Both exercise and aging increase reactive oxygen species (ROS), which can result in damage to cells. Aging is the result of damage caused by ROS to the mitochondrial genome in post mitotic cells and numerous studies...Both exercise and aging increase reactive oxygen species (ROS), which can result in damage to cells. Aging is the result of damage caused by ROS to the mitochondrial genome in post mitotic cells and numerous studies have demonstrated an increase in ROS or their byproducts with exercise. ROS can cause oxidative stress as they overwhelm the antioxidant cellular defenses. Therefore interventions aimed at limiting or inhibiting ROS production, such as supplementation with antioxidant vitamins, should be able to reduce fatigue during muscle contraction and the rate of formation of aging changes with a consequent reduction of the aging rate and disease pathogenesis. However, it has been shown that ROS are essential signaling molecules which are required to promote the health benefits of exercise and longevity. In young individuals, ROS are required for normal force production in skeletal muscle, for the development of training-induced adaptations in endurance performance, as well as for the induction of the endogenous defense systems. Thus, taking antioxidants during training, in young athletes, seems to be detrimental. However, antioxidant supplementation may be expected to be beneficial and is receiving growing attention in the active old population. In this manuscript we review the literature associated with the main areas of interest in this topic.展开更多
Objective: The aim of the study was to analyze the CT morphology features of pulmonary sclerosing hemangiomas (PSHs) and improve the diagnosis ability of this disease.Methods: The 18 cases of pulmonary sclerosing hema...Objective: The aim of the study was to analyze the CT morphology features of pulmonary sclerosing hemangiomas (PSHs) and improve the diagnosis ability of this disease.Methods: The 18 cases of pulmonary sclerosing hemangioma (PSH) confirmed by operation and histopathology from August 2002 to May 2009 were collected,including 17 females and 2 males,aged from 19 to 60 years old,with an average age of 43 years.All the cases underwent plain CT scan,among them,16 cases received enhanced CT scan.Results: The 18 cases had isolated mass.Mean long-axis diameter of these lesions was (2.7 ± 1.3) cm (range,1.9–4.2 cm).Of all cases,5 cases (27.8%) were round in shape,9 cases (50%) were oval,4 cases (22.2%) were lobulated,and 14 cases (77.8%) were smooth margin.The air meniscus sign was in 2 cases (11.1%),and the halo sign in 3 cases (16.7%).Two cases (11.1%) contained small nodular calcification,the remaining 16 cases (70%) were homogeneous density,the CT density of the masses ranged from 24–47 HU,and the mean value was 35 HU.Sixteen cases received enhanced scan,the welt vessel sign was in 8 cases (44.4%),1 case showed less enhancement,5 cases showed marked homogeneous enhancement and 10 cases showed intense and patchy heterogeneous enhanced.The CT density of the enhancing masses ranged from 60–110 HU,the mean value was 35 HU,and the net enhancement value was 14–80 HU,the mean value was 55 HU.Conclusion: PSH should be considered in middle-aged female whose CT found that single round or oval pulmonary nodules,with smooth margin,or associated with the air meniscus sign,the halo sign,or the marked enhancement.展开更多
Objective: The association between gut microbiota composition and biomarkers of immune activation and inflammation was assessed in the elderly. Patients: Serum inflammation markers of fifty-five outpatients (29 fem...Objective: The association between gut microbiota composition and biomarkers of immune activation and inflammation was assessed in the elderly. Patients: Serum inflammation markers of fifty-five outpatients (29 females, 26 males, aged 78 + 8.5 years) were analyzed. Stool specimens and thus data on gut microbiota were available from a subgroup of 23 individuals (9 females and 14 males). Results: Global cerebral atrophy was found in all magnet resonance tomography scans. Mean mini-mental-score examination in Alzheimer's disease patients was 18.8 ± 7.1, in patients with mild cognitive impairment 27.8 ± 1.5. Serum neopterin concentrations correlated with concentrations of fecal S100A12 (p 〈 0.001) and cq-antitrypsin (p 〈 0.05). Faecalibacterium prausnitzii correlated with MMSE (p 〈 0.05), with Akkermansia muciniphila (p 〈 0.01) and with serum neopterin (p 〈 0.05). Fecal zonulin correlated inversely with Clostridium cluster I (p 〈 0.02). Conclusions: Our results underline earlier in vitro and animal studies that cognitive decline associates with age-related changes in the intestinal microbiota and neuroinflammation. However, only correlational evidence can be reported, and a causative relationship still has to be demonstrated.展开更多
This paper analyzes the current situation of the aging population and low fertility rate.lt is found that the aging process is accelerated, the population growth potential is decreased, and the elderly dependency rati...This paper analyzes the current situation of the aging population and low fertility rate.lt is found that the aging process is accelerated, the population growth potential is decreased, and the elderly dependency ratio is higher.Secondly, this paper mainly analyzes the impact of the new two-child policy on family pension security from three aspects: population policy, family support and social security.There are two aspects of the effects, the positive effects are:improve fertility, reduce elderly dependency ratio, relieve population aging,enhance the family development: the negative effects are: tremendous pressure on public resources, further inequality in birth right, heavy economic pressure on the family.At last. this paper puts forward the constructive countermeasures against the problems of the policy and the was out of the family old-age security.展开更多
