从读心到塑心

塑心论可以分成激进阵营和温和阵营:激进阵营秉持塑心(mindshaping)首位论题(primacy thesis),认为读心(mindreading)是塑心的派生物。温和阵营主张塑心与读心构成合作关系。对这两个阵营的分析与批判可以发现,塑心既不能成为“他心操作”的基础,也不能与读心构成合作关系。在解构塑心论的基础上,表明塑心只能在以读心为根基搭建起的理论大厦下,即读心论框架下,寻找一席之地:塑心既是读心的语境,也是读心的作用。当前,围绕读心的研究多集中于读心机制和读心能力测量,但关于读心的全面探讨还须包括读心语境和读心作用。对塑心地位的澄清,有助于开启读心语境和读心作用研究。

冠心病院外延伸健康管理新模式构建:塑心学堂

冠心病是危害人类生命健康的重大疾病,严重影响病人的身心健康。近年来冠心病院外延伸健康管理受到医护人员的高度重视,广东省中医院冠心病公益学校《塑心学堂》创新引进“学校模式”管理,是一种新型的院外延伸健康管理模式,为冠心病院外延伸健康管理提供了新视野。

思政塑心 美育赋能——图像处理课程“德美融教”设计与实施刍议

课程思政是重要的教育理念,其本质目标是立德树人,是授业解惑与育人育才的有机结合。审美教育的核心是情感教育,它以其特有的审美情感机制引发情感共鸣,引导学生发现美、欣赏美,激发其探求兴趣和创造潜能,从而感受审美愉悦,形成完整人格,实现道德内化。课程思政、审美教育与专业技能学习的融合,不但可以完成学科理论知识、人文价值观念、精神追求、品格塑造等方面的解读和认知,还会对学生的思想、行为、素质、格调产生潜移默化的影响。以“德”立身、立学;以“美”融教、赋能,是促进教育高质量发展的重要举措。

南华小学“心字塑人”课程开发与思考

南华小学为了培养孩予们良好的品德,通过开展＂启于书,博于文,约于礼,游于艺,成于德＂的育人活动,在＂心字塑人＂的育人路上不断开拓,从小让孩子把自己个性得到正能量的体现,培养孩子一种严谨的作风,不但在写字上是这样,在学习上,在生活上都会潜移默化的影响。

新时代做好班主任工作的四个“关键词”

文章借助四句古诗词提炼出新时代的班主任工作的四个要点:“化作春泥更护花”,启发班主任要牢牢抓住做好班级工作的法宝——爱心;“一片冰心在玉壶”,启发班主任要善于培育班级精神和学生的自我精神——塑心;“同在一船和谐处”,启发班主任要充分发挥集体的聪明才智——聚力;“淡妆浓抹总相宜”,启发班主任要善于掌握火候、把握分寸,追求工作的最佳成效——适度。

试论新时期中国体育的发展方向——“人文体育”

本文对大众体育与人文体育的内涵及其相互关系加以分析,总结出随着人民大众的价值观念和生活理想的转变,体育功能也发生了相应的变化。“塑心育人”的体育人文价值被逐渐认识和开发,进而成为广大人民群众精神追求和价值追求的一项重要内容。从大众体育可持续发展的视角出发,旨在揭示新时期的中国体育将是“以人为本”的体育。构建新的体育理念。

社会转型期中国大众体育的发展方向

当前中国正处在经济转轨和社会转型的历史性变革时期,在这个特殊的过渡时期,人民大众的价值观念与生活理想有了很大的转变,人们对健康的关注程度较以前有了很大的提高。作为一种特殊的社会文化活动,体育已经远远超越了强身健体的功能范畴,取而代之的是“塑人育心”和储积精力的功能。体育的人文价值被逐渐认识和开发,进而成为人们精神追求和价值追求的一项重要内容。

让中华优秀传统文化走进中职校园

中华传统文化博大精深,源远流长,是中华民族的 精神根基。让中华优秀传统文化走进校园是当前推动文化传 承的有效途径之一,也是全社会的共识。所以如何让优秀传统 文化真正融入学生的生活和思想,成为广大中职教师开展思想 道德教育的重点。本文以中职校园文化建设为切入点,从让优 秀传统文化走进课堂、开展文化活动、创造良好的校园环境等 几个方面展开深入探究,以促进中华优秀传统文化更好更快地 走进校园。

Endoscopic management of occluded biliary uncovered metal stents:A multicenter experience

