The concept of research-based social work is introduced and discussed from the point of view of preconditions for its realization. Attention is paid both to the academic research of social work and to opportunities fo...The concept of research-based social work is introduced and discussed from the point of view of preconditions for its realization. Attention is paid both to the academic research of social work and to opportunities for developing a knowledge-producing social work practice. Both of these are seen as essential elements of a research-based profession. On the one hand, the academic research is necessary for development of social work as a research-based professional system, and on the other hand, a knowledge-producing practice, conducted by research-oriented practitioners, can only be realized within such a system. Historically, social work has been partly developed as a knowledge-applying instead of a knowledge-producing profession, although the central founding pioneers emphasized the importance of an own-knowledge basis and theory formation, as well as the idea of knowledge-producing practice based on a corresponding professional identity. The future of social work as a professional system in modern society may depend decisively on how it develops a research-based professional identity, not only in the sense of academic research but also through practitioners with research orientation. These are practitioners who would be capable of research-based working in terms of creative knowledge production, thus of developing social work as a credible research-based profession. This can be created only through education in which the development of necessary professional skills is linked to advanced academic meta-skills. There are good reasons to suspect that a three-year education is too short for this.展开更多
AIM: To investigate the efficacy and safety of combined antiviral and immunosuppressant therapy in adult hepatitis B virus-associated glomerulonephritis (HBVGN) patients. METHODS: A computerized literature search was ...AIM: To investigate the efficacy and safety of combined antiviral and immunosuppressant therapy in adult hepatitis B virus-associated glomerulonephritis (HBVGN) patients. METHODS: A computerized literature search was carried out in the PubMed database, Embase, the Cochrane Library, Chinese BioMedical Literature on disc, Chinese Medical Current Contents, Chinese National Knowledge Infrastructure, Wanfang and VIP (Chinese Technological Journal of Database) to collect articles between June 1980 and December 2010 on therapy with immunosuppressants, e.g., glucorticosteroids, mycophenolate mofetil and leflunomide, combined with antivirals, e.g., interferon, lamivudine, entecavir and adefovir dipivoxil, in adult HBV-GN patients. The primary outcomes were remission of proteinuria, clearanceof HBV e-antigen, and elevation of serum albumin. The secondary outcomes were blood levels of alanine aminotransferase, serum creatinine, and HBV-DNA titer. Meta-analysis was performed using Review Manager 5.1. Fixed or random effect models were employed to combine the results after a heterogeneity test. The effects of the combined therapy were analyzed for different doses of glucorticosteroid and different types of HBV-GN. RESULTS: Twelve clinical trials with 317 patients were included. A significantly higher incidence of HBV-GN was found in male patients (relative risk = 2.40, 95% CI: 1.98-2.93). Combined therapy reduced the proteinuria significantly with a mean difference of 4.19 (95% CI: 3.86-4.53) and increased the serum albumin concentration significantly with a mean difference of -11.95 (95% CI: -12.97-10.93) without significant alterations of liver function (mean difference: 4.62, 95% CI: -2.55-11.79) and renal function (mean difference: 10.29, 95% CI: 0.14-20.45). No signif icant activation of HBV-DNA replication occurred (mean difference: 0.12, 95% CI: -0.37-0.62). There was no significant difference between the high dose glucorticosteroid group and the low dose glucorticosteroid group in terms of proteinuria remission (P = 0.76) and between different pathological types of HBV-GN [membranous glomerulonephritis (MN) vs mesangial proliferative glomerulonephritis, P = 0.68; MN vs membranoproliferative glomerulonephritis, P = 0.27]. CONCLUSION: Combined antiviral and immunosuppressant therapy can improve the proteinuria in HBVGN patients without altering HBV replication or damaging liver and renal functions.展开更多
The development of modem information technology brings opportunities to vocational English teaching reform. Teachers use the advantages &modem information technology can create a good teaching situation, optimize the...The development of modem information technology brings opportunities to vocational English teaching reform. Teachers use the advantages &modem information technology can create a good teaching situation, optimize the classroom teaching process, cultivate student' s self-learning ability, and improve the effectiveness of vocational English classroom teaching. The purpose of college English teaching is to enable students to master certain basic knowledge and skills in English, with some listening, speaking, reading, writing, translation ability, a simple verbal and written communication in daily activities and foreign business activities. Modem information technology provides a strong tecbaaical support to achieve this goal. Multimedia teaching methods widely used in teaching activities to vocational English class have brought a series of profound changes. Teachers using modem educational teclmology to fully develop learning resources, build new teaching model, which make vocational English classroom full of vigor and vitality.展开更多
