By comparing the entropy and the conditional entropy in a marker, an entropy-based index has been presented for fine-scale linkage disequilibrium gene mapping using high-density marker maps for human disease genes. Th...By comparing the entropy and the conditional entropy in a marker, an entropy-based index has been presented for fine-scale linkage disequilibrium gene mapping using high-density marker maps for human disease genes. The index can quantify the level of linkage disequilibrium （LD） between the marker and the disease susceptibility locus （DSL） of genes. The advantage of using the index is attributed to the fact that it does not depend on marker allele frequencies across loci. Moreover, it is parallel to Hardy-Weinberg disequilibrium （HWD） measure for DSL fine mapping. Through various simulations, the fine mapping perform- ances of the proposed entropy-based index was extensively investigated under various genetic parameters. The results show that the index presented is both robust and powerful for DSL mapping in genes.展开更多
By comparing the entropy and conditional entropy in a marker, an entropy-based index for fine-scale linkage-disequilibrium gene mapping is presented using high-density marker maps in extreme samples for quantitative t...By comparing the entropy and conditional entropy in a marker, an entropy-based index for fine-scale linkage-disequilibrium gene mapping is presented using high-density marker maps in extreme samples for quantitative trait. The entropy-based index is the function of LD between the marker and the traitlocus and does not depend on marker allele frequencies across the loci. It is parallel to Hardy-Weinberg disequilibrium （HWD） measure for QTL fine mapping, but its power of fine mapping QTL is higher than that of HWD measure. Through simulations, the fine mapping performance of this entropy-based index is investigated extensively under various genetic parameters. The results show that the indices presented here are both robust and powerful.展开更多
In this paper, we integrate inertial navigation system (INS) with wireless sensor network (WSN) to enhance the accuracy of indoor localization. Inertial measurement unit (IMU), the core of the INS, measures the accele...In this paper, we integrate inertial navigation system (INS) with wireless sensor network (WSN) to enhance the accuracy of indoor localization. Inertial measurement unit (IMU), the core of the INS, measures the accelerated and angular rotated speed of moving objects. Meanwhile, the ranges from the object to beacons, which are sensor nodes with known coordinates, are collected by time of arrival (ToA) approach. These messages are simultaneously collected and transmitted to the terminal. At the terminal, we set up the state transition models and observation models. According to them, several recursive Bayesian algorithms are applied to producing position estimations. As shown in the experiments, all of three algorithms do not require constant moving speed and perform better than standalone ToA system or standalone IMU system. And within them, two algorithms can be applied for the tracking on any path which is not restricted by the requirement that the trajectory between the positions at two consecutive time steps is a straight line.展开更多
This paper introduces the significance of indoor positioning and analyzes the related problems. The latest research on indoor positioning is introduced. Further, the positioning accuracy and the cost of typical local ...This paper introduces the significance of indoor positioning and analyzes the related problems. The latest research on indoor positioning is introduced. Further, the positioning accuracy and the cost of typical local and wide area indoor positioning systems are compared. The results of the comparison show that Time & Code Division-Orthogonal Frequency Division Multiplexing (TC-OFDM) is a system that can achieve real-time meter-accuracy of indoor positioning in a wide area. Finally, in this paper, we indicate that the seamless high-accuracy indoor positioning in a wide area is the development trend of indoor positioning. The seamless Location Based Services (LBS) architecture based on a heterogeneous network, key technologies in indoor positioning for decimeter-accuracy and seamless outdoor and indoor Geographic Information System (GIS) are elaborated as the most important research fields of future indoor positioning.展开更多
The rapid development of location-based service(LBS) drives one special kind of LBS, in which the service provider verifies user location before providing services. In distributed location proof generating schemes, pr...The rapid development of location-based service(LBS) drives one special kind of LBS, in which the service provider verifies user location before providing services. In distributed location proof generating schemes, preventing users from colluding with each other to create fake location proofs and protecting user's location privacy at the same time, are the main technical challenges to bring this kind of LBS into practical. Existing solutions tackle these challenges with low collusion-detecting efficiency and defected collusion-detecting method. We proposed two novel location proof generating schemes, which inversely utilized a secure secret-sharing scheme and a pseudonym scheme to settle these shortcomings. Our proposed solution resists and detects user collusion attacks in a more efficient and correct way. Meanwhile, we achieve a higher level of location privacy than that of previous work. The correctness and efficiency of our proposed solution is testified by intensive security analysis, performance analysis, as well as experiments and simulation results.展开更多
Location aware management and location based automation are fast upcoming technologies which are facilitated by availability of reliable, accurate, and cheap global positioning systems and location based services. Thi...Location aware management and location based automation are fast upcoming technologies which are facilitated by availability of reliable, accurate, and cheap global positioning systems and location based services. This paper discusses the development of C＋＋ classes, which may be used for development of software for location aware management and control, specifically in merchant shipping, so as to provide improved safety, increased automation, prevention of pollution and reducing the work burden of the crew. The GPS is used in conjunction with the regionally accessible nested global shorelines （RANGS） dataset for this purpose. The design of two main C＋＋ classes named CShorelines and CGPSInput have been discussed. A control system mandatory on all oil-tankers above 150 GRT （and few other vessels） called ODMCS has been made location aware using the novel software developed and the results obtained have been critically examined and presented.展开更多
文摘By comparing the entropy and the conditional entropy in a marker, an entropy-based index has been presented for fine-scale linkage disequilibrium gene mapping using high-density marker maps for human disease genes. The index can quantify the level of linkage disequilibrium （LD） between the marker and the disease susceptibility locus （DSL） of genes. The advantage of using the index is attributed to the fact that it does not depend on marker allele frequencies across loci. Moreover, it is parallel to Hardy-Weinberg disequilibrium （HWD） measure for DSL fine mapping. Through various simulations, the fine mapping perform- ances of the proposed entropy-based index was extensively investigated under various genetic parameters. The results show that the index presented is both robust and powerful for DSL mapping in genes.
