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增强声环境中嗅球神经前体细胞在耳蜗核的迁移 被引量:2
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作者 陈阳 刘顺利 +4 位作者 陈福权 乔莉 卢连军 邱建华 米文娟 《中华耳科学杂志》 CSCD 2008年第1期104-108,共5页
目的观察增强声环境中移植到大鼠耳蜗核的嗅球神经前体细胞的迁移特点,是否产生部位特异性的修复过程。方法培养嗅球神经前体细胞取自孕14-16d胚胎大鼠,荧光染色Hoechst33342标记后移植到成年大鼠的耳蜗核内侧缘。移植大鼠分为A、B两组,... 目的观察增强声环境中移植到大鼠耳蜗核的嗅球神经前体细胞的迁移特点,是否产生部位特异性的修复过程。方法培养嗅球神经前体细胞取自孕14-16d胚胎大鼠,荧光染色Hoechst33342标记后移植到成年大鼠的耳蜗核内侧缘。移植大鼠分为A、B两组,A组置于增强声环境,B组在正常环境中饲养。14d取材观察移植细胞的迁移和分化。结果A组移植细胞有沿听觉神经通路移动的趋势。免疫荧光技术观察到Hoechst33342和神经元核蛋白(NeuN)、谷氨酸阳性三重标记的移植细胞。结论嗅球神经前体细胞移植耳蜗核短期存活良好,增强声刺激可能促进前体细胞在听觉系统的迁移。 展开更多
关键词 干细胞 嗅球 神经元 移植 增强声环境
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Improved speech absence probability estimation based on environmental noise classification 被引量:2
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作者 SON Young-ho LEE Sang-min 《Journal of Central South University》 SCIE EI CAS 2012年第9期2548-2553,共6页
An improved speech absence probability estimation was proposed using environmental noise classification for speech enhancement.A relevant noise estimation approach,known as the speech presence uncertainty tracking met... An improved speech absence probability estimation was proposed using environmental noise classification for speech enhancement.A relevant noise estimation approach,known as the speech presence uncertainty tracking method,requires seeking the "a priori" probability of speech absence that is derived by applying microphone input signal and the noise signal based on the estimated value of the "a posteriori" signal-to-noise ratio(SNR).To overcome this problem,first,the optimal values in terms of the perceived speech quality of a variety of noise types are derived.Second,the estimated optimal values are assigned according to the determined noise type which is classified by a real-time noise classification algorithm based on the Gaussian mixture model(GMM).The proposed algorithm estimates the speech absence probability using a noise classification algorithm which is based on GMM to apply the optimal parameter of each noise type,unlike the conventional approach which uses a fixed threshold and smoothing parameter.The performance of the proposed method was evaluated by objective tests,such as the perceptual evaluation of speech quality(PESQ) and composite measure.Performance was then evaluated by a subjective test,namely,mean opinion scores(MOS) under various noise environments.The proposed method show better results than existing methods. 展开更多
关键词 speech enhancement soft decision speech absence probability Gaussian mixture model (GMM)
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