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复方党参栓剂的制备及含量测定 被引量:6
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作者 毛丹卓 裴元英 《中国临床药学杂志》 CAS 2004年第2期104-105,共2页
目的 :制备复方党参栓剂 (程氏妇康宁栓剂 )及建立测定其总多糖含量的方法。方法 :以新型半合成脂肪酸酯为基质制备阴道栓。通过正交试验优选多糖显色反应条件后采用苯酚 硫酸法测定其总多糖的含量。结果 :方法的标准曲线线性范围 :12 .... 目的 :制备复方党参栓剂 (程氏妇康宁栓剂 )及建立测定其总多糖含量的方法。方法 :以新型半合成脂肪酸酯为基质制备阴道栓。通过正交试验优选多糖显色反应条件后采用苯酚 硫酸法测定其总多糖的含量。结果 :方法的标准曲线线性范围 :12 .0~ 96 .0mg·L-1(r=0 .9991) ,稳定性、重现性、精密度均符合要求 ,加样回收率 98.5 5 % (RSD =2 .94 % )。结论 :建立的苯酚 展开更多
关键词 复方党参栓剂 备方法 含量测定 多糖含量 脂肪酸醋 基质制 阴道栓 慢性宫颈炎 慢性盆腔炎
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中空栓剂的研究概况及应用展望 被引量:9
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作者 缴万里 刘海洋 胡跃民 《天津药学》 2008年第2期70-72,共3页
关键词 中空栓剂 固体 生物利用度 基质制 阴道给药 药理作用 释药速度 给药途径
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关于中药栓剂融变时限检查的建议 被引量:1
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作者 笔雪艳 张清波 《中国药品标准》 CAS 2007年第4期7-8,共2页
关键词 常规检查项目 中药栓剂 融变时限 药材提取物 固体 腔道给药 适宜温度 基质制
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Conversion of Bio-syngas to Liquid Hydrocarbon over CuCoMn-Zeolite Bifunctional Catalysts 被引量:1
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作者 张朝霞 毕培燕 +1 位作者 姜沛汶 李全新 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2014年第5期573-581,I0004,共10页
A series of bifunctional catalysts composed of a component for higher alcohol synthesis (Cu-CoMn oxides, CCM) and an acidic zeolite (SAPO-34, ZSM-5, Y, MCM-41) were prepared for production of liquid hydrocarbon di... A series of bifunctional catalysts composed of a component for higher alcohol synthesis (Cu-CoMn oxides, CCM) and an acidic zeolite (SAPO-34, ZSM-5, Y, MCM-41) were prepared for production of liquid hydrocarbon directly from a bio-syngas through a one-stage pro-cess. The effects of zeolite type, zeolite content, Si/Al ratio and preparation method on catalyst texture and its reaction performance were investigated. Higher selectivities and yields of liquid products were obtained by using bifunctional catalysts. The yields of liquid hydrocarbons decreased in the order CCM-ZSM-5〉CCM-SAPO-34〉CCM-Y〉CCM-MCM-41. CCM-ZSM-5 (20wt%, Si/Al=100) prepared by coprecipitation method displayed the optimal catalytic performance with the highest CO conversion (76%) and yield of liquid products (30%). The catalysts were characterized by N2 adsorption/desorption, NH3-TPD, XRD, and H2-TPR analysis. The results showed that higher speci c surface areas and pore volumes of bifunctional catalysts were achieved by adding zeolites into CuCoMn precursors. Medium pore dimension and moderate acidity in CCM-ZSM-5 were observed, which proba-bly resulted in its excellent reaction performance. Additionally, a higher number of weaker acid sites (weak and/or medium acid sites) were formed by increasing ZSM-5 content in CCM-ZSM-5 or decreasing Si/Al ratio in ZSM-5. It was also seen that metal dispersion was higher and reducibility of metal ions was easier on the CCM-ZSM-5 catalyst prepared by coprecipitation. The higher alcohols-to-hydrocarbon process provides a promising route to hydrocarbon fuels via higher alcohols from syngas or biobased feedstocks. 展开更多
关键词 BIFUNCTIONAL CuCoMn-zeolite Higher alcohols-to-hydrocarbon process Bio-syngas conversion Liquid hydrocarbon synthesis
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Overexpression and mutations of tumor suppressor gene p53 in hepatocellular carcinoma
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作者 王东 史景泉 《World Journal of Gastroenterology》 SCIE CAS CSCD 1996年第3期161-164,共4页
AIMS To examine the prevalance of p53 mutations in hepatocellular carcinoma (HCC) from Chongqing area and the relationship between the p53 mutations and clinicopathological features of HCC,as well as the risk factors.... AIMS To examine the prevalance of p53 mutations in hepatocellular carcinoma (HCC) from Chongqing area and the relationship between the p53 mutations and clinicopathological features of HCC,as well as the risk factors. METHODS The overexpression and point mutations of tumor suppressor gene p53 in 38 cases of HCC were detected by a sensitive antigen retrieval fluid (ARF) immunohistochemical method and polymerase chain re- action(PCR)-restriction fragment length polymorphism (RFLP),and single strand conformation polymorphism (SSCP)-silver staining analysis. RESULTS The results showed that 16 of 38 HCCs had