One of the emerging technologies is wireless handheld technology. Implication of these devices is enormous for business community and healthcare domain is not an exception to this phenomena. This research paper provid...One of the emerging technologies is wireless handheld technology. Implication of these devices is enormous for business community and healthcare domain is not an exception to this phenomena. This research paper provides some useful findings about the use of PDA＇s in the healthcare environment through actual usage of PDA in the healthcare ward. A qualitative and quantitative approach is adopted to explore these phenomena due to the exploratory nature of the research. Findings of this study identify some of the motivators and issues associated with the wireless handheld technology in healthcare environment. Furthermore, it is also found that these wireless handheld devices can help to improve the quality of care through better decision making processes. This study is limited to only one sate of Australian and further research is needed to see the implication of the findings to wider community and other domains in the Australian environment.展开更多
By adsorbing chitosan(CS)-functionalized Prussian blue(PB) nanoparticles(CS/PB NPs) complexing DNA onto the surface of gas encapsulated microbubbles(MBs), a multifunctional gene delivery system of MBs@CS/PB/DNA was fa...By adsorbing chitosan(CS)-functionalized Prussian blue(PB) nanoparticles(CS/PB NPs) complexing DNA onto the surface of gas encapsulated microbubbles(MBs), a multifunctional gene delivery system of MBs@CS/PB/DNA was fabricated for photothermally enhanced gene transfection through ultrasound-targeted microbubble destruction. CS/PB NPs of(2.69 ± 0.49) nm could complex DNA effectively when the mass ratio was2:1. It was found that MBs@CS/PB/DNA could enhance ultrasound imaging greatly both in vitro and in vivo. In addition, MBs@CS/PB/DNA could be disrupted by applying a higher-intensity ultrasound irradiation to release CS/PB/DNA, which could effectively transform the nearinfrared(NIR) light into heat to assist the uptake of CS/PB/DNA by cells. With the aid of ultrasound irradiation and NIR light irradiation, the gene transfection efficiency was significantly enhanced to(43.08 ± 1.13) %, much higher than polyethylenimine. Moreover, MBs@CS/PB/DNA showed excellent biocompatibility, encouraging the further exploration of MBs@CS/PB/DNA to be a platform for combined ultrasound image, photothermal therapy, drug delivery, and gene therapy.展开更多
文摘One of the emerging technologies is wireless handheld technology. Implication of these devices is enormous for business community and healthcare domain is not an exception to this phenomena. This research paper provides some useful findings about the use of PDA＇s in the healthcare environment through actual usage of PDA in the healthcare ward. A qualitative and quantitative approach is adopted to explore these phenomena due to the exploratory nature of the research. Findings of this study identify some of the motivators and issues associated with the wireless handheld technology in healthcare environment. Furthermore, it is also found that these wireless handheld devices can help to improve the quality of care through better decision making processes. This study is limited to only one sate of Australian and further research is needed to see the implication of the findings to wider community and other domains in the Australian environment.
基金supported by the National Natural Science Foundation of China(81371580 and 21273014)the National Natural Science Foundation for Distinguished Young Scholars(81225011)the State Key Program of National Natural Science of China(81230036)
文摘By adsorbing chitosan(CS)-functionalized Prussian blue(PB) nanoparticles(CS/PB NPs) complexing DNA onto the surface of gas encapsulated microbubbles(MBs), a multifunctional gene delivery system of MBs@CS/PB/DNA was fabricated for photothermally enhanced gene transfection through ultrasound-targeted microbubble destruction. CS/PB NPs of(2.69 ± 0.49) nm could complex DNA effectively when the mass ratio was2:1. It was found that MBs@CS/PB/DNA could enhance ultrasound imaging greatly both in vitro and in vivo. In addition, MBs@CS/PB/DNA could be disrupted by applying a higher-intensity ultrasound irradiation to release CS/PB/DNA, which could effectively transform the nearinfrared(NIR) light into heat to assist the uptake of CS/PB/DNA by cells. With the aid of ultrasound irradiation and NIR light irradiation, the gene transfection efficiency was significantly enhanced to(43.08 ± 1.13) %, much higher than polyethylenimine. Moreover, MBs@CS/PB/DNA showed excellent biocompatibility, encouraging the further exploration of MBs@CS/PB/DNA to be a platform for combined ultrasound image, photothermal therapy, drug delivery, and gene therapy.
