H3K9me2 and H3K27me2 are important epigenetic marks associated with transcription repression, while H3K4me3 is associated with transcription activation. It has been shown that active and repressive histone methylation...H3K9me2 and H3K27me2 are important epigenetic marks associated with transcription repression, while H3K4me3 is associated with transcription activation. It has been shown that active and repressive histone methylations distribute in a mutually exclusive manner, but the underlying mechanism was poorly understood. Here we identified ceKDM7A, a PHD （plant homeodomain）- and JmjC domain-containing protein, as a histone demethylase specific for H3K9me2 and H3K27me2. We further demonstrated that the PHD domain of ceKDM7A bound H3K4me3 and H3K4me3 co-localized with ceKDM7A at the genome-wide level. Disruption of the PHD domain binding to H3K4me3 reduced the demethylase activity in vivo, and loss of ceKDM7A reduced the expression of its associated target genes. These results indicate that ceKDM7A is recruited to the promoter to demethylate H3K9me2 and H3K27me2 and activate gene expression through the binding of the PHD domain to H3K4me3. Thus, our study identifies a dual-specificity histone demethylase and provides novel insights into the regulation of histone methylation.展开更多
The Jesuits played an important role in the transmission of Western science and technology to China during the seventeenth and eighteenth centuries,though their impact on water technology has received scant attention ...The Jesuits played an important role in the transmission of Western science and technology to China during the seventeenth and eighteenth centuries,though their impact on water technology has received scant attention thus far.As a case in point,Sabatino de Ursis,Society of Jesus熊三拔,in collaboration with the Chinese official Xu Guangqi徐光啟,published in 1612 Hydraulic Methods of the Far West(Taixi shuifa泰西水法),the earliest book in China on Western water-lifting devices,which contained a detailed description of the Archimedean screw pump.While the impact of the Archimedean screw pump in China and Korea remained rather limited,the screw pump was used to drain water from gold mines in the Japanese Sado Island from as early as 1637.This fact became known in the West only in the very late 1800s when hand-colored picture scrolls about the Japanese gold mining process became available.These scrolls show various applications of Archimedean screw,which apparently were made according to the manufacturing instructions in Hydraulic Methods of the Far West.展开更多
This paper attempts to explore how Shylock in William Shakespeare＇s The Merchant of Venice （1995） and Heathcliff in Emily Bronte＇s Wuthering Heights （2003） were victimized who became victimizer later to heal the...This paper attempts to explore how Shylock in William Shakespeare＇s The Merchant of Venice （1995） and Heathcliff in Emily Bronte＇s Wuthering Heights （2003） were victimized who became victimizer later to heal their wound and compensate their loss and how they were victimized in turn in doing so. Shylock was victimized by the Christian society along with his own. His daughter left him in favor of the Christians. He later became a victimizer but was ironically victimized in turn in wreaking vengeance on his foes in the court. Similarly, Heathcliffs true spiritual love was rejected by His Catherine, neglected by everyone, physically and mentally abused. Later, he wreaked vengeance upon his foes but was victimized to death in turn. Shylock entered the court as a victimizer but left it as a victimized individual just as Heathcliff entered the Heights, after self-imposed exile, as a victimizer and left it as a victimized individual for good. Therefore, both of them experienced a cycle of victimization.展开更多
Objective Benzophenone semicarbazone(BSC) was synthesized and characterized to identify compounds with anticancer activities. Methods Anticancer activities were studied against Ehrlich Ascites Carcinoma(EAC) cells in ...Objective Benzophenone semicarbazone(BSC) was synthesized and characterized to identify compounds with anticancer activities. Methods Anticancer activities were studied against Ehrlich Ascites Carcinoma(EAC) cells in Swiss albino mice by monitoring parameters such as tumor weight measurement,survival time of tumor bearing mice,tumor cell growth inhibition,and so on.Some hematological parameters,such as red blood cells,white blood cells,and hemoglobin content,were also measured. Results The results showed that BSC has a positive effect against EAC cells.An assessment was conducted by comparing these results with those obtained using the standard drug bleomycin. Conclusions The BSC compound can be considered as a potent anticancer agent.展开更多
To meet the current energy needs of society,the highly efficient and continuous production of clean energy is required.One of the key issues facing the green hydrogen evolution is the construction of efficient,low-cos...To meet the current energy needs of society,the highly efficient and continuous production of clean energy is required.One of the key issues facing the green hydrogen evolution is the construction of efficient,low-cost electrocatalysts.Prussian blue(PB),Prussian blue analogs(PBAs),and their derivatives have tunable metal centers and have attracted significant interest as novel photo-and electrochemical catalysts.In this review,recent research progress into PB/PBA-based hollow structures,substrate-supported nanostructures,and their derivatives for green water splitting is discussed and summarized.First,several remarkable examples of nanostructured PB/PBAs supported on substrates(copper foil,carbon cloth,and nickel foam)and hollow structures(such as single-shelled hollow boxes,open hollow cages,and intricate hollow structures(multi-shell and yolk-shell))are discussed in detail,including their synthesis and formation mechanisms.Subsequently,the applications of PB/PBA derivatives((hydr)oxides,phosphides,chalcogenides,and carbides)for water splitting are discussed.Finally,the limitations in this research area and the most urgent challenges are summarized.We hope that this review will stimulate more researchers to develop technologies based on these intricate PB/PBA structures and their derivatives for highly efficient,green water splitting.展开更多