positive p53 protein (42.1%),7 HCCs had p53 mutation at 249 (18.4 % ) and 2 HCCS had point muta- tion within exon 7 other than 249. Among 9 cases of HCC with mutations,8 cases demonstrated positive p53 protein,its coincidental rate was 88.9%. The overexpression and mutations of p53 were significantly related to the differentiation and metastasis of HCCs. The frequency of p53 mutations was consistent with high prevalence of HBV and a moderate aflatoxin B1 (AFB1) exposure in our area. CONCLUSIONS The results suggest that AFB1 acts synergistically with HBV in the generation of p53 mutations. Furthermore,dietary exposure to AFB1 may mainly contribute to the tumor specific mutation at codon 249,while HBV may account for other scattered mutations in HCC. 展开更多
关键词 liver neoplasms GENES SUPPRESSOR tumor protein p53 point mutation
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Synchronous occurrence of gastrointestinal stromal tumors and other primary gastrointestinal neoplasms 被引量:14
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作者 Marek Wronski Bogna Ziarkiewicz-Wroblewska +4 位作者 Barbara Gornicka Wlodzimierz Cebulski Maciej Slodkowski Aleksander Wasiutynski Ireneusz W Krasnodebski 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第33期5360-5362,共3页
AIM: To review clinical and pathologic features of Gastrointestinal strornal tumors (GISTs) occurring synchronously with other primary gastrointestinal neoplasms. METHODS: 28 patients with primary GIST were treate... AIM: To review clinical and pathologic features of Gastrointestinal strornal tumors (GISTs) occurring synchronously with other primary gastrointestinal neoplasms. METHODS: 28 patients with primary GIST were treated at our institution between 1989 and 2005. Clinical and pathologic records were reviewed. RESULTS: The gastrointestinal stromal tumor occurred simultaneously with other primary GI malignancies in 14% of all patients with GIST. The synchronous stromal tumors were located in the stomach and were incidentally found during the operation. The coexistent neoplasms were colon adenocarcinoma, gastric cancer (2 cases) and gastric lymphoma. CONCLUSION: The synchronous occurrence of GISTs and other gastrointestinal malignancies is more common than it has been considered. The development of gastrointestinal stromal tumors and other neoplasms may involve the same carcinogenic agents. 展开更多
关键词 Gastrointestinal stromal tumors Synchronousneoplasms
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Nectin-like Molecule 1 Inhibits the Migration and Invasion of U251 Glioma Cells by Regulating the Expression of An Extracellular Matrix Protein Osteopontin 被引量:2
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作者 Bin Yin Ke-han Li Tai An Tao Chen Xiao-zhong Peng 《Chinese Medical Sciences Journal》 CAS CSCD 2010年第2期100-104,共5页
Objective To investigate the molecular mechanism of nectin-like molecule 1(NECL1) inhibiting the migration and invasion of U251 glioma cells.Methods We infected U251 glioma cells with adeno-nectin-like molecule 1(Ad-N... Objective To investigate the molecular mechanism of nectin-like molecule 1(NECL1) inhibiting the migration and invasion of U251 glioma cells.Methods We infected U251 glioma cells with adeno-nectin-like molecule 1(Ad-NECL1) or empty adenovirus(Ad).Transwell and wound healing assays were performed to observe the migration of U251 cells incubated with the cell supernatant from Ad-NECL1 or Ad infected U251 cells.DNA microarray was applied to screen the gene expression profile after the restoration of NECL1 in U251 glioma cell lines.The differential expression of osteopontin(OPN),a gene related to migration and invasion,was further analyzed with semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR),Western blot,and immunohistochemistry.Results The restoration of NECL1 inhibited migration of U251 cells significantly(P<0.05).Altogether 195 genes were found differentially expressed by microarray,in which 175 were up-regulated and 20 down-regulated,including 9 extracellular matrix proteins involved in the migration of cells.Both mRNA and protein expressions of OPN,the most markedly reduced extracellular matrix protein,were found decreased in U251 cells after restoration of NECL1.Immunohistochemical assay also detected an increase of OPN in glioma tissues,related with the progressing of malignant grade.Conclusion A link might exist between NECL1 and the extracellular matrix protein OPN in inhibiting the migration and invasion of U251 glioma cells. 展开更多
