A mesoporous silica/gold （MSN/Au） nanocomposite was designed for photo- controlled drug delivery targeted specifically at tumor cells. The MSN/Au nanocomposite was composed of MSN-based drug carriers and gold nanopa...A mesoporous silica/gold （MSN/Au） nanocomposite was designed for photo- controlled drug delivery targeted specifically at tumor cells. The MSN/Au nanocomposite was composed of MSN-based drug carriers and gold nanoparticle （AuNP）-based indicators. While the MSN-based drug carrier was a mesoporous silica nanoparticle immobilized with photo-switchable azobenzene （Azo） moieties, the AuNP-based indicator was a fluorescence-quenched AuNP modified with a matrix metalloproteinase （MMP） substrate and poly（ethylene glycol）. The two kinds of nanoparticles were connected by an α,β cyclodextrin （α,β CD） dimer ＂bridge.＂ In vitro studies demonstrated that the nanocomposite specifically interacted with tumor sites overexpressing MMP-2, which enabled guidance of the subsequent UV light irradiation for releasing entrapped drugs. Through integration of the AuNP-based indicator and the MSN-based drug carrier, the MSN/Au nanocomposite could precisely localize the released drug to tumor sites, thereby significantly improving therapeutic efficacy.展开更多
基金This work was financially supported by the National Natural Science Foundation of China （Nos. 51125014 and 51233003）, National Basic Research Program of China （No. 2011CB606202）, the Ministry of Education of China （No. 20120141130003）, and Fundamental Research Funds for the Central Universities of China （Nos. 2014203020201 and 2014203020204）.
文摘A mesoporous silica/gold （MSN/Au） nanocomposite was designed for photo- controlled drug delivery targeted specifically at tumor cells. The MSN/Au nanocomposite was composed of MSN-based drug carriers and gold nanoparticle （AuNP）-based indicators. While the MSN-based drug carrier was a mesoporous silica nanoparticle immobilized with photo-switchable azobenzene （Azo） moieties, the AuNP-based indicator was a fluorescence-quenched AuNP modified with a matrix metalloproteinase （MMP） substrate and poly（ethylene glycol）. The two kinds of nanoparticles were connected by an α,β cyclodextrin （α,β CD） dimer ＂bridge.＂ In vitro studies demonstrated that the nanocomposite specifically interacted with tumor sites overexpressing MMP-2, which enabled guidance of the subsequent UV light irradiation for releasing entrapped drugs. Through integration of the AuNP-based indicator and the MSN-based drug carrier, the MSN/Au nanocomposite could precisely localize the released drug to tumor sites, thereby significantly improving therapeutic efficacy.