The regular occurrence and the high costs of flooding to both road agencies and communities is a strong impetus to investigate the methodologies applied to evaluating flood immunity road projects. Very little literatu...The regular occurrence and the high costs of flooding to both road agencies and communities is a strong impetus to investigate the methodologies applied to evaluating flood immunity road projects. Very little literature exists on methods of evaluating the benefits of improving flood immunity through better road infrastructure. This paper attempts to address some of the numerous issues hindering the accurate evaluation of flood immunity road projects. The methodologies presented in this paper are designed to evaluate benefits that are not normally included or not fully considered in evaluations; such benefits include reduced flood related road accidents, costs of not travelling during the closure period and additional costs from unanticipated flood events. A key focus of the paper is the consideration of the evaluation of improved flood immunity from a network perspective rather than the typical approach of evaluating flood immunity projects in isolation to each other. The application of the proposed methodologies is demonstrated with a hypothetical example of a typical rural network subjected to regular flooding. The results of the analysis, conducted using the proposed methodologies, reveals that the currently applied methodologies account for less than half the likely value of benefits of a package of projects that will prevent the complete isolation of communities during serious flood events.展开更多
Prussian blue(PB) was used as catalyst to improve the extent of graphitization of polyacrylonitrile(PAN)-based carbon fibers.PB was deposited on carbon fibers by anodic electrodeposition and the thickness of PB coatin...Prussian blue(PB) was used as catalyst to improve the extent of graphitization of polyacrylonitrile(PAN)-based carbon fibers.PB was deposited on carbon fibers by anodic electrodeposition and the thickness of PB coating(PB content) was controlled by adjusting the electrodeposition time.PAN-based carbon fibers with PB coating were heat-treated and the extent of graphitization was measured by X-ray diffractometry and Raman spectroscopy.The results indicate that the extent of graphitization of PAN-based carbon fibers is enhanced in the presence of the coating.When the PB-coated carbon fibers were heat-treated at 1 900 ℃,interlayer spacing(d002) and crystallite size(Lc) reach 0.336 8 and 21.2 nm respectively.Contrarily,the values of d002 and Lc are 0.341 4 and 7.4 nm respectively when the bare carbon fibers were heat-treated at 2 800 ℃.Compared with the bare carbon fibers,PB can make the heat treatment temperature(HTT) drop more than 500 ℃ in order to reach the same extent of graphitization.Furthermore,the research results show that PB content also has a certain influence on the extent of graphitization at the same HTT.展开更多
文摘H3K9me2 and H3K27me2 are important epigenetic marks associated with transcription repression, while H3K4me3 is associated with transcription activation. It has been shown that active and repressive histone methylations distribute in a mutually exclusive manner, but the underlying mechanism was poorly understood. Here we identified ceKDM7A, a PHD （plant homeodomain）- and JmjC domain-containing protein, as a histone demethylase specific for H3K9me2 and H3K27me2. We further demonstrated that the PHD domain of ceKDM7A bound H3K4me3 and H3K4me3 co-localized with ceKDM7A at the genome-wide level. Disruption of the PHD domain binding to H3K4me3 reduced the demethylase activity in vivo, and loss of ceKDM7A reduced the expression of its associated target genes. These results indicate that ceKDM7A is recruited to the promoter to demethylate H3K9me2 and H3K27me2 and activate gene expression through the binding of the PHD domain to H3K4me3. Thus, our study identifies a dual-specificity histone demethylase and provides novel insights into the regulation of histone methylation.
文摘The Jesuits played an important role in the transmission of Western science and technology to China during the seventeenth and eighteenth centuries,though their impact on water technology has received scant attention thus far.As a case in point,Sabatino de Ursis,Society of Jesus熊三拔,in collaboration with the Chinese official Xu Guangqi徐光啟,published in 1612 Hydraulic Methods of the Far West(Taixi shuifa泰西水法),the earliest book in China on Western water-lifting devices,which contained a detailed description of the Archimedean screw pump.While the impact of the Archimedean screw pump in China and Korea remained rather limited,the screw pump was used to drain water from gold mines in the Japanese Sado Island from as early as 1637.This fact became known in the West only in the very late 1800s when hand-colored picture scrolls about the Japanese gold mining process became available.These scrolls show various applications of Archimedean screw,which apparently were made according to the manufacturing instructions in Hydraulic Methods of the Far West.