关键词 nectin-like molecule 1 glioma cell line extracellular matrix protein OSTEOPONTIN
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Cellular and molecular mechanisms of intestinal fibrosis 被引量:34
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作者 Silvia Speca Ilaria Giusti +1 位作者 Florian Rieder Giovanni Latella 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第28期3635-3661,共27页
Fibrosis is a chronic and progressive process characterized by an excessive accumulation of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue. Intestinal fibrosis may develop in s... Fibrosis is a chronic and progressive process characterized by an excessive accumulation of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue. Intestinal fibrosis may develop in several different enteropathies, including inflammatory bowel disease. It develops through complex cell, extracellular matrix, cytokine and growth factor interactions. Distinct cell types are involved in intestinal fibrosis, such as resident mesenchymal cells (fibroblasts, myofibroblasts and smooth muscle cells) but also ECM-producing cells derived from epithelial and endothelial cells (through a process termed epithelialand endothelial-mesenchymal transition), stellate cells, pericytes, local or bone marrow-derived stem cells. The most important soluble factors that regulate the activation of these cells include cytokines, chemokines, growth factors, components of the renin-angiotensin system, angiogenic factors, peroxisome proliferator-activated receptors, mammalian target of rapamycin, and products of oxidative stress. It soon becomes clear that although inflammation is responsible for triggering the onset of the fibrotic proc-ess, it only plays a minor role in the progression of this condition, as fibrosis may advance in a self-perpetuating fashion. Definition of the cellular and molecular mechanisms involved in intestinal fibrosis may provide the key to developing new therapeutic approaches. 展开更多
关键词 Inflammatory bowel disease Intestinal fibrosis Extracellular matrix Molecular mediators MYOFIBROBLASTS Inflammatory cells Epithelial cells Mesenchymal cells Endothelial cells
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Functional Analyses of Mammalian Reovirus Nonstructural Protein μNS 被引量:2
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作者 Chao FAN Qin FANG 《Virologica Sinica》 SCIE CAS CSCD 2009年第1期1-8,共8页
Genome replication of reovirus occurs in cytoplasmic inclusion bodies called viral factories or viroplasms. The viral nonstructural protein uNS, encoded by genome segment M3, is not a component of mature virions, but ... Genome replication of reovirus occurs in cytoplasmic inclusion bodies called viral factories or viroplasms. The viral nonstructural protein uNS, encoded by genome segment M3, is not a component of mature virions, but is expressed to high levels in infected cells and is concentrated in the infected cell factory matrix. Recent studies have demonstrated that uNS plays a central role in forming the matrix of these structures, as well as in recruiting other components to them for putative roles in genome replication and particle assembly. 展开更多
关键词 dsRNA virus Mammalian orthoreoviruses Nonstructural protein uNS
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Factors associated with irritable bowel syndrome symptoms in hemodialysis patients 被引量:5
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作者 Bartosz Fiderkiewicz Alicja Rydzewska-Rosoowska +4 位作者 Micha Myliwiec Magdalena Birecka Bozenna Kaczanowska Grazyna Rydzewska Andrzej Rydzewski 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第15期1976-1981,共6页
