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Breslow算法非容许误差校正
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作者 梁正东 王开发 杨旭 《第三军医大学学报》 CAS CSCD 北大核心 2003年第18期1670-1671,共2页
目的 对多元生存分析Breslow算法的基础生存率So(t)的估计会在实用中产生与概率意义不相符的非容许误差进行校正。方法 根据Cox比例危险度概率模型原理 ,利用参数极大似然估计法对So(t)做推导分析。结果 导出了So(t)的无偏计算公式... 目的 对多元生存分析Breslow算法的基础生存率So(t)的估计会在实用中产生与概率意义不相符的非容许误差进行校正。方法 根据Cox比例危险度概率模型原理 ,利用参数极大似然估计法对So(t)做推导分析。结果 导出了So(t)的无偏计算公式。结论 纠正了原估So(t)计公式的非容许误差 ,并通过不同算法对比的算例 ,说明新估计公式的合理性。 展开更多
关键词 生存分析 基础生存率 校正误差
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Adjuvant chemoradiotherapy versus surgery alone for gastric adenocarcinoma
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作者 Yasser Saleh Hanan Ahmed Wahba +2 位作者 Hend Ahmed El-Hadaad Mohamed Al-Hemaly Tamer Fady Youssef 《The Chinese-German Journal of Clinical Oncology》 CAS 2011年第8期450-454,共5页
Objective:Despite resection with curative intent,a majority of patients with gastric cancer will develop disease recurrence.Postoperative adjuvant chemo-radiotherapy increase the curability of surgery,prevent local re... Objective:Despite resection with curative intent,a majority of patients with gastric cancer will develop disease recurrence.Postoperative adjuvant chemo-radiotherapy increase the curability of surgery,prevent local recurrence and improve survival.Methods:Between December 2005 and February 2010,33 patients were eligible for the study,17 patients were randomly assigned for chemo-radiotherapy (GI) and 16 patients with surgery alone (GII).Patients in GI received chemotherapy (fluorouracil,425 mg/m 2/day,and leucovorin,20 mg/m 2/day,for 5 days) was initiated on day 1 and was followed by chemo-radiotherapy beginning 28 days after the start of the initial cycle of chemotherapy.Chemo-radiotherapy consisted of 4500 cGy of radiation at 180 cGy/day,five days/week for five weeks,with fluorouracil (400 mg/m 2/day) and leucovorin (20 mg/m 2/day) on the first four and the last four days of radiotherapy.One month after the completion of radiotherapy,two five-day cycles of fluorouracil (425 mg/m 2/day) plus leucovorin (20 mg/m 2/day) were given one month apart.Results:Grade 3 gastrointestinal toxicity was more common (23.2%) while grade 3 hematological toxicity were (5.8%).Both 3-year survival (53%) and disease free survival (41%) rates were higher in GI than in GII in which they were 43.7% and 31% respectively.Relapse rate was higher in GII (56.3%) than in GI (35.3%).Conclusion:The present study revealed that chemo-radiotherapy after gastric resection in patients with gastric adenocarcinoma improves survival and relapse rates with manageable toxicities.However,studies with larger number of patients are recommended to confirm our results. 展开更多
关键词 adjuvant chemoradiotherapy gastric carcinoma SURGERY RADIOTHERAPY
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