文摘This paper attempts to explore how Shylock in William Shakespeare＇s The Merchant of Venice （1995） and Heathcliff in Emily Bronte＇s Wuthering Heights （2003） were victimized who became victimizer later to heal their wound and compensate their loss and how they were victimized in turn in doing so. Shylock was victimized by the Christian society along with his own. His daughter left him in favor of the Christians. He later became a victimizer but was ironically victimized in turn in wreaking vengeance on his foes in the court. Similarly, Heathcliffs true spiritual love was rejected by His Catherine, neglected by everyone, physically and mentally abused. Later, he wreaked vengeance upon his foes but was victimized to death in turn. Shylock entered the court as a victimizer but left it as a victimized individual just as Heathcliff entered the Heights, after self-imposed exile, as a victimizer and left it as a victimized individual for good. Therefore, both of them experienced a cycle of victimization.
基金supported by a grant from the National Science and Information and Communication Technology of Bangladesh
文摘Objective Benzophenone semicarbazone(BSC) was synthesized and characterized to identify compounds with anticancer activities. Methods Anticancer activities were studied against Ehrlich Ascites Carcinoma(EAC) cells in Swiss albino mice by monitoring parameters such as tumor weight measurement,survival time of tumor bearing mice,tumor cell growth inhibition,and so on.Some hematological parameters,such as red blood cells,white blood cells,and hemoglobin content,were also measured. Results The results showed that BSC has a positive effect against EAC cells.An assessment was conducted by comparing these results with those obtained using the standard drug bleomycin. Conclusions The BSC compound can be considered as a potent anticancer agent.
文摘To meet the current energy needs of society,the highly efficient and continuous production of clean energy is required.One of the key issues facing the green hydrogen evolution is the construction of efficient,low-cost electrocatalysts.Prussian blue(PB),Prussian blue analogs(PBAs),and their derivatives have tunable metal centers and have attracted significant interest as novel photo-and electrochemical catalysts.In this review,recent research progress into PB/PBA-based hollow structures,substrate-supported nanostructures,and their derivatives for green water splitting is discussed and summarized.First,several remarkable examples of nanostructured PB/PBAs supported on substrates(copper foil,carbon cloth,and nickel foam)and hollow structures(such as single-shelled hollow boxes,open hollow cages,and intricate hollow structures(multi-shell and yolk-shell))are discussed in detail,including their synthesis and formation mechanisms.Subsequently,the applications of PB/PBA derivatives((hydr)oxides,phosphides,chalcogenides,and carbides)for water splitting are discussed.Finally,the limitations in this research area and the most urgent challenges are summarized.We hope that this review will stimulate more researchers to develop technologies based on these intricate PB/PBA structures and their derivatives for highly efficient,green water splitting.
文摘The regular occurrence and the high costs of flooding to both road agencies and communities is a strong impetus to investigate the methodologies applied to evaluating flood immunity road projects. Very little literature exists on methods of evaluating the benefits of improving flood immunity through better road infrastructure. This paper attempts to address some of the numerous issues hindering the accurate evaluation of flood immunity road projects. The methodologies presented in this paper are designed to evaluate benefits that are not normally included or not fully considered in evaluations; such benefits include reduced flood related road accidents, costs of not travelling during the closure period and additional costs from unanticipated flood events. A key focus of the paper is the consideration of the evaluation of improved flood immunity from a network perspective rather than the typical approach of evaluating flood immunity projects in isolation to each other. The application of the proposed methodologies is demonstrated with a hypothetical example of a typical rural network subjected to regular flooding. The results of the analysis, conducted using the proposed methodologies, reveals that the currently applied methodologies account for less than half the likely value of benefits of a package of projects that will prevent the complete isolation of communities during serious flood events.
基金Project(2006CB600903) supported by the National Basic Research Program of China
文摘Prussian blue(PB) was used as catalyst to improve the extent of graphitization of polyacrylonitrile(PAN)-based carbon fibers.PB was deposited on carbon fibers by anodic electrodeposition and the thickness of PB coating(PB content) was controlled by adjusting the electrodeposition time.PAN-based carbon fibers with PB coating were heat-treated and the extent of graphitization was measured by X-ray diffractometry and Raman spectroscopy.The results indicate that the extent of graphitization of PAN-based carbon fibers is enhanced in the presence of the coating.When the PB-coated carbon fibers were heat-treated at 1 900 ℃,interlayer spacing(d002) and crystallite size(Lc) reach 0.336 8 and 21.2 nm respectively.Contrarily,the values of d002 and Lc are 0.341 4 and 7.4 nm respectively when the bare carbon fibers were heat-treated at 2 800 ℃.Compared with the bare carbon fibers,PB can make the heat treatment temperature(HTT) drop more than 500 ℃ in order to reach the same extent of graphitization.Furthermore,the research results show that PB content also has a certain influence on the extent of graphitization at the same HTT.