AIM: To investigate clinical characteristics associated with the presence of irritable bowel syndrome (IBS) symptoms in hemodialysis (HD) patients.METHODS: This was a cross-sectional study. A questionnaire based on th... AIM: To investigate clinical characteristics associated with the presence of irritable bowel syndrome (IBS) symptoms in hemodialysis (HD) patients.METHODS: This was a cross-sectional study. A questionnaire based on the Bowel Disease Questionnaire that records gastrointestinal symptoms was given to 294 patients in 4 dialysis centers. A total of 196 (67%) subjects returned the survey. A multivariable logistic regression model was used to identify factors significantly associated with IBS symptoms. RESULTS: Symptoms compatible with IBS were present in 27 (13.8%) subjects and independently associated with low post-dialysis serum potassium [OR = 0.258, 95% CI (0.075-0.891), P = 0.032], paracetamol use [OR = 3.159, 95% CI (1.214-8.220), P = 0.018], and Kidney Disease Quality of Life (KDQOL) cognitive function score [OR = 0.977, 95% CI (0.956-0.999), P = 0.042]. Univariate regressions were also performed and the reported significance is for multivariate analysis. No association was detected for age, gender, depressed mood, smoking (present or past), body mass index, albumin level, Kt/V, sodium preor post-dialysis level, change in potassium level during HD, proton pump inhibitor or H2 blocker use, aspirin use, residual diuresis, hepatitis B or C infection, diabetes mellitus, marital status and education level. CONCLUSION: This study examined potential risk factors for symptoms compatible with IBS in HD patients and identified an association with paracetamol use, post-dialysis potassium level and KDQOL-cognitive function score. 展开更多
关键词 HEMODIALYSIS Irritable bowel syndrome Risk factors
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A Case Study of Using External DEM in InSAR DEM Generation 被引量:5
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作者 ZHOUChunxia GELinlin +1 位作者 EDongchen CHANGHsingchung 《Geo-Spatial Information Science》 2005年第1期14-18,共5页
Synthetic aperture radar interferometry (InSAR) has been used as an innovative technique for digital elevation model (DEM) and topographic map generation. In this paper, external DEMs are used for InSAR DEM generation... Synthetic aperture radar interferometry (InSAR) has been used as an innovative technique for digital elevation model (DEM) and topographic map generation. In this paper, external DEMs are used for InSAR DEM generation to reduce the errors in data processing. The DEMs generated from repeat-pass InSAR are compared. For steep slopes and severe changes in topography, phase unwrapping quality can be improved by subtracting the phase calculated from an external DEM. It is affirmative that the absolute height accuracy of the InSAR DEM is improved by using external DEM. The data processing was undertaken without the use of ground control points and other manual operation. 展开更多
关键词 INSAR digital elevation model (DEM) external DEM
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Perforation of the colon by invading recurrent gastrointestinal stromal tumors during sunitinib treatment 被引量:4
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作者 Hoon Hur Ae Ryoung Park +3 位作者 Sung Bae Jee Seung Eun Jung Wook Kim Hae Myung Jeon 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第39期6096-6099,共4页
The molecular targets of sunitinib are receptor tyrosine kinases (RTKs),and this drug has also been known to exert blocking effects on the activation of KIT,which is similar to the mechanism of action of imatinib. Mor... The molecular targets of sunitinib are receptor tyrosine kinases (RTKs),and this drug has also been known to exert blocking effects on the activation of KIT,which is similar to the mechanism of action of imatinib. Moreover,sunitinib has an additional anti-angiogenic effect through its inhibition of the vascular endothelial growth factor receptor activation. We report here a 70-year-old patient diagnosed with a recurrent gastrointestinal stromal tumor (GIST),which invaded the transverse colon and led to a perforation during sunitinib treatment. A computed tomography scan and 3-dimensional reconstruction showed necrosis of the recurrent hepatic mass and perforation of the invaded transverse colon. After percutaneous drainage of the intraperitoneal abscess,antibiotic treatment and restricted diet,the condition of the patient improved. The present case is the first to report that sunitinib,which is administered to treat GIST resistant to imatinib,can cause unexpected colon perforation and subsequent peritonitis. 展开更多
关键词 Gastrointestinal stromal tumors RECURRENCE SUNITINIB Intestinal perforation
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Methyl-CpG binding proteins in the nervous system 被引量:7
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作者 Leah HUTNICK 《Cell Research》 SCIE CAS CSCD 2005年第4期255-261,共7页
Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain(MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional re... Classical methyl-CpG binding proteins contain the conserved DNA binding motif methyl-cytosine binding domain(MBD), which preferentially binds to methylated CpG dinucleotides. These proteins serve as transcriptional repressors,mediating gene silencing via DNA cytosine methylation. Mutations in methyl-CpG binding protein 2 (MeCP2) have beenlinked to the human mental retardation disorder Rett syndrome, suggesting an important role for methyl-CpG bindingproteins in brain development and function. This mini-review summarizes the recent advances in studying the diversefunctions of MeCP2 as a prototype for other methyl-CpG binding proteins in the development and function of thevertebrate nervous system. 展开更多
关键词 MECP2 MBD proteins DNA methylation neuronal differentiation chromatin remodeling gene silencing histone modification.
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Preparation of new tissue engineering bone-CPC/PLGA composite and its application in animal bone defects 被引量:3
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作者 郑治 王剑龙 +4 位作者 米雷 刘咏 侯光辉 陈旦 黄伯云 《Journal of Central South University》 SCIE EI CAS 2010年第2期202-210,共9页
To investigate the feasibility of implanting the biocomposite of calcium phosphate cement(CPC)/polylactic acid-polyglycolic acid(PLGA) into animals for bone defects repairing,the biocomposite of CPC/PLGA was prepared ... To investigate the feasibility of implanting the biocomposite of calcium phosphate cement(CPC)/polylactic acid-polyglycolic acid(PLGA) into animals for bone defects repairing,the biocomposite of CPC/PLGA was prepared and its setting time,compressive strength,elastic modulus,pH values,phase composition of the samples,degradability and biocompatibility in vitro were tested.The above-mentioned composite implanted with bone marrow stromal cells was used to repair defects of the radius in rabbits.Osteogenesis was histomorphologically observed by using an electron-microscope.The results show that compared with the CPC,the physical and chemical properties of CPC/PLGA composite have some differences in which CPC/PLGA composite has better biological properties.The CPC/PLGA composite combined with seed cells is superior to the control in terms of the amount of new bones formed after CPC/PLGA composite is implanted into the rabbits,as well as the speed of repairing bone defects.The results suggest that the constructed CPC/PLGA composite basically meets the requirements of tissue engineering scaffold materials and that the CPC/PLGA composite implanted with bone marrow stromal cells may be a new artificial bone material for repairing bone defects because it can promote the growth of bone tissues. 展开更多
关键词 BIOMATERIALS mesenchymal stem cells (MSCs) calcium phosphate cement (CPC) polylactic acid-polyglycolic acid (PLGA) bone defects
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Gas Chromatography-Based Fingerprinting and Chemical Pattern Recognition of Rosa multiflora Volatile Oil
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作者 Tuniyazi Gulimeikereyi Ablajan Nurpida +1 位作者 Malike Dilinuer Hailaxi Alai 《Journal of Agricultural Science and Technology(A)》 2017年第1期31-38,共8页
In this paper, gas chromatography-mass spectrometry (GS-MS) was used to build the standard fingerprint of volatile oil from Rosa multiflora Thunb. from 12 different habitats. Fourteen components in the volatile oil ... In this paper, gas chromatography-mass spectrometry (GS-MS) was used to build the standard fingerprint of volatile oil from Rosa multiflora Thunb. from 12 different habitats. Fourteen components in the volatile oil were identified as the indicator components ofR. multiflora, of which one was selected as the standard. The GC analysis conditions used for fingerprinting afford a very good separating effect. The similarity of the 12 volatile oils from R. multiflora Thunb. was more than 0.84, and the precision, stability and repeatability of the fingerprints were quite good. It could be concluded that the fingerprints can be used as the standard and as a quality control method for medicinal materials from R. multiflora Thunb.. 展开更多
关键词 Rosa multiflora volatile oil GC-MS fingerprinting main component.
