面向我国人口健康和社会可持续发展的重大战略需求,国家基因组科学数据中心(National Genomics Data Center,NGDC)自2019年成立以来,已初步建成具有自主知识产权、安全可控、涵盖领域广的多维组学数据汇交、存储、管理和共享体系,涵盖...面向我国人口健康和社会可持续发展的重大战略需求,国家基因组科学数据中心(National Genomics Data Center,NGDC)自2019年成立以来,已初步建成具有自主知识产权、安全可控、涵盖领域广的多维组学数据汇交、存储、管理和共享体系,涵盖基础组学数据资源、国家人类遗传资源、重要战略生物资源、生物安全资源以及生物信息分析工具和平台等,为人口健康、公共安全、育种改良、生物多样性等相关研究提供重要资源和参考信息.截至目前,NGDC已存储和管理27.6 PB的数据量,数据编号被Springer Nature,Elsevier,Wiley,Taylor&Francis等全球主要出版集团推荐或认可.尽管NGDC已连续六年被本领域国际权威期刊《核酸研究》称为与美国NCBI、欧洲EBI齐名的国际主要生物数据中心,但与国际一流数据中心仍存在一定差距.展望未来,NGDC将重点聚焦于数据智能审编、数据融合检索、生物大数据云平台、前沿算法工具等,同时在经费争取、人才培养和国际合作方面加大工作力度,建成国际领先的基因组科学数据中心,支撑我国生命与健康科学领域的科技创新发展和自立自强.展开更多
Abstract With the development of genome-wide sequencing technology, 195 types of functional long non-coding RNAs （lncRNAs） have so far been found, and their cellular roles are gradually being revealed. Now lncRNAs h...Abstract With the development of genome-wide sequencing technology, 195 types of functional long non-coding RNAs （lncRNAs） have so far been found, and their cellular roles are gradually being revealed. Now lncRNAs have become a hotspot in the life science. These small molecules exist in almost all higher eukaryotes, and have very important regulatory roles in these organisms. This review briefly summarizes recent progress in researches on antisense non-coding RNA in the INK4 locus.展开更多
Dr. Yang Weiping has been appointed executive vice director-general of the CAS Beijing Institute of Genomics (BIG). He obtained his B.S. degree in biology from Hebei Normal University in 1985, and his PhD in ecology f...Dr. Yang Weiping has been appointed executive vice director-general of the CAS Beijing Institute of Genomics (BIG). He obtained his B.S. degree in biology from Hebei Normal University in 1985, and his PhD in ecology from the CAS Institute of Zoology (IOZ) in 1996. He went to the US in 1998 for six-month training in biology diversity information system management and in 2000 he became a professor of IOZ. Afterwards he went to UK for an advanced study in project administration and organization management. Later he received an MBA from Tsinghua University.展开更多
The Human Genome Project was launched at the end of the 1980s.Since then,the cloning and identification of functional genes has been a major focus of research across the world.In China too,the potentially profound imp...The Human Genome Project was launched at the end of the 1980s.Since then,the cloning and identification of functional genes has been a major focus of research across the world.In China too,the potentially profound impact of such studies on the life sciences and on human health was realized,and relevant studies were initiated in the 1990s.To advance China's involvement in the Human Genome Project,in the mid-1990s,Committee of Experts in Biology from National High Technology Research and Development Program of China(863 Program) proposed the "two 1%" goal.This goal envisaged China contributing 1% of the total sequencing work,and cloning and identifying 1% of the total human functional genes.Over the past 20 years,tremendous achievement has been accomplished by Chinese scientists.It is well known that scientists in China finished the 1% of sequencing work of the Human Genome Project,whereas,there is no comprehensive report about "whether China had finished cloning and identifying 1% of human functional genes".In the present study,the GenBank database at the National Center of Biotechnology Information,the PubMed search tool,and the patent database of the State Intellectual Property Office,China,were used to retrieve entries based on two screening standards:(i) Were the newly cloned and identified genes first reported by Chinese scientists?(ii) Were the Chinese scientists awarded the gene sequence patent? Entries were retrieved from the databases up to the cut-off date of 30 June 2011 and the obtained data were analyzed further.The results showed that 589 new human functional genes were first reported by Chinese scientists and 159 gene sequences were patented(http:gene.fudan.sh.cn/introduction/database/chinagene/chinagene.html).This study systematically summarizes China's contributions to human functional genomics research and answers the question "has China finished cloning and identifying 1% of human functional genes?" in the affirmative.展开更多
Alongside recent advances and booming applications of DNA sequencing technologies, a great number of complete genome sequences for animal species are available to researchers. Hundreds of animals have been involved in...Alongside recent advances and booming applications of DNA sequencing technologies, a great number of complete genome sequences for animal species are available to researchers. Hundreds of animals have been involved in whole genome se- quencing, and at least 87 non-human animal species＇ complete or draft genome sequences have been published since 1998. Based on these technological advances and the subsequent accumulation of large quantity of genomic data, evolutionary genomics has become one of the most rapidly advancing disciplines in biology. Scientists now can perform a number of comparative and evolu- tionary genomic studies for animals, to identify conserved genes or other functional elements among species, genomic elements that confer animals their own specific characteristics and new phenotypes for adaptation. This review deals with the current ge- nomic and evolutionary research on non-human animals, and displays a comprehensive landscape of genomes and the evolution- ary genomics of non-human animals. It is very helpful to a better understanding of the biology and evolution of the myriad forms within the animal kingdom [Current Zoology 59 （1）： 87-98, 2013].展开更多
This article seeks to depict the management science＇s new trend - managerial bioengineering system which is making decisive influence to enterprise management, generalizes the characteristics and categories of manage...This article seeks to depict the management science＇s new trend - managerial bioengineering system which is making decisive influence to enterprise management, generalizes the characteristics and categories of managerial gene variation, and brings forward a managerial genome plan with 5-＂All＂： participation of all members, enjoyment of all aspects, accumulation of all time, devotion of all strength and operation of all speed.展开更多
文摘Abstract With the development of genome-wide sequencing technology, 195 types of functional long non-coding RNAs （lncRNAs） have so far been found, and their cellular roles are gradually being revealed. Now lncRNAs have become a hotspot in the life science. These small molecules exist in almost all higher eukaryotes, and have very important regulatory roles in these organisms. This review briefly summarizes recent progress in researches on antisense non-coding RNA in the INK4 locus.