AIM:To compare diverse endoscopic interventions in the management of occluded uncovered self-expanding metal stents(SEMSs) that had been placed for palliative treatment of unresectable malignant biliary obstruction.METHODS:A retrospective review was undertaken in 4 tertiary endoscopic centers to determine optimal management of different types of occluded SEMSs.The technical success of performed treatment in occluded SEMSs,the patency of the stent,the need for re-intervention and the financial costs of each treatment were analyzed.RESULTS:Fifty four patients were included in the analysis;21 received Hanaro,19 Wallstent and 14 Flexus.For the relief of obstruction,a plastic stent was inserted in 24 patients,a second SEMS in 25 and mechanical cleaning was performed in 5 patients.The overall median second patency rates between second SEMSs and plastic stents did not differ(133 d for SEMSs vs 106 d for plastic stents;P = 0.856).Similarly,no difference was found between the overall survival of SEMS and plastic stent groups,and no procedure-related complications occurred.Incremental cost analysis showed that successive plastic stenting was a cost-saving strategy at least in Greece.CONCLUSION:Insertion of uncovered SEMSs or plastic stents is a safe and effective treatment for occluded uncovered SEMSs;insertion of plastic stents appears to be the most cost-effective strategy.

Numerical and experimental analyses for bearing capacity of rigid strip footing subjected to eccentric load

A footing may get an eccentric load caused by earthquake or wind, thus the bearing capacity of footing subjected to eccentric load become a fundamental geotechnical problem. The conventional limit equilibrium method used for this problem usually evaluates the material properties only by its final strength. But the classical finite element method(FEM) does not necessarily provide a clear collapse mechanism associated with the yield condition of elements. To overcome these defects, a numerical procedure is proposed to create an explicit collapse mode combining a modified smeared shear band approach with a modified initial stress method. To understand the practical performance of sand foundation and verify the performance of the proposed procedure applied to the practical problems, the computing results were compared with the laboratory model tests results and some conventional solutions. Furthermore, because the proposed numerical procedure employs a simple elasto-plastic model which requires a small number of soil parameters, it may be applied directly to practical design works.

COMPARISON OF THE EFFECTS OF LOSARTAN,ENALAPRIL AND THEIR COMBINATION IN THE PREVENTION OF LEFT VENTRICULAR REMODELING AFTER ACUTE MYOCARDIAL INFARCTION IN THE RAT

Objectives. To compare the effects of losartan, enalapril and their combination in the prevention ofleft ventricular remodeling (LVRM) after acute myocardial infarction (AMI) in the rat. Methods. AMI model was induced in female SD rats by ligating left coronary artery. Forty-eight hours after the procedure, 83 surviving rats were randomized into one of the following 4 groups: 1 ) AMI control group (n =19), 2) losartan group (n= 22, 3 mg @ kg - 1 @ d - 1 ), 3 ) enalapril group (n = 20, 1 mg @ kg - 1 @ d - 1 ), 4) losartan - enalapril combinative group (n = 22, 3 and 1 mg @ kg- 1 @ d - 1 respectively). 5 ) sham-operated group ( n =10) and 6) normal rats group (n = 10) were selected randomly to serve as non-infarction controls. Losartan and enalapril were delivered by direct gastric gavage. After 4 weeks of medical therapy, hemodynamic studies were performed in each group, then the rat hearts were fixed with 10% formalin and pathologic analysis on them was performed. Complete experimental data was obtained in 56 rats, comprising 1 ) AMI controls (n = 11 ), 2) losartan group (n = 10), 3 ) enalapril group (n = 10), 4) the combination of losartan and enalapril group (n = 11 ),5) sham - operated group (n = 6) and 6) normal controls (n=8). Results. There were no significant differences among the 4 AMI groups in MI size (41.7% ～ 43.4%, all P＞ 0.05). Compared with sham group, the left ventricular (LV) end diastolic pressure (LVEDP), volume (LVV), long and short axis length (L and D), as well as LV absolute and relative weight (LVAW and LVRW)in AMI group were all significantly increased ( P ＜0.05 ～ 0. 001 ); whereas the maximum left ventricular pressure rising and droping rates ( + dp/dt) and their corrected values by LV systolic pressure ( + dp/dt/LVSP)were significantly reduced (all P ＜0.001 ), indicating LVRM occurred and LV systolic and diastolic function impaired after AMI. Compared with AMI group , LVEDP, LVV, LVAW and LVRW were all significantly decreased (P ＜0.05～0.001 ); while + dp/dt/LVSP were significantly enhanced in all 3 treatment groups (P ＜0.05～0.001 ) except -dp/dt/LVSP in losartan group (P＞ 0. 05 ). There were no significant differences in the above indices among the 3 treatment groups (all P＞ 0.05). Conclusion. Both losartan and enalapril can prevent from LVRM after AMI in the rat and improve LV function with equivalent effects. There seems no additive effect when the 2 drugs are used in combination.