This paper examines the role of transformational leadership in transforming an organization into a knowledge based, then into learning organization so that it becomes an innovative company. Important features of the l...This paper examines the role of transformational leadership in transforming an organization into a knowledge based, then into learning organization so that it becomes an innovative company. Important features of the leader such and ability to assist in developing and accommodating the implementation of knowledge management programs, learning organization concepts and innovation protocols are discussed in this paper. This paper demonstrates that shifting the organization to become a knowledge based and then to be learning organization and finally to become innovative company could involve some unique attributes of a transformation leadership. In that regards, the paper also demonstrates that organizations need first to create, capture, transfer, and mobilize knowledge before it can be used for learning and then for innovation. The paper will present a method of a studying how successful innovation leaders of companies could found themselves acting in three roles namely: knowledge leader, learning leader and then innovation leader.展开更多
AIM:To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis.METHODS:The literature on treatment of cholecystitis with traditional Chinese medicines(TCM) was analyzed based o...AIM:To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis.METHODS:The literature on treatment of cholecystitis with traditional Chinese medicines(TCM) was analyzed based on the principles and methods described by evidence-based medicine(EBM).Eight databases including MEDLINE,EMbase,Cochrane Central(CCTR),four Chinese databases(China Biological MedicineDatabase,Chinese National Knowledge Infrastructure Database,Database of Chinese Science and Technology Periodicals,Database of Chinese Ministry of Science and Technology) and Chinese Clinical Registry Center,were searched.Full text articles or abstracts concerning TCM treatment of cholecystitis were selected,categorized according to study design,the strength of evidence,the first author's hospital type,and analyzed statistically.RESULTS:A search of the literature published from 1977 through 2009 yielded 1468 articles in Chinese and 9 in other languages;and 93.92% of the articles focused on clinical studies.No article was of levelⅠevidence,and 9.26% were of level Ⅱ evidence.The literature cited by Science Citation Index(SCI),MEDLINE and core Chinese medical journals accounted for 0.41%,0.68% and 7.29%,respectively.Typically,the articles featured in case reports of illness,examined from the perspective of EBM,were weak in both quality and evidence level,which inconsistently conflicted with the fact that most of the papers were by authors from Level-3 hospitals,the highest possible level evaluated based on their comprehensive quality and academic authenticity in China.CONCLUSION:The published literature on TCM treatment of cholecystitis is of low quality and based on low evidence,and cognitive medicine may functions as a useful supplementary framework for the evaluation.展开更多
AIM: To perform a systematic meta-analysis to in- vestigate the association between X-ray repair crosscomplementing group 1 (XRCC1) polymorphisms and hepatocellular carcinoma (HCC) risk. METHODS: Relevant studie...AIM: To perform a systematic meta-analysis to in- vestigate the association between X-ray repair crosscomplementing group 1 (XRCC1) polymorphisms and hepatocellular carcinoma (HCC) risk. METHODS: Relevant studies extracted from PubMed, Embase, Wanfang, VIP and the Chinese National Knowledge Infrastructure databases up to March 2012 were included in the study. Stata software, version 11.0, was used for the statistical analysis. The odds ratios (ORs) and 95% confidence interval (CI) of the XRCC1 polymorphisms in HCC patients were analyzed and compared with healthy controls. The meta-analysis was performed using fixed-effect or random-effect methods, depending on the absence or presence of significant heterogeneity. RESULTS: Eleven studies with 2075 HCC cases and 2604 controls met our eligibility criteria (four studies, 888 cases and 938 controls for Arg194Trp, four studies, 858 cases and 880 controls for Arg280His, and nine studies, 1845 cases and 2401 controls for Arg399Gln). The meta-analysis revealed no associations between the Arg194Trp and Arg399GIn polymorphisms of the XRCC1 gene and HCC risk under all contrast models (codominant, dominant and recessive models) in the overall analysis and sensitivity analysis (the studies with controls not in the Hardy-Weinberg equilibrium were excluded). For XRCC1 Arg280His polymorphism, the overall analysis revealed the significant associa- tion between the His/His genotype and the increased risk of HCC (His/His vs Arg/Arg model, OR: 1.96, 95% CI: 1.03-3.75, P = 0.04). However, sensitivity analysis showed an altered pattern of result and non-significant association (OR: 2.06, 95% CI: 0.67-6.25, P = 0.20). The heterogeneity hypothesis test did not reveal any heterogeneity, and Begg's and Egger's tests did not find any obvious publication bias. CONCLUSION: The XRCC1 Arg194Trp and Arg399GIn polymorphisms are not associated with HCC risk. More rigorous association studies are needed to verify the involvement ofXRCC1 Arg280His polymorphism in HCC susceptibility.展开更多
