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血管平滑肌细胞增殖抑制剂的研究进展 被引量:1
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作者 曾嵘 李进 《解剖科学进展》 CAS 1996年第3期193-197,共5页
血管平滑肌细胞增殖是动脉粥样硬化、高血压和血管成形术后再狭窄等心血管疾病的核心病理过程。寻找平滑肌细胞增殖的刺激因子和抑制因子将有助于对其发病机制的研究和防治工作,故该研究已成为近年文献报道中的热点.本文概述了肝素、... 血管平滑肌细胞增殖是动脉粥样硬化、高血压和血管成形术后再狭窄等心血管疾病的核心病理过程。寻找平滑肌细胞增殖的刺激因子和抑制因子将有助于对其发病机制的研究和防治工作,故该研究已成为近年文献报道中的热点.本文概述了肝素、前列腺素、cAMP、钙通道阻滞剂、干扰素和雌激素等血管平滑肌细胞增殖的抑制剂的主要作用和研究进展。 展开更多
关键词 血管平滑肌细胞 细胞增殖抑制剂 血管成形术 心血管疾病
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HIV增殖抑制剂研究现状
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作者 臧星星 钱伯初 《现代应用药学》 CSCD 1989年第1期41-43,7,共4页
自1981年美国首次报道AIDS以来,未曾有任何疾病象AIDS那样受到世界各国的高度重视,我国境内也已发现5例AIDS病例和11例抗体阳性者。自从1983—1984年发现AIDS的病原体是人类免疫缺陷病毒(HIV)后,短短数年间已积累了相当的知识。现已明瞭... 自1981年美国首次报道AIDS以来,未曾有任何疾病象AIDS那样受到世界各国的高度重视,我国境内也已发现5例AIDS病例和11例抗体阳性者。自从1983—1984年发现AIDS的病原体是人类免疫缺陷病毒(HIV)后,短短数年间已积累了相当的知识。现已明瞭,HIV是一种逆转录病毒,通过CD_4受体侵入T辅助细胞(T_H,OKT_4^+),经逆转录酶作用形成DNA,以前病毒形式整合到淋巴细胞染色体中,后经mRNA转译为病毒蛋白而装配成病毒颗粒,从而杀死T_H细胞导致机体免疫功能崩溃。由于AIDS疫苗的研究尚未取得突破性进展,所以寻找HIV增殖抑制剂便成为举世瞩目的课题。 展开更多
关键词 HIV 增殖抑制剂
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肿瘤血管生成抑制剂的临床研究现状
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作者 李喆 华积德 +1 位作者 闻兆章 曹贵松 《医师进修杂志》 北大核心 2003年第7期54-56,共3页
关键词 肿瘤血管生成抑制 临床研究 现状 基质金属蛋白酶抑制 血管内皮细胞增殖抑制剂
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内皮抑素及其抗肿瘤作用的研究进展 被引量:1
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作者 张贺诚 王凯 +1 位作者 黄涛 申宝忠 《实用肿瘤学杂志》 CAS 2005年第4期305-309,共5页
关键词 内皮抑素 抗肿瘤作用 血管内皮细胞增殖抑制剂 抑制肿瘤生长 新生血管形成 血管形成抑制 负性调节作用 血管生成 种特异性
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Effect of Nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells 被引量:51
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作者 Geng Tian Jie-Ping Yu He-Sheng Luo Bao-Ping Yu Hui Yue Jian-Ying Li Oiao Mei,Gastroenterology department,Renmin hospital of Wuhan university,Wuhan 430060,Hubei Province,China 《World Journal of Gastroenterology》 SCIE CAS CSCD 2002年第3期483-487,共5页
AIM: Cyclooxygenase-2 (COX-2) has been suggested to be associated with carcinogenesis. We sought to investigate the effect of the selective COX-2 inhibitor, Nimesulide on proliferation and apoptosis of SMMC-7721 human... AIM: Cyclooxygenase-2 (COX-2) has been suggested to be associated with carcinogenesis. We sought to investigate the effect of the selective COX-2 inhibitor, Nimesulide on proliferation and apoptosis of SMMC-7721 human hepatoma cells.METHODS: This study was carried out on the culture of hepatic carcinoma SMMC-7721 cell line. Various concentrations of Nimesulide (0, 200 micromol/L, 300 micromol/L, 400 micromol/L) were added and incubated. Cell proliferation was detected with MTT colorimetric assay, cell apoptosis by electron microscopy, flow cytometry and TUNEL.RESULTS: Nimesulide could significantly inhibit SMMC-7721 cells proliferation dose-dependent and in a dependent manner compared with that of the control group. The duration lowest inhibition rate produced by Nimesulide in SMMC-7721 cells was 19.06%, the highest inhibition rate was 58.49%. After incubation with Nimesulide for 72 h, the most highest apoptosis rate and apoptosis index of SMMC-7721 cells comparing with those of the control were 21.20%+/-1.62% vs 2.24%+/-0.26% and 21.23+/-1.78 vs 2.01+/-0.23 (P【0.05). CONCLUSION:The selective COX-2 inhibitor, Nimesulide can inhibit the proliferation of SMMC-7721 cells and increase apoptosis rate and apoptosis index of SMMC-7721 cells. The apoptosis rate and the apoptosis index are dose-dependent. Under electron microscope SMMC-7721 cells incubated with 300 micromol and 400 micromol Nimesulide show apoptotic characteristics. With the clarification of the mechanism of selective COX-2 inhibitors, These COX-2 selective inhibitors can become the choice of prevention and treatment of cancers. 展开更多
