金Under the auspices of National Natural Science Foundation of China (No. 40635030, 40471038)Knowledge Innova-tion Program of Chinese Academy of Sciences (No. kzcxz-YW-321-04)
文摘Northeast China is the largest old industrial base of China that endured persistent influence of the past planned economy system. This region has lost its leading place since the reform and opening up, and became a backward region by contrast with the coastal areas. This paper elaborates the evolutionary process of the old industrial base of Northeast China, analyses the main reasons for the decline, gives a preliminary evaluation on the revitalizing polices in recent years, and points out major long-term challenges for future revitalization. It concludes that for Northeast China, a relative declining area: 1) it is indispensable to get the long-term policy support from the central government; 2) system reform and structure adjustment are the crucial strategies, particularly the reform of the large and medium state-owned enterprises; and devel-oping new industries is as important as upgrading traditional advantaged industries; 3) the local governments should play an indirect role, avoiding from any unnecessary intervention on economic activity; and 4) social security and investment climate must be improved simultaneously. In addition, the author stresses that the lack of knowledge on the nature of old industrial base had led to failures of the past initiatives, and revitalizing the old industrial base should be treated as a holis-tic regional project including economy growth, society progress and environment improvement.
基金Supported by Non Communicable Disease Division,Indian Council of Medical Research
文摘AIM: To identify alterations in genes and molecular functional pathways in esophageal cancer in a high incidence region of India where there is a widespread use of tobacco and betel quid with fermented areca nuts. METHODS: Total RNA was isolated from tumor and matched normal tissue of 16 patients with esophageal squamous cell carcinoma. Pooled tumor tissue RNA was labeled with Cy3-dUTP and pooled normal tissue RNA was labeled with Cy5-dUTP by direct labeling method. The labeled probes were hybridized with human 10K cDNA chip and expression profiles were analyzed by Genespring GX V 7.3 (Silicon Genetics). RESULTS: Nine hundred twenty three genes were differentially expressed. Of these, 611 genes were upregulated and 312 genes were downregulated. Using stringent criteria (P ≤ 0.05 and ≥ 1.5 fold change), 127 differentially expressed genes (87 upregulated and 40 downregulated) were identified in tumor tissue. On the basis of Gene Ontology, four different molecular functional pathways (HAPK pathway, G-protein coupled receptor family, ion transport activity, and serine or threonine kinase activity)were most significantly upregulated and six different molecular functional pathways (structural constituent of ribosome, endopeptidase inhibitor activity, structural constituent of cytoskeleton, antioxidant activity, acyl group transferase activity, eukaryotic translation elongation factor activity)were most significantly downregulated. CONCLUSION: Several genes that showed alterations in our study have also been reported from a high incidence area of esophageal cancer in China. This indicates that molecular profiles of esophageal cancer in these two different geographic locations are highly consistent.
基金supported by the Ministry of Construction Project,the research of the Code for urban planning on flood control(GB50XXX-20XX)
文摘China is one of the countries with the most serious flooding disasters.In China,above 70% of big cities,50% of population and 75% of industrial and agricultural output value are distributed in eastern coastal areas with serious flooding.Therefore,enhancement of theoretical study and experience summarization of urban flood control is of great theoretical and practical significance.As economy is developing rapidly,urban scale is expanding fast,and urban flood control stand is promoted.Urban flood control calls for new concept and methods.This paper makes a systematic summarization of concept evolution and advanced methods concerning urban flood control at home and abroad.The concept of urban flood control has transformed from simple flood control and drainage to coexistence with and use of flood.Flood control measures have transferred form emphasis upon engineering ones to priority to both engineering and non-engineering ones,with special attention to ecological flood control,such as making full use of ecological revetment,ecological realignment of a river,multi-objective management of urban flood detention region,turning flood into resources and utilization of wetlands.
