The outbreak of oxidative stress, inflammatory diseases and mycoses, constitute an important public health problem. This could be due to the increase of risk factors, side effects and expensive therapeutic molecules a...The outbreak of oxidative stress, inflammatory diseases and mycoses, constitute an important public health problem. This could be due to the increase of risk factors, side effects and expensive therapeutic molecules available. In the aim to find the potential spring of new therapeutic molecules with efficient and wide spectrum of action, the antiradical, anti-inflammatory and antifungal activities of two essential oils were evaluated. The essential oils were extracted by hydrodistillation. The antiradical activity was evaluated to use DPPH （2,2-diphenyl-l-picrylhydrazyl） scavenging method and the anti-inflammatory activity was determined using the enzymatic method. The disc diffusion and dilution methods were used to evaluate growth inhibition of three yeasts, three moulds and three dermatophytes. The yields of extraction of Apium graveolens and Thymus vulgaris essential oils were 0.14% and 0.32% respectively. These essential oils showed antiradical properties with respective SC50 of 0.41 and 0.06 g/L for Apium graveolens and Thymus vulgaris. Only Thymus vulgaris presented an anti-inflammatory activity with an IC50 of 0.19 g/L. Cryptococcus neoformans was the most susceptible fungal strain while C. albicans was the most resistant one. The results were compared with the standard antifungal. These results show that these essential oils could be exploited as potential spring of molecules endowed with antiradical, anti-inflammatory and antifungal activities.展开更多
文摘The outbreak of oxidative stress, inflammatory diseases and mycoses, constitute an important public health problem. This could be due to the increase of risk factors, side effects and expensive therapeutic molecules available. In the aim to find the potential spring of new therapeutic molecules with efficient and wide spectrum of action, the antiradical, anti-inflammatory and antifungal activities of two essential oils were evaluated. The essential oils were extracted by hydrodistillation. The antiradical activity was evaluated to use DPPH （2,2-diphenyl-l-picrylhydrazyl） scavenging method and the anti-inflammatory activity was determined using the enzymatic method. The disc diffusion and dilution methods were used to evaluate growth inhibition of three yeasts, three moulds and three dermatophytes. The yields of extraction of Apium graveolens and Thymus vulgaris essential oils were 0.14% and 0.32% respectively. These essential oils showed antiradical properties with respective SC50 of 0.41 and 0.06 g/L for Apium graveolens and Thymus vulgaris. Only Thymus vulgaris presented an anti-inflammatory activity with an IC50 of 0.19 g/L. Cryptococcus neoformans was the most susceptible fungal strain while C. albicans was the most resistant one. The results were compared with the standard antifungal. These results show that these essential oils could be exploited as potential spring of molecules endowed with antiradical, anti-inflammatory and antifungal activities.