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Matrix metalloproteinase-9 contributes to parenchymal hemorrhage and necrosis in the remnant liver after extended hepatectomy in mice 被引量:3
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作者 Norifumi Ohashi Tomohide Hori +5 位作者 Florence Chen Sura Jermanus Christopher B Eckman Akimasa Nakao Shinji Uemoto Justin H Nguyen 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第19期2320-2333,共14页
AIM: To investigate the effect of matrix metallopro- teinase-9 (MMP-9) on the remnant liver after massivehepatectomy in the mouse.METHODS: Age-matched, C57BL/6 wild-type (WT), MMP-9(-/-), and tissue inhibitors... AIM: To investigate the effect of matrix metallopro- teinase-9 (MMP-9) on the remnant liver after massivehepatectomy in the mouse.METHODS: Age-matched, C57BL/6 wild-type (WT), MMP-9(-/-), and tissue inhibitors of metalloprotein- ases (TIMP)-1(-/-) mice were used. The mice received 80%-partial hepatectomy (PH). Samples were obtained at 6 h after 80%-PH, and we used histology, immuno- histochemical staining, western blotting analysis and zymography to investigate the effect of PH on MMP-9. The role of MMP-9 after PH was investigated using a monoclonal antibody and MMP inhibitor.RESULTS: We examined the remnant liver 6 h after 80%-PH and found that MMP-9 deficiency attenuated the formation of hemorrhage and necrosis. There were significantly fewer and smaller hemorrhagic and ne- crotic lesions in MMP-9(-/-) remnant livers compared with WT and TIMP-1(-/-) livers (P 〈 0.01), with no dif- ference between WT and TIMP-1(-/-) mice. Serum ala- nine aminotransaminase levels were significantly lower in MMP-9(-/-) mice compared with those in TIMP-I(-/-) mice (WT: 476± 83 IU/L, MMP-9(-/-): 392 ± 30 IU/L, TIMP-I(-/-): 673 ± 73 IU/L, P 〈 0.01). Western blot- ting and gelatin zymography demonstrated a lack of MMP-9 expression and activity in MMP-9(-/-) mice, which was in contrast to WT and TIMP-1(-/-) mice. No change in MMP-2 expression was observed in any of the study groups. Similar to MMP-9(-/-) mice, when WT mice were treated with MMP-9 monoclonal antibody or the synthetic inhibitor GM6001, hemorrhagic and necrotic lesions were significantly smaller and fewer than in control mice (P 〈 0.05). These results suggest that MMP-9 plays an important role in the development of parenchymal hemorrhage and necrosis in the small remnant liver.CONCLUSION: Successful MMP-9 inhibition attenuates the formation of hemorrhage and necrosis and mightbe a potential therapy to ameliorate liver injury after massive hepatectomy. 展开更多
关键词 Matrix metalloproteinase Liver remnant HEPATECTOMY Liver failure NECROSIS
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Enhanced Field Emission from Printed Carbon Nanotubes by Hard Hairbrush 被引量:2
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作者 邹儒佳 詹亚歌 +1 位作者 刘洋 薛绍林 《Journal of Donghua University(English Edition)》 EI CAS 2008年第6期612-615,共4页
A method, the morphology of screen printed carbon nanotube pastes is modified using a hard hairbrush, is presented. In this way, the organic matrix material is preferentially removed. Compared to those untreated films... A method, the morphology of screen printed carbon nanotube pastes is modified using a hard hairbrush, is presented. In this way, the organic matrix material is preferentially removed. Compared to those untreated films, the turn-on electric field of the treated film decreases from 2.2V/μm to 1.6V/μm, while the total emission current of the treated increases from 0.6mA/cm2 to 3mA/cm2, and uniform emission site density image has also been observed. 展开更多
关键词 carbon nanotube screen printing hard hairbrush field emission
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Prediction model of slurry pH based on mechanism and error compensation for mineral flotation process 被引量:1
