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玉液汤药物降糖成分与方剂降糖机制研究进展 被引量:3
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作者 胡锦浩 石岩 《辽宁中医药大学学报》 CAS 2024年第4期116-123,共8页
糖尿病(DM)是最为常见的内分泌代谢性疾病之一,我国糖尿病的类型以T2DM为主,其的发病率和病死率居世界首位。当下,人们对DM的发病机制尚未完全阐明。虽然西药降糖药物在糖尿病的治疗中获得较好的疗效,但仍会出现并发症多、敏感性降低、... 糖尿病(DM)是最为常见的内分泌代谢性疾病之一,我国糖尿病的类型以T2DM为主,其的发病率和病死率居世界首位。当下,人们对DM的发病机制尚未完全阐明。虽然西药降糖药物在糖尿病的治疗中获得较好的疗效,但仍会出现并发症多、敏感性降低、不良反应大等问题。玉液汤源自《医学衷中参西录》,临床应用已近百年,具有良好的润燥止渴、益气生津的临床疗效,是治疗消渴病的代表方。经临床观察和实验研究,发现玉液汤及其中每个单味药中的多种有效成分都能够对糖尿病的防治起到良好的疗效。中药有效成分多样、作用靶点多样,能够通过不同的机制作用治疗DM。因此,需要从分子生物学、网络药理学等层面进行系统深入地研究,全面揭示玉液汤防治DM的作用机制。目前玉液汤治疗糖尿病的作用机制主要集中于防止β细胞凋亡,降低炎症因子,改善肠道菌群紊乱等。通过对玉液汤防治DM的研究,阐明玉液汤防治DM的作用机制及其药效物质基础,为玉液汤的临床应用进一步提供重要的科学依据。通过检索中国知网(CNKI)、PubMed、万方(Wanfang Data)、维普(VIP)等数据库,从方证基础、药物的活性成分、网络药理学、临床与实验研究等方面对玉液汤治疗T2DM的方证基础、方中药物的活性成分、方剂的药理作用机制进行论述,为后续玉液汤治疗糖尿病的相关研究提供参考。 展开更多
关键词 玉液汤 糖尿病 方证基础 活性成分 作用机制 研究进展
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PIR-based data integrity verification method in sensor network
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作者 Yong-Ki Kim Kwangnam Choi +1 位作者 Jaesoo Kim JungHo Seok 《Journal of Central South University》 SCIE EI CAS 2014年第10期3883-3888,共6页
Since a sensor node handles wireless communication in data transmission and reception and is installed in poor environment, it is easily exposed to certain attacks such as data transformation and sniffing. Therefore, ... Since a sensor node handles wireless communication in data transmission and reception and is installed in poor environment, it is easily exposed to certain attacks such as data transformation and sniffing. Therefore, it is necessary to verify data integrity to properly respond to an adversary's ill-intentioned data modification. In sensor network environment, the data integrity verification method verifies the final data only, requesting multiple communications. An energy-efficient private information retrieval(PIR)-based data integrity verification method is proposed. Because the proposed method verifies the integrity of data between parent and child nodes, it is more efficient than the existing method which verifies data integrity after receiving data from the entire network or in a cluster. Since the number of messages for verification is reduced, in addition, energy could be used more efficiently. Lastly, the excellence of the proposed method is verified through performance evaluation. 展开更多
关键词 data integrity VERIFICATION private information retrieval sensor network
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Statistical Reconstruction of the Antarctic Oscillation Index Based on Multiple Proxies
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作者 ZHANG Zi-Yin GONG Dao-Yi +2 位作者 HE Xue-Zhao LEI Yang-Na FENG Sheng-Hui 《Atmospheric and Oceanic Science Letters》 2010年第5期283-287,共5页
Based on multiple proxies from the Southern Hemisphere, an austral summer (December-January-February: DJF) Antarctic Oscillation Index (AAO) since 1500 A.D. was reconstructed with a focus on interannual to interdecada... Based on multiple proxies from the Southern Hemisphere, an austral summer (December-January-February: DJF) Antarctic Oscillation Index (AAO) since 1500 A.D. was reconstructed with a focus on interannual to interdecadal variability (<50 a). By applying a multivariate regression method, the observational AAO-proxy relations were calibrated and cross-validated for the period of 1957 89. The regressions were employed to compute the DJF-AAO index for 1500 1956. To verify the results, the authors checked the explained variance (r 2 ), the reduction of error (RE), and the standard error (SE). Cross-validation was performed by applying a leave-one-out validation method. Over the entire reconstruction period, the mean values of r 2 , RE, and SE are 59.9%, 0.47, and 0.67, respectively. These statistics indicate that the DJF-AAO reconstruction is relatively skillful and reliable for the last ~460 years. The reconstructed AAO variations on the interannual and interdecadal timescales compare favorably with those of several shorter sea level pressure (SLP)-based AAO indices. The leading periods of the DJF-AAO index over the last 500 years are ~2.4, ~2.6, ~6.3, ~24.1, and ~37.6 years, all of which are significant at the 95% level as estimated by power spectral analysis. 展开更多
关键词 Antarctic Oscillation RECONSTRUCTION PROXY interannual and interdecadal variability
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射干麻黄汤治疗哮喘研究进展 被引量:1
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作者 李芳琳 王淑敏 +1 位作者 刘晓 陈文霞 《国际中医中药杂志》 2023年第11期1469-1472,共4页
射干麻黄汤是治疗哮喘的经典方剂,具有散寒化痰、止咳平喘功效,临床可单独应用控制急性发作,或辅助西医疗法提高治疗效果,或与其他经方合用针对病机根本,均可改善患者咳喘、咳痰症状,以及肺功能指标。本方治疗哮喘的作用机制主要与减轻... 射干麻黄汤是治疗哮喘的经典方剂,具有散寒化痰、止咳平喘功效,临床可单独应用控制急性发作,或辅助西医疗法提高治疗效果,或与其他经方合用针对病机根本,均可改善患者咳喘、咳痰症状,以及肺功能指标。本方治疗哮喘的作用机制主要与减轻炎症反应、抑制气道重塑相关,主要通过调控免疫性炎性通路,从而发挥作用。 展开更多
关键词 射干麻黄汤 哮喘 基础方证 临床研究 作用机制 综述
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