文摘Dr. Yang Weiping has been appointed executive vice director-general of the CAS Beijing Institute of Genomics (BIG). He obtained his B.S. degree in biology from Hebei Normal University in 1985, and his PhD in ecology from the CAS Institute of Zoology (IOZ) in 1996. He went to the US in 1998 for six-month training in biology diversity information system management and in 2000 he became a professor of IOZ. Afterwards he went to UK for an advanced study in project administration and organization management. Later he received an MBA from Tsinghua University.
基金supported by the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (Grant No. 30024001)the National Basic Research Program of China (Grant No. 2004CB518605)+1 种基金the Major National Science and Technology Program of China (Grant No. 2008ZX10002-020)the National High Technology Research and Development Program of China (Grant Nos. 2006AA020501 and 2001AA221081)
文摘The Human Genome Project was launched at the end of the 1980s.Since then,the cloning and identification of functional genes has been a major focus of research across the world.In China too,the potentially profound impact of such studies on the life sciences and on human health was realized,and relevant studies were initiated in the 1990s.To advance China's involvement in the Human Genome Project,in the mid-1990s,Committee of Experts in Biology from National High Technology Research and Development Program of China(863 Program) proposed the "two 1%" goal.This goal envisaged China contributing 1% of the total sequencing work,and cloning and identifying 1% of the total human functional genes.Over the past 20 years,tremendous achievement has been accomplished by Chinese scientists.It is well known that scientists in China finished the 1% of sequencing work of the Human Genome Project,whereas,there is no comprehensive report about "whether China had finished cloning and identifying 1% of human functional genes".In the present study,the GenBank database at the National Center of Biotechnology Information,the PubMed search tool,and the patent database of the State Intellectual Property Office,China,were used to retrieve entries based on two screening standards:(i) Were the newly cloned and identified genes first reported by Chinese scientists?(ii) Were the Chinese scientists awarded the gene sequence patent? Entries were retrieved from the databases up to the cut-off date of 30 June 2011 and the obtained data were analyzed further.The results showed that 589 new human functional genes were first reported by Chinese scientists and 159 gene sequences were patented(http:gene.fudan.sh.cn/introduction/database/chinagene/chinagene.html).This study systematically summarizes China's contributions to human functional genomics research and answers the question "has China finished cloning and identifying 1% of human functional genes?" in the affirmative.
文摘Alongside recent advances and booming applications of DNA sequencing technologies, a great number of complete genome sequences for animal species are available to researchers. Hundreds of animals have been involved in whole genome se- quencing, and at least 87 non-human animal species＇ complete or draft genome sequences have been published since 1998. Based on these technological advances and the subsequent accumulation of large quantity of genomic data, evolutionary genomics has become one of the most rapidly advancing disciplines in biology. Scientists now can perform a number of comparative and evolu- tionary genomic studies for animals, to identify conserved genes or other functional elements among species, genomic elements that confer animals their own specific characteristics and new phenotypes for adaptation. This review deals with the current ge- nomic and evolutionary research on non-human animals, and displays a comprehensive landscape of genomes and the evolution- ary genomics of non-human animals. It is very helpful to a better understanding of the biology and evolution of the myriad forms within the animal kingdom [Current Zoology 59 （1）： 87-98, 2013].
文摘This article seeks to depict the management science＇s new trend - managerial bioengineering system which is making decisive influence to enterprise management, generalizes the characteristics and categories of managerial gene variation, and brings forward a managerial genome plan with 5-＂All＂： participation of all members, enjoyment of all aspects, accumulation of all time, devotion of all strength and operation of all speed.