Objective To investigate the association between two polymorphisms of follicle stimulating hormone receptor (FSHR) gene and polycystic ovary syndrome (PCOS) susceptibility. Methods Case-control studies on relatio...Objective To investigate the association between two polymorphisms of follicle stimulating hormone receptor (FSHR) gene and polycystic ovary syndrome (PCOS) susceptibility. Methods Case-control studies on relationship of Thr307Ala and Asn680Ser polymorphisms in FSHR gene and PCOS susceptibility were searched from PubMed, ISI web of knowledge, EBSCO, and China National Knowledge Infrastructure (CNKI) databases up to March 21, 2013. The pooled odds ratio (OR) and 95% confidence interval (CO were calculated using fixed- or random-effect model based on heterogeneity test in 5 genotype models analyses. Results A total of 11 studies were included in the Meta-analysis. The random-effect analysis showed Asn680Ser was significantly associated with the reduced susceptibility to PCOS with dominant model (Asn/Asn+Asn/Ser vs. Ser/Ser, OR=0.83, 95% CI: 0.69-1.00), recessive model (Asn/Asn vs. Asn/Ser+ Ser/Ser, OR=0.84, 95% CI: 0.72-0.98), homozygote comparison (Ash/Ash vs. Ser/Ser, 0R=0.79, 95% CI: 0.63-0.98), and the allele contrast (Asn vs. Ser, OR=0.87, 95% CI: 0.79-0.97) respectively(P=0.02, I2=56.0%), being protective factors for PCOS. However, no significant associations were found between Thr307Ala and PCOS. Conclusion There might be a significant association between Asn680Ser polymorphism and PCOS.展开更多
The key issues and challenges facing TEFL teachers in China with respect to prospective teacher preparation and professional development are discussed. Drawing upon earlier research on conceptual frameworks, the knowl...The key issues and challenges facing TEFL teachers in China with respect to prospective teacher preparation and professional development are discussed. Drawing upon earlier research on conceptual frameworks, the knowledge base of pre-service teachers is examined through research into the curriculums in TEFL education across diploma, undergraduate and postgraduate levels. A comparative study of the curriculum structures in the education of TEFL teachers reveals a number of key areas of concern: the main hindrance to the development of a stronger knowledge base of pre-service teachers lies in the serious shortage of pedagogical content knowledge, fundamental pedagogical knowledge that are currently available, as well as with the overall inadequacy of practicum hours. It strongly argues for the breadth versus depth in course design and calls for the imperative to reconceptualize the knowledge base of pre-service teachers.展开更多
In this paper, the authors propose a method that incorporates mechanisms for handling ambiguity in speech and the ability of humans to create associations, and for formulating conversations based on rule base knowledg...In this paper, the authors propose a method that incorporates mechanisms for handling ambiguity in speech and the ability of humans to create associations, and for formulating conversations based on rule base knowledge and common knowledge. Go beyond the level that can be achieved, using only conventional natural language processing and vast repositories of sample patterns. In this paper, the authors propose a method for computer conversation sentences generated using newspaper headlines as an example of how the common knowledge and associative ability are applied.展开更多
The purpose of the present research was to develop an innovative knowledge-based hyper-multimedia to promote a culture of using information and communication Technology (ICT) creatively for adolescents. Their learni...The purpose of the present research was to develop an innovative knowledge-based hyper-multimedia to promote a culture of using information and communication Technology (ICT) creatively for adolescents. Their learning processes and attitudes toward such innovation in their community were also examined. Thirty juveniles, 13-18 years of age in each Hangdong and Maerim districts, Chiang Mai province were employed in the study. Data collections were made through questionnaires, interview, test, group discussion and brainstorming. Analysis and evaluation were carried out with the applications of sufficient economy philosophy, constructivism theory and Torrance's future problem-solving instructional model. Results showed that the learning innovation of hyper-multimedia presented by the use of animation, video, scene and sound with related action script synchronization was considerably effective. With the application of sufficient economy philosophy, the result indicated that performance efficiency (El/E2) was 92.228/9.83 and the adolescents learning processes and attitudes were very good. These included purchasing of moderate ICT equipments, information screening for self-immunity and creative using of internet and ICT morally and ethically according to the computer laws. This independent learning system was properly designed for the juveniles with the right to retrieve the data or stop using at anytime. By using Torrance's approach and constructivism theory emphasizing on brainstorming techniques, it was noted that learning process was very well adopted by the adolescents with high satisfaction. They had good attitudes toward the extension of sufficient ICT cultural using in their community with emphasis on brotherly relationship. Related organizations should educate their parents to instruct the juveniles to use the internet properly and encourage people to be aware of ICT business in order to protect social and cultural problems encountered in the future.展开更多
