Hevein, a lectin_like protein, is a major factor of lutoids in the latex of rubber trees ( Hevea brasiliensis Muell._Arg.). This factor is involved in coagulation of the latex and has the ability to bind chitin. Th...Hevein, a lectin_like protein, is a major factor of lutoids in the latex of rubber trees ( Hevea brasiliensis Muell._Arg.). This factor is involved in coagulation of the latex and has the ability to bind chitin. The hevein gene with a length of 680 bp was cloned by the method of RT_PCR. Its promoter region with 1 306 bp of this gene was also isolated by genome walking, and its sequence included the typical TATA and CAAT boxes as well as the homologous sequence of abscisic acid (ABA) response elements. Expression of the hevein gene in the latex and leaves was detected by Northern blot. After treatment of the trees with ethylene and ABA, the results showed that the hevein gene was expressed principally in latex, and the expression could be induced by ethylene and ABA.展开更多
AIM:To analyze the epidermal growth factor receptor pathway substrate 8(EPS8) expression status and role in colorectal carcinogenesis given that EPS8 has a conserved actin barbed-end capping function that is required ...AIM:To analyze the epidermal growth factor receptor pathway substrate 8(EPS8) expression status and role in colorectal carcinogenesis given that EPS8 has a conserved actin barbed-end capping function that is required for proper maturation in intestinal cells.METHODS:We studied 8 colon cancer cell lines and 58 colorectal tumors(19 adenomas and 39 carcinomas).We performed expression microarray analysis of colon cancer cell lines followed by loss of heterozygosity(LOH)analysis and immunohistochemistry for EPS8 expression in colon tumors.Subsequently,we performed mutation analysis by direct sequencing and methylation analysis by bisulfite sequencing and methylation-specific polymerase chain reaction assays.RESULTS:Expression microarray analysis of colon cancer cell lines showed overexpression of EPS8 transcript in all lines but RKO.Genome wide loss of heterozygosity(LOH) analysis of colon tumors,showed considerable LOH at the EPS8 gene locus.Immunohistochemically,EPS8 was constitutively expressed in normal colonic mucosa with a dot-like supranuclear localization with accentuation at the luminal surface supporting its proposed role in epithelial maturation.Nineteen colon tumors(4 adenoma,15 carcinoma) out of 51(37%) showed strikingly tumor specific EPS8 protein loss.Of the remaining tumors,5/51(2 adenoma,and 3 carcinoma,10%) showed marked overexpression,while 27/51 tumors(53%) showed retained expression.Mutation analysis revealed a missense mutation(c.794C>T,p.R265C) in exon 8 in RKO.The EPS8 promoter was also methylated in RKO,but there was no significant methylation in other cell lines or carcinoma specimens.CONCLUSION:The loss of EPS8 expression in colorectal adenomas and carcinomas suggests that down regulation of this gene contributes to the development of a subset of colorectal cancers,a finding which could have applications in diagnosis and treatment.展开更多
A new method of constructing bornological vector topologies for vector spaces is discussed.In general,the convergent sequence and bounded set are concepts only in topological spaces.However,in this paper,it is first i...A new method of constructing bornological vector topologies for vector spaces is discussed.In general,the convergent sequence and bounded set are concepts only in topological spaces.However,in this paper,it is first introduced sequential convergence C and L * space which is a vector space giving some relation:x mCx between sequences and points in it,then the bounded set is defined in vector space.Let C be a sequential convergence,T(C) be a vector topology on X determined by C and B(C) be the collection of bounded sets determined by C.Then B(C)=B(T(C)).Furthermore,the bornological locally convex topological vector space is constructed by L * vector space.展开更多
The degree of accuracy in predicting the photovoltaic power generation plays an important role in appropriate allocations and economic operations of the power plants based on the generating capacity data gathered from...The degree of accuracy in predicting the photovoltaic power generation plays an important role in appropriate allocations and economic operations of the power plants based on the generating capacity data gathered from the geographically separated photovoltaic plants through network. In this paper, a forecasting model is designed with an optimization algorithm which is developed with the combination of PSO （Particle Swarm Optimization） and BP （Back Propagation） neural network. The proposed model is further validated and the experiment results show that the predication model assures the prediction accuracy regardless the day type transitions and other relevant factors, in the proposed model, the prediction error rate is worth less than 20% in all different climatic conditions and most of the prediction error accuracy is less than 10% in sunny day, and whose precision satisfies the management requirements of the power grid companies, reflecting the significance of the proposed model in engineering applications.展开更多
Monolithic integration of resonant tunneling diodes (RTDs) and high electron mobility transistors (HEMTs) is an important development direction of ultra-high speed integrated circuit. A kind of top-RTD and bottom-HEMT...Monolithic integration of resonant tunneling diodes (RTDs) and high electron mobility transistors (HEMTs) is an important development direction of ultra-high speed integrated circuit. A kind of top-RTD and bottom-HEMT material structure is epitaxied on InP substrate through molecular beam epitaxy. Based on wet chemical etching, metal lift-off and air bridge interconnection technology, RTD and HEMT are fabricated simultaneously. The peak-to-valley current ratio of RTD is 7.7 and the peak voltage is 0.33 V at room temperature. The pinch-off voltage is -0.5 V and the current gain cut-frequency is 30 GHz for a 1.0 μm gate length depletion mode HEMT. The two devices are conformable in current magnitude, which is suitable for the construction of various RTD/HEMT monolithic integration logic circuits.展开更多