关键词 Apoptosis Carcinoma Hepatocellular control Cell Division Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Humans ISOENZYMES inhibitors Liver Neoplasms Membrane Proteins Prostaglandin-Endoperoxide Synthases SULFONAMIDES Tumor Cells Cultured
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Time delays in proliferation process for solid avascular tumor under the action of external inhibitors
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作者 Shihe Xu Meng Bai 《International Journal of Biomathematics》 2015年第2期77-89,共13页
In this paper a delayed mathematical model for tumor growth under the action of external inhibitors is studied. The delay represents the time taken for cells to undergo mitosis. External inhibitor means that an inhibi... In this paper a delayed mathematical model for tumor growth under the action of external inhibitors is studied. The delay represents the time taken for cells to undergo mitosis. External inhibitor means that an inhibitor is either developed from the immune system of the body or administered by medical treatment to distinguish with that secreted by tumor itself. Non-negativity of solutions is studied. Local and global stabilities of the stationary solutions are proved for some parameter values. The analysis of the effect of inhibitor's parameters on tumor's growth is presented. The results show that dynamical behavior of solutions of this model is similar to that of solutions for corresponding nondelayed model for some parameter values. 展开更多
关键词 Tumor growth INHIBITORS time delay local stability global stability.
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Regulatory Action of Charred Gossamer Urocteae on the Functions of Mouse Oral Fibroblasts
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作者 代剑平 陈钧 +3 位作者 韩邦兴 贝宇飞 周晓坤 王友京 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2010年第2期126-131,共6页
Objective: To explore the influence of charred Gossamer urocteae (CGU) on the functions of primary cultured mouse oral fibroblasts and reveal its mechanism in wound healing. Methods: CGU was extracted with differe... Objective: To explore the influence of charred Gossamer urocteae (CGU) on the functions of primary cultured mouse oral fibroblasts and reveal its mechanism in wound healing. Methods: CGU was extracted with different solvents and ethanol extract (EE), ethyl acetate fraction (EF), n-butanol fraction (BF) and aqueous fraction (AF) were obtained. The effects of different fractions on the proliferation, matrix metaUoproteinase-2,9 (MMP-2,9) activities, synthesis of collagen and tissue inhibitor of metalloproteinase 1 (TIMP-1) in the mouse oral fibroblasts were determined by MTT, gelatin zymography, chloramine-T method, and enzyme-linked immunosorbent assay (ELISA) respectively. Results: EE, EF and BF at high concentrations could significantly inhibit proliferation of fibroblasts (P〈0.05 or P〈0.01), and at low concentrations EF and BF could promote proliferation of fibroblasts, and BF and AF could significantly inhibit collagen synthesis (P〈0.05 or P〈0.01). EE, EF and AF at high concentrations could significantly increase the MMP-9 activity, and BF and AF could significantly inhibit synthesis of TIMP-1. Conclusion: CGU at high concentrations can inhibit the proliferations of fibroblasts and synthesis of collagen, and in healing of wound, CGU at high concentrations possibly has the functions of anti-fibrosis and anti-scar, and the mechanism to promote degradation of collagen is possibly related to the increase in MMP-9 activity and the inhibition of TIMP-1 synthesis. 展开更多
关键词 collagen synthesis mouse oral fibroblast matrix metalloproteinase-2 9 (MMP-2 9) tissueinhibitor of metalloproteinase 1 (TIMP- 1)
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