基础底面承载力的验算及附加压力的计算

依据有关规范 ,阐述了基底压力设计值与基底压力标准值的内涵及差异 ,给出了它们的计算表达式。论述了地基沉降计算参数———基底附加压力的计算前提及正确方法。

孟加拉笛鲷与四带笛鲷的微卫星分析

采用聚丙烯酰胺凝胶电泳技术,从西大西洋笛鲷(Lutjanus campechanus)和勒氏笛鲷(L.russel-lii)的微卫星引物中筛选出适用于孟加拉笛鲷(L.bengalensis)和四带笛鲷(L.kasmira)的微卫星引物,并应用于三亚和湛江群体的遗传结构分析.结果表明:25对引物中筛选出13对可以稳定扩增出特异片段的引物,其中12对可在孟加拉笛鲷基因组中扩增出重复性好的特异性条带;10对可在四带笛鲷中扩增出重复性好的特异性条带,并且全部呈现出种内多态;9对为两个种通用.孟加拉笛鲷的湛江群体(ZMJ)和三亚群体(SMJ)、四带笛鲷的湛江群体(ZSD)和三亚群体(SSD)的平均等位基因数分别为:3.888 9、4.111 1、4.333 3、4.222 2;平均观测杂合度分别为:0.583 3、0.638 9、0.594 4、0.638 9;平均多态信息含量分别为:0.472 0、0.469 2、0.547 4、0.525 7.将本实验所得结果与笛鲷鱼其他研究结果进行比较分析,可以看出目前湛江海域野生笛鲷的遗传多样性整体比较丰富,但部分野生笛鲷已表现出杂合子缺失的趋势,这势必会引起将来遗传多样性的降低,所以要尽早对野生群体进行摸底调查,并找出解决养殖群体污染野生群体这一问题的方法.

Mitigation of floor heave in West Kentucky Coal Mine

A West Kentucky mine operation in No. 11 seam encountered floor heave, due to the localized increase in the thickness of the fireclay mine floor. Floor heave has overridden seals installed in two mined out panels. The third seal's location was planned for isolating that area from the Mains. A plan of support has been developed to prevent repetition of the floor heave and related problems outby the seals. The applied ground control measures were successful. An attempt of a 3D numerical modeling was made; thus, it would match the observed behavior of the mine floor and could be used as a design tool in similar conditions. The paper describes sequence of events, an applied mitigation ground control system, and the first stage of numerical modeling.

谷氨酰胺胶囊在健康人体的生物等效性研究

目的研究中国健康受试者单次口服谷氨酰胺胶囊的人体生物等效性。方法将36名男性健康受试者随机分为2组,分别单剂量口服试验药或参比药4.0 g,洗脱1周后,交叉给药,用高效液相色谱与二级质谱联用(HPLC-MS/MS)方法测定血药浓度,计算两者的主要药代动力学参数和相对生物利用度。结果口服试验药和参比药后,血浆中谷氨酰胺主要药动学参数如下:tmax分别为(0.69±0.66)和(0.66±0.33)h,Cmax分别为(127.80±53.48)和(123.10±40.42)μg·m L-1,以AUC0→∞计算,试验药相对生物利用度为(99.96±39.92)%。结论试验药与参比药在健康受试者体内生物作用等效。