Coordinated numerical ensemble experiments with six different state-of-the-art atmosphere models were used to evaluate and quantify the impact of global SST(from reanalysis data)on the early winter Arctic warming duri...Coordinated numerical ensemble experiments with six different state-of-the-art atmosphere models were used to evaluate and quantify the impact of global SST(from reanalysis data)on the early winter Arctic warming during 1982-2014.Two sets of experiments were designed:in the first set(EXP1),OISSTv2 daily sea-ice concentration and SST variations were used as the lower boundary forcing,while in the second set(EXP2)the SST data were replaced by the daily SST climatology.In the results,the multi-model ensemble mean of EXP1 showed a nearsurface(~850 hPa)warming trend of 0.4℃/10 yr,which was 80%of the warming trend in the reanalysis.The simulated warming trend was robust across the six models,with a magnitude of 0.36-0.50℃/10 yr.The global SST could explain most of the simulated warming trend in EXP1 in the mid and low troposphere over the Arctic,and accounted for 58%of the simulated near-surface warming.The results also suggest that the uppertropospheric warming(~200 hPa)over the Arctic in the reanalysis is likely not a forced signal;rather,it is caused by natural climate variability.The source regions that can potentially impact the early winter Arctic warming are explored and the limitations of the study are discussed.展开更多
In the past 30 years, China has gone from the transformation from a planned economy to a market economy, from the extensive economic growth mode to intensive economic growth model, and from relying on investment and e...In the past 30 years, China has gone from the transformation from a planned economy to a market economy, from the extensive economic growth mode to intensive economic growth model, and from relying on investment and export-led economy to relying on domestic demand and stimulating economic. China＇s economic transformation includes three parts： The first is the reform of economic system, the second is the change in the pattern of economic growth and the third is the adjustment of economic structure. This article describes the historical evolution and the reality of China＇s economic transformation, analysis the obstacles to China＇s economic transformation, and on this basis, put forward some suggestions.展开更多
The content of China＇s economic transformation is not single, and this article argues that it includes three parts. The first is the reform of economic system, the second is the change in the pattern of economic grow...The content of China＇s economic transformation is not single, and this article argues that it includes three parts. The first is the reform of economic system, the second is the change in the pattern of economic growth, and the third is the adjustment of economic structure. Government is the leading force of China＇s economic transformation, and repeated reform of government institutions has brought about some changes to government functions. But problems are obvious that lag changes of government functions have become an obstacle in China＇s economic transformation. This article describes the historical evolution and the reality of China＇s economic transformation, and analyzes the main reasons of lag changes in government functions, and reveals that the transformation of government functions is the key for successful transformation of China＇s economy.展开更多
We have studied 172 field-aligned currents （FACs） cases observed by the ClusterlI satellites when they crossed the plasma sheet boundary layer （PSBL） in the magnetotail from July to October 2001. We mainly analyze...We have studied 172 field-aligned currents （FACs） cases observed by the ClusterlI satellites when they crossed the plasma sheet boundary layer （PSBL） in the magnetotail from July to October 2001. We mainly analyzed the relationship between the characteristic of FACs at the PSBL in magnetotail and the Kp index. The main results indicated the followings： 1） In the different geomagnetic activity levels, the relative occurrence of FACs in PSBL increased monotonically with geomagnetic activity. 2） The density of FACs in PSBL increased monotonically with Kp index. In the storm main phase, the density of FACs increased dramatically, the maximum FACs approximately equaled 19.05 nA m-2 while Kp equaled 5.3） The variation of FACs density in PSBL was consistent with the variation of the Kp index. However, when AE〈800 nT, FACs density in PSBL increased with increasing AE, and when AE〉800 nT, it decreased with increasing AE. Therefore, our results suggested that the FACs density in PSBL had a closer correlation with Kp index.展开更多
Aerobic glycolysis,also known as the Warburg effect,is a hallmark of cancer and essential for metabolism in malignancies,but its regulation and modulation in cancer cells remain poorly understood.Here,using large-scal...Aerobic glycolysis,also known as the Warburg effect,is a hallmark of cancer and essential for metabolism in malignancies,but its regulation and modulation in cancer cells remain poorly understood.Here,using large-scale functional screening,we identified a tumor-associated and broadly expressed oncogenic long noncoding RNA LINC00973.Notably,knocking down LINC00973 significantly inhibits the proliferation of multiple types of cancer cells and reduces tumor growth in vivo.Mechanistically,LINC00973 directly binds to lactate dehydrogenase A(LDHA),an essential glycolytic enzyme,and enhances its enzymatic activity,thereby promoting glycolysis.Clinically,high expression of LINC00973 is significantly associated with poor prognosis in many types of human cancers.This work demonstrates that LINC00973 modulates cancer-specific regulation of the Warburg effect,and may represent a potential target for broad-acting anti-cancer therapies.展开更多