基金supported by grants SAF2010-19498 from the Spanish Ministry of Education and Science(MEC(gsl))ISCIII2006-RED13-027 from the Red Tematica de investigacion cooperativa en envejecimiento y fragilidad (RETICEF(gs2))+3 种基金P2011/02 RM from Catedra Real Madrid-UEM (gs3)PROMETEO2010/074 from Conselleria de Sanitat de la Generalitat Valenciana(gs4)35NEURO Gentx Gent from Fundacio Gent Per Gent de la Comunitat Valenciana(gs5) and EU(gs6) Funded COSTB35 and CM 1001co-financed by funds from the European Union
文摘Both exercise and aging increase reactive oxygen species (ROS), which can result in damage to cells. Aging is the result of damage caused by ROS to the mitochondrial genome in post mitotic cells and numerous studies have demonstrated an increase in ROS or their byproducts with exercise. ROS can cause oxidative stress as they overwhelm the antioxidant cellular defenses. Therefore interventions aimed at limiting or inhibiting ROS production, such as supplementation with antioxidant vitamins, should be able to reduce fatigue during muscle contraction and the rate of formation of aging changes with a consequent reduction of the aging rate and disease pathogenesis. However, it has been shown that ROS are essential signaling molecules which are required to promote the health benefits of exercise and longevity. In young individuals, ROS are required for normal force production in skeletal muscle, for the development of training-induced adaptations in endurance performance, as well as for the induction of the endogenous defense systems. Thus, taking antioxidants during training, in young athletes, seems to be detrimental. However, antioxidant supplementation may be expected to be beneficial and is receiving growing attention in the active old population. In this manuscript we review the literature associated with the main areas of interest in this topic.
文摘Objective: The aim of the study was to analyze the CT morphology features of pulmonary sclerosing hemangiomas (PSHs) and improve the diagnosis ability of this disease.Methods: The 18 cases of pulmonary sclerosing hemangioma (PSH) confirmed by operation and histopathology from August 2002 to May 2009 were collected,including 17 females and 2 males,aged from 19 to 60 years old,with an average age of 43 years.All the cases underwent plain CT scan,among them,16 cases received enhanced CT scan.Results: The 18 cases had isolated mass.Mean long-axis diameter of these lesions was (2.7 ± 1.3) cm (range,1.9–4.2 cm).Of all cases,5 cases (27.8%) were round in shape,9 cases (50%) were oval,4 cases (22.2%) were lobulated,and 14 cases (77.8%) were smooth margin.The air meniscus sign was in 2 cases (11.1%),and the halo sign in 3 cases (16.7%).Two cases (11.1%) contained small nodular calcification,the remaining 16 cases (70%) were homogeneous density,the CT density of the masses ranged from 24–47 HU,and the mean value was 35 HU.Sixteen cases received enhanced scan,the welt vessel sign was in 8 cases (44.4%),1 case showed less enhancement,5 cases showed marked homogeneous enhancement and 10 cases showed intense and patchy heterogeneous enhanced.The CT density of the enhancing masses ranged from 60–110 HU,the mean value was 35 HU,and the net enhancement value was 14–80 HU,the mean value was 55 HU.Conclusion: PSH should be considered in middle-aged female whose CT found that single round or oval pulmonary nodules,with smooth margin,or associated with the air meniscus sign,the halo sign,or the marked enhancement.
文摘Objective: The association between gut microbiota composition and biomarkers of immune activation and inflammation was assessed in the elderly. Patients: Serum inflammation markers of fifty-five outpatients (29 females, 26 males, aged 78 + 8.5 years) were analyzed. Stool specimens and thus data on gut microbiota were available from a subgroup of 23 individuals (9 females and 14 males). Results: Global cerebral atrophy was found in all magnet resonance tomography scans. Mean mini-mental-score examination in Alzheimer's disease patients was 18.8 ± 7.1, in patients with mild cognitive impairment 27.8 ± 1.5. Serum neopterin concentrations correlated with concentrations of fecal S100A12 (p 〈 0.001) and cq-antitrypsin (p 〈 0.05). Faecalibacterium prausnitzii correlated with MMSE (p 〈 0.05), with Akkermansia muciniphila (p 〈 0.01) and with serum neopterin (p 〈 0.05). Fecal zonulin correlated inversely with Clostridium cluster I (p 〈 0.02). Conclusions: Our results underline earlier in vitro and animal studies that cognitive decline associates with age-related changes in the intestinal microbiota and neuroinflammation. However, only correlational evidence can be reported, and a causative relationship still has to be demonstrated.
文摘This paper analyzes the current situation of the aging population and low fertility rate.lt is found that the aging process is accelerated, the population growth potential is decreased, and the elderly dependency ratio is higher.Secondly, this paper mainly analyzes the impact of the new two-child policy on family pension security from three aspects: population policy, family support and social security.There are two aspects of the effects, the positive effects are:improve fertility, reduce elderly dependency ratio, relieve population aging,enhance the family development: the negative effects are: tremendous pressure on public resources, further inequality in birth right, heavy economic pressure on the family.At last. this paper puts forward the constructive countermeasures against the problems of the policy and the was out of the family old-age security.