文摘The concept of research-based social work is introduced and discussed from the point of view of preconditions for its realization. Attention is paid both to the academic research of social work and to opportunities for developing a knowledge-producing social work practice. Both of these are seen as essential elements of a research-based profession. On the one hand, the academic research is necessary for development of social work as a research-based professional system, and on the other hand, a knowledge-producing practice, conducted by research-oriented practitioners, can only be realized within such a system. Historically, social work has been partly developed as a knowledge-applying instead of a knowledge-producing profession, although the central founding pioneers emphasized the importance of an own-knowledge basis and theory formation, as well as the idea of knowledge-producing practice based on a corresponding professional identity. The future of social work as a professional system in modern society may depend decisively on how it develops a research-based professional identity, not only in the sense of academic research but also through practitioners with research orientation. These are practitioners who would be capable of research-based working in terms of creative knowledge production, thus of developing social work as a credible research-based profession. This can be created only through education in which the development of necessary professional skills is linked to advanced academic meta-skills. There are good reasons to suspect that a three-year education is too short for this.
基金Supported by National Natural Science Foundation, No. 81072914Major Project Foundation of National Science and Technology, No. 2010ZX9102-204Traditional Chinese Medicine Research Grant for Military Organization, No. 10ZYZ255
文摘AIM: To investigate the efficacy and safety of combined antiviral and immunosuppressant therapy in adult hepatitis B virus-associated glomerulonephritis (HBVGN) patients. METHODS: A computerized literature search was carried out in the PubMed database, Embase, the Cochrane Library, Chinese BioMedical Literature on disc, Chinese Medical Current Contents, Chinese National Knowledge Infrastructure, Wanfang and VIP (Chinese Technological Journal of Database) to collect articles between June 1980 and December 2010 on therapy with immunosuppressants, e.g., glucorticosteroids, mycophenolate mofetil and leflunomide, combined with antivirals, e.g., interferon, lamivudine, entecavir and adefovir dipivoxil, in adult HBV-GN patients. The primary outcomes were remission of proteinuria, clearanceof HBV e-antigen, and elevation of serum albumin. The secondary outcomes were blood levels of alanine aminotransferase, serum creatinine, and HBV-DNA titer. Meta-analysis was performed using Review Manager 5.1. Fixed or random effect models were employed to combine the results after a heterogeneity test. The effects of the combined therapy were analyzed for different doses of glucorticosteroid and different types of HBV-GN. RESULTS: Twelve clinical trials with 317 patients were included. A significantly higher incidence of HBV-GN was found in male patients (relative risk = 2.40, 95% CI: 1.98-2.93). Combined therapy reduced the proteinuria significantly with a mean difference of 4.19 (95% CI: 3.86-4.53) and increased the serum albumin concentration significantly with a mean difference of -11.95 (95% CI: -12.97-10.93) without significant alterations of liver function (mean difference: 4.62, 95% CI: -2.55-11.79) and renal function (mean difference: 10.29, 95% CI: 0.14-20.45). No signif icant activation of HBV-DNA replication occurred (mean difference: 0.12, 95% CI: -0.37-0.62). There was no significant difference between the high dose glucorticosteroid group and the low dose glucorticosteroid group in terms of proteinuria remission (P = 0.76) and between different pathological types of HBV-GN [membranous glomerulonephritis (MN) vs mesangial proliferative glomerulonephritis, P = 0.68; MN vs membranoproliferative glomerulonephritis, P = 0.27]. CONCLUSION: Combined antiviral and immunosuppressant therapy can improve the proteinuria in HBVGN patients without altering HBV replication or damaging liver and renal functions.
文摘The development of modem information technology brings opportunities to vocational English teaching reform. Teachers use the advantages &modem information technology can create a good teaching situation, optimize the classroom teaching process, cultivate student' s self-learning ability, and improve the effectiveness of vocational English classroom teaching. The purpose of college English teaching is to enable students to master certain basic knowledge and skills in English, with some listening, speaking, reading, writing, translation ability, a simple verbal and written communication in daily activities and foreign business activities. Modem information technology provides a strong tecbaaical support to achieve this goal. Multimedia teaching methods widely used in teaching activities to vocational English class have brought a series of profound changes. Teachers using modem educational teclmology to fully develop learning resources, build new teaching model, which make vocational English classroom full of vigor and vitality.