基金supported by the National Key R&D Program of China[grant number 2017YFE0111800]the National Natural Science Foundation of China[grant numbers 41790472 and 41661144005]partly supported by the EU H2020 Blue-Action project[grant number 727852]。
文摘Coordinated numerical ensemble experiments with six different state-of-the-art atmosphere models were used to evaluate and quantify the impact of global SST(from reanalysis data)on the early winter Arctic warming during 1982-2014.Two sets of experiments were designed:in the first set(EXP1),OISSTv2 daily sea-ice concentration and SST variations were used as the lower boundary forcing,while in the second set(EXP2)the SST data were replaced by the daily SST climatology.In the results,the multi-model ensemble mean of EXP1 showed a nearsurface(~850 hPa)warming trend of 0.4℃/10 yr,which was 80%of the warming trend in the reanalysis.The simulated warming trend was robust across the six models,with a magnitude of 0.36-0.50℃/10 yr.The global SST could explain most of the simulated warming trend in EXP1 in the mid and low troposphere over the Arctic,and accounted for 58%of the simulated near-surface warming.The results also suggest that the uppertropospheric warming(~200 hPa)over the Arctic in the reanalysis is likely not a forced signal;rather,it is caused by natural climate variability.The source regions that can potentially impact the early winter Arctic warming are explored and the limitations of the study are discussed.
文摘In the past 30 years, China has gone from the transformation from a planned economy to a market economy, from the extensive economic growth mode to intensive economic growth model, and from relying on investment and export-led economy to relying on domestic demand and stimulating economic. China＇s economic transformation includes three parts： The first is the reform of economic system, the second is the change in the pattern of economic growth and the third is the adjustment of economic structure. This article describes the historical evolution and the reality of China＇s economic transformation, analysis the obstacles to China＇s economic transformation, and on this basis, put forward some suggestions.
文摘The content of China＇s economic transformation is not single, and this article argues that it includes three parts. The first is the reform of economic system, the second is the change in the pattern of economic growth, and the third is the adjustment of economic structure. Government is the leading force of China＇s economic transformation, and repeated reform of government institutions has brought about some changes to government functions. But problems are obvious that lag changes of government functions have become an obstacle in China＇s economic transformation. This article describes the historical evolution and the reality of China＇s economic transformation, and analyzes the main reasons of lag changes in government functions, and reveals that the transformation of government functions is the key for successful transformation of China＇s economy.
基金supported by the National Natural Science Foundation of China (Grant Nos. 40804031, 41074114, 40921063)the Specialized Research Fund for State Key Laboratories
文摘We have studied 172 field-aligned currents （FACs） cases observed by the ClusterlI satellites when they crossed the plasma sheet boundary layer （PSBL） in the magnetotail from July to October 2001. We mainly analyzed the relationship between the characteristic of FACs at the PSBL in magnetotail and the Kp index. The main results indicated the followings： 1） In the different geomagnetic activity levels, the relative occurrence of FACs in PSBL increased monotonically with geomagnetic activity. 2） The density of FACs in PSBL increased monotonically with Kp index. In the storm main phase, the density of FACs increased dramatically, the maximum FACs approximately equaled 19.05 nA m-2 while Kp equaled 5.3） The variation of FACs density in PSBL was consistent with the variation of the Kp index. However, when AE〈800 nT, FACs density in PSBL increased with increasing AE, and when AE〉800 nT, it decreased with increasing AE. Therefore, our results suggested that the FACs density in PSBL had a closer correlation with Kp index.
基金This work was supported by the National Natural Science Foundation of China(31371314 and 81673460)Sichuan Youth Science and Technology Innovation Research Team of Experimental Formulology(2020JDTD0022).
文摘Aerobic glycolysis,also known as the Warburg effect,is a hallmark of cancer and essential for metabolism in malignancies,but its regulation and modulation in cancer cells remain poorly understood.Here,using large-scale functional screening,we identified a tumor-associated and broadly expressed oncogenic long noncoding RNA LINC00973.Notably,knocking down LINC00973 significantly inhibits the proliferation of multiple types of cancer cells and reduces tumor growth in vivo.Mechanistically,LINC00973 directly binds to lactate dehydrogenase A(LDHA),an essential glycolytic enzyme,and enhances its enzymatic activity,thereby promoting glycolysis.Clinically,high expression of LINC00973 is significantly associated with poor prognosis in many types of human cancers.This work demonstrates that LINC00973 modulates cancer-specific regulation of the Warburg effect,and may represent a potential target for broad-acting anti-cancer therapies.