Analysis of complete plasticity assumption for solid circular shaft under pure torsion and calculation of shear stress

The distribution of shear stress on the cross-section of plastic metal solid circular shaft under pure torsion yielding, the applicability of complete plastic model assumption and the shear stress formula were researched. Based on the shear stress formula of circular shaft under pure torsion in elastic stage, the formula of torque in elastic stage and the definition of yield, it is obtained that the yielding stage of plastic metal shaft under pure torsion is only a surface phenomenon of torque-torsion angle relationship, and the distribution of shear stress is essentially different from that of tensile stress when yielding under uniaxial tension. The pure torsion platform-torsion angle and the shape of torque-torsion angle curve cannot change the distribution of shear stress on the shaft cross-section. The distribution of shear stress is still linear with the maximum shear stress ts. The complete plasticity model assumption is not in accordance with the actual situation of shaft under torsion. The experimental strength data of nine plastic metals are consistent with the calculated results of the new limiting strain energy strength theory （LSEST）. The traditional yield stress formula for plastic shaft under torsion is reasonable. The shear stress formula based on the plane assumption in material mechanics is applicable for all loaded stages of torsion shaft.

Modeling and Numerical Simulation of Yield Viscoplastic Fluid Flow in Concentric and Eccentric Annuli

Numerical solution of yield viscoplastic fluid flow is hindered by the singularity inherent to the Herschel-Bulkley model. A finite difference method over the boundary-fitted orthogonal coordinate system is util- ized to investigate numerically the fully developed steady flow of non-Newtonian yield viscoplastic fluid through concentric and eccentric annuli. The fluid rheology is described with the Herschel-Bulkley model. The numerical simulation based on a continuous viscoplastic approach to the Herschel-Bulkley model is found in poor accordance with the experimental data on volumetric flow rate of a bentonite suspension. A strict mathematical model for Herschel-Bulkley fluid flow is established and the corresponding numerical procedures are proposed. However, only the case of flow of a Herschel-Bulkley fluid in a concentric annulus is resolved based on the presumed flow stnicture by using the common optimization technique. Possible flow structures in an eccentric afinulus are presumed, and further challenges in numerical simulation of the Herschel-Bulkley fluid flow are suggested.

Role of voltage-gated potassium channel α subunits in cardiovascular system

Voltage-gated ion channels(VGICs) are central to cellular excitation, orchestrating skeletal and cardiac muscle contractions and enabling neural signal transduction. Among these, voltage-gated potassium(Kv) channels are particularly significant in cardiac electrophysiology, especially during the repolarization phase of the cardiac action potential. In cardiac myocytes, Kv channels are integral to a multitude of sophisticated functions, including electrical conduction. Despite their importance, research on Kv channels in the context of cardiovascular diseases is limited. This review offers a comprehensive summary of the structural complexities of Kv channels, delineating the regulatory mechanisms involved in channel gating, expression, and membrane localization. Additionally, we examine the role of different Kv α-subunits in modulating Kv channels and their impact on cardiac remodeling, and assess the potential of targeting Kv channels for the development of anti-arrhythmic therapies.

Effect of Huanglian Jiedu Decoction on cardiac endoplasmic reticulum stress in spontaneously hypertensive rats

Huanglian Jiedu Decoction(HLJDD)is a quintessential prescription renowned for its heat-clearing and detoxifying properties.It is primarily prescribed to counteract the syndrome characterized by the excessive heat of the Sanjiao fire.Notably,the hyperactivity of liver fire is frequently linked with hypertension,where wind fire and wind toxicity emerge as pivotal pathogenic factors.This study aimed to investigate the impact of HLJDD on the endoplasmic reticulum in spontaneously hypertensive rats(SHR),further delving into the interplay between endoplasmic reticulum stress(ERS)and myocardial remodeling and damage.Fifty SHR rats were stratified randomly into five cohorts:model,low-dose HLJDD,medium-dose HLJDD,high-dose HLJDD,and captopril groups.For comparison,a set of Wistar-Kyoto(WKY)rats served as the baseline control group,with each group comprising 10 rats.While the model and control groups received equivalent volumes of normal saline via gavage,the other groups were administered the respective drug dosages through the same route daily for a span of 6 weeks.Upon the experiment’s conclusion,metrics such as the heart mass index(HWI)and left ventricular mass index(LVWI)were assessed.Cardiac tissue anomalies were identified using H&E staining,while ERS-related protein and mRNA expression levels were ascertained via Western blotting analysis and qPCR.Moreover,TUNEL staining was employed to detect cardiomyocyte apoptosis.The findings indicated that increasing HLJDD concentrations corresponded with escalated HWI and LVWI in rat hearts(P<0.05).There was a marked enhancement in myocardial structural integrity,accompanied by a notable reduction in collagen fibers.The mRNA and protein expressions of myocardial inositol-dependent enzyme 1α(IRE1α),X-box binding protein 1(XBP1),glycoregulatory protein 78(GRP78),and CCAAT enhancer binding protein homologous protein(CHOP)in the medium and high-dose groups saw significant declines(P<0.05).These effects mirrored those observed in the captopril group.The study underscored HLJDD’s efficacy in mitigating myocardial tissue damage in SHR.This therapeutic effect was potentially attributed to the downregulation of IRE1α,XBP1,GRP78,and CHOP,curbing excessive ERS,diminishing cardiomyocyte apoptosis,and thereby conferring cardioprotection.