The authors take all isomorphism classes of indecomposable representations as new generators, and obtain all skew-commutators between these generators by using the Ringel-Hall algebra method. Then they prove that the ...The authors take all isomorphism classes of indecomposable representations as new generators, and obtain all skew-commutators between these generators by using the Ringel-Hall algebra method. Then they prove that the set of these skew-commutators is a GrSbner-Shirshov basis for quantum group of type D4.展开更多
A vertex of a graph is said to dominate itself and all of its neighbors. A double dominating set of a graph G is a set D of vertices of G, such that every vertex of G is dominated by at least two vertices of D. The do...A vertex of a graph is said to dominate itself and all of its neighbors. A double dominating set of a graph G is a set D of vertices of G, such that every vertex of G is dominated by at least two vertices of D. The double domination number of a graph G is the minimum cardinality of a double dominating set of G. For a graph G = （V, E）, a subset D C V（G） is a 2-dominating set if every vertex of V（G） ／ D has at least two neighbors in D, while it is a 2-outer-independent dominating set of G if additionally the set V（G）／D is independent. The 2-outer-independent domination number of G is the minimum cardinality of a 2-outer-independent dominating set of G. This paper characterizes all trees with the double domination number equal to the 2-outer-independent domination number plus one.展开更多
In the past three decades, molecular magnetism has been a rapidly growing interdisciplinary field in chemistry, phys- ics and materials sciences. It covers diverse range of topics including inorganic/organic/hybrid ma...In the past three decades, molecular magnetism has been a rapidly growing interdisciplinary field in chemistry, phys- ics and materials sciences. It covers diverse range of topics including inorganic/organic/hybrid magnetic molecular ma- terials, multifunctional and/or switchable magnetic molecu- lar materials, molecular nanomagnets, nanostructural mo- lecular magnets, molecular spintronics and biomagnetism. Much research on molecular magnetism has been carried out in China both before and after we organized the Interna- tional Conference on Molecule-Based Magnets 2010 （ICMM 2010） in Beijing.展开更多
A dynalnic model of skeletal muscle is developed to describe its activation kinetics and contraction dynamics based on the collective working mechanism of myosin II motors with a statistical mechanics method. Accordin...A dynalnic model of skeletal muscle is developed to describe its activation kinetics and contraction dynamics based on the collective working mechanism of myosin II motors with a statistical mechanics method. According to the structure of sar- comeres arranged in series and in parallel, the mechanical properties of skeletal muscle are studied. This model reveals the re- lations between action potential and muscle characteristics. It is shown that calcium concentration in sarcoplasmic （SP） in- creases linearly with the increasing stimulation frequency and gradually reaches saturation. Active force and contraction veloc- ity follow the trend of calcium concentration and reach a peak value at the maximum stimulation frequency. Contraction ve- locity is inversely proportional to the load while the contraction power increases to maximum and then reduces to zero with the increasing load. These properties are consistent with published physiological experimental results of skeletal muscle.展开更多
The ground and low-lying collective states of a rotating system of N=3 bosons harmonically confined in quasi-two-dimension and interacting via repulsive finite-range Gaussian potential is studied in weakly to moderate...The ground and low-lying collective states of a rotating system of N=3 bosons harmonically confined in quasi-two-dimension and interacting via repulsive finite-range Gaussian potential is studied in weakly to moderately interacting regime.The N-body Hamiltonian matrix is diagonalized in subspaces of quantized total angular momenta 0 ≤ L ≤ 4N to obtain the ground and low-lying eigenstates.Our numerical results show that breathing modes with N-body eigenenergy spacing of 2hω⊥,known to exist in strictly 2D system with zero-range(δ-function) interaction potential,may as well exist in quasi-2D system with finite-range Gaussian interaction potential.To gain an insight into the many-body states,the von Neumann entropy is calculated as a measure of quantum correlation and the conditional probability distribution is analyzed for the internal structure of the eigenstates.In the rapidly rotating regime the ground state in angular momentum subspaces L=(q/2)N(N-1) with q=2,4 is found to exhibit the anticorrelation structure suggesting that it may variationally be described by a Bose–Laughlin like state.We further observe that the first breathing mode exhibits features similar to the Bose–Laughlin state in having eigenenergy,von Neumann entropy and internal structure independent of interaction for the three-boson system considered here.On the contrary,for eigenstates lying between the Bose–Laughlin like ground state and the first breathing mode,values of eigenenergy,von Neumann entropy and internal structure are found to vary with interaction.展开更多
文摘Hevein, a lectin_like protein, is a major factor of lutoids in the latex of rubber trees ( Hevea brasiliensis Muell._Arg.). This factor is involved in coagulation of the latex and has the ability to bind chitin. The hevein gene with a length of 680 bp was cloned by the method of RT_PCR. Its promoter region with 1 306 bp of this gene was also isolated by genome walking, and its sequence included the typical TATA and CAAT boxes as well as the homologous sequence of abscisic acid (ABA) response elements. Expression of the hevein gene in the latex and leaves was detected by Northern blot. After treatment of the trees with ethylene and ABA, the results showed that the hevein gene was expressed principally in latex, and the expression could be induced by ethylene and ABA.
