The clinical and histologic spectrum of melanotic macule of the nail unit is examined and the differences in the clinical appearance of longitudinal melanonychia caused by melanotic macule and by other kinds of prolif...The clinical and histologic spectrum of melanotic macule of the nail unit is examined and the differences in the clinical appearance of longitudinal melanonychia caused by melanotic macule and by other kinds of proliferations of melanocytes are assessed. We observed that the clinical appearance of the pigmented band was of little help in establishing the underlying basic pathologic process. This underscores the importance of obtaining a biopsy of the nail matrix in patients who present with solitary longitudinal melanonychia.展开更多
流行性出血热(EHF)和汉坦病毒肺综合征(HPS)均是由汉坦病毒属病毒(Hantaviruses,HV)引起的急性传染病.EHF的病原体--汉滩病毒(HTNV)、汉城病毒(SEOV)、普马拉病毒(PUUV)和多布拉伐病毒(DOBV)等主要分布于有着几千年文明历史的欧亚大陆,...流行性出血热(EHF)和汉坦病毒肺综合征(HPS)均是由汉坦病毒属病毒(Hantaviruses,HV)引起的急性传染病.EHF的病原体--汉滩病毒(HTNV)、汉城病毒(SEOV)、普马拉病毒(PUUV)和多布拉伐病毒(DOBV)等主要分布于有着几千年文明历史的欧亚大陆,国际上称为旧世界汉坦病毒(Hantavirusin old world);而辛诺柏病毒(SNV)、安弟斯病毒(ANDV)等HPS的病原体主要分布于仅有几百年文明史的南北美洲新大陆,故称为新世界汉坦病毒(Hantavirus in newworld).2类疾病虽然在病原、病变部位、临床表现和诊治方法等方面有所不同,但是其病原体均属于汉坦病毒属,基因组结构和功能大多相同,基本病理改变均为小血管和毛细血管渗漏(capillaryleakage),少数EHF可以表现为呼吸功能衰竭为主,而少数南美国家的HPS病例可伴有明显的肾衰竭.本文就近年EHF和HPS发病机制的研究进展综述如下.展开更多
文摘The clinical and histologic spectrum of melanotic macule of the nail unit is examined and the differences in the clinical appearance of longitudinal melanonychia caused by melanotic macule and by other kinds of proliferations of melanocytes are assessed. We observed that the clinical appearance of the pigmented band was of little help in establishing the underlying basic pathologic process. This underscores the importance of obtaining a biopsy of the nail matrix in patients who present with solitary longitudinal melanonychia.
文摘流行性出血热(EHF)和汉坦病毒肺综合征(HPS)均是由汉坦病毒属病毒(Hantaviruses,HV)引起的急性传染病.EHF的病原体--汉滩病毒(HTNV)、汉城病毒(SEOV)、普马拉病毒(PUUV)和多布拉伐病毒(DOBV)等主要分布于有着几千年文明历史的欧亚大陆,国际上称为旧世界汉坦病毒(Hantavirusin old world);而辛诺柏病毒(SNV)、安弟斯病毒(ANDV)等HPS的病原体主要分布于仅有几百年文明史的南北美洲新大陆,故称为新世界汉坦病毒(Hantavirus in newworld).2类疾病虽然在病原、病变部位、临床表现和诊治方法等方面有所不同,但是其病原体均属于汉坦病毒属,基因组结构和功能大多相同,基本病理改变均为小血管和毛细血管渗漏(capillaryleakage),少数EHF可以表现为呼吸功能衰竭为主,而少数南美国家的HPS病例可伴有明显的肾衰竭.本文就近年EHF和HPS发病机制的研究进展综述如下.