基金This work was supported by Scientific Research Fund of Huaihua University and the National Natural Foundation of China (No.10371133).
文摘By comparing the entropy and conditional entropy in a marker, an entropy-based index for fine-scale linkage-disequilibrium gene mapping is presented using high-density marker maps in extreme samples for quantitative trait. The entropy-based index is the function of LD between the marker and the traitlocus and does not depend on marker allele frequencies across the loci. It is parallel to Hardy-Weinberg disequilibrium （HWD） measure for QTL fine mapping, but its power of fine mapping QTL is higher than that of HWD measure. Through simulations, the fine mapping performance of this entropy-based index is investigated extensively under various genetic parameters. The results show that the indices presented here are both robust and powerful.
基金Project(61301181) supported by the National Natural Science Foundation of China
文摘In this paper, we integrate inertial navigation system (INS) with wireless sensor network (WSN) to enhance the accuracy of indoor localization. Inertial measurement unit (IMU), the core of the INS, measures the accelerated and angular rotated speed of moving objects. Meanwhile, the ranges from the object to beacons, which are sensor nodes with known coordinates, are collected by time of arrival (ToA) approach. These messages are simultaneously collected and transmitted to the terminal. At the terminal, we set up the state transition models and observation models. According to them, several recursive Bayesian algorithms are applied to producing position estimations. As shown in the experiments, all of three algorithms do not require constant moving speed and perform better than standalone ToA system or standalone IMU system. And within them, two algorithms can be applied for the tracking on any path which is not restricted by the requirement that the trajectory between the positions at two consecutive time steps is a straight line.
基金This work was supported by the National High Technology Research and Development Program (863 Program) of China under Grant No.2012AA120801the National High Technology Research and Development Program (863 Program) of China under Grant No.2012AA120802
文摘This paper introduces the significance of indoor positioning and analyzes the related problems. The latest research on indoor positioning is introduced. Further, the positioning accuracy and the cost of typical local and wide area indoor positioning systems are compared. The results of the comparison show that Time & Code Division-Orthogonal Frequency Division Multiplexing (TC-OFDM) is a system that can achieve real-time meter-accuracy of indoor positioning in a wide area. Finally, in this paper, we indicate that the seamless high-accuracy indoor positioning in a wide area is the development trend of indoor positioning. The seamless Location Based Services (LBS) architecture based on a heterogeneous network, key technologies in indoor positioning for decimeter-accuracy and seamless outdoor and indoor Geographic Information System (GIS) are elaborated as the most important research fields of future indoor positioning.
基金supported by the National Natural Science Foundation of China(Grant No.41371402)the National Basic Research Program of China("973"Program)(Grant No.2011CB302306)the Fundamental Research Funds for the Central University(Grant No.2015211020201 and No.211274230)
文摘The rapid development of location-based service(LBS) drives one special kind of LBS, in which the service provider verifies user location before providing services. In distributed location proof generating schemes, preventing users from colluding with each other to create fake location proofs and protecting user's location privacy at the same time, are the main technical challenges to bring this kind of LBS into practical. Existing solutions tackle these challenges with low collusion-detecting efficiency and defected collusion-detecting method. We proposed two novel location proof generating schemes, which inversely utilized a secure secret-sharing scheme and a pseudonym scheme to settle these shortcomings. Our proposed solution resists and detects user collusion attacks in a more efficient and correct way. Meanwhile, we achieve a higher level of location privacy than that of previous work. The correctness and efficiency of our proposed solution is testified by intensive security analysis, performance analysis, as well as experiments and simulation results.
文摘Location aware management and location based automation are fast upcoming technologies which are facilitated by availability of reliable, accurate, and cheap global positioning systems and location based services. This paper discusses the development of C＋＋ classes, which may be used for development of software for location aware management and control, specifically in merchant shipping, so as to provide improved safety, increased automation, prevention of pollution and reducing the work burden of the crew. The GPS is used in conjunction with the regionally accessible nested global shorelines （RANGS） dataset for this purpose. The design of two main C＋＋ classes named CShorelines and CGPSInput have been discussed. A control system mandatory on all oil-tankers above 150 GRT （and few other vessels） called ODMCS has been made location aware using the novel software developed and the results obtained have been critically examined and presented.