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作者 Xiaoli Wang Lei Huang Chunhua Yang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2018年第8期1766-1772,共7页
A suitable pH value of the slurry is a key to efficient mineral flotation. Considering the control delay problem of pH value caused by offline pH measurement, an integrated prediction model for pH value in bauxite fro... A suitable pH value of the slurry is a key to efficient mineral flotation. Considering the control delay problem of pH value caused by offline pH measurement, an integrated prediction model for pH value in bauxite froth flotation is proposed, which considers the effect of ore compositions on pH value. Firstly, a regression model is obtained for alkali(Na_2CO_3) consumed by the reaction between ore and alkali. According to the first-order hydrolysis of the remaining alkali, a mechanism-based prediction model is presented for the pH value. Then, considering the complexity of the flotation mechanism, an error prediction model which uses time series of the error of the mechanism model as inputs is presented based on autoregressive moving average(ARMA) method to compensate the mechanism model. Finally, expert rules are established to correct the error compensation direction, which could reflect the dynamic changes during the process accurately and effectively. Simulation results using industrial data show that the presented model meets the needs of the industrial process, which laid the foundation for predictive control of pH regulator. 展开更多
关键词 Froth flotation PH value prediction HYDROLYSIS Mechanism model ARMA Expert rule
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How regenerative medicine and tissue engineering may complement the available armamentarium in gastroenterology? 被引量:2
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作者 Marco Carbone Jan Lerut James Neuberger 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第47期6908-6917,共10页
The increasing shortage of donors and the adverse effects of immunosuppression have restricted the impact of solid organ transplantation.Despite the initial promising developments in xenotransplantation,roadblocks sti... The increasing shortage of donors and the adverse effects of immunosuppression have restricted the impact of solid organ transplantation.Despite the initial promising developments in xenotransplantation,roadblocks still need to be overcome and this form of organ support remains a long way from clinical practice.While hepatocyte transplantation may be effectively correct metabolic defects,it is far less effective in restoring liver function than liver transplantation.Tissue engineering,using extracellular matrix scaffolds with an intact but decellularized vascular network that is repopulated with autologous or allogeneic stem cells and/or adult cells,holds great promise for the treatment of failure of organs within gastrointestinal tract,such as endstage liver disease,pancreatic insufficiency,bowel failure and type 1 diabetes.Particularly in the liver field,where there is a significant mortality of patients awaiting transplant,human bioengineering may offer a source of readily available organs for transplantation.The use of autologous cells will mitigate the need for long term immunosuppression thus removing a major hurdle in transplantation. 展开更多
关键词 Regenerative medicine Tissue engineering Organ transplantation Cellular transplantation XENOTRANSPLANTATION
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Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer 被引量:10
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作者 Ozgur Kemik Ahu Sarbay Kemik +9 位作者 Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第16期2109-2112,共4页
AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gast... AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer. 展开更多
关键词 Gastric cancer Matrix metalloproteinase-1 Tissue matrix metalloproteinase-1
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