谈谈德育工作中的沟通艺术

在德育工作中,最重要的就是心与心的沟通,就是要温暖感化心灵和塑造心灵。为此,在开学之初重在收心,既要收家长的,更要收学生的心。在教育过程中重在读心,加强与学生的沟通与理解。在解决学生问题时重在暖心,让学生每时每刻都感受到老师的关心爱护。最终的教育目标重在塑心,把学生培养成有用之才。

Antihypertension and anti-cardiovascular remodeling by phenylalanine in spontaneously hypertensive rats: effectiveness and mechanisms

odeling · mechanismObjective To investigate mechanisms of anti hypertension and anti cardiovascular remodeling by phenylalanine (phe) in spontaneously hypertensive rats (SHRs) Methods The comparison of blood pressure (BP) increment with the ages and cardiovascular changes of SHRs was made between the 3% phe intervented group (SHR phe) and the control SHRs group Detection of the structural changes with the VIDAS digital vedio frequency processing technique and light and electron microscopy were made The cell growth and proliferation of cultured smooth muscle cells (CSMCs) of the thoracic aortas or myocardial fibroblasts were evaluated by measuring the 3 H thymidine counts per minute (cpm) incorporated into the new synthesized desoxyribonucleic acid (DNA) and determining the cell number with the crystal violet stain technique The Ca 2+ influx was measured in counts/min of 45 CaCl 2 after incubating it with 5 different concentrations of phenylalanine and the intracellular [Ca 2+ ] i by Fura Ⅱ/Am indicator The total messenger ribonucleic acid (mRNA) of the myocardium was extracted and Northern blot analysis was performed with the probe collagen α 2(Ⅰ)cDNA The tyrosine hydroxylase (TH) activity was measured by high performance liquid chromatography (HPLC) with electrochemical detector after having reacted with its substrate tyrosine and other reagents The catecholamine contents in brain homogenat were detected by HPLC method The comparison of pharmacokinetics of phenylalanine among SHR phe, SHRs and control Wistar Kyoto (WKY) rats was made after intravenous injection of 3 H L phe (1?ml/kg) by PK GRAPH Program for kinetic calculation The 3H L phe uptake by CSMCs after incubating for difinite intervals was also detected and compared Results Phenylalanine could prevent the increase of BP with ages and the heart weight (heart/body weight index) The aortic media thickness and the collagen content in the myocardium were decreased significantly in SHR phe Whereas the dearranged cardiovascular structure was much improved The mechanisms might be direct and specific inhibition of the DNA synthesis and proliferation of cardiovascular cells which may be related to the inhibition of collagen α 2(Ⅰ)cDNA, c fos and c myc expression Other mechanisms may include decrease of intracellular [Ca 2+ ] i and an inhibition of central sympathetic activity due to the results of higher TH activity in the caudate nucleus and higher adrenaline content in the posterior hypothalamus Besides, partial recovery of phenylalanine metabolic aberrants existed in SHRs seems to be another possibility for its effectiveness Conclusions Phenylalanine intervention could exert a definite anti hypertension and anti cardiovascular remodeling effects on SHRs like seen in human essential hypertension Its mechanisms might be related to direct inhibition of growth in the cardiovascular cells, decrease of central sympathetic activity, the reverse of the exhibited phenylalanine metabolic aberrants in SHRs, and a decrement of intracellular [Ca 2+ ] i

这技艺 怎一个“奇”字了得——《泥人张》教学谈

以《泥人张》教学为例,通过“创设情境富乐趣、关键词句巧聚焦、咬文嚼字细思量、大智若愚塑身心”四个步骤整合课程资源,“创造性地理解和使用教材”,落实学科核心素养,使语文教学常教常新,焕发出新的活力。

“五育”课程体系的建构与实施

全面育人的关键在于实现学生德智体美劳全面发展,中宁县第三小学落实“五育”工作,以“1+X”课程体系为抓手,从学生的发展需求出发,保障“五育”工作更加有效,更加生动活泼。