基金Supported by The Academy of Finlandigrid Juselius Foundation+4 种基金University of SharjahTerry Fox FundFinnish Cancer FoundationBiocentrum Helsinkithe European Research Council
文摘AIM:To analyze the epidermal growth factor receptor pathway substrate 8(EPS8) expression status and role in colorectal carcinogenesis given that EPS8 has a conserved actin barbed-end capping function that is required for proper maturation in intestinal cells.METHODS:We studied 8 colon cancer cell lines and 58 colorectal tumors(19 adenomas and 39 carcinomas).We performed expression microarray analysis of colon cancer cell lines followed by loss of heterozygosity(LOH)analysis and immunohistochemistry for EPS8 expression in colon tumors.Subsequently,we performed mutation analysis by direct sequencing and methylation analysis by bisulfite sequencing and methylation-specific polymerase chain reaction assays.RESULTS:Expression microarray analysis of colon cancer cell lines showed overexpression of EPS8 transcript in all lines but RKO.Genome wide loss of heterozygosity(LOH) analysis of colon tumors,showed considerable LOH at the EPS8 gene locus.Immunohistochemically,EPS8 was constitutively expressed in normal colonic mucosa with a dot-like supranuclear localization with accentuation at the luminal surface supporting its proposed role in epithelial maturation.Nineteen colon tumors(4 adenoma,15 carcinoma) out of 51(37%) showed strikingly tumor specific EPS8 protein loss.Of the remaining tumors,5/51(2 adenoma,and 3 carcinoma,10%) showed marked overexpression,while 27/51 tumors(53%) showed retained expression.Mutation analysis revealed a missense mutation(c.794C>T,p.R265C) in exon 8 in RKO.The EPS8 promoter was also methylated in RKO,but there was no significant methylation in other cell lines or carcinoma specimens.CONCLUSION:The loss of EPS8 expression in colorectal adenomas and carcinomas suggests that down regulation of this gene contributes to the development of a subset of colorectal cancers,a finding which could have applications in diagnosis and treatment.
文摘A new method of constructing bornological vector topologies for vector spaces is discussed.In general,the convergent sequence and bounded set are concepts only in topological spaces.However,in this paper,it is first introduced sequential convergence C and L * space which is a vector space giving some relation:x mCx between sequences and points in it,then the bounded set is defined in vector space.Let C be a sequential convergence,T(C) be a vector topology on X determined by C and B(C) be the collection of bounded sets determined by C.Then B(C)=B(T(C)).Furthermore,the bornological locally convex topological vector space is constructed by L * vector space.
基金the National Natural Science Foundation of China under Grant No.61261016，Wuhan Science and technology project for the Solar energy intelligent management system development and application demonstration
文摘The degree of accuracy in predicting the photovoltaic power generation plays an important role in appropriate allocations and economic operations of the power plants based on the generating capacity data gathered from the geographically separated photovoltaic plants through network. In this paper, a forecasting model is designed with an optimization algorithm which is developed with the combination of PSO （Particle Swarm Optimization） and BP （Back Propagation） neural network. The proposed model is further validated and the experiment results show that the predication model assures the prediction accuracy regardless the day type transitions and other relevant factors, in the proposed model, the prediction error rate is worth less than 20% in all different climatic conditions and most of the prediction error accuracy is less than 10% in sunny day, and whose precision satisfies the management requirements of the power grid companies, reflecting the significance of the proposed model in engineering applications.