文摘This paper examines the role of transformational leadership in transforming an organization into a knowledge based, then into learning organization so that it becomes an innovative company. Important features of the leader such and ability to assist in developing and accommodating the implementation of knowledge management programs, learning organization concepts and innovation protocols are discussed in this paper. This paper demonstrates that shifting the organization to become a knowledge based and then to be learning organization and finally to become innovative company could involve some unique attributes of a transformation leadership. In that regards, the paper also demonstrates that organizations need first to create, capture, transfer, and mobilize knowledge before it can be used for learning and then for innovation. The paper will present a method of a studying how successful innovation leaders of companies could found themselves acting in three roles namely: knowledge leader, learning leader and then innovation leader.
文摘AIM:To analyze the literature on the use of Chinese herbal medicines for the treatment of cholecystitis.METHODS:The literature on treatment of cholecystitis with traditional Chinese medicines(TCM) was analyzed based on the principles and methods described by evidence-based medicine(EBM).Eight databases including MEDLINE,EMbase,Cochrane Central(CCTR),four Chinese databases(China Biological MedicineDatabase,Chinese National Knowledge Infrastructure Database,Database of Chinese Science and Technology Periodicals,Database of Chinese Ministry of Science and Technology) and Chinese Clinical Registry Center,were searched.Full text articles or abstracts concerning TCM treatment of cholecystitis were selected,categorized according to study design,the strength of evidence,the first author's hospital type,and analyzed statistically.RESULTS:A search of the literature published from 1977 through 2009 yielded 1468 articles in Chinese and 9 in other languages;and 93.92% of the articles focused on clinical studies.No article was of levelⅠevidence,and 9.26% were of level Ⅱ evidence.The literature cited by Science Citation Index(SCI),MEDLINE and core Chinese medical journals accounted for 0.41%,0.68% and 7.29%,respectively.Typically,the articles featured in case reports of illness,examined from the perspective of EBM,were weak in both quality and evidence level,which inconsistently conflicted with the fact that most of the papers were by authors from Level-3 hospitals,the highest possible level evaluated based on their comprehensive quality and academic authenticity in China.CONCLUSION:The published literature on TCM treatment of cholecystitis is of low quality and based on low evidence,and cognitive medicine may functions as a useful supplementary framework for the evaluation.
基金Supported by International Science and Technology Cooperation Program of the Ministry of Science and Technology,No.010S2012ZR0058the National Basic Research Program of China,No. 2012CB526706+2 种基金the Innovation Program of Shanghai Municipal Education Commission,No.13ZZ060the Fund of Shanghai Municipal Health Bureau,No. 2008Y077the Special Program for Military Medicine,No. 2010JS15
文摘AIM: To perform a systematic meta-analysis to in- vestigate the association between X-ray repair crosscomplementing group 1 (XRCC1) polymorphisms and hepatocellular carcinoma (HCC) risk. METHODS: Relevant studies extracted from PubMed, Embase, Wanfang, VIP and the Chinese National Knowledge Infrastructure databases up to March 2012 were included in the study. Stata software, version 11.0, was used for the statistical analysis. The odds ratios (ORs) and 95% confidence interval (CI) of the XRCC1 polymorphisms in HCC patients were analyzed and compared with healthy controls. The meta-analysis was performed using fixed-effect or random-effect methods, depending on the absence or presence of significant heterogeneity. RESULTS: Eleven studies with 2075 HCC cases and 2604 controls met our eligibility criteria (four studies, 888 cases and 938 controls for Arg194Trp, four studies, 858 cases and 880 controls for Arg280His, and nine studies, 1845 cases and 2401 controls for Arg399Gln). The meta-analysis revealed no associations between the Arg194Trp and Arg399GIn polymorphisms of the XRCC1 gene and HCC risk under all contrast models (codominant, dominant and recessive models) in the overall analysis and sensitivity analysis (the studies with controls not in the Hardy-Weinberg equilibrium were excluded). For XRCC1 Arg280His polymorphism, the overall analysis revealed the significant associa- tion between the His/His genotype and the increased risk of HCC (His/His vs Arg/Arg model, OR: 1.96, 95% CI: 1.03-3.75, P = 0.04). However, sensitivity analysis showed an altered pattern of result and non-significant association (OR: 2.06, 95% CI: 0.67-6.25, P = 0.20). The heterogeneity hypothesis test did not reveal any heterogeneity, and Begg's and Egger's tests did not find any obvious publication bias. CONCLUSION: The XRCC1 Arg194Trp and Arg399GIn polymorphisms are not associated with HCC risk. More rigorous association studies are needed to verify the involvement ofXRCC1 Arg280His polymorphism in HCC susceptibility.