文摘Marriage is one of the valued institutions in the traditional African society. Incidentally, it has its own challenges. When a young man or woman gets to a certain age and he/she is not married, society frowns at it. Thus, many couples enter into marriage relationships with a lot of excitements and expectations. However, losing one's spouse to death robs one of all these excitements and expectations and exposes the bereaved spouse to some dehumanizing challenges. These challenges are mostly experienced by women in the Eastern Region of Nigeria. These women are subjected to dehumanizing practices which are socially accepted in the region. This paper attempts a comparative study of some of the practices imposed on widows in Eastern Nigeria. A sample of 200 participants was purposively selected from two states in the Eastern Region of Nigeria. The study adopted the qualitative research method. Thus, the analysis was made using descriptive method. The study showed that these inhuman traditional practices in Eastern Nigeria are initiated and perpetrated by the kinsmen (Umunna and Umuada). It also showed that the widowhood treatment is meted out on all widows, but the severity or less severity of these treatments are dependent on the socio-economic and other attributes of the widow. Finally, recommendations were made, which include the need to protect the fundamental rights of widows and their children.
文摘The world today is .faced with the critical challenge of developing industries .for both high technological efficiency and possibly less impact on resources and the environment. This paper employs the Slacks-based measure (SBM) to conduct an empirical analysis of China's industrial environmental efficiency between 1998 and 2008. We.found a slight decline in SBM nationwide due to the combined effects of resource^environmental constraint as well as technological progress. From a static perspective, there is a clear disparity in coordination among regions, particularly between western regions and eastern coastal regions. From a dynamic perspective, there is limited change in the coordination of industries with natural resources and the environment in coastal and central regions, but a marked decline in the northeast and western regions. This contrast can be traced to the .following reasons: the capital-intensive structure of the economy and the high proportion of large industrial enterprises that restrict the improvement of SBM environmental efficiency. Higher living standards, indigenous innovation, acquisition of new technologies, and foreign direct investment will be conducive to industries'synchronous development with natural resources and the environment.
基金National Natural Science Foundation of China No.41201089No.41271112+3 种基金The Fundamental Research Funds for the Central UniversitiesNo.CCNU15A05058National Nonprofit Institute Research Grant of CAASNo.IARRP-2015-28
文摘Spatially explicit modeling techniques recently emerged as an alternative to monitor land use changes. This study adopted the well-known CLUE-S(Conversion of Land Use and its Effects at Small regional extent) model to analyze the spatio-temporal land use changes in a hot-spot in Northeast China(NEC). In total,13 driving factors were selected to statistically analyze the spatial relationships between biophysical and socioeconomic factors and individual land use types. These relationships were then used to simulate land use dynamic changes during 1980–2010 at a 1 km spatial resolution,and to capture the overall land use change patterns. The obtained results indicate that increases in cropland area in NEC were mainly distributed in the Sanjiang Plain and the Songnen Plain during 1980–2000,with a small reduction between 2000 and 2010. An opposite pattern was identified for changes in forest areas. Forest decreases were mainly distributed in the Khingan Mountains and the Changbai Mountains between 1980 and 2000,with a slight increase during 2000–2010. The urban areas have expanded to occupy surrounding croplands and grasslands,particularly after the year 2000. More attention is needed on the newly gained croplands,which have largely replaced wetlands in the Sanjiang Plain over the last decade. Land use change patterns identified here should be considered in future policy making so as to strengthen local eco-environmental security.
基金supported by National Natural Science Foundation of China(Grant Nos. 40675003 and 41075011)
文摘Up to now, all analysis of the distribution of water vapor over the Taklimakan desert area only depends on limited ground measurements and radio soundings setting mostly on the outer margin area. This paper establishes an approach to retrieve the water vapor over the desert at high temporal and spatial resolutions by the use of FY2C geostationary satellite split-window channels in cooperation with ground-based GPS water vapor measurement. Results show that the water vapor distribution over the Taklimakan desert is affected highly by topography and surface properties. The outer margin area has generally more water vapor than the inner area. Over the outer margin area, the western part has more water vapor than the eastern part, and the northern part has more than the southern part. The driest area lies to the south of Tazhong, east of Hotan River, and extended to the south boundary of the desert. Similar to elsewhere, water vapor over the desert area shows diurnal, monthly, seasonal and annual variations even at the driest inner area of the desert. In summer, the water vapor is transported from west to east over a long distance along the westerlies at a height between 700-400 hPa and with the average speed of 50 km h-1.