基金Supported by National Natural Science Foundation of China (No. 60876009)Tianjin Research Program of Application Foundation and Advanced Technology (No. 09JCZDJC16600)
文摘Monolithic integration of resonant tunneling diodes (RTDs) and high electron mobility transistors (HEMTs) is an important development direction of ultra-high speed integrated circuit. A kind of top-RTD and bottom-HEMT material structure is epitaxied on InP substrate through molecular beam epitaxy. Based on wet chemical etching, metal lift-off and air bridge interconnection technology, RTD and HEMT are fabricated simultaneously. The peak-to-valley current ratio of RTD is 7.7 and the peak voltage is 0.33 V at room temperature. The pinch-off voltage is -0.5 V and the current gain cut-frequency is 30 GHz for a 1.0 μm gate length depletion mode HEMT. The two devices are conformable in current magnitude, which is suitable for the construction of various RTD/HEMT monolithic integration logic circuits.
基金Project supported by the Natural Science Foundation of Xinjiang University (the Starting Research Fund for Doctors) (No. BS080103)
文摘The authors take all isomorphism classes of indecomposable representations as new generators, and obtain all skew-commutators between these generators by using the Ringel-Hall algebra method. Then they prove that the set of these skew-commutators is a GrSbner-Shirshov basis for quantum group of type D4.
文摘A vertex of a graph is said to dominate itself and all of its neighbors. A double dominating set of a graph G is a set D of vertices of G, such that every vertex of G is dominated by at least two vertices of D. The double domination number of a graph G is the minimum cardinality of a double dominating set of G. For a graph G = （V, E）, a subset D C V（G） is a 2-dominating set if every vertex of V（G） ／ D has at least two neighbors in D, while it is a 2-outer-independent dominating set of G if additionally the set V（G）／D is independent. The 2-outer-independent domination number of G is the minimum cardinality of a 2-outer-independent dominating set of G. This paper characterizes all trees with the double domination number equal to the 2-outer-independent domination number plus one.
文摘In the past three decades, molecular magnetism has been a rapidly growing interdisciplinary field in chemistry, phys- ics and materials sciences. It covers diverse range of topics including inorganic/organic/hybrid magnetic molecular ma- terials, multifunctional and/or switchable magnetic molecu- lar materials, molecular nanomagnets, nanostructural mo- lecular magnets, molecular spintronics and biomagnetism. Much research on molecular magnetism has been carried out in China both before and after we organized the Interna- tional Conference on Molecule-Based Magnets 2010 （ICMM 2010） in Beijing.
基金supported by the National Natural Science Foundation of China (Grant No. 61075101/60643002)the Research Fund of State Key Lab of MSV,China (Grant No. MSV-2010-1)+1 种基金the Science and Technology Intercrossingthe Medical and Technology Intercrossing Research Foundation of Shanghai Jiao Tong University (Grant No. YG2010ZD101)
文摘A dynalnic model of skeletal muscle is developed to describe its activation kinetics and contraction dynamics based on the collective working mechanism of myosin II motors with a statistical mechanics method. According to the structure of sar- comeres arranged in series and in parallel, the mechanical properties of skeletal muscle are studied. This model reveals the re- lations between action potential and muscle characteristics. It is shown that calcium concentration in sarcoplasmic （SP） in- creases linearly with the increasing stimulation frequency and gradually reaches saturation. Active force and contraction veloc- ity follow the trend of calcium concentration and reach a peak value at the maximum stimulation frequency. Contraction ve- locity is inversely proportional to the load while the contraction power increases to maximum and then reduces to zero with the increasing load. These properties are consistent with published physiological experimental results of skeletal muscle.
文摘The ground and low-lying collective states of a rotating system of N=3 bosons harmonically confined in quasi-two-dimension and interacting via repulsive finite-range Gaussian potential is studied in weakly to moderately interacting regime.The N-body Hamiltonian matrix is diagonalized in subspaces of quantized total angular momenta 0 ≤ L ≤ 4N to obtain the ground and low-lying eigenstates.Our numerical results show that breathing modes with N-body eigenenergy spacing of 2hω⊥,known to exist in strictly 2D system with zero-range(δ-function) interaction potential,may as well exist in quasi-2D system with finite-range Gaussian interaction potential.To gain an insight into the many-body states,the von Neumann entropy is calculated as a measure of quantum correlation and the conditional probability distribution is analyzed for the internal structure of the eigenstates.In the rapidly rotating regime the ground state in angular momentum subspaces L=(q/2)N(N-1) with q=2,4 is found to exhibit the anticorrelation structure suggesting that it may variationally be described by a Bose–Laughlin like state.We further observe that the first breathing mode exhibits features similar to the Bose–Laughlin state in having eigenenergy,von Neumann entropy and internal structure independent of interaction for the three-boson system considered here.On the contrary,for eigenstates lying between the Bose–Laughlin like ground state and the first breathing mode,values of eigenenergy,von Neumann entropy and internal structure are found to vary with interaction.