文摘Objective To investigate the association between two polymorphisms of follicle stimulating hormone receptor (FSHR) gene and polycystic ovary syndrome (PCOS) susceptibility. Methods Case-control studies on relationship of Thr307Ala and Asn680Ser polymorphisms in FSHR gene and PCOS susceptibility were searched from PubMed, ISI web of knowledge, EBSCO, and China National Knowledge Infrastructure (CNKI) databases up to March 21, 2013. The pooled odds ratio (OR) and 95% confidence interval (CO were calculated using fixed- or random-effect model based on heterogeneity test in 5 genotype models analyses. Results A total of 11 studies were included in the Meta-analysis. The random-effect analysis showed Asn680Ser was significantly associated with the reduced susceptibility to PCOS with dominant model (Asn/Asn+Asn/Ser vs. Ser/Ser, OR=0.83, 95% CI: 0.69-1.00), recessive model (Asn/Asn vs. Asn/Ser+ Ser/Ser, OR=0.84, 95% CI: 0.72-0.98), homozygote comparison (Ash/Ash vs. Ser/Ser, 0R=0.79, 95% CI: 0.63-0.98), and the allele contrast (Asn vs. Ser, OR=0.87, 95% CI: 0.79-0.97) respectively(P=0.02, I2=56.0%), being protective factors for PCOS. However, no significant associations were found between Thr307Ala and PCOS. Conclusion There might be a significant association between Asn680Ser polymorphism and PCOS.
文摘The key issues and challenges facing TEFL teachers in China with respect to prospective teacher preparation and professional development are discussed. Drawing upon earlier research on conceptual frameworks, the knowledge base of pre-service teachers is examined through research into the curriculums in TEFL education across diploma, undergraduate and postgraduate levels. A comparative study of the curriculum structures in the education of TEFL teachers reveals a number of key areas of concern: the main hindrance to the development of a stronger knowledge base of pre-service teachers lies in the serious shortage of pedagogical content knowledge, fundamental pedagogical knowledge that are currently available, as well as with the overall inadequacy of practicum hours. It strongly argues for the breadth versus depth in course design and calls for the imperative to reconceptualize the knowledge base of pre-service teachers.
文摘In this paper, the authors propose a method that incorporates mechanisms for handling ambiguity in speech and the ability of humans to create associations, and for formulating conversations based on rule base knowledge and common knowledge. Go beyond the level that can be achieved, using only conventional natural language processing and vast repositories of sample patterns. In this paper, the authors propose a method for computer conversation sentences generated using newspaper headlines as an example of how the common knowledge and associative ability are applied.
文摘The purpose of the present research was to develop an innovative knowledge-based hyper-multimedia to promote a culture of using information and communication Technology (ICT) creatively for adolescents. Their learning processes and attitudes toward such innovation in their community were also examined. Thirty juveniles, 13-18 years of age in each Hangdong and Maerim districts, Chiang Mai province were employed in the study. Data collections were made through questionnaires, interview, test, group discussion and brainstorming. Analysis and evaluation were carried out with the applications of sufficient economy philosophy, constructivism theory and Torrance's future problem-solving instructional model. Results showed that the learning innovation of hyper-multimedia presented by the use of animation, video, scene and sound with related action script synchronization was considerably effective. With the application of sufficient economy philosophy, the result indicated that performance efficiency (El/E2) was 92.228/9.83 and the adolescents learning processes and attitudes were very good. These included purchasing of moderate ICT equipments, information screening for self-immunity and creative using of internet and ICT morally and ethically according to the computer laws. This independent learning system was properly designed for the juveniles with the right to retrieve the data or stop using at anytime. By using Torrance's approach and constructivism theory emphasizing on brainstorming techniques, it was noted that learning process was very well adopted by the adolescents with high satisfaction. They had good attitudes toward the extension of sufficient ICT cultural using in their community with emphasis on brotherly relationship. Related organizations should educate their parents to instruct the juveniles to use the internet properly and encourage people to be aware of ICT business in order to protect social and cultural problems encountered in the future.